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The map label for this gene is gltT [H]

Identifier: 73542352

GI number: 73542352

Start: 2928901

End: 2930301

Strand: Direct

Name: gltT [H]

Synonym: Reut_A2667

Alternate gene names: 73542352

Gene position: 2928901-2930301 (Clockwise)

Preceding gene: 73542351

Following gene: 73542353

Centisome position: 76.94

GC content: 65.45

Gene sequence:

>1401_bases
ATGGCGTTCCGGCCGAGCCGATCTCGCAATACAGCCGTCCGGCTTCTTCCCGTCTTGCGGAAGAAGCCGGGCGCACGGCC
TGACCCCACGATGAAACTGAACCGACTACCCACTCTGATCTTCATTGCGATGCTGCTTGGCGTGCTGGTCGGCACCGCCG
CGCACAATCTGTCGCCGGACGCTGCCACCACCAAATCGATCGCGGACCATCTGTCCATCCTCACCGACGTGTTCCTGCGG
ATGATCAAGATGATCATCGGGCCGCTGGTGTTCGCCACGCTGGTCGCCGGCATCGCCAGCATGGGCGACGGCCGCGCCGT
CGGCCGCATCGGCATGAAGGCCATGGCCTGGTTTATCGGCGCGTCGATCACGTCGCTGCTGCTGGGCCTGGTGATGGCCA
ACCTGCTGACGCCCGGCCAGGGCATGAACCTGCCGCTGCCGGCCGCCGACGCCGCCTCCAGCGTGAAAACCGCGTCGCTG
AACCTGCGCGATTTCATCGCGCACATGTTCCCCAAGAGCATCGCGGAGGCCATGGCCACCAATGAGATCCTGCAGATCGT
GGTGTTCTCGCTGTTCTTCGGCTTTGCCCTGGGCACCATCAAGGACGGCGTGGGCAAGCCCGTGCTGGACGCCATTGAAG
GCCTCGGCAAGGTGATGCTGAAAGTCACCAATTACGTGATGGCGTTCGCGCCGGTGGGCGTGTTCGGCGCGATCTCGGCC
GTCATCACCGCGCAGGGTCTGGGCGTGCTGGTGGTCTATGCCAAGCTGCTGGGGAGCCTGTACCTGGCGCTGGCGTTGCT
GTGGGCGGCGCTGATCGCCGGCGGCTACTACTTCCTGGGCCGCGACGTGTTCCGCCTGCTCAAGATGGTGCGCGCGCCGC
TGATGATCGGCTTCGCCACCGCCAGCAGCGAATCGGCCTACCCGAAGGTCATCGACCAGCTGACCCATTTCGGCGTCAAG
GAACGCATCACCAACTTCGTGCTGCCGCTAGGCTACTCGTTCAACCTGGACGGCTCGATCATGTACACCTCCTTCGCGGC
GCTGTTCGTCGCCCAGGTGTACGGCATCCATCTGTCGCTGACCCAGCAGATCACCATGCTGCTGGTGCTGCTGGTCACCA
GCAAGGGCATCGCCGGCGTGCCGCGCGCCTCGCTGGTGGTGGTCGCGGCCGTGCTGCCGATGTTCGGCCTGCCTGAGGCC
GGCATCCTGCTGGTGCTCGGCATCGACCACGTCCTGGACATGGGTCGCACCGTGACCAATGTGCTTGGCAATGCGATTGC
CACGGCTGTCGTCGCCAAAAGCGAAGGCGCCATCGGCGCGCCCGTGCCGTCCGACGAGGATGAACCCGTCGCGGACAGCG
CCCCTGCCCTGGCACCCGCCCAGGTGCTGGCGGGCAAGTAA

Upstream 100 bases:

>100_bases
GCCCATCGATGTGCCCGCGCCGCCCCGGCGCGAATGCGGCGCCTGTTGCCCCGCTAACGTCCCCGGCGTCCGCCGGCGCG
ACAGCCGCCTCACCGGCGGC

Downstream 100 bases:

>100_bases
GCCGCCCTGTTCCGACAGGGCACGCGCCGGAGCCCGGCTGCCGATCAGGCAGCCGGGCTTTTTTGTTTTGACGTCGCGCG
GGTGTGGTAAAAGTAGGCGC

Product: Sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MAFRPSRSRNTAVRLLPVLRKKPGARPDPTMKLNRLPTLIFIAMLLGVLVGTAAHNLSPDAATTKSIADHLSILTDVFLR
MIKMIIGPLVFATLVAGIASMGDGRAVGRIGMKAMAWFIGASITSLLLGLVMANLLTPGQGMNLPLPAADAASSVKTASL
NLRDFIAHMFPKSIAEAMATNEILQIVVFSLFFGFALGTIKDGVGKPVLDAIEGLGKVMLKVTNYVMAFAPVGVFGAISA
VITAQGLGVLVVYAKLLGSLYLALALLWAALIAGGYYFLGRDVFRLLKMVRAPLMIGFATASSESAYPKVIDQLTHFGVK
ERITNFVLPLGYSFNLDGSIMYTSFAALFVAQVYGIHLSLTQQITMLLVLLVTSKGIAGVPRASLVVVAAVLPMFGLPEA
GILLVLGIDHVLDMGRTVTNVLGNAIATAVVAKSEGAIGAPVPSDEDEPVADSAPALAPAQVLAGK

Sequences:

>Translated_466_residues
MAFRPSRSRNTAVRLLPVLRKKPGARPDPTMKLNRLPTLIFIAMLLGVLVGTAAHNLSPDAATTKSIADHLSILTDVFLR
MIKMIIGPLVFATLVAGIASMGDGRAVGRIGMKAMAWFIGASITSLLLGLVMANLLTPGQGMNLPLPAADAASSVKTASL
NLRDFIAHMFPKSIAEAMATNEILQIVVFSLFFGFALGTIKDGVGKPVLDAIEGLGKVMLKVTNYVMAFAPVGVFGAISA
VITAQGLGVLVVYAKLLGSLYLALALLWAALIAGGYYFLGRDVFRLLKMVRAPLMIGFATASSESAYPKVIDQLTHFGVK
ERITNFVLPLGYSFNLDGSIMYTSFAALFVAQVYGIHLSLTQQITMLLVLLVTSKGIAGVPRASLVVVAAVLPMFGLPEA
GILLVLGIDHVLDMGRTVTNVLGNAIATAVVAKSEGAIGAPVPSDEDEPVADSAPALAPAQVLAGK
>Mature_465_residues
AFRPSRSRNTAVRLLPVLRKKPGARPDPTMKLNRLPTLIFIAMLLGVLVGTAAHNLSPDAATTKSIADHLSILTDVFLRM
IKMIIGPLVFATLVAGIASMGDGRAVGRIGMKAMAWFIGASITSLLLGLVMANLLTPGQGMNLPLPAADAASSVKTASLN
LRDFIAHMFPKSIAEAMATNEILQIVVFSLFFGFALGTIKDGVGKPVLDAIEGLGKVMLKVTNYVMAFAPVGVFGAISAV
ITAQGLGVLVVYAKLLGSLYLALALLWAALIAGGYYFLGRDVFRLLKMVRAPLMIGFATASSESAYPKVIDQLTHFGVKE
RITNFVLPLGYSFNLDGSIMYTSFAALFVAQVYGIHLSLTQQITMLLVLLVTSKGIAGVPRASLVVVAAVLPMFGLPEAG
ILLVLGIDHVLDMGRTVTNVLGNAIATAVVAKSEGAIGAPVPSDEDEPVADSAPALAPAQVLAGK

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=443, Percent_Identity=27.0880361173815, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI21314632, Length=418, Percent_Identity=27.2727272727273, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI40254478, Length=424, Percent_Identity=27.122641509434, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI66773030, Length=413, Percent_Identity=25.4237288135593, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4827012, Length=407, Percent_Identity=28.2555282555283, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI5032093, Length=423, Percent_Identity=27.1867612293144, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI194239697, Length=266, Percent_Identity=31.5789473684211, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI262359914, Length=387, Percent_Identity=24.8062015503876, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI223468564, Length=298, Percent_Identity=28.5234899328859, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI223468566, Length=298, Percent_Identity=28.5234899328859, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI301601644, Length=155, Percent_Identity=30.9677419354839, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1790514, Length=405, Percent_Identity=39.2592592592593, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI1789947, Length=412, Percent_Identity=36.6504854368932, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1788024, Length=418, Percent_Identity=24.8803827751196, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789473, Length=297, Percent_Identity=22.8956228956229, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71996953, Length=461, Percent_Identity=28.1995661605206, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17537407, Length=458, Percent_Identity=25.9825327510917, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI193206505, Length=459, Percent_Identity=26.797385620915, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI71983099, Length=416, Percent_Identity=25.9615384615385, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71983106, Length=416, Percent_Identity=25.9615384615385, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI193206654, Length=401, Percent_Identity=26.6832917705736, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17541374, Length=406, Percent_Identity=24.384236453202, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24583025, Length=453, Percent_Identity=26.4900662251656, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17137668, Length=453, Percent_Identity=26.4900662251656, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24583023, Length=453, Percent_Identity=26.4900662251656, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI281360483, Length=452, Percent_Identity=27.6548672566372, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137666, Length=452, Percent_Identity=27.6548672566372, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281360481, Length=451, Percent_Identity=27.7161862527716, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 48865; Mature: 48734

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFRPSRSRNTAVRLLPVLRKKPGARPDPTMKLNRLPTLIFIAMLLGVLVGTAAHNLSPD
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AATTKSIADHLSILTDVFLRMIKMIIGPLVFATLVAGIASMGDGRAVGRIGMKAMAWFIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ASITSLLLGLVMANLLTPGQGMNLPLPAADAASSVKTASLNLRDFIAHMFPKSIAEAMAT
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
NEILQIVVFSLFFGFALGTIKDGVGKPVLDAIEGLGKVMLKVTNYVMAFAPVGVFGAISA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VITAQGLGVLVVYAKLLGSLYLALALLWAALIAGGYYFLGRDVFRLLKMVRAPLMIGFAT
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEC
ASSESAYPKVIDQLTHFGVKERITNFVLPLGYSFNLDGSIMYTSFAALFVAQVYGIHLSL
CCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
TQQITMLLVLLVTSKGIAGVPRASLVVVAAVLPMFGLPEAGILLVLGIDHVLDMGRTVTN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHH
VLGNAIATAVVAKSEGAIGAPVPSDEDEPVADSAPALAPAQVLAGK
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCC
>Mature Secondary Structure 
AFRPSRSRNTAVRLLPVLRKKPGARPDPTMKLNRLPTLIFIAMLLGVLVGTAAHNLSPD
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AATTKSIADHLSILTDVFLRMIKMIIGPLVFATLVAGIASMGDGRAVGRIGMKAMAWFIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ASITSLLLGLVMANLLTPGQGMNLPLPAADAASSVKTASLNLRDFIAHMFPKSIAEAMAT
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
NEILQIVVFSLFFGFALGTIKDGVGKPVLDAIEGLGKVMLKVTNYVMAFAPVGVFGAISA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VITAQGLGVLVVYAKLLGSLYLALALLWAALIAGGYYFLGRDVFRLLKMVRAPLMIGFAT
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEC
ASSESAYPKVIDQLTHFGVKERITNFVLPLGYSFNLDGSIMYTSFAALFVAQVYGIHLSL
CCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
TQQITMLLVLLVTSKGIAGVPRASLVVVAAVLPMFGLPEAGILLVLGIDHVLDMGRTVTN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHH
VLGNAIATAVVAKSEGAIGAPVPSDEDEPVADSAPALAPAQVLAGK
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1359385 [H]