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The map label for this gene is hisC

Identifier: 71892238

GI number: 71892238

Start: 571938

End: 573014

Strand: Direct

Name: hisC

Synonym: BPEN_479

Alternate gene names: 71892238

Gene position: 571938-573014 (Clockwise)

Preceding gene: 71892237

Following gene: 71892239

Centisome position: 72.25

GC content: 32.13

Gene sequence:

>1077_bases
ATGAACATTCGTTACTTGGCTAGGAATAATATATTAACTCTTAAACCTTATCAATCTGCTAGAAAATGCACACATTCAGG
TAACATATGGCTGAACGCTAATGAATTTCCAATCGCTCCCGACTATCAATTTCGTTATAAAAAAATTCATAGATATCCTA
CTTGTCAACCACAAGAAGTGATCAACAATTATGCTTATTATGCCGGGGTTCGATCTGATCAAATTTTAGTGTCGAGAGGA
GCCGATGAAAGTATTGAATTATTAATGAAAGTTTTTTGTAACCCTGGAAAAGACGTTATTATATTTTGCCCTCCGACATA
CGGTATGTATAAAACCACTGCAGAAATTTTAGGAATTAATTATCGGATTATACCTAAAAAGGAAAACTGGCAACTTGATT
TAGCATCCATTAAATCACAATTAAACAATGTTAAATTAATTTATATTTGTAATCCAAACAACCCTACCGGTAACATTATT
CATTTAAATAGTTTAAAAAAGTTATTAAAAATTATTCAAAACCGAGCGTTATTAGTAACTGATGAAGCATATATTGATTT
TTGCCCGGACGCAAGCCTAGTACGTTGGCTACCAATGTATCCTCATCTGGTTATATTAAGAACTTTATCTAAAGCTTTCG
CGTTAGCAGGATTACGCTGTGGTTTCACTTTAGCTAATCCAGAAATTATTAAATTATTAGAAAAAGTGATCGCACCATAC
CCATTGTCTACTCCAGTAATTGATATCGCAGAACAAGCTTTAACCCCTATAAGCATACAATACACCCAGAATAGAATAGC
TACAGTCAATACAAACCGAAACATATTAATTACAGGCTTAAAAAAATGTTCTTGTGTTCAACAAGTATTTAATAGTCACG
CTAATTATGTATTGGTTAAATTCAATCCAAAATATCAGGTTTTTAAGACATTATTGCATCAAGGTATAGTTTTAAGAGAT
CAAAGCAATCAACCAGGATTAGTTAATTGCTTGCGTATCACTGTCGGCACATATAATGAATGCAAACACGTAGTTTCTGT
TTTAAAAAAATTACATGTTGCATCTTTATCTATATAG

Upstream 100 bases:

>100_bases
TTGCAGCTATCATCAACCATTACAACATTAACACAAATCGAACAATTAAAAGCTCATGAATATGCCATAACACATCGTAT
AAACTATATCAAGGAACAAA

Downstream 100 bases:

>100_bases
ATAAATAGGAGCGCTCATGAATCATAAAGTTTTATTTATAGATCGTGATGGAACCTTAATTAATGAACCAAAAGACAATT
TTCAAATTGATTCTTTAGAC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MNIRYLARNNILTLKPYQSARKCTHSGNIWLNANEFPIAPDYQFRYKKIHRYPTCQPQEVINNYAYYAGVRSDQILVSRG
ADESIELLMKVFCNPGKDVIIFCPPTYGMYKTTAEILGINYRIIPKKENWQLDLASIKSQLNNVKLIYICNPNNPTGNII
HLNSLKKLLKIIQNRALLVTDEAYIDFCPDASLVRWLPMYPHLVILRTLSKAFALAGLRCGFTLANPEIIKLLEKVIAPY
PLSTPVIDIAEQALTPISIQYTQNRIATVNTNRNILITGLKKCSCVQQVFNSHANYVLVKFNPKYQVFKTLLHQGIVLRD
QSNQPGLVNCLRITVGTYNECKHVVSVLKKLHVASLSI

Sequences:

>Translated_358_residues
MNIRYLARNNILTLKPYQSARKCTHSGNIWLNANEFPIAPDYQFRYKKIHRYPTCQPQEVINNYAYYAGVRSDQILVSRG
ADESIELLMKVFCNPGKDVIIFCPPTYGMYKTTAEILGINYRIIPKKENWQLDLASIKSQLNNVKLIYICNPNNPTGNII
HLNSLKKLLKIIQNRALLVTDEAYIDFCPDASLVRWLPMYPHLVILRTLSKAFALAGLRCGFTLANPEIIKLLEKVIAPY
PLSTPVIDIAEQALTPISIQYTQNRIATVNTNRNILITGLKKCSCVQQVFNSHANYVLVKFNPKYQVFKTLLHQGIVLRD
QSNQPGLVNCLRITVGTYNECKHVVSVLKKLHVASLSI
>Mature_358_residues
MNIRYLARNNILTLKPYQSARKCTHSGNIWLNANEFPIAPDYQFRYKKIHRYPTCQPQEVINNYAYYAGVRSDQILVSRG
ADESIELLMKVFCNPGKDVIIFCPPTYGMYKTTAEILGINYRIIPKKENWQLDLASIKSQLNNVKLIYICNPNNPTGNII
HLNSLKKLLKIIQNRALLVTDEAYIDFCPDASLVRWLPMYPHLVILRTLSKAFALAGLRCGFTLANPEIIKLLEKVIAPY
PLSTPVIDIAEQALTPISIQYTQNRIATVNTNRNILITGLKKCSCVQQVFNSHANYVLVKFNPKYQVFKTLLHQGIVLRD
QSNQPGLVNCLRITVGTYNECKHVVSVLKKLHVASLSI

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Homo sapiens, GI4507369, Length=268, Percent_Identity=23.134328358209, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1788332, Length=353, Percent_Identity=56.3739376770538, Blast_Score=441, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322075, Length=378, Percent_Identity=32.5396825396825, Blast_Score=176, Evalue=8e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_BLOPB (Q492K2)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277971.1
- ProteinModelPortal:   Q492K2
- SMR:   Q492K2
- STRING:   Q492K2
- GeneID:   3562986
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_479
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   DDCIRIS
- ProtClustDB:   PRK01688
- BioCyc:   CBLO291272:BPEN_479-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40707; Mature: 40707

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIRYLARNNILTLKPYQSARKCTHSGNIWLNANEFPIAPDYQFRYKKIHRYPTCQPQEV
CCEEEEECCCEEEECCCHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHCCCCCCHHHH
INNYAYYAGVRSDQILVSRGADESIELLMKVFCNPGKDVIIFCPPTYGMYKTTAEILGIN
HCCHHEEECCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCE
YRIIPKKENWQLDLASIKSQLNNVKLIYICNPNNPTGNIIHLNSLKKLLKIIQNRALLVT
EEEEECCCCCEEEHHHHHHHHCCEEEEEEECCCCCCCCEEEHHHHHHHHHHHCCCEEEEE
DEAYIDFCPDASLVRWLPMYPHLVILRTLSKAFALAGLRCGFTLANPEIIKLLEKVIAPY
CCHHEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCC
PLSTPVIDIAEQALTPISIQYTQNRIATVNTNRNILITGLKKCSCVQQVFNSHANYVLVK
CCCCCHHHHHHHHCCCEEEEEECCEEEEEECCCEEEEECCHHHHHHHHHHHCCCCEEEEE
FNPKYQVFKTLLHQGIVLRDQSNQPGLVNCLRITVGTYNECKHVVSVLKKLHVASLSI
ECCCHHHHHHHHHCCEEEEECCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNIRYLARNNILTLKPYQSARKCTHSGNIWLNANEFPIAPDYQFRYKKIHRYPTCQPQEV
CCEEEEECCCEEEECCCHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHCCCCCCHHHH
INNYAYYAGVRSDQILVSRGADESIELLMKVFCNPGKDVIIFCPPTYGMYKTTAEILGIN
HCCHHEEECCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCE
YRIIPKKENWQLDLASIKSQLNNVKLIYICNPNNPTGNIIHLNSLKKLLKIIQNRALLVT
EEEEECCCCCEEEHHHHHHHHCCEEEEEEECCCCCCCCEEEHHHHHHHHHHHCCCEEEEE
DEAYIDFCPDASLVRWLPMYPHLVILRTLSKAFALAGLRCGFTLANPEIIKLLEKVIAPY
CCHHEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCC
PLSTPVIDIAEQALTPISIQYTQNRIATVNTNRNILITGLKKCSCVQQVFNSHANYVLVK
CCCCCHHHHHHHHCCCEEEEEECCEEEEEECCCEEEEECCHHHHHHHHHHHCCCCEEEEE
FNPKYQVFKTLLHQGIVLRDQSNQPGLVNCLRITVGTYNECKHVVSVLKKLHVASLSI
ECCCHHHHHHHHHCCEEEEECCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA