Click here to switch to the map view.

The map label for this gene is livH [H]

Identifier: 73539968

GI number: 73539968

Start: 291708

End: 292622

Strand: Direct

Name: livH [H]

Synonym: Reut_A0262

Alternate gene names: 73539968

Gene position: 291708-292622 (Clockwise)

Preceding gene: 73539967

Following gene: 73539969

Centisome position: 7.66

GC content: 64.04

Gene sequence:

>915_bases
ATGACGTTCTTCATTGAAATCCTGCTCGGCGGCTTGCTGTCGGGCCTGATGTACTCGCTGGTGGCGCTGGGCTTCGTGCT
GATCTACAAGGCCTCCGGCGTGTTCAACTTCGCGCAGGGCGCGATGGTGTACTTCGCCGCGCTGGCCGTGGTGGGCCTGA
TGGACAAGGGCCTGCCGATGTGGGCCGCCGTGATCGGCGCCTTCGTGGTGATGATCCTCGTCGGTATGAGCACCGAGCGC
TTCGTGTTGCGAAAGCTGGTCAACCAGCCGCCGATCACGCTGTTCATGGCGACCATCGGCCTGTCGTTCTTCCTCGAAGG
ACTGGGGCCGCTGCTGTTCGGCAACGAAGTGCGCCCGATCAATCTCGGCATCGTCGATGAGCCGATCGAAGCCATCCTCA
CGCGCTTCAACGTCGTTCTCTCCAAGTTCGATCTCGCTGCCGCCGCGATCGCAGGTCTGCTGGTCGGTTCGCTCGCGCTG
TTCTTCCAGTACACGAAGGTTGGACGCGCGCTGCGCGCCGTTGCCGATGACCATCAGGCCGCGCTGTCGCTGGGCATTCC
GCTGCAGCATATCTGGGCGATCGTGTGGGGCGTTGCAGGCTTTGTGGCACTGGTGGCCGGCATGCTGTGGGGCTCGCGCA
ATGGCGTGCAGTTCGCGCTGACGCTGACCGCGCTGAAGGCGCTGCCGGTGCTGATTCTTGGCGGCTTCACCTCGGTGCCG
GGCGCCATCGTTGGCGGGCTGATCATCGGCGCGTCGGAGAAGCTCGCCGAGATCTACATCCCGCCGGTGTTCCAGTCGGC
GTTCGGCGGAAACTTCGGCGGCATCGAAGGCTGGTTCCCGTATGTGTTCGCGCTGCTCTTCCTGCTGGTCCGTCCGGAAG
GGCTGTTCGGCGAGAAGCACATCGACCGCGTCTGA

Upstream 100 bases:

>100_bases
GAGGTGAAGGCGAATCCAGATGTGATCAAGGCCTACCTCGGTACGTCGCACTGAGCCCGCACGCGGCTTTCCATTCAACT
GATTCCACCGGAACGCAGCC

Downstream 100 bases:

>100_bases
ACTGACTACGCTCCAGGAGACTTTCCATGTTCTATCGTGAAGCCGGCCAGTTCAAGACGAGCTACGTCTCGGACAGCCAG
ATCTTCCCCATCCGTCAGGA

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MTFFIEILLGGLLSGLMYSLVALGFVLIYKASGVFNFAQGAMVYFAALAVVGLMDKGLPMWAAVIGAFVVMILVGMSTER
FVLRKLVNQPPITLFMATIGLSFFLEGLGPLLFGNEVRPINLGIVDEPIEAILTRFNVVLSKFDLAAAAIAGLLVGSLAL
FFQYTKVGRALRAVADDHQAALSLGIPLQHIWAIVWGVAGFVALVAGMLWGSRNGVQFALTLTALKALPVLILGGFTSVP
GAIVGGLIIGASEKLAEIYIPPVFQSAFGGNFGGIEGWFPYVFALLFLLVRPEGLFGEKHIDRV

Sequences:

>Translated_304_residues
MTFFIEILLGGLLSGLMYSLVALGFVLIYKASGVFNFAQGAMVYFAALAVVGLMDKGLPMWAAVIGAFVVMILVGMSTER
FVLRKLVNQPPITLFMATIGLSFFLEGLGPLLFGNEVRPINLGIVDEPIEAILTRFNVVLSKFDLAAAAIAGLLVGSLAL
FFQYTKVGRALRAVADDHQAALSLGIPLQHIWAIVWGVAGFVALVAGMLWGSRNGVQFALTLTALKALPVLILGGFTSVP
GAIVGGLIIGASEKLAEIYIPPVFQSAFGGNFGGIEGWFPYVFALLFLLVRPEGLFGEKHIDRV
>Mature_303_residues
TFFIEILLGGLLSGLMYSLVALGFVLIYKASGVFNFAQGAMVYFAALAVVGLMDKGLPMWAAVIGAFVVMILVGMSTERF
VLRKLVNQPPITLFMATIGLSFFLEGLGPLLFGNEVRPINLGIVDEPIEAILTRFNVVLSKFDLAAAAIAGLLVGSLALF
FQYTKVGRALRAVADDHQAALSLGIPLQHIWAIVWGVAGFVALVAGMLWGSRNGVQFALTLTALKALPVLILGGFTSVPG
AIVGGLIIGASEKLAEIYIPPVFQSAFGGNFGGIEGWFPYVFALLFLLVRPEGLFGEKHIDRV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=313, Percent_Identity=27.1565495207668, Blast_Score=105, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 32395; Mature: 32264

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFFIEILLGGLLSGLMYSLVALGFVLIYKASGVFNFAQGAMVYFAALAVVGLMDKGLPM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
WAAVIGAFVVMILVGMSTERFVLRKLVNQPPITLFMATIGLSFFLEGLGPLLFGNEVRPI
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHCCCCCCEE
NLGIVDEPIEAILTRFNVVLSKFDLAAAAIAGLLVGSLALFFQYTKVGRALRAVADDHQA
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALSLGIPLQHIWAIVWGVAGFVALVAGMLWGSRNGVQFALTLTALKALPVLILGGFTSVP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
GAIVGGLIIGASEKLAEIYIPPVFQSAFGGNFGGIEGWFPYVFALLFLLVRPEGLFGEKH
HHHHHHHHHCCCHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHH
IDRV
CCCC
>Mature Secondary Structure 
TFFIEILLGGLLSGLMYSLVALGFVLIYKASGVFNFAQGAMVYFAALAVVGLMDKGLPM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHH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CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]