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The map label for this gene is hemH [H]

Identifier: 73540262

GI number: 73540262

Start: 601784

End: 602692

Strand: Reverse

Name: hemH [H]

Synonym: Reut_A0556

Alternate gene names: 73540262

Gene position: 602692-601784 (Counterclockwise)

Preceding gene: 73540263

Following gene: 73540261

Centisome position: 15.83

GC content: 64.58

Gene sequence:

>909_bases
ATGTCCAACGCTCTCTACCAGTCCTCCATCTCTTCCCTGCCGCTGCTTGGCCACGGCAAGGTGCGCGACAACTACGCCGT
CGGCGAAGACAAGCTGCTCATCGTCACCACGGACCGCCTGTCGGCCTTCGACGTCATCATGGGCGAGCCGATTCCCGACA
AGGGCCGCGTGCTGAACCAGATGGCGAATTTCTGGTTCCGCAAGCTCGCGCATATCGTGCCGAACCACGAGACCGGCGTT
GCTGCCGAAACCGTCGTCGCGCCCGCAGAAGTGGAACAGGTCAAGGGCCGCGCCGTGGTGGTCAAGCGCCTGAAGCCGAT
CCTGGTCGAAGCCGTGGTGCGCGGCTACCTGGCTGGCAGCGGCTGGAAGGACTACCAGGCGACGGGCAAGGTCTGCGGCA
TCGAACTGCCGGCCGGCCTGCAGAACGCGCAGAAGCTGCCCGAACCGATCTTCACGCCGGCCGCCAAGGCCGAGATGGGC
GAGCACGACGAGAACATCTCGTTCGGCGAAGTGGAAGAGCGCATCGGCATCGCGCTGGCCCGCCAGATGCGCGACATCTC
GATCCGGCTGTACAAGGAAGCGGCCGAATTCGCCGCCACGCGCGGCATCATCATCGCCGACACCAAGTTCGAGTTCGGCC
TGGATGAAAACGGCACGCTCACGCTGATGGACGAAGTGCTGACCGCCGATTCGTCGCGCTTCTGGCCGGCCGATTCGTAC
CAGGTCGGCACCAACCCGCCGTCGTTCGACAAGCAGTTCGTGCGCGACTGGCTTGAAGCCGTGCGCATCGACGGCAAGCC
GTGGCCGAAGACCGCGCCGGCGCCAAAGCTCCCGGATGACGTGATCGAAAAGACCGCCGCCAAGTACCGTGAAGCGCTGA
CCCGCTTGACGGGTGAAGAACTCCAGTAA

Upstream 100 bases:

>100_bases
TCCCCTGACCGCCATCCGCGCAAGCGGAAGGCGGTTTGACGTTCCGGCCGCCGCGGCAGCATTCAGTGCCCGGCGGCTTC
GCCGTTTTATCGGAACCACC

Downstream 100 bases:

>100_bases
GCCCGGAGAACAAGACGTGAGCAAGCAAGAAAAGCCGGTCGTCGGCGTCGTAATGGGCAGCAGTTCCGACTGGGACGTGA
TGCAGCACGCCGTGGCCATG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSNALYQSSISSLPLLGHGKVRDNYAVGEDKLLIVTTDRLSAFDVIMGEPIPDKGRVLNQMANFWFRKLAHIVPNHETGV
AAETVVAPAEVEQVKGRAVVVKRLKPILVEAVVRGYLAGSGWKDYQATGKVCGIELPAGLQNAQKLPEPIFTPAAKAEMG
EHDENISFGEVEERIGIALARQMRDISIRLYKEAAEFAATRGIIIADTKFEFGLDENGTLTLMDEVLTADSSRFWPADSY
QVGTNPPSFDKQFVRDWLEAVRIDGKPWPKTAPAPKLPDDVIEKTAAKYREALTRLTGEELQ

Sequences:

>Translated_302_residues
MSNALYQSSISSLPLLGHGKVRDNYAVGEDKLLIVTTDRLSAFDVIMGEPIPDKGRVLNQMANFWFRKLAHIVPNHETGV
AAETVVAPAEVEQVKGRAVVVKRLKPILVEAVVRGYLAGSGWKDYQATGKVCGIELPAGLQNAQKLPEPIFTPAAKAEMG
EHDENISFGEVEERIGIALARQMRDISIRLYKEAAEFAATRGIIIADTKFEFGLDENGTLTLMDEVLTADSSRFWPADSY
QVGTNPPSFDKQFVRDWLEAVRIDGKPWPKTAPAPKLPDDVIEKTAAKYREALTRLTGEELQ
>Mature_301_residues
SNALYQSSISSLPLLGHGKVRDNYAVGEDKLLIVTTDRLSAFDVIMGEPIPDKGRVLNQMANFWFRKLAHIVPNHETGVA
AETVVAPAEVEQVKGRAVVVKRLKPILVEAVVRGYLAGSGWKDYQATGKVCGIELPAGLQNAQKLPEPIFTPAAKAEMGE
HDENISFGEVEERIGIALARQMRDISIRLYKEAAEFAATRGIIIADTKFEFGLDENGTLTLMDEVLTADSSRFWPADSYQ
VGTNPPSFDKQFVRDWLEAVRIDGKPWPKTAPAPKLPDDVIEKTAAKYREALTRLTGEELQ

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=296, Percent_Identity=46.6216216216216, Blast_Score=273, Evalue=3e-74,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 33304; Mature: 33173

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNALYQSSISSLPLLGHGKVRDNYAVGEDKLLIVTTDRLSAFDVIMGEPIPDKGRVLNQ
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCHHHHHHH
MANFWFRKLAHIVPNHETGVAAETVVAPAEVEQVKGRAVVVKRLKPILVEAVVRGYLAGS
HHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
GWKDYQATGKVCGIELPAGLQNAQKLPEPIFTPAAKAEMGEHDENISFGEVEERIGIALA
CCCCHHCCCCEEEEECCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHH
RQMRDISIRLYKEAAEFAATRGIIIADTKFEFGLDENGTLTLMDEVLTADSSRFWPADSY
HHHHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCCCEEEHHHHHHCCCCCCCCCCCE
QVGTNPPSFDKQFVRDWLEAVRIDGKPWPKTAPAPKLPDDVIEKTAAKYREALTRLTGEE
ECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
LQ
CC
>Mature Secondary Structure 
SNALYQSSISSLPLLGHGKVRDNYAVGEDKLLIVTTDRLSAFDVIMGEPIPDKGRVLNQ
CCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCHHHHHHH
MANFWFRKLAHIVPNHETGVAAETVVAPAEVEQVKGRAVVVKRLKPILVEAVVRGYLAGS
HHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
GWKDYQATGKVCGIELPAGLQNAQKLPEPIFTPAAKAEMGEHDENISFGEVEERIGIALA
CCCCHHCCCCEEEEECCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHH
RQMRDISIRLYKEAAEFAATRGIIIADTKFEFGLDENGTLTLMDEVLTADSSRFWPADSY
HHHHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCCCEEEHHHHHHCCCCCCCCCCCE
QVGTNPPSFDKQFVRDWLEAVRIDGKPWPKTAPAPKLPDDVIEKTAAKYREALTRLTGEE
ECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
LQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA