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The map label for this gene is parE [H]

Identifier: 52785813

GI number: 52785813

Start: 1994881

End: 1996848

Strand: Direct

Name: parE [H]

Synonym: BLi02059

Alternate gene names: 52785813

Gene position: 1994881-1996848 (Clockwise)

Preceding gene: 52785812

Following gene: 52785814

Centisome position: 47.24

GC content: 47.97

Gene sequence:

>1968_bases
TTGGTTAAAAAACAGCAAGTTGACTATAATGATGATTCCATACAGGTGCTCGAAGGCCTTGAAGCGGTCAGAAAACGCCC
CGGTATGTACATCGGTTCGACAGACAGCCGGGGACTGCACCATCTCGTATATGAAATCGTCGATAATTCCGTCGATGAAG
TCCTTGCGGGCCATGGGGATCACATTATAGTAAAAATACATAAAGATAACAGCATATCGGTGCAAGACAGAGGCCGGGGA
ATGCCAACAGGAATGCATAAGCTCGGCAAGCCGACTCCAGAAATTATTTTGACAGTGCTGCATGCCGGAGGAAAGTTCGG
CCAAGGCGGCTATAAAACGAGCGGGGGGCTGCACGGCGTCGGTGCATCCGTTGTAAACGCCCTGTCCGAGTGGCTGACAG
TCACGATTGAGCGGGACGGAAATGTTTACAGGCAGCGTTTTGAAAACGGCGGCAAACCGGTGACATCCCTTGATAAAATC
GGAACGACCAAAAAGACCGGCACCCTGATTCATTTCAAGCCTGATCCTGCGATGTTCAGCACGACGACGTTTAACTTTGA
AACGCTTTCAGAGCGTCTGAGAGAATCAGCCTTTTTGTTAAAAGGACTAAAAATAGAATTGATCGATGAACGCGATCAAA
CAAAAGAAACGTTTTTATACGAAAACGGAATCGAAGCTTTTGTCGCTTATTTAAATGAGGAGAAAGACGCGCTTTCTGAA
GTGGTCTCATTTGAAGGAGAGCACAACGGCATCGAGGTTGACTTCGCGTTTCAGTTTAATGACGGCTATTCCGAAAACAT
CCTGTCGTTCGTCAATAATGTCAGAACGAAAGATGGAGGAACCCATGAGTCCGGTGCCAAAACGGCGATGACGAGAGCAT
TCAACGAGTATGCGAGAAAGGTGGCCCTTTTAAAAGAAAAGGACAAAAACCTTGAAGGAACGGATATCAGGGAAGGCCTG
TCAGCCATCGTTTCCGTCCGGATTCCCGAAGAGCTTCTTCAATTTGAAGGACAGACAAAAGGAAAGCTCGGCACAAGTGA
AGCACGGTCAGCCGTTGATGCAATCGTCTCTGAGCAGCTCGCCTATTTTCTTGAAGAAAACAGGGAAACGGCAACATTGC
TTGTCAAAAAAGCGATTAAAGCCTCCCAGGCGAGAGAGGCTGCGAGAAAAGCAAGAGAAGAGGCAAGAAGCGGAAAGAAA
AGAAAGAAATCCGAAGCGACGCTCTCCGGGAAGCTGACGCCTGCACAATCAAGGAATCCATCCAAGAACGAATTGTATCT
CGTGGAGGGTGATTCTGCGGGAGGATCAGCAAAGCAGGGACGAGACCGGAAATTCCAGGCTGTCCTGCCGCTCCGCGGAA
AAGTTATCAATACGGAAAAAGCGAAGCTGGCCGATATTTTTAAAAATGAAGAGATCAATACGATCATTCACGCGATCGGC
GGAGGGGTCGGCGCCGATTTTGACATTGAGGACATCAATTACGACAAAGTCATTATCATGACAGATGCGGATACAGACGG
CGCGCATATCCAAGTGCTGCTCCTGACTTTTTTCTACCGCTATATGAAGCCGCTGATCGAGCACGGAAAAGTGTTTATCG
CACTGCCGCCGCTCTATAAAGTGAGCAAAGGGTCGGGCAAAAAAGAAATCATTGAATATGCCTGGTCTGATGAGGAAATG
GACGACGTCCTCAAAAAAGTCGGAAAAGGATATACGATCCAGCGCTATAAAGGTCTCGGCGAAATGAACGCTGACCAGCT
TTGGGAAACGACAATGAACCCCGAGTCAAGAACACTTGTCAGGGTTAAAATCGATGACGCGGCCCGGGTGGAACGGCGCG
TAACGACATTGATGGGCGACAAAGTTGAGCCGAGGAGAAAATGGATTGAGAAAAACGTCGCTTTCGGACTTGATGAAGAA
AGCAACATTTTGGAAAACGAGAATTTATCGGTCGCTGAGGAGGTTTAA

