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The map label for this gene is lpxA [H]

Identifier: 54293500

GI number: 54293500

Start: 598120

End: 598890

Strand: Direct

Name: lpxA [H]

Synonym: lpl0549

Alternate gene names: 54293500

Gene position: 598120-598890 (Clockwise)

Preceding gene: 54293499

Following gene: 54293501

Centisome position: 17.88

GC content: 41.89

Gene sequence:

>771_bases
GTGATAGATGAAAGAGCAATGATTCACCCTTCGGCGAAGCTGGCAAGCGGAGTGTCAATAGGCCCCGGAACAGTAATAGG
CGCTGATGTTGAGATTGGTGAAAATACCTGGATAGGGCCGCATGTGGTAATTGAAGGACCTACTGTAATTGGGAAAAACA
ATAAGATCTTTCAATTTGCTTCCGTAGGAGATGAGCCACAAGATATCACTTACAAGGGCGAGCCAACTCGTCTTGAAATC
GGCGATAATAATGTAATCAGAGAGTATTGCATGATTAGCCGAGGTACTGTCAAAGGTGGAGGTGTCACTCGTATTGGCAA
TAGCAATTATTTAATGGCCTATTCACATATTGGCCATGATTGTATGGTAGGCAATCATATTATTATGGTCAATTATGCAG
CCTTATCAGGTCATGTCACAATTAATGATTACGCAATTATTGGCCCTTATGCTGCCGTTCACCAATTTTGTCAGGTGGGA
GCCTACGCATTCATAGCCCGAGCTACCTATGTTACTAAAGACGTATTGCCTTATGTTATGATTGCAGGTCATACCACTTC
TGCTTGTGGAATCAACACTGTTGGTTTAAGAAGGAGAGGTTTTTCTTCTGCTGCGATTGATTGTTTGCGACGCGCATATA
AAATTATCTTTCGCAAAGGGTTAACCGTTCAACAGGCGGTTTCAGAATTAGAGTTGATTCAAAATGAGTGTCCAGAAATT
ACTCCTATGATTGATGCTTTGAATCAATCCACAAGAGGCATTGTGAGGTAA

Upstream 100 bases:

>100_bases
GGCAAAAAAGAGATTTTTGGCGTATGCACGGAGAAGCTTATATCGGTGATAAATTAGCTTGTTCCGCAGACTTGTTGAGC
GCAACAAAGGAAATTAAAAA

Downstream 100 bases:

>100_bases
GCAATGGTTGTTGCACCCTATTTGGCTGTAGCTATCGGAGGCTCTTTAGGCGCAATGTCTCGTTATTTAGTTACAATAAT
GGCGCAAAATGCCTGGGGGA

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MIDERAMIHPSAKLASGVSIGPGTVIGADVEIGENTWIGPHVVIEGPTVIGKNNKIFQFASVGDEPQDITYKGEPTRLEI
GDNNVIREYCMISRGTVKGGGVTRIGNSNYLMAYSHIGHDCMVGNHIIMVNYAALSGHVTINDYAIIGPYAAVHQFCQVG
AYAFIARATYVTKDVLPYVMIAGHTTSACGINTVGLRRRGFSSAAIDCLRRAYKIIFRKGLTVQQAVSELELIQNECPEI
TPMIDALNQSTRGIVR

Sequences:

>Translated_256_residues
MIDERAMIHPSAKLASGVSIGPGTVIGADVEIGENTWIGPHVVIEGPTVIGKNNKIFQFASVGDEPQDITYKGEPTRLEI
GDNNVIREYCMISRGTVKGGGVTRIGNSNYLMAYSHIGHDCMVGNHIIMVNYAALSGHVTINDYAIIGPYAAVHQFCQVG
AYAFIARATYVTKDVLPYVMIAGHTTSACGINTVGLRRRGFSSAAIDCLRRAYKIIFRKGLTVQQAVSELELIQNECPEI
TPMIDALNQSTRGIVR
>Mature_256_residues
MIDERAMIHPSAKLASGVSIGPGTVIGADVEIGENTWIGPHVVIEGPTVIGKNNKIFQFASVGDEPQDITYKGEPTRLEI
GDNNVIREYCMISRGTVKGGGVTRIGNSNYLMAYSHIGHDCMVGNHIIMVNYAALSGHVTINDYAIIGPYAAVHQFCQVG
AYAFIARATYVTKDVLPYVMIAGHTTSACGINTVGLRRRGFSSAAIDCLRRAYKIIFRKGLTVQQAVSELELIQNECPEI
TPMIDALNQSTRGIVR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=262, Percent_Identity=47.7099236641221, Blast_Score=256, Evalue=9e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: NA

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 27714; Mature: 27714

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDERAMIHPSAKLASGVSIGPGTVIGADVEIGENTWIGPHVVIEGPTVIGKNNKIFQFA
CCCCCCEECCCHHHHCCCCCCCCCEEECEEEECCCCCCCCEEEEECCEEECCCCCEEEEE
SVGDEPQDITYKGEPTRLEIGDNNVIREYCMISRGTVKGGGVTRIGNSNYLMAYSHIGHD
CCCCCCCCEEECCCCCEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCCE
CMVGNHIIMVNYAALSGHVTINDYAIIGPYAAVHQFCQVGAYAFIARATYVTKDVLPYVM
EEECCEEEEEEEEEEECEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEE
IAGHTTSACGINTVGLRRRGFSSAAIDCLRRAYKIIFRKGLTVQQAVSELELIQNECPEI
EECCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC
TPMIDALNQSTRGIVR
CHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIDERAMIHPSAKLASGVSIGPGTVIGADVEIGENTWIGPHVVIEGPTVIGKNNKIFQFA
CCCCCCEECCCHHHHCCCCCCCCCEEECEEEECCCCCCCCEEEEECCEEECCCCCEEEEE
SVGDEPQDITYKGEPTRLEIGDNNVIREYCMISRGTVKGGGVTRIGNSNYLMAYSHIGHD
CCCCCCCCEEECCCCCEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCCE
CMVGNHIIMVNYAALSGHVTINDYAIIGPYAAVHQFCQVGAYAFIARATYVTKDVLPYVM
EEECCEEEEEEEEEEECEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEE
IAGHTTSACGINTVGLRRRGFSSAAIDCLRRAYKIIFRKGLTVQQAVSELELIQNECPEI
EECCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC
TPMIDALNQSTRGIVR
CHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA