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The map label for this gene is ald [H]

Identifier: 59711510

GI number: 59711510

Start: 994968

End: 996086

Strand: Reverse

Name: ald [H]

Synonym: VF_0903

Alternate gene names: 59711510

Gene position: 996086-994968 (Counterclockwise)

Preceding gene: 59711516

Following gene: 59711509

Centisome position: 34.38

GC content: 42.81

Gene sequence:

>1119_bases
ATGATCATTGGAGTACCTAAAGAAATAAAAAATCATGAATATCGCGTTGGTATGATCCCTGCGAGTGTTCGCGAATTAAT
ATCTCATGGCCACACCGTATTTGTCGAAACAAAAGCCGGCTCAGGCATTGGTTTTACCGACGAAGACTACATCGCGGTTG
GTGCATCCATTCTTCCTACAGCTGAAGACGTATTTGCTAAAGCTGAAATGATTATTAAAGTTAAAGAACCTCAGGCTGTT
GAGCGTGCAATGCTTCGTGAAGGGCAAATTTTATTCACGTATTTACATCTTGCACCAGATCTTCCACAAACTAAAGACCT
AATCAAGAGTAAAGCTGTCTGCATCGCATATGAGACTGTAACAGATAATATGGGTCGTCTGCCACTATTAGCGCCAATGT
CAGAAGTTGCAGGTCGAATGTCCATTCAAGCAGGTGCACAAACATTAGAAAAATCAAATGGGGGTCGAGGCTTACTTTTA
GGTGGTGTTCCGGGTGTTGAACCTGCAAAAGTCGTCATTGTTGGCGGTGGTGTTGTTGGAGCAAATGCTGCTCGTATGGC
CGTAGGAATGCGTGCTGATGTCACCATATTAGATCGCAATATCGATACGCTACGTCATCTAGATGAAGAGTTTCAAGGTC
GAGCTAAAGTCGTTTATTCTACGGTTGATGCCATTGAAAAACACGTCCTAGAAGCTGATTTAGTCGTTGGTGCCGTACTT
ATTCCGGGCGCAGCAGCACCTAAGTTAATTACAGCAGAACATATTAAACGCATGAAACCGGGCGCAGCCGTTGTTGATGT
TGCCATTGACCAAGGCGGTTGTTTTGAAACCTCTCATGCCACCACTCATGCTGACCCAACTTATATTGTGGATGATGTTG
TTCATTATTGTGTTGCTAACATGCCAGGAGCGGTTGCTCGAACCTCTACATTTGCCCTAAATAATGCAACACTTCCTTAC
ATAATTAAATTAGCAGATAAGGGATATAAAGCGGCTTTATTAGAAGATAAAGGCTTTTTAGGTGGTTTGAACGTTATTCA
CGGAAAAGTAACCTGCAAAGAAGTAGCAGAAAGTTTCGACTTAGAATACGTTGCTCCTGAAACGGCTATCAGTGCTTAA

Upstream 100 bases:

>100_bases
TTAGCATCAAATTTTGCCATTTACAATCTATACTAGATAAAAACTCGAAACAAAAACCCTACAACCAGTCATAATAACCA
TAAAACAAAAGGAAATCAGG

Downstream 100 bases:

>100_bases
AAAGCATATCCTATAACCAAATCATTTTAGGGCGCTTATTACGGTGCCCTTTCTTTCATCGAATAAATTCCCTACAATCA
GGATATTGGTTGATAACTCG

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MIIGVPKEIKNHEYRVGMIPASVRELISHGHTVFVETKAGSGIGFTDEDYIAVGASILPTAEDVFAKAEMIIKVKEPQAV
ERAMLREGQILFTYLHLAPDLPQTKDLIKSKAVCIAYETVTDNMGRLPLLAPMSEVAGRMSIQAGAQTLEKSNGGRGLLL
GGVPGVEPAKVVIVGGGVVGANAARMAVGMRADVTILDRNIDTLRHLDEEFQGRAKVVYSTVDAIEKHVLEADLVVGAVL
IPGAAAPKLITAEHIKRMKPGAAVVDVAIDQGGCFETSHATTHADPTYIVDDVVHYCVANMPGAVARTSTFALNNATLPY
IIKLADKGYKAALLEDKGFLGGLNVIHGKVTCKEVAESFDLEYVAPETAISA

Sequences:

>Translated_372_residues
MIIGVPKEIKNHEYRVGMIPASVRELISHGHTVFVETKAGSGIGFTDEDYIAVGASILPTAEDVFAKAEMIIKVKEPQAV
ERAMLREGQILFTYLHLAPDLPQTKDLIKSKAVCIAYETVTDNMGRLPLLAPMSEVAGRMSIQAGAQTLEKSNGGRGLLL
GGVPGVEPAKVVIVGGGVVGANAARMAVGMRADVTILDRNIDTLRHLDEEFQGRAKVVYSTVDAIEKHVLEADLVVGAVL
IPGAAAPKLITAEHIKRMKPGAAVVDVAIDQGGCFETSHATTHADPTYIVDDVVHYCVANMPGAVARTSTFALNNATLPY
IIKLADKGYKAALLEDKGFLGGLNVIHGKVTCKEVAESFDLEYVAPETAISA
>Mature_372_residues
MIIGVPKEIKNHEYRVGMIPASVRELISHGHTVFVETKAGSGIGFTDEDYIAVGASILPTAEDVFAKAEMIIKVKEPQAV
ERAMLREGQILFTYLHLAPDLPQTKDLIKSKAVCIAYETVTDNMGRLPLLAPMSEVAGRMSIQAGAQTLEKSNGGRGLLL
GGVPGVEPAKVVIVGGGVVGANAARMAVGMRADVTILDRNIDTLRHLDEEFQGRAKVVYSTVDAIEKHVLEADLVVGAVL
IPGAAAPKLITAEHIKRMKPGAAVVDVAIDQGGCFETSHATTHADPTYIVDDVVHYCVANMPGAVARTSTFALNNATLPY
IIKLADKGYKAALLEDKGFLGGLNVIHGKVTCKEVAESFDLEYVAPETAISA

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=354, Percent_Identity=29.9435028248588, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI122939153, Length=354, Percent_Identity=29.9435028248588, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1787887, Length=302, Percent_Identity=30.4635761589404, Blast_Score=111, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17550456, Length=350, Percent_Identity=29.1428571428571, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39502; Mature: 39502

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIGVPKEIKNHEYRVGMIPASVRELISHGHTVFVETKAGSGIGFTDEDYIAVGASILPT
CEECCCHHHCCCCEEEEECCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEECCCCCCC
AEDVFAKAEMIIKVKEPQAVERAMLREGQILFTYLHLAPDLPQTKDLIKSKAVCIAYETV
HHHHHHCEEEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHCCCEEEEEEEH
TDNMGRLPLLAPMSEVAGRMSIQAGAQTLEKSNGGRGLLLGGVPGVEPAKVVIVGGGVVG
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCEEC
ANAARMAVGMRADVTILDRNIDTLRHLDEEFQGRAKVVYSTVDAIEKHVLEADLVVGAVL
CCHHHHEECCCCCEEEEECCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHEE
IPGAAAPKLITAEHIKRMKPGAAVVDVAIDQGGCFETSHATTHADPTYIVDDVVHYCVAN
ECCCCCCCEEEHHHHHHCCCCCEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHC
MPGAVARTSTFALNNATLPYIIKLADKGYKAALLEDKGFLGGLNVIHGKVTCKEVAESFD
CCCCHHCCEEEEECCCCCEEEEEEECCCCEEEEECCCCCCCCCEEEECCEEHHHHHHHCC
LEYVAPETAISA
CEEECCHHHCCC
>Mature Secondary Structure
MIIGVPKEIKNHEYRVGMIPASVRELISHGHTVFVETKAGSGIGFTDEDYIAVGASILPT
CEECCCHHHCCCCEEEEECCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEECCCCCCC
AEDVFAKAEMIIKVKEPQAVERAMLREGQILFTYLHLAPDLPQTKDLIKSKAVCIAYETV
HHHHHHCEEEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHCCCEEEEEEEH
TDNMGRLPLLAPMSEVAGRMSIQAGAQTLEKSNGGRGLLLGGVPGVEPAKVVIVGGGVVG
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCEEC
ANAARMAVGMRADVTILDRNIDTLRHLDEEFQGRAKVVYSTVDAIEKHVLEADLVVGAVL
CCHHHHEECCCCCEEEEECCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHEE
IPGAAAPKLITAEHIKRMKPGAAVVDVAIDQGGCFETSHATTHADPTYIVDDVVHYCVAN
ECCCCCCCEEEHHHHHHCCCCCEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHC
MPGAVARTSTFALNNATLPYIIKLADKGYKAALLEDKGFLGGLNVIHGKVTCKEVAESFD
CCCCHHCCEEEEECCCCCEEEEEEECCCCEEEEECCCCCCCCCEEEECCEEHHHHHHHCC
LEYVAPETAISA
CEEECCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA