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The map label for this gene is spoIIAB

Identifier: 52786235

GI number: 52786235

Start: 2426525

End: 2426965

Strand: Reverse

Name: spoIIAB

Synonym: BLi02496

Alternate gene names: 52786235

Gene position: 2426965-2426525 (Counterclockwise)

Preceding gene: 52786236

Following gene: 52786234

Centisome position: 57.47

GC content: 45.8

Gene sequence:

>441_bases
ATGAAAAATGAAATGAACATTCAGTTTACAGCGCTCAGCCAAAATGAATCGTTTGCACGGGTGACAGTCGCTGCTTTTAT
CGCTCAGCTTGACCCGACGATGGATGAACTGACCGAAATTAAAACGGTCGTATCCGAAGCGGTCACAAACGCGATCATTC
ACGGTTATGAAAACTCAGGGCAGGGAAACGTATATATTTCCGTCACTCTCGAGGACCATATTGTCTATTTAACGATCCGC
GACGAAGGAGTCGGCATCCCTAATCTTGAAGAAGCGCGCCAGCCCCTGTTCACGACAAAGCCTGAACTCGAGCGGTCGGG
AATGGGCTTTACGATCATGGAAAATTTCATGGATGATATTTCGATCGACTCCTCACCTGAGATGGGAACCACAATACACT
TAACAAAGCACTTATCAAAAAGCAAAGCGCTTTGCAATTAA

Upstream 100 bases:

>100_bases
CCCCTGCTGTCAAACGTTTATTTGATATGTCCGGGCTGTTTAAAATCATTCGCCTTGAGCAATCAGAGCAGCGTGCACTT
GAAACGTTGGGGGTGGCGTC

Downstream 100 bases:

>100_bases
GGGAGATTTGTTATGGATGTGGAGGTTAAAAAAGAAAACCAGAACACTCAGCTTAAAGACCATGAAGTGAAAGAACTGAT
TAAAAACAGCCAGAACGGCG

Product: anti-sigma F factor

Products: NA

Alternate protein names: Stage II sporulation protein AB

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MKNEMNIQFTALSQNESFARVTVAAFIAQLDPTMDELTEIKTVVSEAVTNAIIHGYENSGQGNVYISVTLEDHIVYLTIR
DEGVGIPNLEEARQPLFTTKPELERSGMGFTIMENFMDDISIDSSPEMGTTIHLTKHLSKSKALCN

Sequences:

>Translated_146_residues
MKNEMNIQFTALSQNESFARVTVAAFIAQLDPTMDELTEIKTVVSEAVTNAIIHGYENSGQGNVYISVTLEDHIVYLTIR
DEGVGIPNLEEARQPLFTTKPELERSGMGFTIMENFMDDISIDSSPEMGTTIHLTKHLSKSKALCN
>Mature_146_residues
MKNEMNIQFTALSQNESFARVTVAAFIAQLDPTMDELTEIKTVVSEAVTNAIIHGYENSGQGNVYISVTLEDHIVYLTIR
DEGVGIPNLEEARQPLFTTKPELERSGMGFTIMENFMDDISIDSSPEMGTTIHLTKHLSKSKALCN

Specific function: Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases si

COG id: COG2172

COG function: function code T; Anti-sigma regulatory factor (Ser/Thr protein kinase)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anti-sigma-factor family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SP2AB_BACLD (Q65HU3)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_079654.1
- RefSeq:   YP_092064.1
- ProteinModelPortal:   Q65HU3
- SMR:   Q65HU3
- STRING:   Q65HU3
- EnsemblBacteria:   EBBACT00000054494
- EnsemblBacteria:   EBBACT00000060311
- GeneID:   3028499
- GeneID:   3097987
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi02496
- KEGG:   bli:BL00777
- NMPDR:   fig|279010.5.peg.369
- eggNOG:   COG2172
- GeneTree:   EBGT00050000001549
- HOGENOM:   HBG425195
- OMA:   KSKALCN
- ProtClustDB:   PRK03660
- BioCyc:   BLIC279010-1:BLI02496-MONOMER
- BioCyc:   BLIC279010:BL00777-MONOMER
- HAMAP:   MF_00637
- InterPro:   IPR010194
- InterPro:   IPR003594
- Gene3D:   G3DSA:3.30.565.10
- SMART:   SM00387
- TIGRFAMs:   TIGR01925

Pfam domain/function: PF02518 HATPase_c; SSF55874 ATP_bd_ATPase

EC number: =2.7.11.1

Molecular weight: Translated: 16199; Mature: 16199

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNEMNIQFTALSQNESFARVTVAAFIAQLDPTMDELTEIKTVVSEAVTNAIIHGYENSG
CCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
QGNVYISVTLEDHIVYLTIRDEGVGIPNLEEARQPLFTTKPELERSGMGFTIMENFMDDI
CCCEEEEEEEECEEEEEEECCCCCCCCCHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHC
SIDSSPEMGTTIHLTKHLSKSKALCN
CCCCCCCCCCEEEEEHHHHHHCCCCC
>Mature Secondary Structure
MKNEMNIQFTALSQNESFARVTVAAFIAQLDPTMDELTEIKTVVSEAVTNAIIHGYENSG
CCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
QGNVYISVTLEDHIVYLTIRDEGVGIPNLEEARQPLFTTKPELERSGMGFTIMENFMDDI
CCCEEEEEEEECEEEEEEECCCCCCCCCHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHC
SIDSSPEMGTTIHLTKHLSKSKALCN
CCCCCCCCCCEEEEEHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA