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The map label for this gene is parC [H]

Identifier: 52785814

GI number: 52785814

Start: 1996853

End: 1999276

Strand: Direct

Name: parC [H]

Synonym: BLi02060

Alternate gene names: 52785814

Gene position: 1996853-1999276 (Clockwise)

Preceding gene: 52785813

Following gene: 52785816

Centisome position: 47.29

GC content: 47.57

Gene sequence:

>2424_bases
ATGGCACAGCCAGAGATTTATCATGATTTACCATTGGAAGACGTGATCGGCGACCGTTTCGGCCGATACAGCAAATATAT
TATTCAGGACCGGGCGCTCCCTGATGCGCGCGACGGCCTGAAGCCTGTTCAAAGAAGAATCTTATACGCCATGCATGCGG
AAGGGAACACATACGATAAGAATTTCCGCAAGGCCGCAAAAACGGTCGGTAATGTAATCGGAAACTATCATCCTCACGGA
GACAGCTCGGTCTACGAAGCGATGGTGCGGATGAGCCAGGACTGGAAGGTTCGCAACGTGCTGATTGAAATGCACGGAAA
CAACGGAAGCATCGACGGTGATCCGCCGGCTGCGATGCGTTATACAGAAGCAAGGCTCGCGGCGATCGCGTCAGAGCTAT
TGCGGGATATTGACAAAGAAACGGTCGAGTTTGTACCAAACTTTGATGATACGAGCAAAGAGCCTGTCGTCCTTCCGGCA
ATGTTCCCGAACCTGCTTGTCAACGGATCGACAGGGATTTCCGCCGGGTATGCGACTGACATTCCGCCGCATCATCTCGG
GGAAGTGATCGATGCCGTGATTAAGCGGATCGACTCGCCGAACTGCAGCGTGGATGACCTCATGGAGTTCGTAAAAGGTC
CGGACTTTCCGACCGGAGGAATCATCCAGGGGAAAGAAGGCATAAAAAAAGCCTATGAAACCGGAAAAGGAAAAATCATC
ATCAGGGGCAAAGCCGAGATCGAAACAATCAGAGGCGGCCGCCAGCAAATTGTCATTACTGAAATTCCGTTTGAAGTCAA
CAAAGCGAATTTAGTGAAAAAAATGGACGAATTCAGGATTGAACGGAAGGTCGAAGGGATTTCAGAAGTCCGTGACGAGA
CCGACCGGACAGGCCTCAGAATCGTGATTGAGCTGAAAAAAGAAGCGGATGCACAAGGCATTTTAAATTTCTTATACAAA
AACACGGATTTGCAGATTCCTTACAACTTTAACATGGTCGCCATCCATAACAGAAGACCGATGCTGATGAATCTCACATC
GATTTTGGACGCTTATATCGGCCACCAAAAAGAAGTCATCACCAACCGTTCTCAGTATGAGCTGAAAAAAGCGAAGGAAA
GGCATCATATCGTAGAAGGCTTAATGAAGGCACTGTCCATTTTGGATGAGGTCATTGCGACGATCCGCTCCTCCAATGAC
AAGCGCGATGCCAAAAACAATCTGATCGAAAAGTTCGCATTTACTGAGCCGCAGGCTGAAGCGATCGTTTCCTTGCAGCT
GTACAGGCTGACAAACACAGATATTACGGCCCTCCAGGAAGAAGCAAAAGAACTGGACCAGAAGATCAAAGAGCTGGAAG
AGATCCTTTCCAATGATAAGAAACTTTTGAAAGTGATCAAAGACAGCTTGAAAAAGGTTAAAAAAACCTATGCCAGTCAA
AGGCGCTCTGTCATCGAAGAAAAAATCGAAGAAATTAAAATCAACCTTGAAGTGATGGTGGCGTCGGAAGACGTTTATGT
GACCGTAACGAAAGACGGTTATATTAAACGAACGAGCCAGCGGTCTTTCGCCGCATCAAACGGCCAGGACTTCGGCATGA
AAGATACCGACCGTCTGCTCTGTCAGCTGGAAATGAATACGACAGACGTTCTGCTCTTGTTCACAAATAAAGGGAGCTAT
GTCTATTGTCCAGTTCACCAGCTCCCTGATATCAGATGGAAAGATTTAGGTCAGCATATAACGAATATCATATCGATTGA
CAGCGATGAGTCCATCGTCAAGGCGATTCCTGTCAGAGAGTTTACCGAATCTGAATACCTGCTGTTCTTTACGAAAAACG
GAATGGCGAAAAGAACTCAGCTGATGCAGTATAAAGCACAGCGCTATTCAAAAGCACTGGTTGCCCTTAATTTAAAAGGC
GACGATGAAGTGGTCGATGTTCATGTAACGGACGGAACGAAAGATTTGTTTATTGCGACACATTCCGGCTACGGTCTGTG
GTTCACAGAAGATGAAGTCAGCGTCGTCGGCGCAAGGGCGGCCGGTGTCAAGGGCGTCAATTTGAAAGACGGCGACTTTG
TCGCCAGCGGACAGGTTTTAGAGGAAAAAGACGTGCTTGTGCTCGTGACCCAGCGCGGATCTATTAAGCGGATGAACCGC
AGCGAATTTGAAAAAACGTCAAGGGCGAAACGAGGGGTTCTCATGCTGAGGGAACTGAAGAAAAAACCTCACCGCATTGC
CGGCCTGCTCGCATGTTCATATCATGATCAAATCACGCTTCAAACCGAAAAAGGCATCACAGAGGAGATGCTTGTCAAAG
AAATCAAGCTTCATGACCGGTACAGCAACGGTTCTTTCATCATCGACGAAGATGAAGCAGGGGAAGTAACGGATGTATGG
ATCAGCAAACATGAGCTGGAGTGA

Upstream 100 bases:

>100_bases
AGGAGAAAATGGATTGAGAAAAACGTCGCTTTCGGACTTGATGAAGAAAGCAACATTTTGGAAAACGAGAATTTATCGGT
CGCTGAGGAGGTTTAAATAA

Downstream 100 bases:

>100_bases
AATCGAACAGCACGCCGTTGATCATTCAATATCTAGGGGCGTCACCACATGTCTATCAAGCCGTTTCAATGCTCAGAAAA
AGAGCATGCCGGATAAACCT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MAQPEIYHDLPLEDVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHAEGNTYDKNFRKAAKTVGNVIGNYHPHG
DSSVYEAMVRMSQDWKVRNVLIEMHGNNGSIDGDPPAAMRYTEARLAAIASELLRDIDKETVEFVPNFDDTSKEPVVLPA
MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIDSPNCSVDDLMEFVKGPDFPTGGIIQGKEGIKKAYETGKGKII
IRGKAEIETIRGGRQQIVITEIPFEVNKANLVKKMDEFRIERKVEGISEVRDETDRTGLRIVIELKKEADAQGILNFLYK
NTDLQIPYNFNMVAIHNRRPMLMNLTSILDAYIGHQKEVITNRSQYELKKAKERHHIVEGLMKALSILDEVIATIRSSND
KRDAKNNLIEKFAFTEPQAEAIVSLQLYRLTNTDITALQEEAKELDQKIKELEEILSNDKKLLKVIKDSLKKVKKTYASQ
RRSVIEEKIEEIKINLEVMVASEDVYVTVTKDGYIKRTSQRSFAASNGQDFGMKDTDRLLCQLEMNTTDVLLLFTNKGSY
VYCPVHQLPDIRWKDLGQHITNIISIDSDESIVKAIPVREFTESEYLLFFTKNGMAKRTQLMQYKAQRYSKALVALNLKG
DDEVVDVHVTDGTKDLFIATHSGYGLWFTEDEVSVVGARAAGVKGVNLKDGDFVASGQVLEEKDVLVLVTQRGSIKRMNR
SEFEKTSRAKRGVLMLRELKKKPHRIAGLLACSYHDQITLQTEKGITEEMLVKEIKLHDRYSNGSFIIDEDEAGEVTDVW
ISKHELE

Sequences:

>Translated_807_residues
MAQPEIYHDLPLEDVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHAEGNTYDKNFRKAAKTVGNVIGNYHPHG
DSSVYEAMVRMSQDWKVRNVLIEMHGNNGSIDGDPPAAMRYTEARLAAIASELLRDIDKETVEFVPNFDDTSKEPVVLPA
MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIDSPNCSVDDLMEFVKGPDFPTGGIIQGKEGIKKAYETGKGKII
IRGKAEIETIRGGRQQIVITEIPFEVNKANLVKKMDEFRIERKVEGISEVRDETDRTGLRIVIELKKEADAQGILNFLYK
NTDLQIPYNFNMVAIHNRRPMLMNLTSILDAYIGHQKEVITNRSQYELKKAKERHHIVEGLMKALSILDEVIATIRSSND
KRDAKNNLIEKFAFTEPQAEAIVSLQLYRLTNTDITALQEEAKELDQKIKELEEILSNDKKLLKVIKDSLKKVKKTYASQ
RRSVIEEKIEEIKINLEVMVASEDVYVTVTKDGYIKRTSQRSFAASNGQDFGMKDTDRLLCQLEMNTTDVLLLFTNKGSY
VYCPVHQLPDIRWKDLGQHITNIISIDSDESIVKAIPVREFTESEYLLFFTKNGMAKRTQLMQYKAQRYSKALVALNLKG
DDEVVDVHVTDGTKDLFIATHSGYGLWFTEDEVSVVGARAAGVKGVNLKDGDFVASGQVLEEKDVLVLVTQRGSIKRMNR
SEFEKTSRAKRGVLMLRELKKKPHRIAGLLACSYHDQITLQTEKGITEEMLVKEIKLHDRYSNGSFIIDEDEAGEVTDVW
ISKHELE
>Mature_806_residues
AQPEIYHDLPLEDVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHAEGNTYDKNFRKAAKTVGNVIGNYHPHGD
SSVYEAMVRMSQDWKVRNVLIEMHGNNGSIDGDPPAAMRYTEARLAAIASELLRDIDKETVEFVPNFDDTSKEPVVLPAM
FPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIDSPNCSVDDLMEFVKGPDFPTGGIIQGKEGIKKAYETGKGKIII
RGKAEIETIRGGRQQIVITEIPFEVNKANLVKKMDEFRIERKVEGISEVRDETDRTGLRIVIELKKEADAQGILNFLYKN
TDLQIPYNFNMVAIHNRRPMLMNLTSILDAYIGHQKEVITNRSQYELKKAKERHHIVEGLMKALSILDEVIATIRSSNDK
RDAKNNLIEKFAFTEPQAEAIVSLQLYRLTNTDITALQEEAKELDQKIKELEEILSNDKKLLKVIKDSLKKVKKTYASQR
RSVIEEKIEEIKINLEVMVASEDVYVTVTKDGYIKRTSQRSFAASNGQDFGMKDTDRLLCQLEMNTTDVLLLFTNKGSYV
YCPVHQLPDIRWKDLGQHITNIISIDSDESIVKAIPVREFTESEYLLFFTKNGMAKRTQLMQYKAQRYSKALVALNLKGD
DEVVDVHVTDGTKDLFIATHSGYGLWFTEDEVSVVGARAAGVKGVNLKDGDFVASGQVLEEKDVLVLVTQRGSIKRMNRS
EFEKTSRAKRGVLMLRELKKKPHRIAGLLACSYHDQITLQTEKGITEEMLVKEIKLHDRYSNGSFIIDEDEAGEVTDVWI
SKHELE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm. Note=Bipolarly localized [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=354, Percent_Identity=24.0112994350282, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI19913406, Length=182, Percent_Identity=28.021978021978, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI1788562, Length=806, Percent_Identity=39.7022332506204, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI1789396, Length=743, Percent_Identity=32.8398384925976, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17535065, Length=175, Percent_Identity=30.8571428571429, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI212645845, Length=495, Percent_Identity=23.4343434343434, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI212645657, Length=174, Percent_Identity=30.4597701149425, Blast_Score=66, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=191, Percent_Identity=25.6544502617801, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 91357; Mature: 91226

Theoretical pI: Translated: 6.49; Mature: 6.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQPEIYHDLPLEDVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHAEGNTYDK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHEEEECCCCCCHH
NFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLIEMHGNNGSIDGDPPAAMR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHHHH
YTEARLAAIASELLRDIDKETVEFVPNFDDTSKEPVVLPAMFPNLLVNGSTGISAGYATD
HHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCEEEHHHCCHHEECCCCCCCCCCCCC
IPPHHLGEVIDAVIKRIDSPNCSVDDLMEFVKGPDFPTGGIIQGKEGIKKAYETGKGKII
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHHCCCCEEE
IRGKAEIETIRGGRQQIVITEIPFEVNKANLVKKMDEFRIERKVEGISEVRDETDRTGLR
EECCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IVIELKKEADAQGILNFLYKNTDLQIPYNFNMVAIHNRRPMLMNLTSILDAYIGHQKEVI
EEEEECCCCCHHHHHHHHHCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCHHHH
TNRSQYELKKAKERHHIVEGLMKALSILDEVIATIRSSNDKRDAKNNLIEKFAFTEPQAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHH
AIVSLQLYRLTNTDITALQEEAKELDQKIKELEEILSNDKKLLKVIKDSLKKVKKTYASQ
HEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RRSVIEEKIEEIKINLEVMVASEDVYVTVTKDGYIKRTSQRSFAASNGQDFGMKDTDRLL
HHHHHHHHHHHHEEEEEEEEECCCEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCEEE
CQLEMNTTDVLLLFTNKGSYVYCPVHQLPDIRWKDLGQHITNIISIDSDESIVKAIPVRE
EEEECCCCEEEEEEECCCCEEEEEHHHCCCCCHHHHHHHHHHHEECCCCCHHHHHCCCHH
FTESEYLLFFTKNGMAKRTQLMQYKAQRYSKALVALNLKGDDEVVDVHVTDGTKDLFIAT
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCCEEEEEE
HSGYGLWFTEDEVSVVGARAAGVKGVNLKDGDFVASGQVLEEKDVLVLVTQRGSIKRMNR
ECCCEEEEECCCCEEEEEHHCCCCCCCCCCCCEEECCCEECCCCEEEEEECCCCCHHCCH
SEFEKTSRAKRGVLMLRELKKKPHRIAGLLACSYHDQITLQTEKGITEEMLVKEIKLHDR
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHEEEECCCEEEEECCCCCHHHHHHHHHHHHCC
YSNGSFIIDEDEAGEVTDVWISKHELE
CCCCCEEEECCCCCCEEEEEEECCCCC
>Mature Secondary Structure 
AQPEIYHDLPLEDVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHAEGNTYDK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHEEEECCCCCCHH
NFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLIEMHGNNGSIDGDPPAAMR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHHHH
YTEARLAAIASELLRDIDKETVEFVPNFDDTSKEPVVLPAMFPNLLVNGSTGISAGYATD
HHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCEEEHHHCCHHEECCCCCCCCCCCCC
IPPHHLGEVIDAVIKRIDSPNCSVDDLMEFVKGPDFPTGGIIQGKEGIKKAYETGKGKII
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHHCCCCEEE
IRGKAEIETIRGGRQQIVITEIPFEVNKANLVKKMDEFRIERKVEGISEVRDETDRTGLR
EECCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IVIELKKEADAQGILNFLYKNTDLQIPYNFNMVAIHNRRPMLMNLTSILDAYIGHQKEVI
EEEEECCCCCHHHHHHHHHCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCHHHH
TNRSQYELKKAKERHHIVEGLMKALSILDEVIATIRSSNDKRDAKNNLIEKFAFTEPQAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHH
AIVSLQLYRLTNTDITALQEEAKELDQKIKELEEILSNDKKLLKVIKDSLKKVKKTYASQ
HEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RRSVIEEKIEEIKINLEVMVASEDVYVTVTKDGYIKRTSQRSFAASNGQDFGMKDTDRLL
HHHHHHHHHHHHEEEEEEEEECCCEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCEEE
CQLEMNTTDVLLLFTNKGSYVYCPVHQLPDIRWKDLGQHITNIISIDSDESIVKAIPVRE
EEEECCCCEEEEEEECCCCEEEEEHHHCCCCCHHHHHHHHHHHEECCCCCHHHHHCCCHH
FTESEYLLFFTKNGMAKRTQLMQYKAQRYSKALVALNLKGDDEVVDVHVTDGTKDLFIAT
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCCEEEEEE
HSGYGLWFTEDEVSVVGARAAGVKGVNLKDGDFVASGQVLEEKDVLVLVTQRGSIKRMNR
ECCCEEEEECCCCEEEEEHHCCCCCCCCCCCCEEECCCEECCCCEEEEEECCCCCHHCCH
SEFEKTSRAKRGVLMLRELKKKPHRIAGLLACSYHDQITLQTEKGITEEMLVKEIKLHDR
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHEEEECCCEEEEECCCCCHHHHHHHHHHHHCC
YSNGSFIIDEDEAGEVTDVWISKHELE
CCCCCEEEECCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]