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The map label for this gene is ycsA [H]

Identifier: 52787446

GI number: 52787446

Start: 3587300

End: 3588358

Strand: Reverse

Name: ycsA [H]

Synonym: BLi03766

Alternate gene names: 52787446

Gene position: 3588358-3587300 (Counterclockwise)

Preceding gene: 52787447

Following gene: 52787445

Centisome position: 84.98

GC content: 48.44

Gene sequence:

>1059_bases
ATGAAAGTATTCAACATTGCCAGCATACCCGGTGACGGGGTAGGGAAAGAAGTCGTACCTGCTGCACAACGAGTTTTGAA
AGCGGTTTCGGATGTTCACGGGGGACTCTCATTTCGGTTTACGGAGTTTCCATACAGCTGTGAGTATTATTTGGAACACG
GGGAAATGATGCCTGATGACGGCTTGGAGCAGCTGAAAGAGTTCGACAGCATCTTTCTTGGGGCTGTAGGAAACAGCAAG
CTTGTCCCCGACCATATTTCCCTGTGGGGGCTGCTCATTAAAATCCGCCGCGAATTTGAACAGGTCATCAACATTAGACC
TGCGAAATATTTGCAAGGAATCAAGTCTCCGCTGGCCAACCCAAAAGATTTCGATCTGCTTGTCGTCAGGGAAAACAGTG
AAGGGGAATACAGCTCGATCGGAGGCAGAATCTTCAGGGATGAAGATGAAATCGCCATTCAAAATGCCGTTTTTTCAAGA
AAAGGGGCGGAGAGGGCGATGCGCTTTGCTTTTGAGTTGGCGGCTAAGCGGAAAAAGCATGTCACAAGCGCAACAAAGTC
GAACGGAATCGTTTATTCAATGCCTTTTTGGGATGAAGTCTTTGAGAACACGGCAAAAGACTACCCCGATATTACCGCAG
ATTCGCAGCACATTGACGCGCTGTCGGCCTTTTTTGTAACGAGGCCAGAGAAGCTTGACGTCATTGTTGCCAGCAATTTA
TTCGGCGATATTTTGACCGATATCGGGGCGGCGATTATGGGAAGCATAGGTGTGGCGCCGGCCGCCAACATTAATGTAAA
CGGCAAATATCCATCTATGTTTGAGCCTGTGCACGGCTCTGCTCCGGACATCATCGGAAAAGGAATCGCCAATCCGATCG
GCCAAATTTGGACGGCAAAAATGATGCTCGATCATTTCGGGGAAGAAGAACTCGGTGCAAGATTGCTTGACGTGATTGAA
GACGTTCTAAAGAGCGGCTACTTAACGCCTGATATCGGCGGTTCAAGTACGACGGATGATGTGACAGAAGAAATCATCAA
GCGCGTGAGGACCATATAA

Upstream 100 bases:

>100_bases
GGGTTTTTCTCAAAATTTATTCTTGTCAGAAAATAACACAAGGTATAGAATGAAAGTGACAACTGTCGACAGTCGACAAT
TTGAAATAGGGGATGATCCA

Downstream 100 bases:

>100_bases
GCGAAAGCTGCCAGCACTCCGGCAGCTTTTTTTGCTGTGGAATGGAAAATCGATTACATGATACGGGCGGTTTTGGCGCA
TACTACATCAAGCAACAAAA

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MKVFNIASIPGDGVGKEVVPAAQRVLKAVSDVHGGLSFRFTEFPYSCEYYLEHGEMMPDDGLEQLKEFDSIFLGAVGNSK
LVPDHISLWGLLIKIRREFEQVINIRPAKYLQGIKSPLANPKDFDLLVVRENSEGEYSSIGGRIFRDEDEIAIQNAVFSR
KGAERAMRFAFELAAKRKKHVTSATKSNGIVYSMPFWDEVFENTAKDYPDITADSQHIDALSAFFVTRPEKLDVIVASNL
FGDILTDIGAAIMGSIGVAPAANINVNGKYPSMFEPVHGSAPDIIGKGIANPIGQIWTAKMMLDHFGEEELGARLLDVIE
DVLKSGYLTPDIGGSSTTDDVTEEIIKRVRTI

Sequences:

>Translated_352_residues
MKVFNIASIPGDGVGKEVVPAAQRVLKAVSDVHGGLSFRFTEFPYSCEYYLEHGEMMPDDGLEQLKEFDSIFLGAVGNSK
LVPDHISLWGLLIKIRREFEQVINIRPAKYLQGIKSPLANPKDFDLLVVRENSEGEYSSIGGRIFRDEDEIAIQNAVFSR
KGAERAMRFAFELAAKRKKHVTSATKSNGIVYSMPFWDEVFENTAKDYPDITADSQHIDALSAFFVTRPEKLDVIVASNL
FGDILTDIGAAIMGSIGVAPAANINVNGKYPSMFEPVHGSAPDIIGKGIANPIGQIWTAKMMLDHFGEEELGARLLDVIE
DVLKSGYLTPDIGGSSTTDDVTEEIIKRVRTI
>Mature_352_residues
MKVFNIASIPGDGVGKEVVPAAQRVLKAVSDVHGGLSFRFTEFPYSCEYYLEHGEMMPDDGLEQLKEFDSIFLGAVGNSK
LVPDHISLWGLLIKIRREFEQVINIRPAKYLQGIKSPLANPKDFDLLVVRENSEGEYSSIGGRIFRDEDEIAIQNAVFSR
KGAERAMRFAFELAAKRKKHVTSATKSNGIVYSMPFWDEVFENTAKDYPDITADSQHIDALSAFFVTRPEKLDVIVASNL
FGDILTDIGAAIMGSIGVAPAANINVNGKYPSMFEPVHGSAPDIIGKGIANPIGQIWTAKMMLDHFGEEELGARLLDVIE
DVLKSGYLTPDIGGSSTTDDVTEEIIKRVRTI

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=352, Percent_Identity=31.5340909090909, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI4758582, Length=357, Percent_Identity=28.0112044817927, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI28178821, Length=354, Percent_Identity=27.683615819209, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI28178816, Length=349, Percent_Identity=27.7936962750716, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI28178838, Length=307, Percent_Identity=27.6872964169381, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI28178819, Length=197, Percent_Identity=28.9340101522843, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788101, Length=357, Percent_Identity=54.9019607843137, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI87081683, Length=361, Percent_Identity=35.7340720221607, Blast_Score=191, Evalue=7e-50,
Organism=Escherichia coli, GI1787381, Length=375, Percent_Identity=27.7333333333333, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17550882, Length=351, Percent_Identity=31.6239316239316, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71986051, Length=369, Percent_Identity=31.4363143631436, Blast_Score=150, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI25144293, Length=348, Percent_Identity=26.4367816091954, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17505779, Length=355, Percent_Identity=24.2253521126761, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322097, Length=362, Percent_Identity=34.8066298342541, Blast_Score=190, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319830, Length=363, Percent_Identity=33.3333333333333, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6324291, Length=367, Percent_Identity=32.1525885558583, Blast_Score=152, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6324709, Length=359, Percent_Identity=30.6406685236769, Blast_Score=146, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24643268, Length=350, Percent_Identity=30.5714285714286, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24643270, Length=350, Percent_Identity=30.5714285714286, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24661184, Length=356, Percent_Identity=28.9325842696629, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI161078633, Length=262, Percent_Identity=31.2977099236641, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24650122, Length=262, Percent_Identity=31.2977099236641, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI161078639, Length=262, Percent_Identity=31.2977099236641, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI161078635, Length=262, Percent_Identity=31.2977099236641, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI161078637, Length=262, Percent_Identity=31.2977099236641, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI281362242, Length=354, Percent_Identity=27.1186440677966, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24648872, Length=354, Percent_Identity=27.1186440677966, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI20130355, Length=355, Percent_Identity=25.6338028169014, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 38747; Mature: 38747

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFNIASIPGDGVGKEVVPAAQRVLKAVSDVHGGLSFRFTEFPYSCEYYLEHGEMMPDD
CCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCCCCH
GLEQLKEFDSIFLGAVGNSKLVPDHISLWGLLIKIRREFEQVINIRPAKYLQGIKSPLAN
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
PKDFDLLVVRENSEGEYSSIGGRIFRDEDEIAIQNAVFSRKGAERAMRFAFELAAKRKKH
CCCCEEEEEEECCCCCHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTSATKSNGIVYSMPFWDEVFENTAKDYPDITADSQHIDALSAFFVTRPEKLDVIVASNL
HHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHH
FGDILTDIGAAIMGSIGVAPAANINVNGKYPSMFEPVHGSAPDIIGKGIANPIGQIWTAK
HHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MMLDHFGEEELGARLLDVIEDVLKSGYLTPDIGGSSTTDDVTEEIIKRVRTI
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVFNIASIPGDGVGKEVVPAAQRVLKAVSDVHGGLSFRFTEFPYSCEYYLEHGEMMPDD
CCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCCCCH
GLEQLKEFDSIFLGAVGNSKLVPDHISLWGLLIKIRREFEQVINIRPAKYLQGIKSPLAN
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
PKDFDLLVVRENSEGEYSSIGGRIFRDEDEIAIQNAVFSRKGAERAMRFAFELAAKRKKH
CCCCEEEEEEECCCCCHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTSATKSNGIVYSMPFWDEVFENTAKDYPDITADSQHIDALSAFFVTRPEKLDVIVASNL
HHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHH
FGDILTDIGAAIMGSIGVAPAANINVNGKYPSMFEPVHGSAPDIIGKGIANPIGQIWTAK
HHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MMLDHFGEEELGARLLDVIEDVLKSGYLTPDIGGSSTTDDVTEEIIKRVRTI
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10568751 [H]