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The map label for this gene is dctB [H]

Identifier: 73542353

GI number: 73542353

Start: 2930458

End: 2932374

Strand: Direct

Name: dctB [H]

Synonym: Reut_A2668

Alternate gene names: 73542353

Gene position: 2930458-2932374 (Clockwise)

Preceding gene: 73542352

Following gene: 73542354

Centisome position: 76.98

GC content: 69.9

Gene sequence:

>1917_bases
ATGACCGGCCAGCCTGACCCCTTTCGTGACCCTGCCGGCGACTCTGCCAGCCATCCCGGCCATCCCGTTCCCCGCCCCGC
CGCCCTGCGCGGCGCCGCGCCGTTGCTCGCGCTGCTGGCGCTGGCGGCACTGGTCAGCCTGGCGGGATGGCTCGGCTACC
GCTACAGCTTCGACACGGCGCTGGCGCGCCAGGCCGAGCGCGGGCAGGTGCAGCTGCGCCTGTACGCGCAGGCCCTCGAA
AGCGAACTGGCGCACTACGACTACGTTCCCGGATTACTGACGCTGGACGATCGCATCGGCACGCTGCTGCGCCAGCCCGG
CAATGCCGACGCCGTCGCGCGCGCCAATGATTACCTGTCGGCGCTCAACACGCGCGCCGGCACGCGCGTGGTCTATGTGC
TCGACGCCCGCGGCAAGGTGCTGGCCACCAGCAACTGGCAGCGTCCGGACAGCTACCTCGGCGAGGACCTGAGCTTCCGC
CCGTACTTCCGCGCCGCCATGGAAGGCCAGCTCGGCCGCTTCTACGGCGTGGGCACCACGCGCAGCGAGTCGGGCTATTA
CCTGTCCGCTCCGCTCGGCGAGCGTGACAACCCCGACGGCGTGGCGGTGGTCAAGATCGGGCTGGAGCCGCTGGAGAACC
GCTGGCAAGGCGCCGACAGCCAGATGCTGCTGGCCGACGAGAACGGCGTGGTGATTCTGGCTTCGGACCCATCGTGGAAG
CTCGCGGCATTGCGCCCGCTGTCGCCCGAGGCACGCGCTCGGTTCGCTCGCGACCTGCAATACAACCGCGCGCCATTGCC
CCAGCTGCCGCTGCAGGACTTCCGCGTGCTCGGCAACGGCAGCGACCGCCTGGTGCGGCTGCGCCAGGGTCCGGCGATGC
TCGCGCAGCAGTCCGCGCTGCCCGGAACCGACTGGCACCTCACGCTGCTGTCCAACACGTCGGGCGCGCGCGTGGTAGCG
CTGAACAGCGCCGCGCTGGCCGGCGTGCTGACGGCCTTCGTGCTGCTGCTGGGCGCCGCGTGGAATGTGCGCCGGCGCAT
CATTGGCGAACGGCTTGCCGCACGCGCGGCGCTCGAAGCCGCCAACAGCGAACTCGAACGCAAGGTGGCTGAGCGCACCG
GCGACCTGTCGGCCACCAACCAGCGCCTGCAGGCCGAGATAGCCGAGCGCATCCGCACCGAAGCCGTGCTGCGCCAGGCT
CAGGACGGCCTGCTGCAAGCGGGCAAGCTCGCAGCGGTCGGGCAGATGTCGACCGGCATCGCTCACGAGCTCAATCAGCC
GCTGGCGGCGCTGCGCACGATCTCGGGCAATACCGGCAAGTTCCTGGAACGCGGCGACTACGAGACGGTCCGCGCCAACC
TCGGCACGATCATCGGCCTGGTCGAGCGCATGGGCCGCATCACCGGCGCGCTCAAGTCCTTTGCGCGCAAGCCCGGCAAC
GGCCTGCGCCAGGCGGACATCGCCCAGGCCGTGGATAACGCACTGTTCCTGCTCAACACGCGTATCGAAGACGTGCAGCC
GCAGCTGCAGCGCGAGATCGAACCCGGGCTGGTGGTGGCATGCGACGCGAACCGGCTGGAACAGGTGCTGGTCAACCTGG
TCGGCAATGCGCTCGATGCCGTCGCGGGGCGCGCGCAGCCAATGGTGTCGCTGCACGCCCATGTCAGCGGCAGCATGGCG
CACCTGACCGTGCGCGACAACGGCGCAGGCCTGTCCGAGGACGCGTTCTCCCAGCTGTTCGAGCCGTTCTTCACGACCAA
GCCGGCCGGCGAAGGCCTTGGCCTGGGTCTGACCCTGTCGGCAGGCATCCTCAACGAGAACGGTGGCAGCCTGTCCGCGT
CCAATCACCCCGACGGCGGCGCGTGCTTCACGGTGGTCCTGCCCTTGGTCCGCCAGGAAATCCCACATGCCGGCTGA

Upstream 100 bases:

>100_bases
GCTTTTTTGTTTTGACGTCGCGCGGGTGTGGTAAAAGTAGGCGCCCGCTGGCCTCCCGCGGGCCGCACATCGTCAGCCTC
ACTGCCTTAGCCAGCACTTC

Downstream 100 bases:

>100_bases
ACTGACTGTACTGATCGTCGAAGACGACGCCGACGTGCGTCTGGGCTGCGAGCAGGCACTGCGGCTCGAAGGCATCGCCA
CGCAAGGCGTGGCAAGTGCC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MTGQPDPFRDPAGDSASHPGHPVPRPAALRGAAPLLALLALAALVSLAGWLGYRYSFDTALARQAERGQVQLRLYAQALE
SELAHYDYVPGLLTLDDRIGTLLRQPGNADAVARANDYLSALNTRAGTRVVYVLDARGKVLATSNWQRPDSYLGEDLSFR
PYFRAAMEGQLGRFYGVGTTRSESGYYLSAPLGERDNPDGVAVVKIGLEPLENRWQGADSQMLLADENGVVILASDPSWK
LAALRPLSPEARARFARDLQYNRAPLPQLPLQDFRVLGNGSDRLVRLRQGPAMLAQQSALPGTDWHLTLLSNTSGARVVA
LNSAALAGVLTAFVLLLGAAWNVRRRIIGERLAARAALEAANSELERKVAERTGDLSATNQRLQAEIAERIRTEAVLRQA
QDGLLQAGKLAAVGQMSTGIAHELNQPLAALRTISGNTGKFLERGDYETVRANLGTIIGLVERMGRITGALKSFARKPGN
GLRQADIAQAVDNALFLLNTRIEDVQPQLQREIEPGLVVACDANRLEQVLVNLVGNALDAVAGRAQPMVSLHAHVSGSMA
HLTVRDNGAGLSEDAFSQLFEPFFTTKPAGEGLGLGLTLSAGILNENGGSLSASNHPDGGACFTVVLPLVRQEIPHAG

Sequences:

>Translated_638_residues
MTGQPDPFRDPAGDSASHPGHPVPRPAALRGAAPLLALLALAALVSLAGWLGYRYSFDTALARQAERGQVQLRLYAQALE
SELAHYDYVPGLLTLDDRIGTLLRQPGNADAVARANDYLSALNTRAGTRVVYVLDARGKVLATSNWQRPDSYLGEDLSFR
PYFRAAMEGQLGRFYGVGTTRSESGYYLSAPLGERDNPDGVAVVKIGLEPLENRWQGADSQMLLADENGVVILASDPSWK
LAALRPLSPEARARFARDLQYNRAPLPQLPLQDFRVLGNGSDRLVRLRQGPAMLAQQSALPGTDWHLTLLSNTSGARVVA
LNSAALAGVLTAFVLLLGAAWNVRRRIIGERLAARAALEAANSELERKVAERTGDLSATNQRLQAEIAERIRTEAVLRQA
QDGLLQAGKLAAVGQMSTGIAHELNQPLAALRTISGNTGKFLERGDYETVRANLGTIIGLVERMGRITGALKSFARKPGN
GLRQADIAQAVDNALFLLNTRIEDVQPQLQREIEPGLVVACDANRLEQVLVNLVGNALDAVAGRAQPMVSLHAHVSGSMA
HLTVRDNGAGLSEDAFSQLFEPFFTTKPAGEGLGLGLTLSAGILNENGGSLSASNHPDGGACFTVVLPLVRQEIPHAG
>Mature_637_residues
TGQPDPFRDPAGDSASHPGHPVPRPAALRGAAPLLALLALAALVSLAGWLGYRYSFDTALARQAERGQVQLRLYAQALES
ELAHYDYVPGLLTLDDRIGTLLRQPGNADAVARANDYLSALNTRAGTRVVYVLDARGKVLATSNWQRPDSYLGEDLSFRP
YFRAAMEGQLGRFYGVGTTRSESGYYLSAPLGERDNPDGVAVVKIGLEPLENRWQGADSQMLLADENGVVILASDPSWKL
AALRPLSPEARARFARDLQYNRAPLPQLPLQDFRVLGNGSDRLVRLRQGPAMLAQQSALPGTDWHLTLLSNTSGARVVAL
NSAALAGVLTAFVLLLGAAWNVRRRIIGERLAARAALEAANSELERKVAERTGDLSATNQRLQAEIAERIRTEAVLRQAQ
DGLLQAGKLAAVGQMSTGIAHELNQPLAALRTISGNTGKFLERGDYETVRANLGTIIGLVERMGRITGALKSFARKPGNG
LRQADIAQAVDNALFLLNTRIEDVQPQLQREIEPGLVVACDANRLEQVLVNLVGNALDAVAGRAQPMVSLHAHVSGSMAH
LTVRDNGAGLSEDAFSQLFEPFFTTKPAGEGLGLGLTLSAGILNENGGSLSASNHPDGGACFTVVLPLVRQEIPHAG

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: COG4191

COG function: function code T; Signal transduction histidine kinase regulating C4-dicarboxylate transport system

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=270, Percent_Identity=28.5185185185185, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI1790436, Length=231, Percent_Identity=29.4372294372294, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786912, Length=117, Percent_Identity=37.6068376068376, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788393, Length=224, Percent_Identity=29.4642857142857, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081816, Length=108, Percent_Identity=34.2592592592593, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1787894, Length=276, Percent_Identity=28.6231884057971, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI145693157, Length=130, Percent_Identity=32.3076923076923, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1790300, Length=281, Percent_Identity=25.9786476868327, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 68274; Mature: 68143

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGQPDPFRDPAGDSASHPGHPVPRPAALRGAAPLLALLALAALVSLAGWLGYRYSFDTA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEHHHH
LARQAERGQVQLRLYAQALESELAHYDYVPGLLTLDDRIGTLLRQPGNADAVARANDYLS
HHHHHHCCCEEHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHH
ALNTRAGTRVVYVLDARGKVLATSNWQRPDSYLGEDLSFRPYFRAAMEGQLGRFYGVGTT
HHHCCCCCEEEEEEECCCCEEECCCCCCCHHHHCCCCCCCHHHHHHHHCCCCCEEECCCC
RSESGYYLSAPLGERDNPDGVAVVKIGLEPLENRWQGADSQMLLADENGVVILASDPSWK
CCCCCEEEECCCCCCCCCCCEEEEEECCHHHHHHHCCCCCCEEEECCCCEEEEECCCCCE
LAALRPLSPEARARFARDLQYNRAPLPQLPLQDFRVLGNGSDRLVRLRQGPAMLAQQSAL
EEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHEEEECCCCHHHHHHCCC
PGTDWHLTLLSNTSGARVVALNSAALAGVLTAFVLLLGAAWNVRRRIIGERLAARAALEA
CCCCEEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
ANSELERKVAERTGDLSATNQRLQAEIAERIRTEAVLRQAQDGLLQAGKLAAVGQMSTGI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
AHELNQPLAALRTISGNTGKFLERGDYETVRANLGTIIGLVERMGRITGALKSFARKPGN
HHHHCCHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GLRQADIAQAVDNALFLLNTRIEDVQPQLQREIEPGLVVACDANRLEQVLVNLVGNALDA
CCHHHHHHHHHHHHEEEEECCHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHH
VAGRAQPMVSLHAHVSGSMAHLTVRDNGAGLSEDAFSQLFEPFFTTKPAGEGLGLGLTLS
HHCCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEE
AGILNENGGSLSASNHPDGGACFTVVLPLVRQEIPHAG
CCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TGQPDPFRDPAGDSASHPGHPVPRPAALRGAAPLLALLALAALVSLAGWLGYRYSFDTA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEHHHH
LARQAERGQVQLRLYAQALESELAHYDYVPGLLTLDDRIGTLLRQPGNADAVARANDYLS
HHHHHHCCCEEHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHH
ALNTRAGTRVVYVLDARGKVLATSNWQRPDSYLGEDLSFRPYFRAAMEGQLGRFYGVGTT
HHHCCCCCEEEEEEECCCCEEECCCCCCCHHHHCCCCCCCHHHHHHHHCCCCCEEECCCC
RSESGYYLSAPLGERDNPDGVAVVKIGLEPLENRWQGADSQMLLADENGVVILASDPSWK
CCCCCEEEECCCCCCCCCCCEEEEEECCHHHHHHHCCCCCCEEEECCCCEEEEECCCCCE
LAALRPLSPEARARFARDLQYNRAPLPQLPLQDFRVLGNGSDRLVRLRQGPAMLAQQSAL
EEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHEEEECCCCHHHHHHCCC
PGTDWHLTLLSNTSGARVVALNSAALAGVLTAFVLLLGAAWNVRRRIIGERLAARAALEA
CCCCEEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
ANSELERKVAERTGDLSATNQRLQAEIAERIRTEAVLRQAQDGLLQAGKLAAVGQMSTGI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
AHELNQPLAALRTISGNTGKFLERGDYETVRANLGTIIGLVERMGRITGALKSFARKPGN
HHHHCCHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GLRQADIAQAVDNALFLLNTRIEDVQPQLQREIEPGLVVACDANRLEQVLVNLVGNALDA
CCHHHHHHHHHHHHEEEEECCHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHH
VAGRAQPMVSLHAHVSGSMAHLTVRDNGAGLSEDAFSQLFEPFFTTKPAGEGLGLGLTLS
HHCCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEE
AGILNENGGSLSASNHPDGGACFTVVLPLVRQEIPHAG
CCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2134335; 2793824; 11481431; 2551890; 2695394 [H]