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The map label for this gene is hisD

Identifier: 71892237

GI number: 71892237

Start: 570629

End: 571960

Strand: Direct

Name: hisD

Synonym: BPEN_478

Alternate gene names: 71892237

Gene position: 570629-571960 (Clockwise)

Preceding gene: 71892236

Following gene: 71892238

Centisome position: 72.08

GC content: 35.36

Gene sequence:

>1332_bases
ATGATTTCTCATGAACATCCTATATCTATTTATTGGAATGATTGTTCCAAATCTGAACAAAAAAAACTGCTGACCCGTCC
AATAAATAACAAATTAAACGATATTTATATAAATGTTAAAAATATACTTACAAAAGTTTATAACGAAGGCGATCGTGCTT
TATTTAAATTTAATTTTGATTTTGACAACGTCCAAACTACACAATTGCAAATCCCAACTGAAATTATCATGAATTCGGGA
CGTAACTTGTCTAATGAAATAAAACAAGCAATACATACCGCCATGACCAATATAACACGGTTTCATCAAGCACAATGTTA
TTCAGAGATAATCGTGGAAACTCTTCCAGGCGTATATTGCCAACAAATTATTCGCCCATTAAATATTGTTGGACTATATG
TACCAGGAGGAACTGCACCGCTGTTGTCAACAGTTATGATGTTAGGTGTCCCAGCTCGTATTGCAAAATGTAAACGTGTA
ATATTATGTTCACCCCCACCAATTCCGGACGTAATTATATATACCGCACAACTTTGCGGTATCGACGAAATTTATCAAAT
AGGAGGTAGTCAATCTATAGCCGCTATGGGATTTGGCACTGAGTCTATTCCGAAAGTAGATAAGATATTTGGACCAGGTA
ATATATGGGTTACAGAAGCAAAACGACAAATTAATCTTGCTCCAAATGGAGCTGCTATTGATATGCTAGCTGGACCTTCC
GAAATATTAATTATTGCAGATAATACGGCTAATCCTATTTTTATCGCAGCAGACCTTTTGTCACAATCAGAGCACGGACC
TGATTCGCACGCAATACTTATAACGCCCTACTCGTGCATTGCAGAAAAAACAAAAAAAGAGCTACATAAACAATTAAAAA
TATTACCACGAAATGATATCGTTCGTAACGTATTATTGAATAGTCGCATGATTATTACTAATAATTTAATGGAATGTTTT
TCTATAAGCAATAGCTATGCTCCAGAGCATTTGATTATTCAAATTGAAAATGCATCAGATTATTTACATTACATCACGAA
TGCCGGATCAATATTCCTTGGAAATTGGTCTCCGGAAACTGCTGGAGATTATGCAAGCGGGCCTAATCACGTTTTACCTA
CATACGGGCGCGCAGTTGCCACATCTGGTCTAGGAGTTATAGATTTTCAAAAAAGAATGTCGGTACAACAATTAACCCAA
AATGGATTATTGCAGCTATCATCAACCATTACAACATTAACACAAATCGAACAATTAAAAGCTCATGAATATGCCATAAC
ACATCGTATAAACTATATCAAGGAACAAAATGAACATTCGTTACTTGGCTAG

Upstream 100 bases:

>100_bases
AGTAATGAAACATTATTTTGGGAAACAATGGAAAATTTAAAAAATCTTGGAGCTAGTTCTATTTTAGTATTACCAATAGA
AAAAATGATGGAATAATATT

Downstream 100 bases:

>100_bases
GAATAATATATTAACTCTTAAACCTTATCAATCTGCTAGAAAATGCACACATTCAGGTAACATATGGCTGAACGCTAATG
AATTTCCAATCGCTCCCGAC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MISHEHPISIYWNDCSKSEQKKLLTRPINNKLNDIYINVKNILTKVYNEGDRALFKFNFDFDNVQTTQLQIPTEIIMNSG
RNLSNEIKQAIHTAMTNITRFHQAQCYSEIIVETLPGVYCQQIIRPLNIVGLYVPGGTAPLLSTVMMLGVPARIAKCKRV
ILCSPPPIPDVIIYTAQLCGIDEIYQIGGSQSIAAMGFGTESIPKVDKIFGPGNIWVTEAKRQINLAPNGAAIDMLAGPS
EILIIADNTANPIFIAADLLSQSEHGPDSHAILITPYSCIAEKTKKELHKQLKILPRNDIVRNVLLNSRMIITNNLMECF
SISNSYAPEHLIIQIENASDYLHYITNAGSIFLGNWSPETAGDYASGPNHVLPTYGRAVATSGLGVIDFQKRMSVQQLTQ
NGLLQLSSTITTLTQIEQLKAHEYAITHRINYIKEQNEHSLLG

Sequences:

>Translated_443_residues
MISHEHPISIYWNDCSKSEQKKLLTRPINNKLNDIYINVKNILTKVYNEGDRALFKFNFDFDNVQTTQLQIPTEIIMNSG
RNLSNEIKQAIHTAMTNITRFHQAQCYSEIIVETLPGVYCQQIIRPLNIVGLYVPGGTAPLLSTVMMLGVPARIAKCKRV
ILCSPPPIPDVIIYTAQLCGIDEIYQIGGSQSIAAMGFGTESIPKVDKIFGPGNIWVTEAKRQINLAPNGAAIDMLAGPS
EILIIADNTANPIFIAADLLSQSEHGPDSHAILITPYSCIAEKTKKELHKQLKILPRNDIVRNVLLNSRMIITNNLMECF
SISNSYAPEHLIIQIENASDYLHYITNAGSIFLGNWSPETAGDYASGPNHVLPTYGRAVATSGLGVIDFQKRMSVQQLTQ
NGLLQLSSTITTLTQIEQLKAHEYAITHRINYIKEQNEHSLLG
>Mature_443_residues
MISHEHPISIYWNDCSKSEQKKLLTRPINNKLNDIYINVKNILTKVYNEGDRALFKFNFDFDNVQTTQLQIPTEIIMNSG
RNLSNEIKQAIHTAMTNITRFHQAQCYSEIIVETLPGVYCQQIIRPLNIVGLYVPGGTAPLLSTVMMLGVPARIAKCKRV
ILCSPPPIPDVIIYTAQLCGIDEIYQIGGSQSIAAMGFGTESIPKVDKIFGPGNIWVTEAKRQINLAPNGAAIDMLAGPS
EILIIADNTANPIFIAADLLSQSEHGPDSHAILITPYSCIAEKTKKELHKQLKILPRNDIVRNVLLNSRMIITNNLMECF
SISNSYAPEHLIIQIENASDYLHYITNAGSIFLGNWSPETAGDYASGPNHVLPTYGRAVATSGLGVIDFQKRMSVQQLTQ
NGLLQLSSTITTLTQIEQLKAHEYAITHRINYIKEQNEHSLLG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=427, Percent_Identity=54.3325526932084, Blast_Score=506, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6319819, Length=424, Percent_Identity=42.4528301886792, Blast_Score=335, Evalue=1e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_BLOPB (Q492K3)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277970.1
- ProteinModelPortal:   Q492K3
- SMR:   Q492K3
- STRING:   Q492K3
- GeneID:   3562985
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_478
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   CBLO291272:BPEN_478-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 49150; Mature: 49150

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 329-329 ACT_SITE 330-330 BINDING 133-133 BINDING 191-191 BINDING 214-214 BINDING 240-240 BINDING 262-262 BINDING 265-265 BINDING 330-330 BINDING 363-363 BINDING 417-417 BINDING 422-422

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISHEHPISIYWNDCSKSEQKKLLTRPINNKLNDIYINVKNILTKVYNEGDRALFKFNFD
CCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHCCCCEEEEEEECC
FDNVQTTQLQIPTEIIMNSGRNLSNEIKQAIHTAMTNITRFHQAQCYSEIIVETLPGVYC
CCCEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
QQIIRPLNIVGLYVPGGTAPLLSTVMMLGVPARIAKCKRVILCSPPPIPDVIIYTAQLCG
HHHHCCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHCCEEEEECCCCCCHHHHHHHHHCC
IDEIYQIGGSQSIAAMGFGTESIPKVDKIFGPGNIWVTEAKRQINLAPNGAAIDMLAGPS
HHHHHHCCCCCCEEEECCCCCCCCCHHHHCCCCCEEEEECCEEEEECCCCCEEEEECCCC
EILIIADNTANPIFIAADLLSQSEHGPDSHAILITPYSCIAEKTKKELHKQLKILPRNDI
EEEEEECCCCCCEEEEEEHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCHHH
VRNVLLNSRMIITNNLMECFSISNSYAPEHLIIQIENASDYLHYITNAGSIFLGNWSPET
HHHHHHCCCEEEHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHCCCEEEEECCCCCC
AGDYASGPNHVLPTYGRAVATSGLGVIDFQKRMSVQQLTQNGLLQLSSTITTLTQIEQLK
CCCCCCCCCCCCCCCCCHHHHCCCCEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AHEYAITHRINYIKEQNEHSLLG
HHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MISHEHPISIYWNDCSKSEQKKLLTRPINNKLNDIYINVKNILTKVYNEGDRALFKFNFD
CCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHCCCCEEEEEEECC
FDNVQTTQLQIPTEIIMNSGRNLSNEIKQAIHTAMTNITRFHQAQCYSEIIVETLPGVYC
CCCEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
QQIIRPLNIVGLYVPGGTAPLLSTVMMLGVPARIAKCKRVILCSPPPIPDVIIYTAQLCG
HHHHCCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHCCEEEEECCCCCCHHHHHHHHHCC
IDEIYQIGGSQSIAAMGFGTESIPKVDKIFGPGNIWVTEAKRQINLAPNGAAIDMLAGPS
HHHHHHCCCCCCEEEECCCCCCCCCHHHHCCCCCEEEEECCEEEEECCCCCEEEEECCCC
EILIIADNTANPIFIAADLLSQSEHGPDSHAILITPYSCIAEKTKKELHKQLKILPRNDI
EEEEEECCCCCCEEEEEEHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCHHH
VRNVLLNSRMIITNNLMECFSISNSYAPEHLIIQIENASDYLHYITNAGSIFLGNWSPET
HHHHHHCCCEEEHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHCCCEEEEECCCCCC
AGDYASGPNHVLPTYGRAVATSGLGVIDFQKRMSVQQLTQNGLLQLSSTITTLTQIEQLK
CCCCCCCCCCCCCCCCCHHHHCCCCEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AHEYAITHRINYIKEQNEHSLLG
HHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA