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The map label for this gene is lon [H]

Identifier: 73541076

GI number: 73541076

Start: 1490132

End: 1492543

Strand: Direct

Name: lon [H]

Synonym: Reut_A1382

Alternate gene names: 73541076

Gene position: 1490132-1492543 (Clockwise)

Preceding gene: 73541075

Following gene: 73541077

Centisome position: 39.15

GC content: 61.61

Gene sequence:

>2412_bases
ATGTCCGGAACACAACTCCTCCCGGCCGAGCCGATTCGCCTCCCACTGTTGCCCTTGCGCGACGTGGTGGTGTTTCCGCA
CATGGTGATCCCGTTGTTCGTGGGACGCCCGAAGTCCATCAAGGCGCTTGAGACTGCGATGGAGTCGGGCAAGAGCATTA
TGCTCGTGGCGCAGAAGACTGCCGCCAAAGACGAACCGACCGCCGACGACCTGTATGAGGTCGGCTGCATCGCTAACATT
CTGCAGATGCTGAAGCTGCCCGACGGTACCGTGAAGGTGCTGGTGGAAGGCACGCAGCGTGCAAACATCCGCGAGGTCAG
CGAGGACGAGTCGCACTTCATGTGCGAAGCCGTTCCCGTGCCACCCGCAGCGGTTGAAAGCGCCGAGACCGAGGCCCTGC
GCCGCGCGATCGTGTCGCAGTTCGACCAGTACGTGAAGCTCAACAAGAAGATCCCGCCGGAGATCCTGACCTCGCTGTCG
GGCATCGATGAGGCAGGCCGCCTGGCCGACACGATCGCCGCGCACCTGCCGATCAAGCTCGAGCAGAAGCAGAAGATCCT
GGAAATGGTCAATGTGACCGAGCGCCTGGAAAGCCTGCTGTCGCAACTCGAGGGCGAGATCGACATCCTGCAGGTCGAAA
AGCGCATCCGTGGCCGCGTCAAGCGCCAGATGGAAAAGAGCCAGCGCGAGTACTACCTGAACGAGCAGGTCAAGGCGATC
CAGAAGGAACTCGGCGAAGGCGAAGAGGGCGCCGACCTGGAAGAACTCGACAAGCGCATCAAGGCTGCGCGCATGCCGAA
GGAAGCCAAGAAGAAGGCCGACGCTGAATTCAAGAAGCTCAAGCTGATGTCGCCGATGTCGGCGGAAGCCACCGTCGTGC
GCAACTACATCGACACGCTGGTGAACCTGCCGTGGCGCAAGAAGAGCAAGGTCAACAACGACCTGGCCAACGCCGAGCGC
GTGCTTGATGAAGACCACTACGGTCTCGAGAAGGTCAAGGAACGTATCCTTGAATATCTTGCCGTGCAACAGCGCGTGGA
CAAGGTCAAGGCTCCGATCCTGTGCCTGGTCGGGCCTCCCGGCGTGGGTAAGACCTCGCTCGGCCAGTCGGTGGCGCGCG
CGACGAACCGCAAGTTCGTGCGCATGGCACTCGGTGGCGTGCGTGACGAAGCCGAGATCCGCGGTCACCGCCGTACCTAC
ATTGGTTCGATGCCGGGCAAGATCCTGCAGAGCCTGTCGAAGGTCGGCGTGCGCAATCCGCTCTTCCTGCTCGACGAAAT
CGACAAGATGGGCATGGATTTCCGTGGCGACCCGTCTTCGGCGCTGCTTGAAGTGCTGGACCCGGAACAGAACCACACGT
TCCAGGACCACTACATCGAAGTGGACTTCGACCTGTCCGACGTAATGTTCGTGGCGACGTCGAACTCGCTGAACATTCCG
CCGCCGCTGCTCGACCGTATGGAAGTGATCCGCCTGTCGGGTTACACCGAGGACGAGAAGCTCAACATCGCGACGCGATA
CCTGCTGCCCAAGCAGATCAAGAACAACGGTCTGAAGGCTGGCGAGATCGAGGTCACCGATGCGGCGATCCGCGACATCA
TTCGCTATTACACACGCGAAGCCGGTGTGCGTTCGCTTGAGCGCGAGGTGTCCAAGATTGCTCGCAAGGCGGTCAAGCTC
CTGCTGCTGAAGAAGGAGTCGGGCACGATCAAGGTCGATTCGGAGAACCTCGACAAGTTCCTCGGCGTGCGCAAGTACGA
CTTCGGCCTGGCCGGCAAGGAAAACCAGGTCGGTCAGGTGACCGGTCTGGCGTGGACGGAAGTGGGCGGCGATCTGCTGA
CCATCGAAGCCGCGATCATGCCGGGCAAGGGCAACATCACGCGTACTGGTTCGCTAGGCGACGTGATGAAGGAGTCGGTC
GAGGCGGCACGTTCGGTGGTGCGTTCGCGGGCGCGTCGGCTGGGCATCACGGATGAGATGTTCGAGAAGCGTGACATCCA
TATCCACGTGCCTGAAGGCGCAACGCCCAAGGACGGTCCGTCGGCTGGCGGTGCCATGACCACGGCGCTGGTGTCGGTGC
TGACCGGTATCCCGGTGCGGGCGGATGTCGCCATGACCGGAGAGATCACACTGCGCGGTGAAGTGTTGCCGATCGGTGGC
CTCAAGGAAAAGCTGCTGGCTGCCCACCGTGGTGGTATCAAGCTGGTGCTGATCCCTGAGGAAAACGTGAAGGATCTCGC
CGAAATTCCCGACAACGTGAAGAACGCCATCGAGATCGTGCCGGTCCGCTGGATCGACAAGGTGCTGGAGCTGGCACTCG
AGCGCAAGCCCGAGCCGCTGCCCGAGGAAGACGCCAAGCCTGCCGAAGTGGCGGACAAGGCGGCGTCCAAGGTCGAGATG
ATCCACCACTGA

Upstream 100 bases:

>100_bases
GCGGCATCAGCCTGTCAATCCAAATCGGTTTCGTCTCGGTATCTTGTAATCGATTTGGGCGGCCCAATTTACGCCTTAAA
TGACTGACTTGGGGAAAATG

Downstream 100 bases:

>100_bases
TCCGTCTGCTTCACAGCAGGTGAGAACGCCGCGGAGTGAAACCCGCGGCGTTTTACTTTCCGGAGGTGGCTTCTGCGAGA
TTGTTGAGATTATTGCGTTC

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 803; Mature: 802

Protein sequence:

>803_residues
MSGTQLLPAEPIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETAMESGKSIMLVAQKTAAKDEPTADDLYEVGCIANI
LQMLKLPDGTVKVLVEGTQRANIREVSEDESHFMCEAVPVPPAAVESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADTIAAHLPIKLEQKQKILEMVNVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELDKRIKAARMPKEAKKKADAEFKKLKLMSPMSAEATVVRNYIDTLVNLPWRKKSKVNNDLANAER
VLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLSKVGVRNPLFLLDEIDKMGMDFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKLNIATRYLLPKQIKNNGLKAGEIEVTDAAIRDIIRYYTREAGVRSLEREVSKIARKAVKL
LLLKKESGTIKVDSENLDKFLGVRKYDFGLAGKENQVGQVTGLAWTEVGGDLLTIEAAIMPGKGNITRTGSLGDVMKESV
EAARSVVRSRARRLGITDEMFEKRDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLAEIPDNVKNAIEIVPVRWIDKVLELALERKPEPLPEEDAKPAEVADKAASKVEM
IHH

Sequences:

>Translated_803_residues
MSGTQLLPAEPIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETAMESGKSIMLVAQKTAAKDEPTADDLYEVGCIANI
LQMLKLPDGTVKVLVEGTQRANIREVSEDESHFMCEAVPVPPAAVESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADTIAAHLPIKLEQKQKILEMVNVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELDKRIKAARMPKEAKKKADAEFKKLKLMSPMSAEATVVRNYIDTLVNLPWRKKSKVNNDLANAER
VLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLSKVGVRNPLFLLDEIDKMGMDFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKLNIATRYLLPKQIKNNGLKAGEIEVTDAAIRDIIRYYTREAGVRSLEREVSKIARKAVKL
LLLKKESGTIKVDSENLDKFLGVRKYDFGLAGKENQVGQVTGLAWTEVGGDLLTIEAAIMPGKGNITRTGSLGDVMKESV
EAARSVVRSRARRLGITDEMFEKRDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLAEIPDNVKNAIEIVPVRWIDKVLELALERKPEPLPEEDAKPAEVADKAASKVEM
IHH
>Mature_802_residues
SGTQLLPAEPIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETAMESGKSIMLVAQKTAAKDEPTADDLYEVGCIANIL
QMLKLPDGTVKVLVEGTQRANIREVSEDESHFMCEAVPVPPAAVESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSG
IDEAGRLADTIAAHLPIKLEQKQKILEMVNVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGEGEEGADLEELDKRIKAARMPKEAKKKADAEFKKLKLMSPMSAEATVVRNYIDTLVNLPWRKKSKVNNDLANAERV
LDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTYI
GSMPGKILQSLSKVGVRNPLFLLDEIDKMGMDFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIPP
PLLDRMEVIRLSGYTEDEKLNIATRYLLPKQIKNNGLKAGEIEVTDAAIRDIIRYYTREAGVRSLEREVSKIARKAVKLL
LLKKESGTIKVDSENLDKFLGVRKYDFGLAGKENQVGQVTGLAWTEVGGDLLTIEAAIMPGKGNITRTGSLGDVMKESVE
AARSVVRSRARRLGITDEMFEKRDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGGL
KEKLLAAHRGGIKLVLIPEENVKDLAEIPDNVKNAIEIVPVRWIDKVLELALERKPEPLPEEDAKPAEVADKAASKVEMI
HH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=838, Percent_Identity=39.1408114558473, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI21396489, Length=827, Percent_Identity=37.0012091898428, Blast_Score=512, Evalue=1e-145,
Organism=Escherichia coli, GI1786643, Length=770, Percent_Identity=70.6493506493507, Blast_Score=1093, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=705, Percent_Identity=40.1418439716312, Blast_Score=490, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17556486, Length=801, Percent_Identity=33.3333333333333, Blast_Score=421, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319449, Length=710, Percent_Identity=41.1267605633803, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24666867, Length=620, Percent_Identity=43.8709677419355, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI221513036, Length=620, Percent_Identity=43.8709677419355, Blast_Score=511, Evalue=1e-144,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88933; Mature: 88802

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTQLLPAEPIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETAMESGKSIMLVAQKT
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECC
AAKDEPTADDLYEVGCIANILQMLKLPDGTVKVLVEGTQRANIREVSEDESHFMCEAVPV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHCCCCCCCEEEEECCC
PPAAVESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPIKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCH
EQKQKILEMVNVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELDKRIKAARMPKEAKKKADAEFKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHH
VNLPWRKKSKVNNDLANAERVLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLSKVGVRNP
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCC
LFLLDEIDKMGMDFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKLNIATRYLLPKQIKNNGLKAGEIEVTDAAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHH
AGVRSLEREVSKIARKAVKLLLLKKESGTIKVDSENLDKFLGVRKYDFGLAGKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECHHHHHHHHCCHHCCCCCCCCCCCCCEE
TGLAWTEVGGDLLTIEAAIMPGKGNITRTGSLGDVMKESVEAARSVVRSRARRLGITDEM
ECEEHHHCCCCEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FEKRDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
HCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLAEIPDNVKNAIEIVPVRWIDKVLELALERKPEPL
HHHHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHHHHEEECHHHHHHHHHHHHHCCCCCC
PEEDAKPAEVADKAASKVEMIHH
CCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGTQLLPAEPIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETAMESGKSIMLVAQKT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECC
AAKDEPTADDLYEVGCIANILQMLKLPDGTVKVLVEGTQRANIREVSEDESHFMCEAVPV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHCCCCCCCEEEEECCC
PPAAVESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPIKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCH
EQKQKILEMVNVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELDKRIKAARMPKEAKKKADAEFKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHH
VNLPWRKKSKVNNDLANAERVLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLSKVGVRNP
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCC
LFLLDEIDKMGMDFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKLNIATRYLLPKQIKNNGLKAGEIEVTDAAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHH
AGVRSLEREVSKIARKAVKLLLLKKESGTIKVDSENLDKFLGVRKYDFGLAGKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECHHHHHHHHCCHHCCCCCCCCCCCCCEE
TGLAWTEVGGDLLTIEAAIMPGKGNITRTGSLGDVMKESVEAARSVVRSRARRLGITDEM
ECEEHHHCCCCEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FEKRDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
HCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLAEIPDNVKNAIEIVPVRWIDKVLELALERKPEPL
HHHHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHHHHEEECHHHHHHHHHHHHHCCCCCC
PEEDAKPAEVADKAASKVEMIHH
CCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]