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The map label for this gene is purE [H]

Identifier: 73540261

GI number: 73540261

Start: 601270

End: 601767

Strand: Reverse

Name: purE [H]

Synonym: Reut_A0555

Alternate gene names: 73540261

Gene position: 601767-601270 (Counterclockwise)

Preceding gene: 73540262

Following gene: 73540260

Centisome position: 15.81

GC content: 68.88

Gene sequence:

>498_bases
GTGAGCAAGCAAGAAAAGCCGGTCGTCGGCGTCGTAATGGGCAGCAGTTCCGACTGGGACGTGATGCAGCACGCCGTGGC
CATGCTGAAGGATTTCGGCGTGCCGTTCGAGGCACAGGTCGTTTCGGCGCACCGCATGGCCGACGACATGTTCCGCTATG
CGGAGACCGCGCGCAGCCGTGGCATCCGCGCGATCATCGCCGGTGCCGGCGGTGCCGCGCATCTGCCGGGCATGATCGCC
GCCAAGACCATCGTGCCGGTGTTCGGCGTGCCGGTGCCGTCCAAGTACCTGCGCGGCGAGGACTCGCTGCTGTCGATCGT
GCAGATGCCCAAGGGCGTGCCCGTCGCGACGTTCGCGATCGGCGAAGCCGGCGCGGCCAATGCGGCGCTGCATGCGATCG
CCACGCTGGCCACCACCGACGACGCGCTGGCCAGCGCGCTGGAAGCATTCCGCGCCAGGCAGACCGAAGCCGCGCGCGCG
ATGACGCTGCCGCTGTAA

Upstream 100 bases:

>100_bases
AAGCTCCCGGATGACGTGATCGAAAAGACCGCCGCCAAGTACCGTGAAGCGCTGACCCGCTTGACGGGTGAAGAACTCCA
GTAAGCCCGGAGAACAAGAC

Downstream 100 bases:

>100_bases
TCCATCGCGCAGTAACCCCCGGAAACCACGGAACCGAGCAATGCCGACCGATATCCATCCCTACCTCTCCGAAGCCCACA
CGCCGGAGTCGCGCGCCGAA

Product: 1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MSKQEKPVVGVVMGSSSDWDVMQHAVAMLKDFGVPFEAQVVSAHRMADDMFRYAETARSRGIRAIIAGAGGAAHLPGMIA
AKTIVPVFGVPVPSKYLRGEDSLLSIVQMPKGVPVATFAIGEAGAANAALHAIATLATTDDALASALEAFRARQTEAARA
MTLPL

Sequences:

>Translated_165_residues
MSKQEKPVVGVVMGSSSDWDVMQHAVAMLKDFGVPFEAQVVSAHRMADDMFRYAETARSRGIRAIIAGAGGAAHLPGMIA
AKTIVPVFGVPVPSKYLRGEDSLLSIVQMPKGVPVATFAIGEAGAANAALHAIATLATTDDALASALEAFRARQTEAARA
MTLPL
>Mature_164_residues
SKQEKPVVGVVMGSSSDWDVMQHAVAMLKDFGVPFEAQVVSAHRMADDMFRYAETARSRGIRAIIAGAGGAAHLPGMIAA
KTIVPVFGVPVPSKYLRGEDSLLSIVQMPKGVPVATFAIGEAGAANAALHAIATLATTDDALASALEAFRARQTEAARAM
TLPL

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=157, Percent_Identity=57.9617834394904, Blast_Score=145, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324702, Length=151, Percent_Identity=57.6158940397351, Blast_Score=161, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17203; Mature: 17072

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQEKPVVGVVMGSSSDWDVMQHAVAMLKDFGVPFEAQVVSAHRMADDMFRYAETARSR
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GIRAIIAGAGGAAHLPGMIAAKTIVPVFGVPVPSKYLRGEDSLLSIVQMPKGVPVATFAI
CCEEEEECCCCCHHCCHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHCCCCCCEEEEEC
GEAGAANAALHAIATLATTDDALASALEAFRARQTEAARAMTLPL
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SKQEKPVVGVVMGSSSDWDVMQHAVAMLKDFGVPFEAQVVSAHRMADDMFRYAETARSR
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GIRAIIAGAGGAAHLPGMIAAKTIVPVFGVPVPSKYLRGEDSLLSIVQMPKGVPVATFAI
CCEEEEECCCCCHHCCHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHCCCCCCEEEEEC
GEAGAANAALHAIATLATTDDALASALEAFRARQTEAARAMTLPL
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]