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The map label for this gene is guaC [H]

Identifier: 71910670

GI number: 71910670

Start: 848037

End: 849020

Strand: Direct

Name: guaC [H]

Synonym: M5005_Spy_0857

Alternate gene names: 71910670

Gene position: 848037-849020 (Clockwise)

Preceding gene: 71910669

Following gene: 71910671

Centisome position: 46.13

GC content: 39.63

Gene sequence:

>984_bases
ATGTTTAATGACATCCCTGTATTTGATTATGAAGATATTCAACTGATTCCTAACAAGTGCATTATTACTAGTCGTTCACA
AGCAGATACAAGTGTGACACTCGGAAAATACCAGTTCAAGCTACCAGTTATCCCAGCAAATATGCAAACCATTATTGATG
AAACAATTGCTGAGCAGTTGGCAAAAGAGGGTTATTTTTATATTATGCATCGTTTTGATGAAGATAGCCGCAAACCTTTT
ATCAAACGCATGCATGAACAAGGCTTGATTGCATCAATCTCTGTTGGGGTTAAAGCTTGTGAATATGAATTTGTGACCTC
TTTGAAAGAGGATGCTCCTGAGTTTATCACCATTGATATTGCTCATGGTCATGCTAACAGTGTTATTGATATGATTAAGC
ATATCAAGACTGAATTACCAGAAACATTTGTCATTGCTGGAAATGTTGGTACGCCAGAAGCTGTACGAGAACTCGAAAAT
GCAGGTGCTGATGCTACTAAAGTAGGCATCGGTCCAGGCAAAGTATGTATCACTAAAGTTAAAACCGGTTTCGGTACAGG
TGGTTGGCAGCTAGCAGCACTGCGCTGGTGCGCAAAGGCAGCTCGTAAACCTATCATTGCTGATGGTGGGATTCGCACAC
ATGGTGATATTGCTAAATCCATCCGCTTTGGAGCTAGTATGGTCATGATTGGATCGCTTTTTGCAGGACATTTTGAAAGT
CCTGGAAAAACGGTAGAAGTGGATGGTGAAACGTTTAAAGAATATTATGGCTCGGCGTCAGAATATCAAAAAGGCGAGCA
TAAAAATGTAGAAGGCAAAAAAATCTTATTGCCTACAAAAGGTCACTTATCAGATACCCTGACCGAAATGCAACAGGATT
TGCAATCGTCCATTTCTTACGCGGGTGGTAAAGATTTAGACAGTTTGCGTCATGTTGATTATGTTATCGTCAAAAATTCT
ATTTGGAATGGTGATTCCATTTAA

Upstream 100 bases:

>100_bases
TCATCAGAGGTCATAGGAAGATTATTTTGTATAGAGGACTTAGAGAAGAAGGTGAGAACTAACTTGTTTTTCTTAATCTA
TGTTAAAAGAGGAGAAACTT

Downstream 100 bases:

>100_bases
ATGATATGGAGTTAGCTAGGACCAGTAAAGAATTTTTTAGCTTAATGCTGGAGATGCTTTTATCATATCTCTGTAGGTAT
TGAAAAAAATAAGAAACATG

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MFNDIPVFDYEDIQLIPNKCIITSRSQADTSVTLGKYQFKLPVIPANMQTIIDETIAEQLAKEGYFYIMHRFDEDSRKPF
IKRMHEQGLIASISVGVKACEYEFVTSLKEDAPEFITIDIAHGHANSVIDMIKHIKTELPETFVIAGNVGTPEAVRELEN
AGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMVMIGSLFAGHFES
PGKTVEVDGETFKEYYGSASEYQKGEHKNVEGKKILLPTKGHLSDTLTEMQQDLQSSISYAGGKDLDSLRHVDYVIVKNS
IWNGDSI

Sequences:

>Translated_327_residues
MFNDIPVFDYEDIQLIPNKCIITSRSQADTSVTLGKYQFKLPVIPANMQTIIDETIAEQLAKEGYFYIMHRFDEDSRKPF
IKRMHEQGLIASISVGVKACEYEFVTSLKEDAPEFITIDIAHGHANSVIDMIKHIKTELPETFVIAGNVGTPEAVRELEN
AGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMVMIGSLFAGHFES
PGKTVEVDGETFKEYYGSASEYQKGEHKNVEGKKILLPTKGHLSDTLTEMQQDLQSSISYAGGKDLDSLRHVDYVIVKNS
IWNGDSI
>Mature_327_residues
MFNDIPVFDYEDIQLIPNKCIITSRSQADTSVTLGKYQFKLPVIPANMQTIIDETIAEQLAKEGYFYIMHRFDEDSRKPF
IKRMHEQGLIASISVGVKACEYEFVTSLKEDAPEFITIDIAHGHANSVIDMIKHIKTELPETFVIAGNVGTPEAVRELEN
AGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMVMIGSLFAGHFES
PGKTVEVDGETFKEYYGSASEYQKGEHKNVEGKKILLPTKGHLSDTLTEMQQDLQSSISYAGGKDLDSLRHVDYVIVKNS
IWNGDSI

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI156104880, Length=329, Percent_Identity=33.1306990881459, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI50541954, Length=338, Percent_Identity=33.1360946745562, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI50541952, Length=338, Percent_Identity=33.1360946745562, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI50541948, Length=338, Percent_Identity=33.1360946745562, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI50541956, Length=338, Percent_Identity=33.1360946745562, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI66933016, Length=235, Percent_Identity=33.1914893617021, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI217035150, Length=263, Percent_Identity=31.9391634980989, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI217035148, Length=263, Percent_Identity=31.9391634980989, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI217035146, Length=263, Percent_Identity=31.9391634980989, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI156616279, Length=263, Percent_Identity=31.9391634980989, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI217035152, Length=263, Percent_Identity=31.9391634980989, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI34328930, Length=263, Percent_Identity=31.9391634980989, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI34328928, Length=263, Percent_Identity=31.9391634980989, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1786293, Length=337, Percent_Identity=32.3442136498516, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1788855, Length=259, Percent_Identity=33.976833976834, Blast_Score=104, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17560440, Length=326, Percent_Identity=31.9018404907975, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=158, Percent_Identity=36.0759493670886, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71994389, Length=158, Percent_Identity=36.0759493670886, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323585, Length=175, Percent_Identity=34.2857142857143, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6323464, Length=175, Percent_Identity=34.2857142857143, Blast_Score=99, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6322012, Length=182, Percent_Identity=32.967032967033, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319352, Length=136, Percent_Identity=30.8823529411765, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28571163, Length=247, Percent_Identity=31.5789473684211, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641071, Length=257, Percent_Identity=30.7392996108949, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641073, Length=257, Percent_Identity=30.7392996108949, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005994
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 35963; Mature: 35963

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNDIPVFDYEDIQLIPNKCIITSRSQADTSVTLGKYQFKLPVIPANMQTIIDETIAEQL
CCCCCCCCCCCCCEECCCEEEEECCCCCCCEEEECEEEEEEEEECCHHHHHHHHHHHHHH
AKEGYFYIMHRFDEDSRKPFIKRMHEQGLIASISVGVKACEYEFVTSLKEDAPEFITIDI
HHCCEEEEEEECCCCCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEE
AHGHANSVIDMIKHIKTELPETFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKV
ECCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEE
KTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMVMIGSLFAGHFES
CCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCC
PGKTVEVDGETFKEYYGSASEYQKGEHKNVEGKKILLPTKGHLSDTLTEMQQDLQSSISY
CCCEEEECCHHHHHHCCCHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHC
AGGKDLDSLRHVDYVIVKNSIWNGDSI
CCCCCHHHHHHCEEEEEECCCCCCCCC
>Mature Secondary Structure
MFNDIPVFDYEDIQLIPNKCIITSRSQADTSVTLGKYQFKLPVIPANMQTIIDETIAEQL
CCCCCCCCCCCCCEECCCEEEEECCCCCCCEEEECEEEEEEEEECCHHHHHHHHHHHHHH
AKEGYFYIMHRFDEDSRKPFIKRMHEQGLIASISVGVKACEYEFVTSLKEDAPEFITIDI
HHCCEEEEEEECCCCCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEE
AHGHANSVIDMIKHIKTELPETFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKV
ECCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEE
KTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMVMIGSLFAGHFES
CCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCC
PGKTVEVDGETFKEYYGSASEYQKGEHKNVEGKKILLPTKGHLSDTLTEMQQDLQSSISY
CCCEEEECCHHHHHHCCCHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHC
AGGKDLDSLRHVDYVIVKNSIWNGDSI
CCCCCHHHHHHCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11917108 [H]