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The map label for this gene is leuS [H]

Identifier: 59711360

GI number: 59711360

Start: 819983

End: 822559

Strand: Reverse

Name: leuS [H]

Synonym: VF_0753

Alternate gene names: 59711360

Gene position: 822559-819983 (Counterclockwise)

Preceding gene: 59711362

Following gene: 59711359

Centisome position: 28.39

GC content: 42.22

Gene sequence:

>2577_bases
ATGCAAGAACAATATAATCCACAGGATCTTGAACAAAAGATCCAAAAACATTGGGACGACAACAAAACGTTTGTTGTAAC
TGAAGACGCAAACAAAGAAAAATTCTACTGTCTCTCAATGTTCCCATACCCAAGTGGTCGTCTACACATGGGTCACGTTC
GTAACTACACTATCGGTGATGTAGTTTCGCGTTACCAACGTCTACAAGGTAAAAACGTAATGCAACCTATCGGTTGGGAT
GCGTTTGGTCTTCCTGCTGAAAATGCGGCTGTTAAAAATAAAACCGCTCCAGCACCTTGGACTTATGAAAATATCGAGTA
CATGAAGAACCAACTTAAACTATTAGGCTTTGGTTACGACTGGAACCGTGAATTTGCAACATGTACTCCTGAATACTACC
GTTGGGAACAAGAGTTCTTCACAAAACTGTACAACAAAGGTCTAGTTTACAAGAAAACCTCTTCTGTAAACTGGTGTCCT
AATGACCAAACGGTTCTGGCTAACGAACAAGTTGAAGATGGTTGTTGTTGGCGTTGTGATACCCCTGTTGAACAAAAGAA
AATTCCACAGTGGTTCATTAAAATTACTGAATACGCACAAGAGCTTCTTGATGATCTAGATAACCTTGATGGTTGGCCTG
AAATGGTTAAAACCATGCAACGTAACTGGATTGGCCGCTCTGAAGGTGTTGAACTTTCATTTGCTGTTAATGGCGAAACC
TCTCCTTTAGAAGTATATACTACACGTCCTGATACGCTAATGGGCGTAACTTACGTTGGTATTGCAGCTGGTCACCCTCT
TGCAGAGAAAGCATCTCAAAATAACCCTGAGTTAGCCGCTTTTGTTGAAGAGTGCCGCAACACTAAAGTTGCTGAAGCAG
AATTAGCAACAATGGAAAAGAAAGGCATGGACACTGGTCTACGTGCTATTCACCCATTAAATGGTCGTGAAGTACCAGTA
TTTGTTGCTAACTTCGTATTAATGGATTACGGCACAGGTGCGGTAATGGCGGTTCCTGCTCACGATCAACGTGACTTTGA
ATTTGCAACTAAATACGGTCTAGATATTATCCCTGTAATCAAACCAGAAGATGGTTCTGATTTAGATGTATCTGAAGCAG
CTTACACAGAAAAAGGTGTTCTATTCGATTCAGGTGAATTCGACGGTCTTGCTTTCCAAGAAGCATTCGATGCTATCGCA
GCGAAACTTGAAGCTGAAGGCAAAGGTAAGAAAACAGTAAACTTCCGTCTACGTGACTGGGGTGTATCTCGTCAACGTTA
CTGGGGTGCTCCAATCCCAATGGTAACAACTGAAGATGGTGAAGTTCACCCAGTACCTGCTGACCAATTACCAGTAATTC
TTCCTGAAGACGTAGTAATGGATGGCGTTACTAGTCCAATTAAAGCAGACAAAGAGTGGGCTAAAACAACATTTAACGGC
GAGCCAGCTCTACGTGAAACAGATACGTTCGATACCTTTATGGAATCATCTTGGTACTATGCACGTTACTGTTCACCACA
AGCTGACGATATCCTAGATCCAGAAAAAGCAAACTACTGGTTACCAGTAGACCAATACATTGGTGGTATCGAGCACGCTT
GTATGCACCTATTGTATTCTCGCTTCTTCCATAAGCTTCTACGTGATGCGGGTTATGTTACTTCTGACGAACCATTCAAG
CAGCTTTTATGTCAAGGTATGGTACTTGCGGATGCATTCTACTACACCAACGACAAAGGCGGTAAAGAGTGGGTTGCTCC
TACGGATGTAACTATCGAGCGTGATGGTAAAGGTCGTATCGAGAAAGCCATTGATGACCAAGGTCGTGAAGTTGAACACT
CAGGCATGATCAAAATGTCTAAGTCTAAAAACAACGGTATCGACCCACAAGAAATGGTAGACAAATACGGTGCTGATACC
GTTCGTCTATTCATGATGTTTGCTTCACCAGCAGACATGACACTTGAATGGCAAGAGTCTGGCGTTGAGGGTGCAAACCG
TTTCCTTAAACGTGTATGGAAACTGGTTCACGAGCACACAAACAAAGGCACAACTGAAGCGCTAGATACATCATCACTAA
CAGGTGATCAAAAAGCACTTCGTCGTGACGTTCACAAAACAATCGCAAAAGTAAGTGATGATATTGGCCGTCGTCAAACA
TTCAATACAGCAATCGCTGCTATTATGGAATTGATGAACAAGCTAAACAAAGCACCTCAAGAATCAGCACAAGATCGTGC
TCTTCTTGATGAAGCACTAAAAGCGGTTGTTGCTATGCTTTACCCAATGACACCACACGCAAGTTTTGCAATGTGGGAAG
CACTAGGTGAATCAGATTTAGATTCTGCAACATGGCCAACATTCGATGAGAATGCACTAGTTGAAGATGAAAAAACAATC
GTAGTAATGATCAACGGTAAACTTCGTGCAAAACTGGTTGTTGCAGCTGATGCAACAGAAGAACACGTACGTGAACTAGG
TCTAAAAGACGAAAACGCAATGAAGTTCCTAGATGGCTTAACGATTCGTAAAGTTATCTACGTACCTGGTAAGTTATTAA
ACATCGTTGCGAACTAA

Upstream 100 bases:

>100_bases
GAGTATAAGCGCTCCATTAGTTATTCTATGCCGATCAAGTATTATCTGATCAAACCGATCTCACATTTTTTGTGATCCAC
TGACATAACTGGGTAAATCG

Downstream 100 bases:

>100_bases
GAAACGATAAGAAAAGTAATTTGAACCATTTTTCTTATTACTTTTCTACTAAAGCATAAGCGGCTATCCGCTTGTGCTTA
TTTAACCATTTTGTCTTATG

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS [H]

Number of amino acids: Translated: 858; Mature: 858

Protein sequence:

>858_residues
MQEQYNPQDLEQKIQKHWDDNKTFVVTEDANKEKFYCLSMFPYPSGRLHMGHVRNYTIGDVVSRYQRLQGKNVMQPIGWD
AFGLPAENAAVKNKTAPAPWTYENIEYMKNQLKLLGFGYDWNREFATCTPEYYRWEQEFFTKLYNKGLVYKKTSSVNWCP
NDQTVLANEQVEDGCCWRCDTPVEQKKIPQWFIKITEYAQELLDDLDNLDGWPEMVKTMQRNWIGRSEGVELSFAVNGET
SPLEVYTTRPDTLMGVTYVGIAAGHPLAEKASQNNPELAAFVEECRNTKVAEAELATMEKKGMDTGLRAIHPLNGREVPV
FVANFVLMDYGTGAVMAVPAHDQRDFEFATKYGLDIIPVIKPEDGSDLDVSEAAYTEKGVLFDSGEFDGLAFQEAFDAIA
AKLEAEGKGKKTVNFRLRDWGVSRQRYWGAPIPMVTTEDGEVHPVPADQLPVILPEDVVMDGVTSPIKADKEWAKTTFNG
EPALRETDTFDTFMESSWYYARYCSPQADDILDPEKANYWLPVDQYIGGIEHACMHLLYSRFFHKLLRDAGYVTSDEPFK
QLLCQGMVLADAFYYTNDKGGKEWVAPTDVTIERDGKGRIEKAIDDQGREVEHSGMIKMSKSKNNGIDPQEMVDKYGADT
VRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVHEHTNKGTTEALDTSSLTGDQKALRRDVHKTIAKVSDDIGRRQT
FNTAIAAIMELMNKLNKAPQESAQDRALLDEALKAVVAMLYPMTPHASFAMWEALGESDLDSATWPTFDENALVEDEKTI
VVMINGKLRAKLVVAADATEEHVRELGLKDENAMKFLDGLTIRKVIYVPGKLLNIVAN

Sequences:

>Translated_858_residues
MQEQYNPQDLEQKIQKHWDDNKTFVVTEDANKEKFYCLSMFPYPSGRLHMGHVRNYTIGDVVSRYQRLQGKNVMQPIGWD
AFGLPAENAAVKNKTAPAPWTYENIEYMKNQLKLLGFGYDWNREFATCTPEYYRWEQEFFTKLYNKGLVYKKTSSVNWCP
NDQTVLANEQVEDGCCWRCDTPVEQKKIPQWFIKITEYAQELLDDLDNLDGWPEMVKTMQRNWIGRSEGVELSFAVNGET
SPLEVYTTRPDTLMGVTYVGIAAGHPLAEKASQNNPELAAFVEECRNTKVAEAELATMEKKGMDTGLRAIHPLNGREVPV
FVANFVLMDYGTGAVMAVPAHDQRDFEFATKYGLDIIPVIKPEDGSDLDVSEAAYTEKGVLFDSGEFDGLAFQEAFDAIA
AKLEAEGKGKKTVNFRLRDWGVSRQRYWGAPIPMVTTEDGEVHPVPADQLPVILPEDVVMDGVTSPIKADKEWAKTTFNG
EPALRETDTFDTFMESSWYYARYCSPQADDILDPEKANYWLPVDQYIGGIEHACMHLLYSRFFHKLLRDAGYVTSDEPFK
QLLCQGMVLADAFYYTNDKGGKEWVAPTDVTIERDGKGRIEKAIDDQGREVEHSGMIKMSKSKNNGIDPQEMVDKYGADT
VRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVHEHTNKGTTEALDTSSLTGDQKALRRDVHKTIAKVSDDIGRRQT
FNTAIAAIMELMNKLNKAPQESAQDRALLDEALKAVVAMLYPMTPHASFAMWEALGESDLDSATWPTFDENALVEDEKTI
VVMINGKLRAKLVVAADATEEHVRELGLKDENAMKFLDGLTIRKVIYVPGKLLNIVAN
>Mature_858_residues
MQEQYNPQDLEQKIQKHWDDNKTFVVTEDANKEKFYCLSMFPYPSGRLHMGHVRNYTIGDVVSRYQRLQGKNVMQPIGWD
AFGLPAENAAVKNKTAPAPWTYENIEYMKNQLKLLGFGYDWNREFATCTPEYYRWEQEFFTKLYNKGLVYKKTSSVNWCP
NDQTVLANEQVEDGCCWRCDTPVEQKKIPQWFIKITEYAQELLDDLDNLDGWPEMVKTMQRNWIGRSEGVELSFAVNGET
SPLEVYTTRPDTLMGVTYVGIAAGHPLAEKASQNNPELAAFVEECRNTKVAEAELATMEKKGMDTGLRAIHPLNGREVPV
FVANFVLMDYGTGAVMAVPAHDQRDFEFATKYGLDIIPVIKPEDGSDLDVSEAAYTEKGVLFDSGEFDGLAFQEAFDAIA
AKLEAEGKGKKTVNFRLRDWGVSRQRYWGAPIPMVTTEDGEVHPVPADQLPVILPEDVVMDGVTSPIKADKEWAKTTFNG
EPALRETDTFDTFMESSWYYARYCSPQADDILDPEKANYWLPVDQYIGGIEHACMHLLYSRFFHKLLRDAGYVTSDEPFK
QLLCQGMVLADAFYYTNDKGGKEWVAPTDVTIERDGKGRIEKAIDDQGREVEHSGMIKMSKSKNNGIDPQEMVDKYGADT
VRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVHEHTNKGTTEALDTSSLTGDQKALRRDVHKTIAKVSDDIGRRQT
FNTAIAAIMELMNKLNKAPQESAQDRALLDEALKAVVAMLYPMTPHASFAMWEALGESDLDSATWPTFDENALVEDEKTI
VVMINGKLRAKLVVAADATEEHVRELGLKDENAMKFLDGLTIRKVIYVPGKLLNIVAN

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7661872, Length=887, Percent_Identity=34.9492671927847, Blast_Score=511, Evalue=1e-144,
Organism=Homo sapiens, GI46852147, Length=490, Percent_Identity=22.8571428571429, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1786861, Length=858, Percent_Identity=74.9417249417249, Blast_Score=1367, Evalue=0.0,
Organism=Escherichia coli, GI1790708, Length=392, Percent_Identity=27.0408163265306, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71997517, Length=811, Percent_Identity=31.6892725030826, Blast_Score=373, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI71997510, Length=811, Percent_Identity=31.6892725030826, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI212645227, Length=379, Percent_Identity=29.5514511873351, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71980946, Length=154, Percent_Identity=29.8701298701299, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323414, Length=813, Percent_Identity=37.3923739237392, Blast_Score=511, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6321531, Length=381, Percent_Identity=25.7217847769029, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6325217, Length=408, Percent_Identity=22.5490196078431, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21355409, Length=888, Percent_Identity=33.1081081081081, Blast_Score=437, Evalue=1e-122,
Organism=Drosophila melanogaster, GI17864482, Length=441, Percent_Identity=23.8095238095238, Blast_Score=103, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24653289, Length=441, Percent_Identity=23.8095238095238, Blast_Score=103, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281366294, Length=476, Percent_Identity=23.3193277310924, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008 [H]

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 97020; Mature: 97020

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00178 AA_TRNA_LIGASE_I ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEQYNPQDLEQKIQKHWDDNKTFVVTEDANKEKFYCLSMFPYPSGRLHMGHVRNYTIGD
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCCCEEECCCCCCCHHH
VVSRYQRLQGKNVMQPIGWDAFGLPAENAAVKNKTAPAPWTYENIEYMKNQLKLLGFGYD
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEECCC
WNREFATCTPEYYRWEQEFFTKLYNKGLVYKKTSSVNWCPNDQTVLANEQVEDGCCWRCD
CCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEECCCCCCCCCCCCC
TPVEQKKIPQWFIKITEYAQELLDDLDNLDGWPEMVKTMQRNWIGRSEGVELSFAVNGET
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCC
SPLEVYTTRPDTLMGVTYVGIAAGHPLAEKASQNNPELAAFVEECRNTKVAEAELATMEK
CCEEEEECCCCCEEHHEEEEEECCCCHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHH
KGMDTGLRAIHPLNGREVPVFVANFVLMDYGTGAVMAVPAHDQRDFEFATKYGLDIIPVI
HCCCCCHHHCCCCCCCCCHHHEEEEHHEECCCCEEEEECCCCCCCCHHHHHCCCEEEEEE
KPEDGSDLDVSEAAYTEKGVLFDSGEFDGLAFQEAFDAIAAKLEAEGKGKKTVNFRLRDW
CCCCCCCCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECC
GVSRQRYWGAPIPMVTTEDGEVHPVPADQLPVILPEDVVMDGVTSPIKADKEWAKTTFNG
CCCCHHCCCCCCCEEECCCCCCCCCCCCCCCEECCCHHHHCCCCCCCCCCHHHHHCCCCC
EPALRETDTFDTFMESSWYYARYCSPQADDILDPEKANYWLPVDQYIGGIEHACMHLLYS
CCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEHHHHHCHHHHHHHHHHHH
RFFHKLLRDAGYVTSDEPFKQLLCQGMVLADAFYYTNDKGGKEWVAPTDVTIERDGKGRI
HHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHEEEECCCCCCCCCCCCCEEEEECCCCHH
EKAIDDQGREVEHSGMIKMSKSKNNGIDPQEMVDKYGADTVRLFMMFASPADMTLEWQES
HHHHCCCCCEECCCCCEEEECCCCCCCCHHHHHHHHCCHHEEEEHHHCCCCCCEEEEHHC
GVEGANRFLKRVWKLVHEHTNKGTTEALDTSSLTGDQKALRRDVHKTIAKVSDDIGRRQT
CCHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FNTAIAAIMELMNKLNKAPQESAQDRALLDEALKAVVAMLYPMTPHASFAMWEALGESDL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC
DSATWPTFDENALVEDEKTIVVMINGKLRAKLVVAADATEEHVRELGLKDENAMKFLDGL
CCCCCCCCCCCCEECCCCEEEEEECCCEEEEEEEEECCHHHHHHHCCCCCHHHHHHHHCC
TIRKVIYVPGKLLNIVAN
CEEHEEECCHHHHHHHCC
>Mature Secondary Structure
MQEQYNPQDLEQKIQKHWDDNKTFVVTEDANKEKFYCLSMFPYPSGRLHMGHVRNYTIGD
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCCCEEECCCCCCCHHH
VVSRYQRLQGKNVMQPIGWDAFGLPAENAAVKNKTAPAPWTYENIEYMKNQLKLLGFGYD
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEECCC
WNREFATCTPEYYRWEQEFFTKLYNKGLVYKKTSSVNWCPNDQTVLANEQVEDGCCWRCD
CCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEECCCCCCCCCCCCC
TPVEQKKIPQWFIKITEYAQELLDDLDNLDGWPEMVKTMQRNWIGRSEGVELSFAVNGET
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCC
SPLEVYTTRPDTLMGVTYVGIAAGHPLAEKASQNNPELAAFVEECRNTKVAEAELATMEK
CCEEEEECCCCCEEHHEEEEEECCCCHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHH
KGMDTGLRAIHPLNGREVPVFVANFVLMDYGTGAVMAVPAHDQRDFEFATKYGLDIIPVI
HCCCCCHHHCCCCCCCCCHHHEEEEHHEECCCCEEEEECCCCCCCCHHHHHCCCEEEEEE
KPEDGSDLDVSEAAYTEKGVLFDSGEFDGLAFQEAFDAIAAKLEAEGKGKKTVNFRLRDW
CCCCCCCCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECC
GVSRQRYWGAPIPMVTTEDGEVHPVPADQLPVILPEDVVMDGVTSPIKADKEWAKTTFNG
CCCCHHCCCCCCCEEECCCCCCCCCCCCCCCEECCCHHHHCCCCCCCCCCHHHHHCCCCC
EPALRETDTFDTFMESSWYYARYCSPQADDILDPEKANYWLPVDQYIGGIEHACMHLLYS
CCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEHHHHHCHHHHHHHHHHHH
RFFHKLLRDAGYVTSDEPFKQLLCQGMVLADAFYYTNDKGGKEWVAPTDVTIERDGKGRI
HHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHEEEECCCCCCCCCCCCCEEEEECCCCHH
EKAIDDQGREVEHSGMIKMSKSKNNGIDPQEMVDKYGADTVRLFMMFASPADMTLEWQES
HHHHCCCCCEECCCCCEEEECCCCCCCCHHHHHHHHCCHHEEEEHHHCCCCCCEEEEHHC
GVEGANRFLKRVWKLVHEHTNKGTTEALDTSSLTGDQKALRRDVHKTIAKVSDDIGRRQT
CCHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FNTAIAAIMELMNKLNKAPQESAQDRALLDEALKAVVAMLYPMTPHASFAMWEALGESDL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC
DSATWPTFDENALVEDEKTIVVMINGKLRAKLVVAADATEEHVRELGLKDENAMKFLDGL
CCCCCCCCCCCCEECCCCEEEEEECCCEEEEEEEEECCHHHHHHHCCCCCHHHHHHHHCC
TIRKVIYVPGKLLNIVAN
CEEHEEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA