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The map label for this gene is pccB [H]

Identifier: 52142949

GI number: 52142949

Start: 2427473

End: 2429014

Strand: Direct

Name: pccB [H]

Synonym: BCZK2291

Alternate gene names: 52142949

Gene position: 2427473-2429014 (Clockwise)

Preceding gene: 52142950

Following gene: 52142948

Centisome position: 45.79

GC content: 38.0

Gene sequence:

>1542_bases
ATGATAGATCAAAAAGAACAATCGAATACATTTGAAGAACGAGTTGAAACGATTAAACAAGGCGGCGCACCAAAATATCA
TGATCAAAACAAAGCGAAAGGTAAACTATTCGTTCGAGATCGCTTAGCTCTTTTATTTGATAATGGTGAATATGTAGAAG
ATGCATTATTTGCAAATTGTGAACAAACAGGATTACCTGCAGATGGTGTTATAACGGCAACGGGAAAAATACATGGTCGT
ACTGCATGCGTAATGGCAAATGATTCTACGGTAAAGGCTGGATCATGGGGCGCGCGTACAGTTGAAAAGATTTTACGTAT
TCAAGAAACAGCAGAAAAATTACGTGTTCCGTTATTTTATTTAGTTGACTCTGCTGGGGCGCGTATTACGGATCAAGTTG
AAATGTTCCCAGGGCGCCGCGGTGCAGGAAGAATCTTCTATAATCAAGTGAAATTATCAGGTAAAGTCCCGCAAGTATGC
TTATTATTTGGACCTTCTGCAGCTGGTGGTGCATATATTCCAGCCTTTTGTGACGTTGTTATGATGGTAGAAGGAAATGC
TTCTATGTATTTAGGATCTCCTCGTATGGCTGAGATGGTTATCGGTGAGAAGGTAACTTTAGAAGAAATGGGCGGAGCTC
GTATGCATTGCTCTGTATCAGGATGCGGAGATGTTTTATGTAAAACAGAAGAAGATGCAATTACACAAGCAAGACAATAC
ATTTCATATTTTCCAAACAACTACTTAGAAAAGACTCCATTGGTTACACCTCAAGAACCGAAACAATTCGATAAAACGTT
AGAACAAATCATTCCAGAAAATCAAAATGCTCCTTTCAATATGAAAGATCTTATTAATAGAGTTATTGATGAAGGTTCTT
TCTATGAAGTGAAAAAATTATTTGCTCAAGAACTCATTACAGGTTTAGCACGTATTGATGGTAAGCCAGTAGGTATTATT
GCAAATCAACCGCGAATGAAAGGCGGCGTATTATTCCACGATTCAGCTGATAAAGCAGCGAAGTTTATAAATTTATGCGA
TGCATATCATATTCCGTTATTATTCCTTGCAGATGTACCTGGATTTATGATTGGTACAAAAGTAGAACGTGCTGGTATTA
TTCGTCACGGTGCAAAAATGATTTCCGCAATGAGCGAAGCAACTGTACCGAAAATTTCTATCGTTGTTCGTAAAGCATAT
GGTGCTGGTTTATATGCGATGGCAGGTCCAGCCTTTGAACCAGATTGTTGTCTTGCATTACCGACAGCTTCTATTGCGGT
AATGGGTCCAGAAGCAGCGGTTAATGCTGTATATGCAAATAAGATTGCAGCTTTACCTGAAGAAGAGCGTGATAGCTTCA
TTGCTGAAAAACGCGAAGAGTATAAGAAAGATATTGATATTTACCATTTAGCATCAGAGATGGTCATTGATGGTATTGTT
CATCCAAACAATTTAAGAGAAGAGTTAAAAGGACGATTCGAAATGTATATGAGTAAATATCAAGTATTTACGGATCGTAA
ACATCCTGTTTATCCAGTTTAA

Upstream 100 bases:

>100_bases
AAAAACAAGCGTATGAAGGTGTAATCCATACGAAAGATAGAATAGAAGGATTACAAGCATTCAAGGAAAAACGCACACCA
ATGTATAAGGGGGAGTAAAT

Downstream 100 bases:

>100_bases
AAGCCCTATTTAGGGCTTTCTTGCTCAAAAAGTTAAGGAGGGGAAAACATTGAAACAAGCAGTTTGGTTTCCAACAGAAG
AGTATAAAGAAAAAACACGT

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MIDQKEQSNTFEERVETIKQGGAPKYHDQNKAKGKLFVRDRLALLFDNGEYVEDALFANCEQTGLPADGVITATGKIHGR
TACVMANDSTVKAGSWGARTVEKILRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVC
LLFGPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGCGDVLCKTEEDAITQARQY
ISYFPNNYLEKTPLVTPQEPKQFDKTLEQIIPENQNAPFNMKDLINRVIDEGSFYEVKKLFAQELITGLARIDGKPVGII
ANQPRMKGGVLFHDSADKAAKFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKAY
GAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERDSFIAEKREEYKKDIDIYHLASEMVIDGIV
HPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV

Sequences:

>Translated_513_residues
MIDQKEQSNTFEERVETIKQGGAPKYHDQNKAKGKLFVRDRLALLFDNGEYVEDALFANCEQTGLPADGVITATGKIHGR
TACVMANDSTVKAGSWGARTVEKILRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVC
LLFGPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGCGDVLCKTEEDAITQARQY
ISYFPNNYLEKTPLVTPQEPKQFDKTLEQIIPENQNAPFNMKDLINRVIDEGSFYEVKKLFAQELITGLARIDGKPVGII
ANQPRMKGGVLFHDSADKAAKFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKAY
GAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERDSFIAEKREEYKKDIDIYHLASEMVIDGIV
HPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV
>Mature_513_residues
MIDQKEQSNTFEERVETIKQGGAPKYHDQNKAKGKLFVRDRLALLFDNGEYVEDALFANCEQTGLPADGVITATGKIHGR
TACVMANDSTVKAGSWGARTVEKILRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVC
LLFGPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGCGDVLCKTEEDAITQARQY
ISYFPNNYLEKTPLVTPQEPKQFDKTLEQIIPENQNAPFNMKDLINRVIDEGSFYEVKKLFAQELITGLARIDGKPVGII
ANQPRMKGGVLFHDSADKAAKFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKAY
GAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERDSFIAEKREEYKKDIDIYHLASEMVIDGIV
HPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=522, Percent_Identity=34.2911877394636, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI295821216, Length=542, Percent_Identity=33.210332103321, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI11545863, Length=497, Percent_Identity=36.4185110663984, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI134142062, Length=342, Percent_Identity=23.3918128654971, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI310133460, Length=120, Percent_Identity=39.1666666666667, Blast_Score=66, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI25147362, Length=516, Percent_Identity=34.4961240310078, Blast_Score=314, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI25147359, Length=516, Percent_Identity=34.4961240310078, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17552936, Length=501, Percent_Identity=34.3313373253493, Blast_Score=308, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24586065, Length=505, Percent_Identity=35.4455445544554, Blast_Score=310, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 56607; Mature: 56607

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDQKEQSNTFEERVETIKQGGAPKYHDQNKAKGKLFVRDRLALLFDNGEYVEDALFANC
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHCC
EQTGLPADGVITATGKIHGRTACVMANDSTVKAGSWGARTVEKILRIQETAEKLRVPLFY
HHCCCCCCCEEEECCEECCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEE
LVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVCLLFGPSAAGGAYIPAFCDVV
EEECCCCCCCHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCHHHHCCEE
MMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGCGDVLCKTEEDAITQARQY
EEEECCCEEEECCCHHHHHHHCCEEEHHHCCCCEEEEECCCCCCCEECCCHHHHHHHHHH
ISYFPNNYLEKTPLVTPQEPKQFDKTLEQIIPENQNAPFNMKDLINRVIDEGSFYEVKKL
HHHCCCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
FAQELITGLARIDGKPVGIIANQPRMKGGVLFHDSADKAAKFINLCDAYHIPLLFLADVP
HHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCEECCCC
GFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKAYGAGLYAMAGPAFEPDCCLAL
CHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCEEEECCCCCCCCCEEEE
PTASIAVMGPEAAVNAVYANKIAALPEEERDSFIAEKREEYKKDIDIYHLASEMVIDGIV
CCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
HPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIDQKEQSNTFEERVETIKQGGAPKYHDQNKAKGKLFVRDRLALLFDNGEYVEDALFANC
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHCC
EQTGLPADGVITATGKIHGRTACVMANDSTVKAGSWGARTVEKILRIQETAEKLRVPLFY
HHCCCCCCCEEEECCEECCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEE
LVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVCLLFGPSAAGGAYIPAFCDVV
EEECCCCCCCHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCHHHHCCEE
MMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGCGDVLCKTEEDAITQARQY
EEEECCCEEEECCCHHHHHHHCCEEEHHHCCCCEEEEECCCCCCCEECCCHHHHHHHHHH
ISYFPNNYLEKTPLVTPQEPKQFDKTLEQIIPENQNAPFNMKDLINRVIDEGSFYEVKKL
HHHCCCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
FAQELITGLARIDGKPVGIIANQPRMKGGVLFHDSADKAAKFINLCDAYHIPLLFLADVP
HHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCEECCCC
GFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKAYGAGLYAMAGPAFEPDCCLAL
CHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCEEEECCCCCCCCCEEEE
PTASIAVMGPEAAVNAVYANKIAALPEEERDSFIAEKREEYKKDIDIYHLASEMVIDGIV
CCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
HPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]