Upstream 100 bases:

>100_bases
GAAGAAATTGGAAAATAATCGGATAATACTTTGCTTTATATGACAGAGTGTGTATTATTCTTTATAAGCAATGTTTGATT
TTTGAAAGGGGTTTATGCAT

Downstream 100 bases:

>100_bases
ATAAATGGCACAGCCAGAGATTTATCATGATTTACCATTGGAAGACGTGATCGGCGACCGTTTCGGCCGATACAGCAAAT
ATATTATTCAGGACCGGGCG

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 655; Mature: 655

Protein sequence:

>655_residues
MVKKQQVDYNDDSIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRG
MPTGMHKLGKPTPEIILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGNVYRQRFENGGKPVTSLDKI
GTTKKTGTLIHFKPDPAMFSTTTFNFETLSERLRESAFLLKGLKIELIDERDQTKETFLYENGIEAFVAYLNEEKDALSE
VVSFEGEHNGIEVDFAFQFNDGYSENILSFVNNVRTKDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGL
SAIVSVRIPEELLQFEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRETATLLVKKAIKASQAREAARKAREEARSGKK
RKKSEATLSGKLTPAQSRNPSKNELYLVEGDSAGGSAKQGRDRKFQAVLPLRGKVINTEKAKLADIFKNEEINTIIHAIG
GGVGADFDIEDINYDKVIIMTDADTDGAHIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEM
DDVLKKVGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEPRRKWIEKNVAFGLDEE
SNILENENLSVAEEV

Sequences:

>Translated_655_residues
MVKKQQVDYNDDSIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRG
MPTGMHKLGKPTPEIILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGNVYRQRFENGGKPVTSLDKI
GTTKKTGTLIHFKPDPAMFSTTTFNFETLSERLRESAFLLKGLKIELIDERDQTKETFLYENGIEAFVAYLNEEKDALSE
VVSFEGEHNGIEVDFAFQFNDGYSENILSFVNNVRTKDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGL
SAIVSVRIPEELLQFEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRETATLLVKKAIKASQAREAARKAREEARSGKK
RKKSEATLSGKLTPAQSRNPSKNELYLVEGDSAGGSAKQGRDRKFQAVLPLRGKVINTEKAKLADIFKNEEINTIIHAIG
GGVGADFDIEDINYDKVIIMTDADTDGAHIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEM
DDVLKKVGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEPRRKWIEKNVAFGLDEE
SNILENENLSVAEEV
>Mature_655_residues
MVKKQQVDYNDDSIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRG
MPTGMHKLGKPTPEIILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGNVYRQRFENGGKPVTSLDKI
GTTKKTGTLIHFKPDPAMFSTTTFNFETLSERLRESAFLLKGLKIELIDERDQTKETFLYENGIEAFVAYLNEEKDALSE
VVSFEGEHNGIEVDFAFQFNDGYSENILSFVNNVRTKDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGL
SAIVSVRIPEELLQFEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRETATLLVKKAIKASQAREAARKAREEARSGKK
RKKSEATLSGKLTPAQSRNPSKNELYLVEGDSAGGSAKQGRDRKFQAVLPLRGKVINTEKAKLADIFKNEEINTIIHAIG
GGVGADFDIEDINYDKVIIMTDADTDGAHIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEM
DDVLKKVGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEPRRKWIEKNVAFGLDEE
SNILENENLSVAEEV

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=621, Percent_Identity=26.2479871175523, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI19913408, Length=666, Percent_Identity=24.7747747747748, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI48994957, Length=558, Percent_Identity=52.3297491039427, Blast_Score=526, Evalue=1e-150,
Organism=Escherichia coli, GI1789408, Length=637, Percent_Identity=40.0313971742543, Blast_Score=429, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17535065, Length=669, Percent_Identity=24.813153961136, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI212645845, Length=605, Percent_Identity=25.7851239669421, Blast_Score=112, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI212645657, Length=232, Percent_Identity=29.7413793103448, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=643, Percent_Identity=26.1275272161742, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17136538, Length=669, Percent_Identity=26.457399103139, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72886; Mature: 72886

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKKQQVDYNDDSIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEVLAGHGD
CCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHCCCC
HIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEIILTVLHAGGKFGQGGYKTSGGLHGV
EEEEEEECCCCEEEHHCCCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCH
GASVVNALSEWLTVTIERDGNVYRQRFENGGKPVTSLDKIGTTKKTGTLIHFKPDPAMFS
HHHHHHHHHHHEEEEEECCCHHHHHHHHCCCCCCCHHHHCCCCCCCCEEEEECCCCCEEE
TTTFNFETLSERLRESAFLLKGLKIELIDERDQTKETFLYENGIEAFVAYLNEEKDALSE
EEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHCCHHHHHHH
VVSFEGEHNGIEVDFAFQFNDGYSENILSFVNNVRTKDGGTHESGAKTAMTRAFNEYARK
HHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
VALLKEKDKNLEGTDIREGLSAIVSVRIPEELLQFEGQTKGKLGTSEARSAVDAIVSEQL
HHHHHHHCCCCCCCHHHHHHHHHEEECCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
AYFLEENRETATLLVKKAIKASQAREAARKAREEARSGKKRKKSEATLSGKLTPAQSRNP
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCC
SKNELYLVEGDSAGGSAKQGRDRKFQAVLPLRGKVINTEKAKLADIFKNEEINTIIHAIG
CCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECCCHHHHHHHHCCCHHHHHHHHHC
GGVGADFDIEDINYDKVIIMTDADTDGAHIQVLLLTFFYRYMKPLIEHGKVFIALPPLYK
CCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEE
VSKGSGKKEIIEYAWSDEEMDDVLKKVGKGYTIQRYKGLGEMNADQLWETTMNPESRTLV
ECCCCCHHHHHHHHCCCCHHHHHHHHHCCCCEEHHHCCCCCCCHHHHHHHCCCCCCCEEE
RVKIDDAARVERRVTTLMGDKVEPRRKWIEKNVAFGLDEESNILENENLSVAEEV
EEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure
MVKKQQVDYNDDSIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEVLAGHGD
CCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHCCCC
HIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEIILTVLHAGGKFGQGGYKTSGGLHGV
EEEEEEECCCCEEEHHCCCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCH
GASVVNALSEWLTVTIERDGNVYRQRFENGGKPVTSLDKIGTTKKTGTLIHFKPDPAMFS
HHHHHHHHHHHEEEEEECCCHHHHHHHHCCCCCCCHHHHCCCCCCCCEEEEECCCCCEEE
TTTFNFETLSERLRESAFLLKGLKIELIDERDQTKETFLYENGIEAFVAYLNEEKDALSE
EEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHCCHHHHHHH
VVSFEGEHNGIEVDFAFQFNDGYSENILSFVNNVRTKDGGTHESGAKTAMTRAFNEYARK
HHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
VALLKEKDKNLEGTDIREGLSAIVSVRIPEELLQFEGQTKGKLGTSEARSAVDAIVSEQL
HHHHHHHCCCCCCCHHHHHHHHHEEECCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
AYFLEENRETATLLVKKAIKASQAREAARKAREEARSGKKRKKSEATLSGKLTPAQSRNP
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCC
SKNELYLVEGDSAGGSAKQGRDRKFQAVLPLRGKVINTEKAKLADIFKNEEINTIIHAIG
CCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECCCHHHHHHHHCCCHHHHHHHHHC
GGVGADFDIEDINYDKVIIMTDADTDGAHIQVLLLTFFYRYMKPLIEHGKVFIALPPLYK
CCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEE
VSKGSGKKEIIEYAWSDEEMDDVLKKVGKGYTIQRYKGLGEMNADQLWETTMNPESRTLV
ECCCCCHHHHHHHHCCCCHHHHHHHHHCCCCEEHHHCCCCCCCHHHHHHHCCCCCCCEEE
RVKIDDAARVERRVTTLMGDKVEPRRKWIEKNVAFGLDEESNILENENLSVAEEV
EEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]