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The map label for this gene is fmt [H]

Identifier: 54295431

GI number: 54295431

Start: 2871705

End: 2872649

Strand: Reverse

Name: fmt [H]

Synonym: lpl2517

Alternate gene names: 54295431

Gene position: 2872649-2871705 (Counterclockwise)

Preceding gene: 54295432

Following gene: 54295430

Centisome position: 85.86

GC content: 41.59

Gene sequence:

>945_bases
ATGAATGGTTTAACTGTCGTTTTTGCTGGAACTCCAGAATTTGGCTTACCCTGTCTGGATGCTTTAATTCAATCAAGGCA
TCATCTCAAGGCTGTTTATACTCAGCCCGACAGGCCGGCTGGCCGAGGCCGTAAATTACAGGAGTCTCCTGTAAAAGAAT
GGGCAATAAATCACCAGATATCAGTTTATCAACCGCTTAATTTTAAAAATCAAGAAGCTGTCGATGAACTTTCTGCCTTA
AAGCCCGATGTAATGGTCGTGATAGCGTATGGATTAATATTACCAAAAGCAGTGTTGGAAATTCCTCGTCTGGGTTGTAT
TAATGTGCATGCTTCTCTGTTACCGCGCTGGCGTGGCGCATCTCCAATACAACATGCCATTTTACATGGTGATGCTGAAT
CCGGAGTGACCATTATGCAAATGGATGTTGGATTGGATACAGGTCCTATGTTATGCAAGGCCGCCTGTCCTGTGACTTCC
TCGGATACCGCTGGTAGTTTGCATGATAAATTAGCAAAAATGTCAGTAAAACCATTATTGGATGTTTTGGAGGCTTTAGC
ATCCAATTCAGCACAATTTGAATTACAAAACAATGAGTTAGCGACTTATGCTGGTAAAATTAATAAAGAAGAGGCACGAA
TTAACTGGCATCAGTCTGCAGTGGAAATAGATAGAAAAATTCGCGCATTTAATCCATGGCCTGTTGCCTATACGCTGGCT
GGGGAATTAATGCTCAGAATTCACCAGGCAAAAGCAACTGATATCATGAGTACCGAGATGCCGGGCATGGTATTAAATAT
CGATAAAACTGGAATGTTGGTCGCTACCAGTGATAATGCATTGTTAGTGGAAAAGATTCAATTTCCCGGAGCAAAGGTCA
TTTCAGTCAGGGATTGGTTAAATTCGGGTAAAACACAATTGCATACTGGTTTAATGTTGCAATGA

Upstream 100 bases:

>100_bases
ATATGAATGGCAAATTGTTTGTCGATATGTTGTCTCCATTGAAGCGAATGATGGCTCGCCGGAAGTTAGATAAGTTCAAG
CGTTTACAAGCTCGTAAGCC

Downstream 100 bases:

>100_bases
AAGTAAATGACAGATTCAACGCCTTAAAAATTTTGACGGCCTTGATAGAAAGCAGAAAAAACCTGTCCTATTTGATGTCT
CCGCAAGAGATTTCTCCCAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MNGLTVVFAGTPEFGLPCLDALIQSRHHLKAVYTQPDRPAGRGRKLQESPVKEWAINHQISVYQPLNFKNQEAVDELSAL
KPDVMVVIAYGLILPKAVLEIPRLGCINVHASLLPRWRGASPIQHAILHGDAESGVTIMQMDVGLDTGPMLCKAACPVTS
SDTAGSLHDKLAKMSVKPLLDVLEALASNSAQFELQNNELATYAGKINKEEARINWHQSAVEIDRKIRAFNPWPVAYTLA
GELMLRIHQAKATDIMSTEMPGMVLNIDKTGMLVATSDNALLVEKIQFPGAKVISVRDWLNSGKTQLHTGLMLQ

Sequences:

