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The map label for this gene is acs [H]

Identifier: 52142948

GI number: 52142948

Start: 2429064

End: 2431004

Strand: Direct

Name: acs [H]

Synonym: BCZK2292

Alternate gene names: 52142948

Gene position: 2429064-2431004 (Clockwise)

Preceding gene: 52142949

Following gene: 52142946

Centisome position: 45.82

GC content: 38.79

Gene sequence:

>1941_bases
TTGAAACAAGCAGTTTGGTTTCCAACAGAAGAGTATAAAGAAAAAACACGTTTATATGGTTGGATGAAATCATTGGGGTA
TGAGGATTATGAAACGTTTTATAATAAATCTATTGAAGAAACAGCTTGGTTTTGGGGAGAAGCTGAGAAAGCGGTTGGCT
ATCAATGGATGAAACCTTATACAGAAGTGTTAGACTTGCAAAATGGTACGCCGTTTGCACAGTGGTATAATGGCGGAACA
TGTAACGTTGTAGAATCAGTGTTATCGCGCTGGCTTGCAGATGATGAAACAAGAACGCAACCAGCACTTCAGTATGAAGG
AGAAAATGGAACTTCAAAATCATTTACATATGAAGAACTTGATAGCTGGGTAAGTCGCGTTGCAAATGGTTTGAAACATG
CGGGTATTGAAAAAGGCGACCGAGTAACAATTTATATGCCAATGATTCCAGAAACAGTTGTTGCGATGCTAGCTGTAATG
AAAATCGGAGCAATTATTTCACCAATATTCTCAGGATTTGCGTCTGATGCAGTCATGACACGCGTGCAAGCAGCAGGATC
AAAGATGATCATTACTGCAGATGGTTTTTCACGCCGAGGTAAGATTGTTTCATTAAAAGATGAAGTAGATAAAGCTTGTG
AGCATTGTCCAACTGTTGAAAAAGTCGTTATCGTGCGCCACGCAGGAAATGATTTTACACCGCATGATTATGATTTCTCA
TGGAGTACGTTAGAAAAAGAAAAGCCATTTGTACATGCTGAAGAAATGCATAGTGACGATCCATTAATGCTCATTTATAC
ATCAGGTACAACTGGAAAACCGAAAGGGACCGTACACACTCATGCTGGTTTCCCTTTGAAAGCAGCATTTGATGCAGGGT
TTGGGATGAATATAAAACAAGGCGACCGTGTATTATGGGTAACTGATATGGGCTGGATGATGGGACCATTTTTACTATTT
GGTTCTCTCATTAATGGGGCAACGATGGTTATGTATGAAGGTGTTCCAGACTTCCCAGAAGCAGATCGTTTATGGGAGAC
AGTTGATAAATATGAAATTACACATCTCGGTATATCACCAACATTAATTCGTGCGTTAATGGCAAAAGGTGATGAGTATG
TAAATAAACATTCGCTTAAGAGTTTAGAAGTATTTGCCTCAACAGGCGAGCCTTGGAATCCAGATCCTTGGATGTGGCTA
TTTGAAACGGTTGGAAAAAGTAATGTGCCAATTTGTAACTATTCAGGCGGAACTGAAATTTCAGGTGGGATTTTCGGGAA
CGTCCTTATTAAACCAATTGCACCGATTAGCTTTAATGCTTCTTTACCAGGAATGGCAGCGGTTGTGCTCGATGATCAAG
GTAATCCAATTCGCGATGAAGTTGGAGAATTATGTTTAGAGAAACCTTGGGTTGGTATGACGAAAAGTTTCTGGGAAGAC
GATGAGCGTTATGTGAACACATATTGGTCACGTTTTGAAAATAAATGGGTTCATGGTGACTGGGTGGTTTATGATGGTGA
GCAATATATTATTACAGGACGCTCAGATGATACGCTAAACATCGCTGGAAAACGCATTGGACCTGCTGAATATGAATCTA
TTCTTGTGAAGCATAATGATGTCATAGAAGCTGCCGCGATTGGTGTACCAGATGATGTAAAAGGTGAAGTTTGTCATTGT
TTTGTAGTATTAAGAGATAATGTAACATTTACAGGAGAATTAAAGAAAGAATTAATGAGTTTAGTAAACTCTCATATTGG
AAAAGCATTATGTCCAAAAGATATTCACGTTGTAGAAGATTTACCGAAAACGCGTAATTCTAAAGTAATGCGACGTGTCA
TTAAAGCTGCTTATTTAGGGAAAGAATTAGGTGATTTATCATCACTTGTAAACCCTGAAGTAGTTTCGTTTATTCAAGGA
TTGCAGTCTAGCAAACTATAA

Upstream 100 bases:

>100_bases
AGTAAATATCAAGTATTTACGGATCGTAAACATCCTGTTTATCCAGTTTAAAAGCCCTATTTAGGGCTTTCTTGCTCAAA
AAGTTAAGGAGGGGAAAACA

Downstream 100 bases:

>100_bases
AACTAGGAATGAGCTCTATTTAATTAGAGCTCATTTTTTGTATTAAATAATTATAGGAGAAAAATAGAAGTTGAAAACAA
GAAGGGAGAAAGTATTGAGG

Product: acetate--CoA ligase (acetyl-CoA synthase)

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFWGEAEKAVGYQWMKPYTEVLDLQNGTPFAQWYNGGT
CNVVESVLSRWLADDETRTQPALQYEGENGTSKSFTYEELDSWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVM
KIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHDYDFS
WSTLEKEKPFVHAEEMHSDDPLMLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLF
GSLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMWL
FETVGKSNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGNPIRDEVGELCLEKPWVGMTKSFWED
DERYVNTYWSRFENKWVHGDWVVYDGEQYIITGRSDDTLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDDVKGEVCHC
FVVLRDNVTFTGELKKELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVVSFIQG
LQSSKL

Sequences:

>Translated_646_residues
MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFWGEAEKAVGYQWMKPYTEVLDLQNGTPFAQWYNGGT
CNVVESVLSRWLADDETRTQPALQYEGENGTSKSFTYEELDSWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVM
KIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHDYDFS
WSTLEKEKPFVHAEEMHSDDPLMLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLF
GSLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMWL
FETVGKSNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGNPIRDEVGELCLEKPWVGMTKSFWED
DERYVNTYWSRFENKWVHGDWVVYDGEQYIITGRSDDTLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDDVKGEVCHC
FVVLRDNVTFTGELKKELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVVSFIQG
LQSSKL
>Mature_646_residues
MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFWGEAEKAVGYQWMKPYTEVLDLQNGTPFAQWYNGGT
CNVVESVLSRWLADDETRTQPALQYEGENGTSKSFTYEELDSWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVM
KIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHDYDFS
WSTLEKEKPFVHAEEMHSDDPLMLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLF
GSLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMWL
FETVGKSNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGNPIRDEVGELCLEKPWVGMTKSFWED
DERYVNTYWSRFENKWVHGDWVVYDGEQYIITGRSDDTLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDDVKGEVCHC
FVVLRDNVTFTGELKKELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVVSFIQG
LQSSKL

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=651, Percent_Identity=36.8663594470046, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI253970489, Length=664, Percent_Identity=36.2951807228916, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI28416953, Length=628, Percent_Identity=36.7834394904459, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI13375727, Length=628, Percent_Identity=28.0254777070064, Blast_Score=246, Evalue=6e-65,
Organism=Homo sapiens, GI31982927, Length=659, Percent_Identity=27.3141122913505, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI42544132, Length=558, Percent_Identity=26.8817204301075, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI38505220, Length=562, Percent_Identity=27.4021352313167, Blast_Score=177, Evalue=4e-44,
Organism=Homo sapiens, GI122937307, Length=562, Percent_Identity=26.3345195729537, Blast_Score=169, Evalue=9e-42,
Organism=Homo sapiens, GI115511026, Length=559, Percent_Identity=26.4758497316637, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI157311624, Length=550, Percent_Identity=27.2727272727273, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI157311622, Length=550, Percent_Identity=27.2727272727273, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI58082049, Length=556, Percent_Identity=26.7985611510791, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI42544134, Length=366, Percent_Identity=27.3224043715847, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI187761345, Length=431, Percent_Identity=23.4338747099768, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI187761343, Length=431, Percent_Identity=23.4338747099768, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI195947378, Length=467, Percent_Identity=21.4132762312634, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790505, Length=623, Percent_Identity=38.3627608346709, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1786529, Length=631, Percent_Identity=32.9635499207607, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI221142682, Length=530, Percent_Identity=23.2075471698113, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1788107, Length=565, Percent_Identity=24.070796460177, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI145693145, Length=525, Percent_Identity=24.1904761904762, Blast_Score=86, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71983001, Length=657, Percent_Identity=35.0076103500761, Blast_Score=343, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI71982997, Length=657, Percent_Identity=35.0076103500761, Blast_Score=343, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17569507, Length=636, Percent_Identity=26.8867924528302, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17531443, Length=562, Percent_Identity=24.5551601423488, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71994694, Length=477, Percent_Identity=24.9475890985325, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71994703, Length=477, Percent_Identity=24.9475890985325, Blast_Score=100, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71994690, Length=477, Percent_Identity=24.9475890985325, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17538037, Length=545, Percent_Identity=23.302752293578, Blast_Score=99, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6319264, Length=643, Percent_Identity=34.8367029548989, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6323182, Length=664, Percent_Identity=34.3373493975904, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319699, Length=527, Percent_Identity=23.5294117647059, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667955, Length=641, Percent_Identity=36.9734789391576, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI62472339, Length=548, Percent_Identity=39.4160583941606, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24667959, Length=514, Percent_Identity=38.3268482490272, Blast_Score=331, Evalue=7e-91,
Organism=Drosophila melanogaster, GI21355225, Length=607, Percent_Identity=29.8187808896211, Blast_Score=269, Evalue=5e-72,
Organism=Drosophila melanogaster, GI21355181, Length=527, Percent_Identity=25.0474383301708, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI18859661, Length=532, Percent_Identity=23.4962406015038, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648260, Length=378, Percent_Identity=26.4550264550265, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21356947, Length=367, Percent_Identity=25.3405994550409, Blast_Score=76, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24648676, Length=376, Percent_Identity=22.6063829787234, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21356441, Length=534, Percent_Identity=22.8464419475655, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72339; Mature: 72339

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFWGEAEKAVGYQWMKPY
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHCCCHHHHCCCHHHHHH
TEVLDLQNGTPFAQWYNGGTCNVVESVLSRWLADDETRTQPALQYEGENGTSKSFTYEEL
HHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHH
DSWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMT
HHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHDYDFS
HHHHCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCC
WSTLEKEKPFVHAEEMHSDDPLMLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQ
HHHHHCCCCCEEHHHCCCCCCEEEEEECCCCCCCCCCEEECCCCCEEECCCCCCCCCCCC
GDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISP
CCEEEEEECCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHEEEEEECCCH
TLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMWLFETVGKSNVPICNYSGGTEI
HHHHHHHHCCHHHHHHHCCHHEEEEECCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCC
SGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGNPIRDEVGELCLEKPWVGMTKSFWED
CCCEECCCCCCCCCCEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHCC
DERYVNTYWSRFENKWVHGDWVVYDGEQYIITGRSDDTLNIAGKRIGPAEYESILVKHND
HHHHHHHHHHHHCCCEECCCEEEECCCEEEEECCCCCEEEECCCCCCHHHHHHEEEECCC
VIEAAAIGVPDDVKGEVCHCFVVLRDNVTFTGELKKELMSLVNSHIGKALCPKDIHVVED
HHHHHHCCCCCCCCCCEEEEEEEEECCEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
LPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVVSFIQGLQSSKL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFWGEAEKAVGYQWMKPY
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHCCCHHHHCCCHHHHHH
TEVLDLQNGTPFAQWYNGGTCNVVESVLSRWLADDETRTQPALQYEGENGTSKSFTYEEL
HHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHH
DSWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMT
HHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHDYDFS
HHHHCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCC
WSTLEKEKPFVHAEEMHSDDPLMLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQ
HHHHHCCCCCEEHHHCCCCCCEEEEEECCCCCCCCCCEEECCCCCEEECCCCCCCCCCCC
GDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISP
CCEEEEEECCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHEEEEEECCCH
TLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMWLFETVGKSNVPICNYSGGTEI
HHHHHHHHCCHHHHHHHCCHHEEEEECCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCC
SGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGNPIRDEVGELCLEKPWVGMTKSFWED
CCCEECCCCCCCCCCEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHCC
DERYVNTYWSRFENKWVHGDWVVYDGEQYIITGRSDDTLNIAGKRIGPAEYESILVKHND
HHHHHHHHHHHHCCCEECCCEEEECCCEEEEECCCCCEEEECCCCCCHHHHHHEEEECCC
VIEAAAIGVPDDVKGEVCHCFVVLRDNVTFTGELKKELMSLVNSHIGKALCPKDIHVVED
HHHHHHCCCCCCCCCCEEEEEEEEECCEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
LPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVVSFIQGLQSSKL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA