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The map label for this gene is xpt

Identifier: 71910671

GI number: 71910671

Start: 849325

End: 849906

Strand: Direct

Name: xpt

Synonym: M5005_Spy_0858

Alternate gene names: 71910671

Gene position: 849325-849906 (Clockwise)

Preceding gene: 71910670

Following gene: 71910672

Centisome position: 46.2

GC content: 38.49

Gene sequence:

>582_bases
ATGCAGTTACTTGAAGAACGCATCTTAACAGATGGCAATATTCTAGGAGAGAATATTCTAAAGGTAGATAATTTTTTAAC
TCATCAAGTTGATTACCGGTTGATGAAAGCAATTGGTAAAGTGTTTGCTCAAAAATATGCTGAGGCTGGCATTACAAAAG
TGGTTACAATCGAAGCTTCAGGTATTGCACCAGCCGTATACGCTGCAGAAGCAATGGATGTTCCTATGATTTTTGCGAAA
AAACATAAAAACATTACCATGACAGAAGGCATTTTGACAGCAGAAGTTTATTCTTTCACTAAACAAGTGACGAGCACGGT
GTCTATCGCTGGTAAATTCCTATCTAAAGAAGACAAGGTTTTGATTATTGATGACTTTTTAGCTAATGGTCAGGCAGCCA
AAGGCTTGATTGAGATTATTGGTCAAGCAGGGGCACAAGTCGTCGGCGTTGGTATTGTGATTGAGAAATCTTTCCAAGAT
GGTCGTCGATTGATTGAAGATATGGGCATTGAAGTGACCTCATTAGCCCGTATTAAAAACTTTGAAAATGGTAATCTAAA
CTTCTTGGAGGCTGACGCATAA

Upstream 100 bases:

>100_bases
AGCTTTTAGGCTTGCTTGGTTTTTAACCTTGCAAAGTGAGAAACTCTTATAGTTTCTGGCTTTGCGGCAGGCTTTTTCTA
TTTGAATCAAAAGGAGATTT

Downstream 100 bases:

>100_bases
TGACACATTCAACAAAGCAGGAACATTCTCACTCGCAATCAGCTGTCCTTGGCTTACAGCATGTGCTTTCGATGTATGCC
GGATCTATTTTAGTACCAAT

Product: xanthine phosphoribosyltransferase

Products: NA

Alternate protein names: XPRTase

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MQLLEERILTDGNILGENILKVDNFLTHQVDYRLMKAIGKVFAQKYAEAGITKVVTIEASGIAPAVYAAEAMDVPMIFAK
KHKNITMTEGILTAEVYSFTKQVTSTVSIAGKFLSKEDKVLIIDDFLANGQAAKGLIEIIGQAGAQVVGVGIVIEKSFQD
GRRLIEDMGIEVTSLARIKNFENGNLNFLEADA

Sequences:

>Translated_193_residues
MQLLEERILTDGNILGENILKVDNFLTHQVDYRLMKAIGKVFAQKYAEAGITKVVTIEASGIAPAVYAAEAMDVPMIFAK
KHKNITMTEGILTAEVYSFTKQVTSTVSIAGKFLSKEDKVLIIDDFLANGQAAKGLIEIIGQAGAQVVGVGIVIEKSFQD
GRRLIEDMGIEVTSLARIKNFENGNLNFLEADA
>Mature_193_residues
MQLLEERILTDGNILGENILKVDNFLTHQVDYRLMKAIGKVFAQKYAEAGITKVVTIEASGIAPAVYAAEAMDVPMIFAK
KHKNITMTEGILTAEVYSFTKQVTSTVSIAGKFLSKEDKVLIIDDFLANGQAAKGLIEIIGQAGAQVVGVGIVIEKSFQD
GRRLIEDMGIEVTSLARIKNFENGNLNFLEADA

Specific function: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XPT subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XPT_STRP1 (Q99ZQ0)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269287.1
- RefSeq:   YP_282221.1
- HSSP:   P42085
- ProteinModelPortal:   Q99ZQ0
- SMR:   Q99ZQ0
- EnsemblBacteria:   EBSTRT00000001145
- EnsemblBacteria:   EBSTRT00000028433
- GeneID:   3572067
- GeneID:   901252
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1136
- KEGG:   spz:M5005_Spy_0858
- GeneTree:   EBGT00050000026781
- HOGENOM:   HBG288993
- OMA:   ATVYSFT
- ProtClustDB:   PRK09219
- BioCyc:   SPYO160490:SPY1136-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0858-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01184
- InterPro:   IPR000836
- InterPro:   IPR010079
- TIGRFAMs:   TIGR01744

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.22

Molecular weight: Translated: 20995; Mature: 20995

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 20-20 BINDING 27-27 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLLEERILTDGNILGENILKVDNFLTHQVDYRLMKAIGKVFAQKYAEAGITKVVTIEAS
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
GIAPAVYAAEAMDVPMIFAKKHKNITMTEGILTAEVYSFTKQVTSTVSIAGKFLSKEDKV
CCCHHHHHHHHCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LIIDDFLANGQAAKGLIEIIGQAGAQVVGVGIVIEKSFQDGRRLIEDMGIEVTSLARIKN
EEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHCCCCHHHHHHHHC
FENGNLNFLEADA
CCCCCEEEEECCC
>Mature Secondary Structure
MQLLEERILTDGNILGENILKVDNFLTHQVDYRLMKAIGKVFAQKYAEAGITKVVTIEAS
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
GIAPAVYAAEAMDVPMIFAKKHKNITMTEGILTAEVYSFTKQVTSTVSIAGKFLSKEDKV
CCCHHHHHHHHCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LIIDDFLANGQAAKGLIEIIGQAGAQVVGVGIVIEKSFQDGRRLIEDMGIEVTSLARIKN
EEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHCCCCHHHHHHHHC
FENGNLNFLEADA
CCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296