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The map label for this gene is uppS [H]

Identifier: 54293493

GI number: 54293493

Start: 590513

End: 591229

Strand: Direct

Name: uppS [H]

Synonym: lpl0542

Alternate gene names: 54293493

Gene position: 590513-591229 (Clockwise)

Preceding gene: 54293487

Following gene: 54293494

Centisome position: 17.65

GC content: 38.77

Gene sequence:

>717_bases
TTGAATCATAAATTACCTCAACACATTGCCGTTGTCATGGATGGAAACGGGCGTTGGGCTGAAAGCCGCGGTTTGCCCCG
TGTAGAGGGACACAAAGCGGGCCTTGACTCAGTTAAAAAAATTATCAATTGTTGCCTGGAAAAAAAAATTTCCTGCTTAA
GCCTGTTTGCATTTAGTTCTGAAAATTGGTCAAGACCAGTGACAGAAGTCAATTTTCTTATGGAGTTGTTTTTGGAGGCT
TTGCGAAAAGAGATAGACGATTTAAACCAGCATGGAATACGGCTAAAGTTTACTGGCGATAGAGAACCTTTGTCTCAAGT
ATTACAAAAGCAAATGAGTGATGCGGAAGCTCTTACCAAGAATAATCAACAATTAATTCTCAATGTTGTTGTGAATTATG
GTGGGAAATGGGATATAGTGACAGCGGCTAGAAAATTAATACGCACGGTTTTGGATGGGAAGTTGGCATATGATGAAATC
AATGAAGCAGTATTCGCTCAATTTCTTGATACGAAAGGCATGCCGGAACCTGATCTGTTTATTCGAACTAGTGGTGAATT
AAGGATAAGTAATTTTTTTCTTTGGCAGTTAGCTTATACTGAGCTGTATTTTACTGATGTTCATTGGCCTGATTTTAATG
AGCATGAGTTTGAATTGGCATTGATTTCTTTTTCCAAGCGGGCAAGAAGGTTTGGGCAAATTTCACAATCTGAATAA

Upstream 100 bases:

>100_bases
TGTTTCATAAACAAGGTCAATTGATTTCTTAAGTAGTACTTAAATTTTTATCTCAAAGAGGTTAGACTATGCATCATTTA
TATTAGTCGGATAAGTTGTT

Downstream 100 bases:

>100_bases
AGGTAAAACCATGTTTATGCAACGTTTGATTACGACATTAATATTAGCGCCTTTGGTTTTGCTTGCTATTTTCTATGCGC
CTTCCTGGATTTTATGGGGT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MNHKLPQHIAVVMDGNGRWAESRGLPRVEGHKAGLDSVKKIINCCLEKKISCLSLFAFSSENWSRPVTEVNFLMELFLEA
LRKEIDDLNQHGIRLKFTGDREPLSQVLQKQMSDAEALTKNNQQLILNVVVNYGGKWDIVTAARKLIRTVLDGKLAYDEI
NEAVFAQFLDTKGMPEPDLFIRTSGELRISNFFLWQLAYTELYFTDVHWPDFNEHEFELALISFSKRARRFGQISQSE

Sequences:

>Translated_238_residues
MNHKLPQHIAVVMDGNGRWAESRGLPRVEGHKAGLDSVKKIINCCLEKKISCLSLFAFSSENWSRPVTEVNFLMELFLEA
LRKEIDDLNQHGIRLKFTGDREPLSQVLQKQMSDAEALTKNNQQLILNVVVNYGGKWDIVTAARKLIRTVLDGKLAYDEI
NEAVFAQFLDTKGMPEPDLFIRTSGELRISNFFLWQLAYTELYFTDVHWPDFNEHEFELALISFSKRARRFGQISQSE
>Mature_238_residues
MNHKLPQHIAVVMDGNGRWAESRGLPRVEGHKAGLDSVKKIINCCLEKKISCLSLFAFSSENWSRPVTEVNFLMELFLEA
LRKEIDDLNQHGIRLKFTGDREPLSQVLQKQMSDAEALTKNNQQLILNVVVNYGGKWDIVTAARKLIRTVLDGKLAYDEI
NEAVFAQFLDTKGMPEPDLFIRTSGELRISNFFLWQLAYTELYFTDVHWPDFNEHEFELALISFSKRARRFGQISQSE

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=212, Percent_Identity=36.3207547169811, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI45580738, Length=212, Percent_Identity=36.3207547169811, Blast_Score=142, Evalue=2e-34,
Organism=Escherichia coli, GI1786371, Length=236, Percent_Identity=49.1525423728814, Blast_Score=240, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=40, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6319474, Length=226, Percent_Identity=34.5132743362832, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=230, Percent_Identity=30, Blast_Score=113, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=36, Blast_Score=147, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27394; Mature: 27394

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHKLPQHIAVVMDGNGRWAESRGLPRVEGHKAGLDSVKKIINCCLEKKISCLSLFAFSS
CCCCCCCEEEEEECCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
ENWSRPVTEVNFLMELFLEALRKEIDDLNQHGIRLKFTGDREPLSQVLQKQMSDAEALTK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHC
NNQQLILNVVVNYGGKWDIVTAARKLIRTVLDGKLAYDEINEAVFAQFLDTKGMPEPDLF
CCHHEEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
IRTSGELRISNFFLWQLAYTELYFTDVHWPDFNEHEFELALISFSKRARRFGQISQSE
EEECCCEEEHHHHHHHHHHHHEEEEECCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNHKLPQHIAVVMDGNGRWAESRGLPRVEGHKAGLDSVKKIINCCLEKKISCLSLFAFSS
CCCCCCCEEEEEECCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
ENWSRPVTEVNFLMELFLEALRKEIDDLNQHGIRLKFTGDREPLSQVLQKQMSDAEALTK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHC
NNQQLILNVVVNYGGKWDIVTAARKLIRTVLDGKLAYDEINEAVFAQFLDTKGMPEPDLF
CCHHEEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
IRTSGELRISNFFLWQLAYTELYFTDVHWPDFNEHEFELALISFSKRARRFGQISQSE
EEECCCEEEHHHHHHHHHHHHEEEEECCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA