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The map label for this gene is pyrH [H]

Identifier: 66044593

GI number: 66044593

Start: 1525220

End: 1525960

Strand: Direct

Name: pyrH [H]

Synonym: Psyr_1345

Alternate gene names: 66044593

Gene position: 1525220-1525960 (Clockwise)

Preceding gene: 66044592

Following gene: 66044594

Centisome position: 25.03

GC content: 58.03

Gene sequence:

>741_bases
ATGGCTCAGCAGGGCAGTGGTTATCAGGCTCGCTATAAACGCATTCTACTCAAGCTTAGCGGTGAGGCCCTCATGGGCTC
GGAAGAGTTCGGCATCGACCCGAAGGTGCTGGATCGCATGGCGCTGGAAGTCGGCCAGCTGGTCGGTATCGGCGTTCAGG
TCGGTCTGGTGATTGGCGGCGGCAACCTGTTCCGTGGCGCGGCCTTGAGTGCTGCGGGCATGGATCGGGTGACAGGCGAT
CACATGGGCATGCTGGCCACTGTGATGAACGCCCTGGCAATGCGCGATGCGCTGGAGCGCGCTAATATCACTGCCATCGT
GATGTCGGCCATTTCCATGGTGGGTGTGACCGATCATTATGATCGCCGTAAGGCCATGCGCCATCTCAGCGCCAAGGAAG
TGGTGATTTTTGCCGCCGGCACCGGTAATCCGTTCTTTACCACCGATTCGGCTGCCTGCCTGCGCGCGATCGAGATCGAC
GCCGATGTAGTGCTCAAGGCCACCAAGGTGGATGGTGTGTACACCGCAGATCCGTTCAAGGACCCGAATGCCGAGAAGTT
TGATCATCTGACCTACGATGAAGTGCTGGATCGCAAGCTGGGTGTGATGGATCTGACCGCAATCTGCCTGTGTCGCGATC
ACAAGATGCCATTGCGCGTCTTCAACATGAACAAGCCGGGTGCCCTTCTGAATATCGTCCATGGTGGCGCTGAAGGGACC
CTGATCGAGGAAGCACAATAA

Upstream 100 bases:

>100_bases
GCATTCTCCCGACGCGCGCAAAGCGTCAAGCTAAAGTAAGCGCAGGCTTGAAATAGCCCGCACAGATTTTTTTCAGAAAA
CGCCGCAGGAGAGATTCGCA

Downstream 100 bases:

>100_bases
TGATCAACGAAATCAAGAAAGATGCTCAGACCCGTATGCAGAAGAGTCTGGAGTCGCTGACCCATGCCTTCACCCGTATC
CGTACCGGCAAGGCGCATCC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MAQQGSGYQARYKRILLKLSGEALMGSEEFGIDPKVLDRMALEVGQLVGIGVQVGLVIGGGNLFRGAALSAAGMDRVTGD
HMGMLATVMNALAMRDALERANITAIVMSAISMVGVTDHYDRRKAMRHLSAKEVVIFAAGTGNPFFTTDSAACLRAIEID
ADVVLKATKVDGVYTADPFKDPNAEKFDHLTYDEVLDRKLGVMDLTAICLCRDHKMPLRVFNMNKPGALLNIVHGGAEGT
LIEEAQ

Sequences:

>Translated_246_residues
MAQQGSGYQARYKRILLKLSGEALMGSEEFGIDPKVLDRMALEVGQLVGIGVQVGLVIGGGNLFRGAALSAAGMDRVTGD
HMGMLATVMNALAMRDALERANITAIVMSAISMVGVTDHYDRRKAMRHLSAKEVVIFAAGTGNPFFTTDSAACLRAIEID
ADVVLKATKVDGVYTADPFKDPNAEKFDHLTYDEVLDRKLGVMDLTAICLCRDHKMPLRVFNMNKPGALLNIVHGGAEGT
LIEEAQ
>Mature_245_residues
AQQGSGYQARYKRILLKLSGEALMGSEEFGIDPKVLDRMALEVGQLVGIGVQVGLVIGGGNLFRGAALSAAGMDRVTGDH
MGMLATVMNALAMRDALERANITAIVMSAISMVGVTDHYDRRKAMRHLSAKEVVIFAAGTGNPFFTTDSAACLRAIEIDA
DVVLKATKVDGVYTADPFKDPNAEKFDHLTYDEVLDRKLGVMDLTAICLCRDHKMPLRVFNMNKPGALLNIVHGGAEGTL
IEEAQ

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=69.0987124463519, Blast_Score=326, Evalue=1e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 26441; Mature: 26310

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQGSGYQARYKRILLKLSGEALMGSEEFGIDPKVLDRMALEVGQLVGIGVQVGLVIGG
CCCCCCCHHHHHHHHHHHCCCCEEECCHHCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEC
GNLFRGAALSAAGMDRVTGDHMGMLATVMNALAMRDALERANITAIVMSAISMVGVTDHY
CCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHH
DRRKAMRHLSAKEVVIFAAGTGNPFFTTDSAACLRAIEIDADVVLKATKVDGVYTADPFK
HHHHHHHHCCCCEEEEEEECCCCCCEECCHHHHHEEEEECCHHEEEEEECCCEEECCCCC
DPNAEKFDHLTYDEVLDRKLGVMDLTAICLCRDHKMPLRVFNMNKPGALLNIVHGGAEGT
CCCCCHHCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCC
LIEEAQ
EEECCC
>Mature Secondary Structure 
AQQGSGYQARYKRILLKLSGEALMGSEEFGIDPKVLDRMALEVGQLVGIGVQVGLVIGG
CCCCCCHHHHHHHHHHHCCCCEEECCHHCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEC
GNLFRGAALSAAGMDRVTGDHMGMLATVMNALAMRDALERANITAIVMSAISMVGVTDHY
CCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHH
DRRKAMRHLSAKEVVIFAAGTGNPFFTTDSAACLRAIEIDADVVLKATKVDGVYTADPFK
HHHHHHHHCCCCEEEEEEECCCCCCEECCHHHHHEEEEECCHHEEEEEECCCEEECCCCC
DPNAEKFDHLTYDEVLDRKLGVMDLTAICLCRDHKMPLRVFNMNKPGALLNIVHGGAEGT
CCCCCHHCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCC
LIEEAQ
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA