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The map label for this gene is hisI [H]

Identifier: 52787414

GI number: 52787414

Start: 3556001

End: 3556633

Strand: Reverse

Name: hisI [H]

Synonym: BLi03731

Alternate gene names: 52787414

Gene position: 3556633-3556001 (Counterclockwise)

Preceding gene: 52787415

Following gene: 52787412

Centisome position: 84.23

GC content: 49.29

Gene sequence:

>633_bases
ATGATCAAGGCAGACGAGTTGACATTTAATGAAGCCGGCTTGATCCCGGCGATTGTCCAGGATGCAGCGAGCAAAGAAGT
GCTGACACTTGCTTATATGAATAAAGAATCGTTTGAAAAAACGCTGGAAACGAAGGAGACATGGTTTTTCAGCAGATCGC
GCGGAGAGCTCTGGCATAAGGGAGCGACGTCGGGTAACATTCAGCGTGTGAAAGACATCAGGCTTGACTGTGATCAAGAT
GCGCTCATCGTGCTTGTTGAACCGGCGGGGCCGGCCTGTCATAAAGGAAGCTACAGCTGTTTCTCGCCCGGCGAACATAT
CAGACAGACTGATGGCGGCCGCTTTGACATCATCAATGAACTTGAAACCGTCATTGCCAAACGGCAGGCTGAAATGCCTG
AAGGCGCATATACAACATATTTGTTCCGTGAAGGCGTTGATAAGATTTTGAAGAAAGTTGGCGAAGAAGCGGCGGAAGTC
ATCATCGCTGCAAAAAACCGTGATCCTGAAGAACTGAAATGGGAGGCGGCTGACCTTCTTTACCATCTGCTCGTTTTGCT
GAGGGAGCAGTCCCTTCCGCTTGATGATGTGCTTGGCGTCTTGAAAGAGCGCCATGAAGGATCTGAATCATAA

Upstream 100 bases:

>100_bases
GCCGGGCGGACGCGGCTCTTGCCGCATCTATCTTTCATTACAAAGAAACATCTGTAAAAGAAGTAAAAGCTTATTTAAAA
GAGCGCGGGGTGAATGTAAG

Downstream 100 bases:

>100_bases
GCACACTGCATACAACCAAAAGGCGGTTGGCCTTTTGGTTGTTTTCCCGGTAGGGGAGCTATTTGATGTTCAATTTCATC
ACGATTTGCTCTCCGATCGG

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MIKADELTFNEAGLIPAIVQDAASKEVLTLAYMNKESFEKTLETKETWFFSRSRGELWHKGATSGNIQRVKDIRLDCDQD
ALIVLVEPAGPACHKGSYSCFSPGEHIRQTDGGRFDIINELETVIAKRQAEMPEGAYTTYLFREGVDKILKKVGEEAAEV
IIAAKNRDPEELKWEAADLLYHLLVLLREQSLPLDDVLGVLKERHEGSES

Sequences:

>Translated_210_residues
MIKADELTFNEAGLIPAIVQDAASKEVLTLAYMNKESFEKTLETKETWFFSRSRGELWHKGATSGNIQRVKDIRLDCDQD
ALIVLVEPAGPACHKGSYSCFSPGEHIRQTDGGRFDIINELETVIAKRQAEMPEGAYTTYLFREGVDKILKKVGEEAAEV
IIAAKNRDPEELKWEAADLLYHLLVLLREQSLPLDDVLGVLKERHEGSES
>Mature_210_residues
MIKADELTFNEAGLIPAIVQDAASKEVLTLAYMNKESFEKTLETKETWFFSRSRGELWHKGATSGNIQRVKDIRLDCDQD
ALIVLVEPAGPACHKGSYSCFSPGEHIRQTDGGRFDIINELETVIAKRQAEMPEGAYTTYLFREGVDKILKKVGEEAAEV
IIAAKNRDPEELKWEAADLLYHLLVLLREQSLPLDDVLGVLKERHEGSES

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=194, Percent_Identity=47.4226804123711, Blast_Score=181, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6319819, Length=194, Percent_Identity=36.5979381443299, Blast_Score=99, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23577; Mature: 23577

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKADELTFNEAGLIPAIVQDAASKEVLTLAYMNKESFEKTLETKETWFFSRSRGELWHK
CCCCCCCCCCCCCCHHHHHHHHCCCCEEHEEHHCHHHHHHHHHHHHHHEEECCCCCHHHC
GATSGNIQRVKDIRLDCDQDALIVLVEPAGPACHKGSYSCFSPGEHIRQTDGGRFDIINE
CCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHH
LETVIAKRQAEMPEGAYTTYLFREGVDKILKKVGEEAAEVIIAAKNRDPEELKWEAADLL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHH
YHLLVLLREQSLPLDDVLGVLKERHEGSES
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIKADELTFNEAGLIPAIVQDAASKEVLTLAYMNKESFEKTLETKETWFFSRSRGELWHK
CCCCCCCCCCCCCCHHHHHHHHCCCCEEHEEHHCHHHHHHHHHHHHHHEEECCCCCHHHC
GATSGNIQRVKDIRLDCDQDALIVLVEPAGPACHKGSYSCFSPGEHIRQTDGGRFDIINE
CCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHH
LETVIAKRQAEMPEGAYTTYLFREGVDKILKKVGEEAAEVIIAAKNRDPEELKWEAADLL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHH
YHLLVLLREQSLPLDDVLGVLKERHEGSES
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]