Click here to switch to the map view.

The map label for this gene is ndk [H]

Identifier: 51598719

GI number: 51598719

Start: 487109

End: 487618

Strand: Direct

Name: ndk [H]

Synonym: BG0476

Alternate gene names: 51598719

Gene position: 487109-487618 (Clockwise)

Preceding gene: 51598718

Following gene: 51598720

Centisome position: 53.87

GC content: 32.35

Gene sequence:

>510_bases
ATGTCAATGTTATTGCAAAAAACTTTATGTATTATTAAGCCAGATGGGGTTAGGAGAGGTTTAATTGGCGATGTAGTTGC
TAGGTTTGAACGAGTAGGTTTAAAAATAGTGGCTGCTAAAATGCTTATTATTGACGAGAGTCTAGCAAAAAAACATTATT
TATATGATGATATTGTTCTTAGGCATAGCGAGGCGGTTTGGAAGTCTTTAATTAAATTTATTTCAAATTCTCCCGTTTTT
GCATTTGTTGTTGAAGGAGTTGAAAGTATTGAGGTTGTCAGAAAGCTTTGTGGCGCTACTGAGCCAAAATTAGCCATTCC
TGGAACAATAAGGGGAGATTTTTCTTATCATAGCTTTAGATATTCAAATGAAAAAGGTTTTTCAATTTATAATGTAATTC
ATGCATCTGCAAATGAGGTAGATGCGATTCGTGAAATACCAATTTGGTTTAAAGATAATGAAATTTTAAACTACAAAAGA
GATGATGAATGCGAACATTATTATTGTTGA

Upstream 100 bases:

>100_bases
CGTATAAATTTAATTAATCAGGTATACTGTTAGTATTAAGTAAGTATTTTAATTTATTTAATTATTTTTAAATAAATGTC
CTAAATTTTAGGGGGATTTT

Downstream 100 bases:

>100_bases
TTTTTATAATCTATTTCTTTAAAGGAATAAGTTTTAAATTGTCATTTTAATACCAATCTAAAATAAGAGCAATTTTTGTA
TTTTATTTTAATTTTTTGGT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MSMLLQKTLCIIKPDGVRRGLIGDVVARFERVGLKIVAAKMLIIDESLAKKHYLYDDIVLRHSEAVWKSLIKFISNSPVF
AFVVEGVESIEVVRKLCGATEPKLAIPGTIRGDFSYHSFRYSNEKGFSIYNVIHASANEVDAIREIPIWFKDNEILNYKR
DDECEHYYC

Sequences:

>Translated_169_residues
MSMLLQKTLCIIKPDGVRRGLIGDVVARFERVGLKIVAAKMLIIDESLAKKHYLYDDIVLRHSEAVWKSLIKFISNSPVF
AFVVEGVESIEVVRKLCGATEPKLAIPGTIRGDFSYHSFRYSNEKGFSIYNVIHASANEVDAIREIPIWFKDNEILNYKR
DDECEHYYC
>Mature_168_residues
SMLLQKTLCIIKPDGVRRGLIGDVVARFERVGLKIVAAKMLIIDESLAKKHYLYDDIVLRHSEAVWKSLIKFISNSPVFA
FVVEGVESIEVVRKLCGATEPKLAIPGTIRGDFSYHSFRYSNEKGFSIYNVIHASANEVDAIREIPIWFKDNEILNYKRD
DECEHYYC

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI4826862, Length=165, Percent_Identity=40, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI66392203, Length=162, Percent_Identity=38.2716049382716, Blast_Score=110, Evalue=4e-25,
Organism=Homo sapiens, GI66392227, Length=162, Percent_Identity=38.2716049382716, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI66392205, Length=162, Percent_Identity=38.2716049382716, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI4505409, Length=162, Percent_Identity=38.2716049382716, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI66392192, Length=162, Percent_Identity=38.2716049382716, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI37693993, Length=162, Percent_Identity=37.6543209876543, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI4557797, Length=153, Percent_Identity=36.6013071895425, Blast_Score=103, Evalue=6e-23,
Organism=Homo sapiens, GI38045913, Length=153, Percent_Identity=36.6013071895425, Blast_Score=103, Evalue=7e-23,
Organism=Escherichia coli, GI1788866, Length=158, Percent_Identity=31.6455696202532, Blast_Score=87, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17506807, Length=153, Percent_Identity=38.562091503268, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322783, Length=162, Percent_Identity=34.5679012345679, Blast_Score=102, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45549037, Length=153, Percent_Identity=35.2941176470588, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 19360; Mature: 19228

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMLLQKTLCIIKPDGVRRGLIGDVVARFERVGLKIVAAKMLIIDESLAKKHYLYDDIVL
CCHHHHHHHEEECCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHSEAVWKSLIKFISNSPVFAFVVEGVESIEVVRKLCGATEPKLAIPGTIRGDFSYHSFR
HHHHHHHHHHHHHHCCCCEEEHHHHCHHHHHHHHHHHCCCCCCEECCCCEECCCCCCEEE
YSNEKGFSIYNVIHASANEVDAIREIPIWFKDNEILNYKRDDECEHYYC
ECCCCCCEEEHEECCCCCHHHHHHHCCCEEECCCEECCCCCCCCCCCCC
>Mature Secondary Structure 
SMLLQKTLCIIKPDGVRRGLIGDVVARFERVGLKIVAAKMLIIDESLAKKHYLYDDIVL
CHHHHHHHEEECCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHSEAVWKSLIKFISNSPVFAFVVEGVESIEVVRKLCGATEPKLAIPGTIRGDFSYHSFR
HHHHHHHHHHHHHHCCCCEEEHHHHCHHHHHHHHHHHCCCCCCEECCCCEECCCCCCEEE
YSNEKGFSIYNVIHASANEVDAIREIPIWFKDNEILNYKRDDECEHYYC
ECCCCCCEEEHEECCCCCHHHHHHHCCCEEECCCEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]