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The map label for this gene is hisG [H]

Identifier: 71892236

GI number: 71892236

Start: 569725

End: 570624

Strand: Direct

Name: hisG [H]

Synonym: BPEN_477

Alternate gene names: 71892236

Gene position: 569725-570624 (Clockwise)

Preceding gene: 71892235

Following gene: 71892237

Centisome position: 71.97

GC content: 35.22

Gene sequence:

>900_bases
ATGCTGGATAGATCGAGGTTACGAATAGCAATACAAAAATCAGGAAGATTGAGCAAAGAATCCCAACAACTTCTTGAACA
ATGTGGAATTAAAATTAATTTACAACAACAACGTCTATTAGCGTTTGCAGAAAACATGGCTATCGATATAATGCGAGTGC
GTGATGATGATATTCCTGGTTTAGTTATGGACGGTATAGTAGATTTAGGTATTATCGGAGAAAATGTATTAGAAGAAGCC
TTATTAACGAGACGATCGCAAGGAGATAATCCTTGTTACATTATGTTACTCCGATTAGATTTTGGAGATTGTCGGTTATC
TATGGCCTTACCCATAGATGAACCATGGAATGGTCCAAAATCCTTACAAGGGAAACGAATTGCCACTTCATACCCACATC
TTCTGAAACAATATTTAGATAAATTAGGTATTCATTTTAAATCTTGTTTACTAAATGGCTCAGTAGAAGTAGCACCACGT
GCTGGATTAGCAGATGCAATTTGTGATCTAGTGTCTACCGGAGCTACCTTAGAAGCTAATGGATTACATGAAGTAGAAGT
AATCTATCGATCTAAAGCATGTCTTATTCAACGATCTGGAGAATTATCCAACATAAAACAATCACTGATAAACAAATTAA
TAATTCGTATTCAAGGAGTAATCCAAGCCAGGGGATCTAAATACATCATGTTGCATGCCCCTGCTGAACAACTAGAGGAA
ATTATTAATTTACTACCTGGAGCAGAAAGTCCAACAGTATTGCCATTAGCAGGCAATCAACATCGTGTGGCAATATACAT
GGTAAGTAATGAAACATTATTTTGGGAAACAATGGAAAATTTAAAAAATCTTGGAGCTAGTTCTATTTTAGTATTACCAA
TAGAAAAAATGATGGAATAA

Upstream 100 bases:

>100_bases
TTTAATATTTTGTTTATTAAAAATATCAAAGGTACTTCTGTTGCAAGAATTTTAAAAAAGTATTTAGTAATGGAAAATTG
TTGACATAAGGTAAAATATC

Downstream 100 bases:

>100_bases
TATTATGATTTCTCATGAACATCCTATATCTATTTATTGGAATGATTGTTCCAAATCTGAACAAAAAAAACTGCTGACCC
GTCCAATAAATAACAAATTA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MLDRSRLRIAIQKSGRLSKESQQLLEQCGIKINLQQQRLLAFAENMAIDIMRVRDDDIPGLVMDGIVDLGIIGENVLEEA
LLTRRSQGDNPCYIMLLRLDFGDCRLSMALPIDEPWNGPKSLQGKRIATSYPHLLKQYLDKLGIHFKSCLLNGSVEVAPR
AGLADAICDLVSTGATLEANGLHEVEVIYRSKACLIQRSGELSNIKQSLINKLIIRIQGVIQARGSKYIMLHAPAEQLEE
IINLLPGAESPTVLPLAGNQHRVAIYMVSNETLFWETMENLKNLGASSILVLPIEKMME

Sequences:

>Translated_299_residues
MLDRSRLRIAIQKSGRLSKESQQLLEQCGIKINLQQQRLLAFAENMAIDIMRVRDDDIPGLVMDGIVDLGIIGENVLEEA
LLTRRSQGDNPCYIMLLRLDFGDCRLSMALPIDEPWNGPKSLQGKRIATSYPHLLKQYLDKLGIHFKSCLLNGSVEVAPR
AGLADAICDLVSTGATLEANGLHEVEVIYRSKACLIQRSGELSNIKQSLINKLIIRIQGVIQARGSKYIMLHAPAEQLEE
IINLLPGAESPTVLPLAGNQHRVAIYMVSNETLFWETMENLKNLGASSILVLPIEKMME
>Mature_299_residues
MLDRSRLRIAIQKSGRLSKESQQLLEQCGIKINLQQQRLLAFAENMAIDIMRVRDDDIPGLVMDGIVDLGIIGENVLEEA
LLTRRSQGDNPCYIMLLRLDFGDCRLSMALPIDEPWNGPKSLQGKRIATSYPHLLKQYLDKLGIHFKSCLLNGSVEVAPR
AGLADAICDLVSTGATLEANGLHEVEVIYRSKACLIQRSGELSNIKQSLINKLIIRIQGVIQARGSKYIMLHAPAEQLEE
IINLLPGAESPTVLPLAGNQHRVAIYMVSNETLFWETMENLKNLGASSILVLPIEKMME

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=299, Percent_Identity=78.5953177257525, Blast_Score=486, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6320896, Length=297, Percent_Identity=29.96632996633, Blast_Score=129, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 33236; Mature: 33236

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRSRLRIAIQKSGRLSKESQQLLEQCGIKINLQQQRLLAFAENMAIDIMRVRDDDIPG
CCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHCCEEEEEEECCCCCCC
LVMDGIVDLGIIGENVLEEALLTRRSQGDNPCYIMLLRLDFGDCRLSMALPIDEPWNGPK
HHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCC
SLQGKRIATSYPHLLKQYLDKLGIHFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEAN
CCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCEEECC
GLHEVEVIYRSKACLIQRSGELSNIKQSLINKLIIRIQGVIQARGSKYIMLHAPAEQLEE
CCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
IINLLPGAESPTVLPLAGNQHRVAIYMVSNETLFWETMENLKNLGASSILVLPIEKMME
HHHHCCCCCCCEEEEECCCCCEEEEEEEECCEEHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure
MLDRSRLRIAIQKSGRLSKESQQLLEQCGIKINLQQQRLLAFAENMAIDIMRVRDDDIPG
CCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHCCEEEEEEECCCCCCC
LVMDGIVDLGIIGENVLEEALLTRRSQGDNPCYIMLLRLDFGDCRLSMALPIDEPWNGPK
HHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCC
SLQGKRIATSYPHLLKQYLDKLGIHFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEAN
CCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCEEECC
GLHEVEVIYRSKACLIQRSGELSNIKQSLINKLIIRIQGVIQARGSKYIMLHAPAEQLEE
CCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
IINLLPGAESPTVLPLAGNQHRVAIYMVSNETLFWETMENLKNLGASSILVLPIEKMME
HHHHCCCCCCCEEEEECCCCCEEEEEEEECCEEHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12886019 [H]