Click here to switch to the map view.

The map label for this gene is rhbB [H]

Identifier: 73541314

GI number: 73541314

Start: 1745718

End: 1747376

Strand: Reverse

Name: rhbB [H]

Synonym: Reut_A1624

Alternate gene names: 73541314

Gene position: 1747376-1745718 (Counterclockwise)

Preceding gene: 73541315

Following gene: 73541312

Centisome position: 45.9

GC content: 63.59

Gene sequence:

>1659_bases
ATGACGCCGGACACCTCTCTCGAAAAGACCTCCCAAAGCACGGACGGGGGCGACGACTGCCCCTTGCGCTGGTTCGATGC
GGATCTCGGTGCGTTCGAATCGCTCGAGCGGCTGATCGCCGAGCATCCGGCGGATTTTTTCGCCGGCAAGAGCTTTGAAC
CGGTAGGCGCTTGCCACACACGCGAGGCGGTGTTCGCGTCGGTAGAACTGCCAGAGACGCCGACATCGCCGCAAGCGCAT
GCCGATCATCTGCTCCATGACGTGTTTCGGCACGTGATGCCCGTGGCATCGCCGACCTTCGTCGGACACATGACGTCGTC
GCTGCCATCGTTCATGCCTTCTCTGGCCAAGGTGGTCGCTGCGCTGAATCAGAACGTCGTGAAGCTGGAGACGTCGGGTG
CGCTGACCGGGCTCGAGCGCCAGGTCGTCGGCATGCTGCACAAGCTGGTGTTTAGCCAGGACAGTGCGTTCTATGGCAGA
TGGCTGCACGATGCCGATCACGCGCTTGGCGCCATCTGTTCTGGTGGCACGGTCGCCAACCTCACCGCCTTATGGGCGAG
CCGCAACAAGCTGCTGGGCGCGCGTGATGGCTTCGCCGGCATCCATCGTGCCGGCATGGTGGCAGCGCTGCGCCATTATG
GCTATGACGGCCTCGCGATCGTCGTCTCGGAGCGCGGCCACTACTCGTTGGGCAAGGCAGCCGATGTGCTTGGCATCGGG
CGCGACAATCTCGTGCCTGTCGAGGTCGATGCGGAAGGCCGCATGCGCATCGACTTGCTGCGCGACACCATGCGTGACCT
GCAGCAGCGCAACATCCGGCCGATGGCGATCGTCGGCATAGCGGGGACCACCGAGACAGGCTCGGTCGATCCGCTGGATG
CGATTGCGGATATTGCGCAGGAGGCCGGCTGCCATTTCCACGTGGATGCAGCATGGGGCGGCGCAACGCTGCTGTCGGAG
CGCGAGCGCTGGCGCTTCGCGGGCATCGAGCGTGCCGATTCCGTCGTCATCGATGCGCACAAGCAGTTCTACGTGCCGAT
GGGCGCCGGCATGGTGCTGTTCCGCAGCCCCGCGTGGACGCAGGAAATCATCCAGCATGCGAACTACATCGTGCGCAAGG
GCTCGGTGGACCTGGGCCGTCATACGCTCGAAGGCTCGCGTGGCGCGGCGGCTGTCATGCTTTACGCGAACCTGCATCTG
CTCGGTCGCAAGGGTTTGGCGCAGTTGATCGACCGCAGCATCGACAACGCCCACTACTTTGCTTCGCTGATTGCGCAGCA
GCCGGATTTCGAGCTCGTCAGCCATCCGCAGCTTTGCCTCCTGACCTATCGTTACTTGCCTGAGACCGTGCGCGCAGCAC
TGGCAACGGCTTCGGAGGACAAGCGCGAGAAGATCCTGGATGCGCTCGATGCGTTGACCGTCAGCATCCAGGAAATGCAG
CGCGATGCCGGACGCTCGTTCGTGTCGCGCACGCAGTTGACGTCAACACAGTTTGCAGGGCGCCCGATTGCGGTTTTCCG
CGTGGTGCTGGCCAATCCGGATACAACGCATGCCATCCTGCAGGACATCCTTGACGAACAGCGCATGCTGGCGGCGGCCA
GCCCATGCATGGCTGCGCTGATGGCTCTGGTGGAAGCCAGCGGCAGGCTTCAGCGCTGA

Upstream 100 bases:

>100_bases
GCAAGTCTCGCTGCTGCCATCCGCGTTGATGACACCAAGGGGTGTGGCGCACCGGCCCAAGCTTCACTAGAGACCTCGCT
GCGTTTCACACGCTAATGCA

Downstream 100 bases:

>100_bases
CGCTGGCGCGCGTCAGTGGCTTTCCTTCGGCCGGGATACCGGACCCTCAAAACGAGTCGCCAGCCATTGAGAGAACACTC
GCACGCGCGCCGATAGCTGC

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MTPDTSLEKTSQSTDGGDDCPLRWFDADLGAFESLERLIAEHPADFFAGKSFEPVGACHTREAVFASVELPETPTSPQAH
ADHLLHDVFRHVMPVASPTFVGHMTSSLPSFMPSLAKVVAALNQNVVKLETSGALTGLERQVVGMLHKLVFSQDSAFYGR
WLHDADHALGAICSGGTVANLTALWASRNKLLGARDGFAGIHRAGMVAALRHYGYDGLAIVVSERGHYSLGKAADVLGIG
RDNLVPVEVDAEGRMRIDLLRDTMRDLQQRNIRPMAIVGIAGTTETGSVDPLDAIADIAQEAGCHFHVDAAWGGATLLSE
RERWRFAGIERADSVVIDAHKQFYVPMGAGMVLFRSPAWTQEIIQHANYIVRKGSVDLGRHTLEGSRGAAAVMLYANLHL
LGRKGLAQLIDRSIDNAHYFASLIAQQPDFELVSHPQLCLLTYRYLPETVRAALATASEDKREKILDALDALTVSIQEMQ
RDAGRSFVSRTQLTSTQFAGRPIAVFRVVLANPDTTHAILQDILDEQRMLAAASPCMAALMALVEASGRLQR

Sequences:

>Translated_552_residues
MTPDTSLEKTSQSTDGGDDCPLRWFDADLGAFESLERLIAEHPADFFAGKSFEPVGACHTREAVFASVELPETPTSPQAH
ADHLLHDVFRHVMPVASPTFVGHMTSSLPSFMPSLAKVVAALNQNVVKLETSGALTGLERQVVGMLHKLVFSQDSAFYGR
WLHDADHALGAICSGGTVANLTALWASRNKLLGARDGFAGIHRAGMVAALRHYGYDGLAIVVSERGHYSLGKAADVLGIG
RDNLVPVEVDAEGRMRIDLLRDTMRDLQQRNIRPMAIVGIAGTTETGSVDPLDAIADIAQEAGCHFHVDAAWGGATLLSE
RERWRFAGIERADSVVIDAHKQFYVPMGAGMVLFRSPAWTQEIIQHANYIVRKGSVDLGRHTLEGSRGAAAVMLYANLHL
LGRKGLAQLIDRSIDNAHYFASLIAQQPDFELVSHPQLCLLTYRYLPETVRAALATASEDKREKILDALDALTVSIQEMQ
RDAGRSFVSRTQLTSTQFAGRPIAVFRVVLANPDTTHAILQDILDEQRMLAAASPCMAALMALVEASGRLQR
>Mature_551_residues
TPDTSLEKTSQSTDGGDDCPLRWFDADLGAFESLERLIAEHPADFFAGKSFEPVGACHTREAVFASVELPETPTSPQAHA
DHLLHDVFRHVMPVASPTFVGHMTSSLPSFMPSLAKVVAALNQNVVKLETSGALTGLERQVVGMLHKLVFSQDSAFYGRW
LHDADHALGAICSGGTVANLTALWASRNKLLGARDGFAGIHRAGMVAALRHYGYDGLAIVVSERGHYSLGKAADVLGIGR
DNLVPVEVDAEGRMRIDLLRDTMRDLQQRNIRPMAIVGIAGTTETGSVDPLDAIADIAQEAGCHFHVDAAWGGATLLSER
ERWRFAGIERADSVVIDAHKQFYVPMGAGMVLFRSPAWTQEIIQHANYIVRKGSVDLGRHTLEGSRGAAAVMLYANLHLL
GRKGLAQLIDRSIDNAHYFASLIAQQPDFELVSHPQLCLLTYRYLPETVRAALATASEDKREKILDALDALTVSIQEMQR
DAGRSFVSRTQLTSTQFAGRPIAVFRVVLANPDTTHAILQDILDEQRMLAAASPCMAALMALVEASGRLQR

Specific function: Catalyzes The Production Of Gaba. [C]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197276620, Length=465, Percent_Identity=26.0215053763441, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI4503875, Length=465, Percent_Identity=26.0215053763441, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI58331246, Length=469, Percent_Identity=24.7334754797441, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI197383062, Length=456, Percent_Identity=26.0964912280702, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI194294551, Length=449, Percent_Identity=25.6124721603563, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI92110055, Length=411, Percent_Identity=25.3041362530414, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI4503281, Length=392, Percent_Identity=24.234693877551, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI132814448, Length=392, Percent_Identity=24.234693877551, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17555682, Length=472, Percent_Identity=26.4830508474576, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71993062, Length=454, Percent_Identity=26.6519823788546, Blast_Score=148, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI71993058, Length=378, Percent_Identity=28.042328042328, Blast_Score=138, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17534817, Length=280, Percent_Identity=24.6428571428571, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17534819, Length=280, Percent_Identity=24.6428571428571, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136594, Length=459, Percent_Identity=24.400871459695, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24657193, Length=448, Percent_Identity=25.2232142857143, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24657185, Length=448, Percent_Identity=25.2232142857143, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24657188, Length=448, Percent_Identity=25.2232142857143, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI21356415, Length=473, Percent_Identity=24.1014799154334, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24652373, Length=392, Percent_Identity=29.0816326530612, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28573972, Length=385, Percent_Identity=23.3766233766234, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136190, Length=396, Percent_Identity=25, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 3820 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 60028; Mature: 59897

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPDTSLEKTSQSTDGGDDCPLRWFDADLGAFESLERLIAEHPADFFAGKSFEPVGACHT
CCCCCCCHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCC
REAVFASVELPETPTSPQAHADHLLHDVFRHVMPVASPTFVGHMTSSLPSFMPSLAKVVA
CHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALNQNVVKLETSGALTGLERQVVGMLHKLVFSQDSAFYGRWLHDADHALGAICSGGTVAN
HHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
LTALWASRNKLLGARDGFAGIHRAGMVAALRHYGYDGLAIVVSERGHYSLGKAADVLGIG
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHEEECC
RDNLVPVEVDAEGRMRIDLLRDTMRDLQQRNIRPMAIVGIAGTTETGSVDPLDAIADIAQ
CCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHH
EAGCHFHVDAAWGGATLLSERERWRFAGIERADSVVIDAHKQFYVPMGAGMVLFRSPAWT
HCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCEEEEECCCHH
QEIIQHANYIVRKGSVDLGRHTLEGSRGAAAVMLYANLHLLGRKGLAQLIDRSIDNAHYF
HHHHHHHHHEEECCCCCCCCHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHH
ASLIAQQPDFELVSHPQLCLLTYRYLPETVRAALATASEDKREKILDALDALTVSIQEMQ
HHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RDAGRSFVSRTQLTSTQFAGRPIAVFRVVLANPDTTHAILQDILDEQRMLAAASPCMAAL
HHHHHHHHHHHHHHHHHCCCCCHHHHEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHH
MALVEASGRLQR
HHHHHHCCCCCC
>Mature Secondary Structure 
TPDTSLEKTSQSTDGGDDCPLRWFDADLGAFESLERLIAEHPADFFAGKSFEPVGACHT
CCCCCCHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCC
REAVFASVELPETPTSPQAHADHLLHDVFRHVMPVASPTFVGHMTSSLPSFMPSLAKVVA
CHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALNQNVVKLETSGALTGLERQVVGMLHKLVFSQDSAFYGRWLHDADHALGAICSGGTVAN
HHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
LTALWASRNKLLGARDGFAGIHRAGMVAALRHYGYDGLAIVVSERGHYSLGKAADVLGIG
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHEEECC
RDNLVPVEVDAEGRMRIDLLRDTMRDLQQRNIRPMAIVGIAGTTETGSVDPLDAIADIAQ
CCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHH
EAGCHFHVDAAWGGATLLSERERWRFAGIERADSVVIDAHKQFYVPMGAGMVLFRSPAWT
HCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCEEEEECCCHH
QEIIQHANYIVRKGSVDLGRHTLEGSRGAAAVMLYANLHLLGRKGLAQLIDRSIDNAHYF
HHHHHHHHHEEECCCCCCCCHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHH
ASLIAQQPDFELVSHPQLCLLTYRYLPETVRAALATASEDKREKILDALDALTVSIQEMQ
HHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RDAGRSFVSRTQLTSTQFAGRPIAVFRVVLANPDTTHAILQDILDEQRMLAAASPCMAAL
HHHHHHHHHHHHHHHHHCCCCCHHHHEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHH
MALVEASGRLQR
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11274118; 11481432 [H]