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The map label for this gene is gltC [H]

Identifier: 66045508

GI number: 66045508

Start: 2634007

End: 2634915

Strand: Direct

Name: gltC [H]

Synonym: Psyr_2268

Alternate gene names: 66045508

Gene position: 2634007-2634915 (Clockwise)

Preceding gene: 66045499

Following gene: 66045509

Centisome position: 43.23

GC content: 60.95

Gene sequence:

>909_bases
ATGCAACTCTACGGCGTACAGTCCACGGCCTTGCGCTACTTCCTCGAAGTGGCGCGGTGCGGATCGATCAGCGAAGCCTC
GATCCGCCTCAATGTCGCGTCTTCGGCGGTCAGTCGACAGATCAGCAAACTGGAGCGGGAACTGGATGCGGTGCTTTTCG
AGCGTCAGGCGCGCGGCATGATGCTCAGCGAGGCGGGCGTCCGCCTGGCGGCCTATGCGCGCAAATCACAGCTTGAGGCC
GAGCAGGTGGTGCTGGAAATCACCGAGCTGCAAGGCCTGCAGCGTGGGCATGTGCGCATCGCCTGCTCGGAGGGCTTTGC
CCTGGACTTTCTGCCGCAGTGCATTGCGCGCTTTCGGCGACAGTATCAGGGCATCCATTTCTCGATGGAGGTCTGTGCCC
CGGCGCAGGCCACCGAACGGGTGCGCTCGGGTGATGCAGACCTGTGCCTGACCTTCAGCCTGACGCCGCAGAACGAAATC
AAGGTCGAGCACATCCACAGCGGCGCGATCTGCGCAGTGGTCAGTCATAACCATCCGCTGGCCGCACGCAAGGAGGTCAC
GCTGGCCGAATTGCAACCTTATGCCATCGCCCTGACCAATACCGACACGACCTTGCGCCAGTTGTTTGATATCTGTTGCG
GTGTGCAAGGTCTGCTGTTCGATCCGGTGCTGACCAGCAATTACATCGGTGCCTTGCTGCGGTTTGTTCGGGAGGAGGGC
GGAATCAGCCTGTCCAGCGAGATGACGCTGGACAAACGCGCCCATGAAAAACAGCTCAAATCGCTGCCGATCAGTGACGA
TGGTATGAAGGCACGGCGTATCGAGTTGCAAAGCATGGCCGGGCGCAACCTGCCGGCGGCAGTCGCGGCCTTTCGCGATT
TTCTGATCGAGGAGCTGGCAAAGACCTGA

Upstream 100 bases:

>100_bases
GATGAATTGCGCCTCGACACGACTCTAGGCAAAGCGTATCAATGCCACAAGCACAATATTTCGAACCTTTCATTGCTGAA
AAGGCAACGCAGGAGCATCG

Downstream 100 bases:

>100_bases
GCCGCTGGTGGTAGTGCGGGAGCGTTGTGTGGAGTAAGTAACCTTTGGTTGATGAAGCTGGCGAGCTTAATGTTATAGTG
TAACGAATTTATGGCCGTGC

Product: regulatory protein, LysR:LysR, substrate-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MQLYGVQSTALRYFLEVARCGSISEASIRLNVASSAVSRQISKLERELDAVLFERQARGMMLSEAGVRLAAYARKSQLEA
EQVVLEITELQGLQRGHVRIACSEGFALDFLPQCIARFRRQYQGIHFSMEVCAPAQATERVRSGDADLCLTFSLTPQNEI
KVEHIHSGAICAVVSHNHPLAARKEVTLAELQPYAIALTNTDTTLRQLFDICCGVQGLLFDPVLTSNYIGALLRFVREEG
GISLSSEMTLDKRAHEKQLKSLPISDDGMKARRIELQSMAGRNLPAAVAAFRDFLIEELAKT

Sequences:

>Translated_302_residues
MQLYGVQSTALRYFLEVARCGSISEASIRLNVASSAVSRQISKLERELDAVLFERQARGMMLSEAGVRLAAYARKSQLEA
EQVVLEITELQGLQRGHVRIACSEGFALDFLPQCIARFRRQYQGIHFSMEVCAPAQATERVRSGDADLCLTFSLTPQNEI
KVEHIHSGAICAVVSHNHPLAARKEVTLAELQPYAIALTNTDTTLRQLFDICCGVQGLLFDPVLTSNYIGALLRFVREEG
GISLSSEMTLDKRAHEKQLKSLPISDDGMKARRIELQSMAGRNLPAAVAAFRDFLIEELAKT
>Mature_302_residues
MQLYGVQSTALRYFLEVARCGSISEASIRLNVASSAVSRQISKLERELDAVLFERQARGMMLSEAGVRLAAYARKSQLEA
EQVVLEITELQGLQRGHVRIACSEGFALDFLPQCIARFRRQYQGIHFSMEVCAPAQATERVRSGDADLCLTFSLTPQNEI
KVEHIHSGAICAVVSHNHPLAARKEVTLAELQPYAIALTNTDTTLRQLFDICCGVQGLLFDPVLTSNYIGALLRFVREEG
GISLSSEMTLDKRAHEKQLKSLPISDDGMKARRIELQSMAGRNLPAAVAAFRDFLIEELAKT

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=230, Percent_Identity=28.2608695652174, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1788748, Length=240, Percent_Identity=26.25, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI145693105, Length=188, Percent_Identity=26.063829787234, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1789204, Length=238, Percent_Identity=26.890756302521, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787879, Length=260, Percent_Identity=25, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787530, Length=247, Percent_Identity=25.1012145748988, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787601, Length=303, Percent_Identity=25.4125412541254, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790208, Length=140, Percent_Identity=31.4285714285714, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788481, Length=264, Percent_Identity=27.6515151515151, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081904, Length=209, Percent_Identity=24.4019138755981, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1789440, Length=121, Percent_Identity=29.7520661157025, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33427; Mature: 33427

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLYGVQSTALRYFLEVARCGSISEASIRLNVASSAVSRQISKLERELDAVLFERQARGM
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MLSEAGVRLAAYARKSQLEAEQVVLEITELQGLQRGHVRIACSEGFALDFLPQCIARFRR
CHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
QYQGIHFSMEVCAPAQATERVRSGDADLCLTFSLTPQNEIKVEHIHSGAICAVVSHNHPL
HHCCCEEEEEECCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCEEEEEEECCCCC
AARKEVTLAELQPYAIALTNTDTTLRQLFDICCGVQGLLFDPVLTSNYIGALLRFVREEG
CHHCCCHHHHCCCEEEEEECCCHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHC
GISLSSEMTLDKRAHEKQLKSLPISDDGMKARRIELQSMAGRNLPAAVAAFRDFLIEELA
CCEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
KT
CC
>Mature Secondary Structure
MQLYGVQSTALRYFLEVARCGSISEASIRLNVASSAVSRQISKLERELDAVLFERQARGM
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MLSEAGVRLAAYARKSQLEAEQVVLEITELQGLQRGHVRIACSEGFALDFLPQCIARFRR
CHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
QYQGIHFSMEVCAPAQATERVRSGDADLCLTFSLTPQNEIKVEHIHSGAICAVVSHNHPL
HHCCCEEEEEECCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCEEEEEEECCCCC
AARKEVTLAELQPYAIALTNTDTTLRQLFDICCGVQGLLFDPVLTSNYIGALLRFVREEG
CHHCCCHHHHCCCEEEEEECCCHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHC
GISLSSEMTLDKRAHEKQLKSLPISDDGMKARRIELQSMAGRNLPAAVAAFRDFLIEELA
CCEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
KT
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]