>Translated_314_residues
MNGLTVVFAGTPEFGLPCLDALIQSRHHLKAVYTQPDRPAGRGRKLQESPVKEWAINHQISVYQPLNFKNQEAVDELSAL
KPDVMVVIAYGLILPKAVLEIPRLGCINVHASLLPRWRGASPIQHAILHGDAESGVTIMQMDVGLDTGPMLCKAACPVTS
SDTAGSLHDKLAKMSVKPLLDVLEALASNSAQFELQNNELATYAGKINKEEARINWHQSAVEIDRKIRAFNPWPVAYTLA
GELMLRIHQAKATDIMSTEMPGMVLNIDKTGMLVATSDNALLVEKIQFPGAKVISVRDWLNSGKTQLHTGLMLQ
>Mature_314_residues
MNGLTVVFAGTPEFGLPCLDALIQSRHHLKAVYTQPDRPAGRGRKLQESPVKEWAINHQISVYQPLNFKNQEAVDELSAL
KPDVMVVIAYGLILPKAVLEIPRLGCINVHASLLPRWRGASPIQHAILHGDAESGVTIMQMDVGLDTGPMLCKAACPVTS
SDTAGSLHDKLAKMSVKPLLDVLEALASNSAQFELQNNELATYAGKINKEEARINWHQSAVEIDRKIRAFNPWPVAYTLA
GELMLRIHQAKATDIMSTEMPGMVLNIDKTGMLVATSDNALLVEKIQFPGAKVISVRDWLNSGKTQLHTGLMLQ

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI238814322, Length=318, Percent_Identity=27.0440251572327, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI21614513, Length=317, Percent_Identity=29.3375394321767, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI164663775, Length=236, Percent_Identity=35.1694915254237, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1789683, Length=307, Percent_Identity=51.4657980456026, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI1788589, Length=278, Percent_Identity=28.0575539568345, Blast_Score=121, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI133930964, Length=299, Percent_Identity=25.4180602006689, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319458, Length=351, Percent_Identity=25.3561253561254, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550868, Length=308, Percent_Identity=27.9220779220779, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI28571984, Length=228, Percent_Identity=29.8245614035088, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585660, Length=325, Percent_Identity=26.1538461538462, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 34364; Mature: 34364

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGLTVVFAGTPEFGLPCLDALIQSRHHLKAVYTQPDRPAGRGRKLQESPVKEWAINHQI
CCCEEEEEECCCCCCCHHHHHHHHCCHHEEEEEECCCCCCCCCCCCCCCHHHHHHCCCEE
SVYQPLNFKNQEAVDELSALKPDVMVVIAYGLILPKAVLEIPRLGCINVHASLLPRWRGA
EEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCCC
SPIQHAILHGDAESGVTIMQMDVGLDTGPMLCKAACPVTSSDTAGSLHDKLAKMSVKPLL
CHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
DVLEALASNSAQFELQNNELATYAGKINKEEARINWHQSAVEIDRKIRAFNPWPVAYTLA
HHHHHHHCCCEEEEECCCCEEEECCCCCCCHHHEEHHHHHHHHHHHHCCCCCCCCHHHHH
GELMLRIHQAKATDIMSTEMPGMVLNIDKTGMLVATSDNALLVEKIQFPGAKVISVRDWL
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCEEEEEEECCCCCEEEEEHHHH
NSGKTQLHTGLMLQ
CCCCCEECCCCCCC
>Mature Secondary Structure
MNGLTVVFAGTPEFGLPCLDALIQSRHHLKAVYTQPDRPAGRGRKLQESPVKEWAINHQI
CCCEEEEEECCCCCCCHHHHHHHHCCHHEEEEEECCCCCCCCCCCCCCCHHHHHHCCCEE
SVYQPLNFKNQEAVDELSALKPDVMVVIAYGLILPKAVLEIPRLGCINVHASLLPRWRGA
EEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCCC
SPIQHAILHGDAESGVTIMQMDVGLDTGPMLCKAACPVTSSDTAGSLHDKLAKMSVKPLL
CHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
DVLEALASNSAQFELQNNELATYAGKINKEEARINWHQSAVEIDRKIRAFNPWPVAYTLA
HHHHHHHCCCEEEEECCCCEEEECCCCCCCHHHEEHHHHHHHHHHHHCCCCCCCCHHHHH
GELMLRIHQAKATDIMSTEMPGMVLNIDKTGMLVATSDNALLVEKIQFPGAKVISVRDWL
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCEEEEEEECCCCCEEEEEHHHH
NSGKTQLHTGLMLQ
CCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA