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The map label for this gene is mrdB [H]

Identifier: 59711354

GI number: 59711354

Start: 814310

End: 815431

Strand: Reverse

Name: mrdB [H]

Synonym: VF_0747

Alternate gene names: 59711354

Gene position: 815431-814310 (Counterclockwise)

Preceding gene: 59711355

Following gene: 59711353

Centisome position: 28.14

GC content: 39.57

Gene sequence:

>1122_bases
ATGAGAGTTGATATTGCATCAGGAAAGAATCGCGACTTTTTTCATCGTATCCATTTAGATTTACCACTATTGCTAGGCAT
TTTATTATTGATGGCATGTGCCTTAGTTATTATGTATAGCGCTAGTGGTCAAAGCTTATTGATGATGGATAAGCAAGCAA
TGAGAATGTTGCTTTCTTTGGGTGTCATGTTCTTTCTTGCGCAAATATCACCAAGAGCCTACGAAGCCGCTGCTCCCTAT
GTTTTCACTATAGGAATTTTCCTATTATTAGGGGTTCTCCTTTTTGGAGAGGCGTCAAAAGGCGCTCAACGATGGTTGAA
CTTCGGCTTTGTTCGATTTCAACCATCAGAACTTATCAAATTAGCCGTACCATTAATGGTGGCTCGTTATATCGGCAATA
AACCATTACCGCCAACCGTTAGAACTCTATTTTTTGCTCTATTAATGGTCTTTGTTCCGACCATTATGATTGCTAAACAA
CCAGATCTAGGCACTTCTATACTGATTGCAGCATCGGGTATCTTCGTTATTTTTCTAGCAGGTATCAGTTGGAAAATAAT
CACAGCAGCAGCAGTTGCCGTTGGCGCTTTTATCCCTATTTTATGGTTCTTCTTGATGCGACCTTATCAAAAAGTTCGTG
TTCAAACATTATTTAACCCTGAATCTGATCCACTTGGTGCTGGTTATCATATTATTCAATCCAAGATAGCTATTGGTTCT
GGCGGCCTATTAGGAAAAGGATGGTTACACGGAACCCAATCTCAACTTGAATTCATACCAGAGCGACATACCGATTTCAT
TTTTGCAGTGATTGCTGAAGAATGGGGGCTTATTGGTGTTATCGCTTTACTTGCTCTCTACCTATTTATTATTGGTCGTG
GTTTATTCTTAGCAAGCCAAGCGCAAACTGCATTTGGACGAATGATGGGAGGAAGTGTGGTGCTAAGCTTCTTTGTTTAT
ATTTTTGTAAACATAGGCATGGTAAGTGGTATTCTTCCTGTTGTTGGTGTCCCTCTTCCATTAGTTAGTTATGGAGGAAC
ATCCATGGTTACCCTAATGGCAGGCTTTGGTATTTTAATGTCAATCCATACACATAGAAAAGTTCACTCAAAGGCAAATT
AA

Upstream 100 bases:

>100_bases
TAGAGAATGGTGGTGGTGGCTCTAGCCAAGGTGGTCCAATAGCTCGTCACGTCTTCGATTATGTATTACTACCGAAAACG
GAAGAGGCAGCTAAGAAGTA

Downstream 100 bases:

>100_bases
TGCGTGTTATTCTACTTGCAGTTTCTCTTATATTAGCGGGTTGTGCTTCTGAACCACCCCAAAAAACAACTGATGAACCT
AATGCTGGTCGTTATCAAAT

Product: cell wall shape-determining protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MRVDIASGKNRDFFHRIHLDLPLLLGILLLMACALVIMYSASGQSLLMMDKQAMRMLLSLGVMFFLAQISPRAYEAAAPY
VFTIGIFLLLGVLLFGEASKGAQRWLNFGFVRFQPSELIKLAVPLMVARYIGNKPLPPTVRTLFFALLMVFVPTIMIAKQ
PDLGTSILIAASGIFVIFLAGISWKIITAAAVAVGAFIPILWFFLMRPYQKVRVQTLFNPESDPLGAGYHIIQSKIAIGS
GGLLGKGWLHGTQSQLEFIPERHTDFIFAVIAEEWGLIGVIALLALYLFIIGRGLFLASQAQTAFGRMMGGSVVLSFFVY
IFVNIGMVSGILPVVGVPLPLVSYGGTSMVTLMAGFGILMSIHTHRKVHSKAN

