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The map label for this gene is trxC [H]

Identifier: 59711516

GI number: 59711516

Start: 1003911

End: 1004345

Strand: Reverse

Name: trxC [H]

Synonym: VF_0909

Alternate gene names: 59711516

Gene position: 1004345-1003911 (Counterclockwise)

Preceding gene: 59711517

Following gene: 59711510

Centisome position: 34.66

GC content: 40.69

Gene sequence:

>435_bases
ATGTCACAATTTCAAACTCGATGCCCATCTTGTCATGGGTTAAACCGTCTTCCTACTGAACGAGTCAACGATGGTGCAAC
TTGTGGTCGCTGTAAGGAACCATTATTAGATGGTAAACCAGTAGAAGGTACAATGGATAACCTAGCCGCTTTACTCAATA
GCGATAAAGCTGTTGTTATCGATTTCTGGGCACCTTGGTGTAACCCATGCGTTGGCTTTTCGCCAGTTTTTGAAGATGTT
GCCGCAGAACGTAATGGACAAATTCGTTGTATTAAAGTCAACACAGAAGCTGAACAACAAATTGCAGCACAATATCAGAT
CCGCTCAATACCAACGATCATGGTATTTAAAAACGGTCAGCGTGTAGACATGATTAATGGTGCATTACCTAAAGGTCAAT
TTGATCAATGGTTAAATCAAGCACTGCTTAAATAA

Upstream 100 bases:

>100_bases
AGCTCTTCGCATCCCCATTATTTCTTTATGCTCACAAACTGTTTAAACCAATTTCCCAATGGTAATTGGTATTAACACAG
AATAACGATAAAGGAATACC

Downstream 100 bases:

>100_bases
TGTAAATAGCAGACAAACAAAAAGCCCCTTTATGACTCTGCATAAAGGGGCTTTTTACTATTTATTATGTGTTATCTATT
AATATAGATTAACCGATGAA

Product: thioredoxin 2

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 144; Mature: 143

Protein sequence:

>144_residues
MSQFQTRCPSCHGLNRLPTERVNDGATCGRCKEPLLDGKPVEGTMDNLAALLNSDKAVVIDFWAPWCNPCVGFSPVFEDV
AAERNGQIRCIKVNTEAEQQIAAQYQIRSIPTIMVFKNGQRVDMINGALPKGQFDQWLNQALLK

Sequences:

>Translated_144_residues
MSQFQTRCPSCHGLNRLPTERVNDGATCGRCKEPLLDGKPVEGTMDNLAALLNSDKAVVIDFWAPWCNPCVGFSPVFEDV
AAERNGQIRCIKVNTEAEQQIAAQYQIRSIPTIMVFKNGQRVDMINGALPKGQFDQWLNQALLK
>Mature_143_residues
SQFQTRCPSCHGLNRLPTERVNDGATCGRCKEPLLDGKPVEGTMDNLAALLNSDKAVVIDFWAPWCNPCVGFSPVFEDVA
AERNGQIRCIKVNTEAEQQIAAQYQIRSIPTIMVFKNGQRVDMINGALPKGQFDQWLNQALLK

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=31.5217391304348, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1788936, Length=139, Percent_Identity=56.1151079136691, Blast_Score=180, Evalue=3e-47,
Organism=Escherichia coli, GI87082331, Length=92, Percent_Identity=39.1304347826087, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI87081747, Length=85, Percent_Identity=38.8235294117647, Blast_Score=72, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=102, Percent_Identity=29.4117647058824, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17507705, Length=84, Percent_Identity=38.0952380952381, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71980565, Length=98, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71998175, Length=77, Percent_Identity=38.961038961039, Blast_Score=63, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=77, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI28573567, Length=122, Percent_Identity=32.7868852459016, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17647799, Length=88, Percent_Identity=32.9545454545455, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24639826, Length=77, Percent_Identity=33.7662337662338, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 16010; Mature: 15878

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQFQTRCPSCHGLNRLPTERVNDGATCGRCKEPLLDGKPVEGTMDNLAALLNSDKAVVI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEE
DFWAPWCNPCVGFSPVFEDVAAERNGQIRCIKVNTEAEQQIAAQYQIRSIPTIMVFKNGQ
EECCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCC
RVDMINGALPKGQFDQWLNQALLK
EEEECCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SQFQTRCPSCHGLNRLPTERVNDGATCGRCKEPLLDGKPVEGTMDNLAALLNSDKAVVI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEE
DFWAPWCNPCVGFSPVFEDVAAERNGQIRCIKVNTEAEQQIAAQYQIRSIPTIMVFKNGQ
EECCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCC
RVDMINGALPKGQFDQWLNQALLK
EEEECCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]