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The map label for this gene is uppS [H]

Identifier: 66044595

GI number: 66044595

Start: 1526534

End: 1527289

Strand: Direct

Name: uppS [H]

Synonym: Psyr_1347

Alternate gene names: 66044595

Gene position: 1526534-1527289 (Clockwise)

Preceding gene: 66044594

Following gene: 66044596

Centisome position: 25.05

GC content: 61.9

Gene sequence:

>756_bases
ATGGAAAAGATAAAACCGGCCGTGCCGTCTTCGGTGCCGCGCCATGTCGCGATTATCATGGATGGTAATAATCGCTGGGC
CAAGAAGCGCCTGCTGCCAGGCGTTGCAGGCCATAAGGCCGGCGTCGATGCCGTGCGGGCCGTTATCGAGGTCTGCGCCG
AAGCGCGGGTCGAAGTGCTGACACTGTTCGCGTTCTCCAGTGAAAACTGGCAGCGCCCGGCCGAAGAGGTGGGTGCGTTG
ATGGAGCTGTTTTTCACGGCGCTGCGCCGTGAAACCAAGCGCCTGAACGAAAACGAGATCAGCCTGCGAATTATCGGCGA
CCGCTCACGCTTTCATCCTGAGCTTCAGGCTGCCATGCGCGAGGCGGAAGTGCGCACCTCCGGCAACAGCCGTTTCGTGC
TGCAGATCGCTGCCAACTACGGTGGGCAGTGGGACATCGCGCAGGCTGCCCAGCGGCTGGCGCGTGAGGTTCAGGCCGGG
CACTTGCAGCCGGAGGACATTACTCCCCAGTTGTTGCAGACCTGCCTGGCCACCGGCGACCTGCCGTTGCCGGATCTGTG
CATCCGCACCGGCGGCGAACACCGCATCAGCAATTTTCTGCTTTGGCAGCTGGCCTACGCCGAGCTGTACTTCTCCGACC
TGTTCTGGCCGGACTTCAAACACGATGCCATGCGCGCCGCGCTGGCAGATTTCGCTTCTCGCCAACGTCGCTTCGGTAAA
ACCAGCGAACAGGTAGAAGCTGGAGCCCGGGCTTAA

Upstream 100 bases:

>100_bases
GACGTACAGAAGCTGACTGACAAGTTCGTGGCGGAAATCGAAGTTGCGGTCAAGCAGAAAGAAGCCGATCTGATGGCTGT
TTAAGGTTTCGGACGCTTTC

Downstream 100 bases:

>100_bases
TGCTGAAACAACGGATCATCACGGCACTCATTCTGTTGCCGATCGCCTTGTGCGGGTTTTTCCTGCTGACCGGCATGTAC
TTCGCCCTGTTCATCGGGGT

Product: di-trans-poly-cis-decaprenylcistransferase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MEKIKPAVPSSVPRHVAIIMDGNNRWAKKRLLPGVAGHKAGVDAVRAVIEVCAEARVEVLTLFAFSSENWQRPAEEVGAL
MELFFTALRRETKRLNENEISLRIIGDRSRFHPELQAAMREAEVRTSGNSRFVLQIAANYGGQWDIAQAAQRLAREVQAG
HLQPEDITPQLLQTCLATGDLPLPDLCIRTGGEHRISNFLLWQLAYAELYFSDLFWPDFKHDAMRAALADFASRQRRFGK
TSEQVEAGARA

Sequences:

>Translated_251_residues
MEKIKPAVPSSVPRHVAIIMDGNNRWAKKRLLPGVAGHKAGVDAVRAVIEVCAEARVEVLTLFAFSSENWQRPAEEVGAL
MELFFTALRRETKRLNENEISLRIIGDRSRFHPELQAAMREAEVRTSGNSRFVLQIAANYGGQWDIAQAAQRLAREVQAG
HLQPEDITPQLLQTCLATGDLPLPDLCIRTGGEHRISNFLLWQLAYAELYFSDLFWPDFKHDAMRAALADFASRQRRFGK
TSEQVEAGARA
>Mature_251_residues
MEKIKPAVPSSVPRHVAIIMDGNNRWAKKRLLPGVAGHKAGVDAVRAVIEVCAEARVEVLTLFAFSSENWQRPAEEVGAL
MELFFTALRRETKRLNENEISLRIIGDRSRFHPELQAAMREAEVRTSGNSRFVLQIAANYGGQWDIAQAAQRLAREVQAG
HLQPEDITPQLLQTCLATGDLPLPDLCIRTGGEHRISNFLLWQLAYAELYFSDLFWPDFKHDAMRAALADFASRQRRFGK
TSEQVEAGARA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=34.0807174887892, Blast_Score=144, Evalue=7e-35,
Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=34.0807174887892, Blast_Score=144, Evalue=7e-35,
Organism=Escherichia coli, GI1786371, Length=240, Percent_Identity=54.1666666666667, Blast_Score=266, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=34.6666666666667, Blast_Score=150, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6319474, Length=244, Percent_Identity=34.8360655737705, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=225, Percent_Identity=34.6666666666667, Blast_Score=118, Evalue=7e-28,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=38.2775119617225, Blast_Score=149, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28163; Mature: 28163

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIKPAVPSSVPRHVAIIMDGNNRWAKKRLLPGVAGHKAGVDAVRAVIEVCAEARVEVL
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TLFAFSSENWQRPAEEVGALMELFFTALRRETKRLNENEISLRIIGDRSRFHPELQAAMR
HHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHCCHHHHHHHH
EAEVRTSGNSRFVLQIAANYGGQWDIAQAAQRLAREVQAGHLQPEDITPQLLQTCLATGD
HHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
LPLPDLCIRTGGEHRISNFLLWQLAYAELYFSDLFWPDFKHDAMRAALADFASRQRRFGK
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
TSEQVEAGARA
CHHHHHCCCCC
>Mature Secondary Structure
MEKIKPAVPSSVPRHVAIIMDGNNRWAKKRLLPGVAGHKAGVDAVRAVIEVCAEARVEVL
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TLFAFSSENWQRPAEEVGALMELFFTALRRETKRLNENEISLRIIGDRSRFHPELQAAMR
HHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHCCHHHHHHHH
EAEVRTSGNSRFVLQIAANYGGQWDIAQAAQRLAREVQAGHLQPEDITPQLLQTCLATGD
HHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
LPLPDLCIRTGGEHRISNFLLWQLAYAELYFSDLFWPDFKHDAMRAALADFASRQRRFGK
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
TSEQVEAGARA
CHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]