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The map label for this gene is sucD [H]

Identifier: 54293530

GI number: 54293530

Start: 629290

End: 630165

Strand: Direct

Name: sucD [H]

Synonym: lpl0581

Alternate gene names: 54293530

Gene position: 629290-630165 (Clockwise)

Preceding gene: 54293529

Following gene: 54293531

Centisome position: 18.81

GC content: 43.04

Gene sequence:

>876_bases
ATGAGTGTATTAGTTGATAAACATACAAAAGTACTATGTCAGGGTTTTACTGGAAAACAAGGTACTTATCATACAGAGCA
AGCCCTGGCTTACGGGACTAAGATGGTGGGGGGGGTTACTCCAGGTAAGGGTGGTCAAATGCATCTGGGATTGCCTGTAT
TTAATACTATGCGTGAAGCAGTTGAGGAAACCCAGGCGGATGCAAGCGTTATCTATGTTCCTGCACCATTTTGCAAAGAT
TCCATTATTGAAGCAGCAGAAGCAGGTGTTAAACTGATTGTTTGTATTACAGAAGGTGTGCCTGTATTGGATATGTTGCA
AGTAAAAGTGTATATAGAAAACAATACACAGGCTCGATTAATTGGTCCAAATTGTCCAGGAATAATTACACCAGGCGAAT
GCAAGATAGGTATTATGCCTGGCTATATCCATTTACCCGGAAAAGTTGGAATCGTTTCACGTTCAGGAACTTTAACCTAC
GAGGCAGTAAAACAAACTACTGATAAAGGGTTTGGTCAAAGTACTTGCATAGGAATAGGTGGCGATCCAATTCCAGGAAC
CAGCTTTATTGATGCGTTGTCTTTATTTGAAAAAGATCCTAAAACAGAAGCTATCATCATGGTAGGAGAAATTGGTGGTT
CAGCAGAGGAAGAGGCAGCTGAATTCATTAAGTCTCATGTAAAAAAACCTGTAGTATCTTATATCGCTGGAGTCACAGCA
CCTGCTGGAAAGCGTATGGGGCATGCCGGGGCAATTATCTCTGGTGGGAAGGGAACCGCAGCAGAAAAATATGCTGCTCT
GGAAGCGGCTGGTGTGAAAACAGTTCGATCCCCTGCTGACTTGGGAGACGCAATAGCTGAGGTGACTGGTTGGTAA

Upstream 100 bases:

>100_bases
AAATTGTAGCAGCAGTTTCCGAATAAAGAATAAATTAATTTTGGCATTATTGGTAAGGTAGTTTTCAAAGCGGATATGCC
ATTAAATTACGAGGTTAACA

Downstream 100 bases:

>100_bases
GAAAATACTTTTTCTTACTTAACAGCTCTTGCATTATAGAAATAGGAACTGATTAAGACAAATTGGTGATTTTTCCTCGA
ATCATGTTGGTGCTGTGTAG

Product: succinyl-CoA synthetase, alpha subunit

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSVLVDKHTKVLCQGFTGKQGTYHTEQALAYGTKMVGGVTPGKGGQMHLGLPVFNTMREAVEETQADASVIYVPAPFCKD
SIIEAAEAGVKLIVCITEGVPVLDMLQVKVYIENNTQARLIGPNCPGIITPGECKIGIMPGYIHLPGKVGIVSRSGTLTY
EAVKQTTDKGFGQSTCIGIGGDPIPGTSFIDALSLFEKDPKTEAIIMVGEIGGSAEEEAAEFIKSHVKKPVVSYIAGVTA
PAGKRMGHAGAIISGGKGTAAEKYAALEAAGVKTVRSPADLGDAIAEVTGW

Sequences:

>Translated_291_residues
MSVLVDKHTKVLCQGFTGKQGTYHTEQALAYGTKMVGGVTPGKGGQMHLGLPVFNTMREAVEETQADASVIYVPAPFCKD
SIIEAAEAGVKLIVCITEGVPVLDMLQVKVYIENNTQARLIGPNCPGIITPGECKIGIMPGYIHLPGKVGIVSRSGTLTY
EAVKQTTDKGFGQSTCIGIGGDPIPGTSFIDALSLFEKDPKTEAIIMVGEIGGSAEEEAAEFIKSHVKKPVVSYIAGVTA
PAGKRMGHAGAIISGGKGTAAEKYAALEAAGVKTVRSPADLGDAIAEVTGW
>Mature_290_residues
SVLVDKHTKVLCQGFTGKQGTYHTEQALAYGTKMVGGVTPGKGGQMHLGLPVFNTMREAVEETQADASVIYVPAPFCKDS
IIEAAEAGVKLIVCITEGVPVLDMLQVKVYIENNTQARLIGPNCPGIITPGECKIGIMPGYIHLPGKVGIVSRSGTLTYE
AVKQTTDKGFGQSTCIGIGGDPIPGTSFIDALSLFEKDPKTEAIIMVGEIGGSAEEEAAEFIKSHVKKPVVSYIAGVTAP
AGKRMGHAGAIISGGKGTAAEKYAALEAAGVKTVRSPADLGDAIAEVTGW

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=287, Percent_Identity=66.2020905923345, Blast_Score=334, Evalue=7e-92,
Organism=Homo sapiens, GI38569423, Length=316, Percent_Identity=30.0632911392405, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI38569421, Length=316, Percent_Identity=30.0632911392405, Blast_Score=102, Evalue=3e-22,
Organism=Escherichia coli, GI1786949, Length=288, Percent_Identity=78.4722222222222, Blast_Score=464, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17550194, Length=289, Percent_Identity=61.5916955017301, Blast_Score=338, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI17553126, Length=290, Percent_Identity=60, Blast_Score=330, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI17551266, Length=258, Percent_Identity=32.1705426356589, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17557344, Length=258, Percent_Identity=31.3953488372093, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324716, Length=294, Percent_Identity=52.3809523809524, Blast_Score=286, Evalue=3e-78,
Organism=Drosophila melanogaster, GI21356559, Length=290, Percent_Identity=57.5862068965517, Blast_Score=338, Evalue=3e-93,
Organism=Drosophila melanogaster, GI28574296, Length=288, Percent_Identity=61.4583333333333, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI281363475, Length=261, Percent_Identity=29.5019157088123, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI281363473, Length=261, Percent_Identity=29.5019157088123, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI281363477, Length=261, Percent_Identity=29.5019157088123, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30218; Mature: 30087

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLVDKHTKVLCQGFTGKQGTYHTEQALAYGTKMVGGVTPGKGGQMHLGLPVFNTMREA
CCEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHH
VEETQADASVIYVPAPFCKDSIIEAAEAGVKLIVCITEGVPVLDMLQVKVYIENNTQARL
HHHHCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEEEEEEEECCCEEEE
IGPNCPGIITPGECKIGIMPGYIHLPGKVGIVSRSGTLTYEAVKQTTDKGFGQSTCIGIG
ECCCCCCEECCCCEEEEEECCEEECCCEEEEEECCCCEEHHHHHHHHHCCCCCCEEEECC
GDPIPGTSFIDALSLFEKDPKTEAIIMVGEIGGSAEEEAAEFIKSHVKKPVVSYIAGVTA
CCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PAGKRMGHAGAIISGGKGTAAEKYAALEAAGVKTVRSPADLGDAIAEVTGW
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SVLVDKHTKVLCQGFTGKQGTYHTEQALAYGTKMVGGVTPGKGGQMHLGLPVFNTMREA
CEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHH
VEETQADASVIYVPAPFCKDSIIEAAEAGVKLIVCITEGVPVLDMLQVKVYIENNTQARL
HHHHCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEEEEEEEECCCEEEE
IGPNCPGIITPGECKIGIMPGYIHLPGKVGIVSRSGTLTYEAVKQTTDKGFGQSTCIGIG
ECCCCCCEECCCCEEEEEECCEEECCCEEEEEECCCCEEHHHHHHHHHCCCCCCEEEECC
GDPIPGTSFIDALSLFEKDPKTEAIIMVGEIGGSAEEEAAEFIKSHVKKPVVSYIAGVTA
CCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PAGKRMGHAGAIISGGKGTAAEKYAALEAAGVKTVRSPADLGDAIAEVTGW
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]