Sequences:

>Translated_373_residues
MRVDIASGKNRDFFHRIHLDLPLLLGILLLMACALVIMYSASGQSLLMMDKQAMRMLLSLGVMFFLAQISPRAYEAAAPY
VFTIGIFLLLGVLLFGEASKGAQRWLNFGFVRFQPSELIKLAVPLMVARYIGNKPLPPTVRTLFFALLMVFVPTIMIAKQ
PDLGTSILIAASGIFVIFLAGISWKIITAAAVAVGAFIPILWFFLMRPYQKVRVQTLFNPESDPLGAGYHIIQSKIAIGS
GGLLGKGWLHGTQSQLEFIPERHTDFIFAVIAEEWGLIGVIALLALYLFIIGRGLFLASQAQTAFGRMMGGSVVLSFFVY
IFVNIGMVSGILPVVGVPLPLVSYGGTSMVTLMAGFGILMSIHTHRKVHSKAN
>Mature_373_residues
MRVDIASGKNRDFFHRIHLDLPLLLGILLLMACALVIMYSASGQSLLMMDKQAMRMLLSLGVMFFLAQISPRAYEAAAPY
VFTIGIFLLLGVLLFGEASKGAQRWLNFGFVRFQPSELIKLAVPLMVARYIGNKPLPPTVRTLFFALLMVFVPTIMIAKQ
PDLGTSILIAASGIFVIFLAGISWKIITAAAVAVGAFIPILWFFLMRPYQKVRVQTLFNPESDPLGAGYHIIQSKIAIGS
GGLLGKGWLHGTQSQLEFIPERHTDFIFAVIAEEWGLIGVIALLALYLFIIGRGLFLASQAQTAFGRMMGGSVVLSFFVY
IFVNIGMVSGILPVVGVPLPLVSYGGTSMVTLMAGFGILMSIHTHRKVHSKAN

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=364, Percent_Identity=62.0879120879121, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI1786277, Length=291, Percent_Identity=34.020618556701, Blast_Score=167, Evalue=8e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 40758; Mature: 40758

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVDIASGKNRDFFHRIHLDLPLLLGILLLMACALVIMYSASGQSLLMMDKQAMRMLLSL
CEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHH
GVMFFLAQISPRAYEAAAPYVFTIGIFLLLGVLLFGEASKGAQRWLNFGFVRFQPSELIK
HHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEECHHHHHH
LAVPLMVARYIGNKPLPPTVRTLFFALLMVFVPTIMIAKQPDLGTSILIAASGIFVIFLA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
GISWKIITAAAVAVGAFIPILWFFLMRPYQKVRVQTLFNPESDPLGAGYHIIQSKIAIGS
CCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHEECC
GGLLGKGWLHGTQSQLEFIPERHTDFIFAVIAEEWGLIGVIALLALYLFIIGRGLFLASQ
CCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHH
AQTAFGRMMGGSVVLSFFVYIFVNIGMVSGILPVVGVPLPLVSYGGTSMVTLMAGFGILM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHH
SIHTHRKVHSKAN
HHHHHHHHHCCCC
>Mature Secondary Structure
MRVDIASGKNRDFFHRIHLDLPLLLGILLLMACALVIMYSASGQSLLMMDKQAMRMLLSL
CEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHH
GVMFFLAQISPRAYEAAAPYVFTIGIFLLLGVLLFGEASKGAQRWLNFGFVRFQPSELIK
HHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEECHHHHHH
LAVPLMVARYIGNKPLPPTVRTLFFALLMVFVPTIMIAKQPDLGTSILIAASGIFVIFLA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
GISWKIITAAAVAVGAFIPILWFFLMRPYQKVRVQTLFNPESDPLGAGYHIIQSKIAIGS
CCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHEECC
GGLLGKGWLHGTQSQLEFIPERHTDFIFAVIAEEWGLIGVIALLALYLFIIGRGLFLASQ
CCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHH
AQTAFGRMMGGSVVLSFFVYIFVNIGMVSGILPVVGVPLPLVSYGGTSMVTLMAGFGILM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHH
SIHTHRKVHSKAN
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]