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The map label for this gene is fba [H]

Identifier: 51598700

GI number: 51598700

Start: 466260

End: 467339

Strand: Direct

Name: fba [H]

Synonym: BG0453

Alternate gene names: 51598700

Gene position: 466260-467339 (Clockwise)

Preceding gene: 51598699

Following gene: 51598709

Centisome position: 51.56

GC content: 33.15

Gene sequence:

>1080_bases
GTGGGTGTTTTAGATAAGATTAAACCCGGTGTAGTTTATGGGAAAGAATTACATTCTTTATATGAAATATGTAAAAAGGA
AGGATTTGCTATTCCTTCTATTAATTGTATAGGAACAAATTCTATTAATGCGGTTTTAGAAGCAGCAAAAGAAATTAATT
CTCCTATTATGATACAATTCTCCAATAGTGGTTCTGCTTTTATTTGTGGGAAAGGATTGAAGATGGAAAAACTGCAAGGA
GTTTCAATAGTTGGAGCCATTTCTGGTGCTATGCATGTTCATTTGATGGCAGAGCATTATGGAGTTCCTGTTGTTCTTCA
TACTGATCATTGTGCTAAGAATTTGCTTCCTTGGGTTGAGGGACTTTTAGAGTATGGTGAGAAATACTATAGTCAGCACA
AAAGGCCATTATTTTCTTCACATATGTTAGATTTGTCGGAAGAACCTATTAAAGAAAATATTGAAATTTCTAAAAAATTT
TTAGAAAGAATGGCAAAAATTGAAATGTTTTTAGAAATAGAGCTTGGAATTACGGGTGGAGAAGAGGATGGAGTTGATAA
TTCTGATAGAGCTTTGCATGAACTATTTTCAACTCCCGAAGATATTTACTATGGATATTCAGAGCTTTTAAAGATTAGTC
CAAATTTTCAGATTGCAGCAGCTTTTGGAAATGTTCATGGAGTATATAAACCGGGAAATGTTAAGCTTACTCCAAAAGTG
TTAAAAGATGGTCAAGATTATGTCATATCAAAAACAGGAGTAAATGTTACCAAGCCAGTTTCTTATGTTTTTCATGGGGG
GTCTGGATCTACAATTGATGAGATTAATGAGGCACTTTCTTATGGGGTTGTAAAGATGAATATTGACACAGATACACAGT
GGGCTGCCTGGGAGGGTGTTTTAAATTATTATAAAAAAAATGAAAGTCGTTTACAAGGTCAATTAGGAGATGGTAAGGAC
ATTGATATTCCTAATAAGAAATTTTATGATCCAAGAGTTTGGTTAAGAGAAGCTGAAGTTTCCATAAAAGAGCGTGTAAA
GATTGCATGCAAAAATCTTAATAATATTAATAGGAATTAA

Upstream 100 bases:

>100_bases
ATTTATTTAAATTCAATTCTATTTCTTAGGTGTATAATTTATTATAGGCATTTGATAAAAGAAAAAATAAAGTAAAATAA
AATAGAAAGGAGTGATATAA

Downstream 100 bases:

>100_bases
ATAAAAATTCACTAATTTTTATTTGTAAGCTGCTTTTTAAGCGGCTTTTTTATTATTCTATTATGCTTTAGATATTGAAT
TATAAAATGATTGATGATTC

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MGVLDKIKPGVVYGKELHSLYEICKKEGFAIPSINCIGTNSINAVLEAAKEINSPIMIQFSNSGSAFICGKGLKMEKLQG
VSIVGAISGAMHVHLMAEHYGVPVVLHTDHCAKNLLPWVEGLLEYGEKYYSQHKRPLFSSHMLDLSEEPIKENIEISKKF
LERMAKIEMFLEIELGITGGEEDGVDNSDRALHELFSTPEDIYYGYSELLKISPNFQIAAAFGNVHGVYKPGNVKLTPKV
LKDGQDYVISKTGVNVTKPVSYVFHGGSGSTIDEINEALSYGVVKMNIDTDTQWAAWEGVLNYYKKNESRLQGQLGDGKD
IDIPNKKFYDPRVWLREAEVSIKERVKIACKNLNNINRN

Sequences:

>Translated_359_residues
MGVLDKIKPGVVYGKELHSLYEICKKEGFAIPSINCIGTNSINAVLEAAKEINSPIMIQFSNSGSAFICGKGLKMEKLQG
VSIVGAISGAMHVHLMAEHYGVPVVLHTDHCAKNLLPWVEGLLEYGEKYYSQHKRPLFSSHMLDLSEEPIKENIEISKKF
LERMAKIEMFLEIELGITGGEEDGVDNSDRALHELFSTPEDIYYGYSELLKISPNFQIAAAFGNVHGVYKPGNVKLTPKV
LKDGQDYVISKTGVNVTKPVSYVFHGGSGSTIDEINEALSYGVVKMNIDTDTQWAAWEGVLNYYKKNESRLQGQLGDGKD
IDIPNKKFYDPRVWLREAEVSIKERVKIACKNLNNINRN
>Mature_358_residues
GVLDKIKPGVVYGKELHSLYEICKKEGFAIPSINCIGTNSINAVLEAAKEINSPIMIQFSNSGSAFICGKGLKMEKLQGV
SIVGAISGAMHVHLMAEHYGVPVVLHTDHCAKNLLPWVEGLLEYGEKYYSQHKRPLFSSHMLDLSEEPIKENIEISKKFL
ERMAKIEMFLEIELGITGGEEDGVDNSDRALHELFSTPEDIYYGYSELLKISPNFQIAAAFGNVHGVYKPGNVKLTPKVL
KDGQDYVISKTGVNVTKPVSYVFHGGSGSTIDEINEALSYGVVKMNIDTDTQWAAWEGVLNYYKKNESRLQGQLGDGKDI
DIPNKKFYDPRVWLREAEVSIKERVKIACKNLNNINRN

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=355, Percent_Identity=61.1267605633803, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI87082041, Length=328, Percent_Identity=22.5609756097561, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788072, Length=271, Percent_Identity=26.9372693726937, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322790, Length=359, Percent_Identity=45.9610027855153, Blast_Score=336, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 39989; Mature: 39858

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVLDKIKPGVVYGKELHSLYEICKKEGFAIPSINCIGTNSINAVLEAAKEINSPIMIQF
CCCCHHCCCCEEEHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEE
SNSGSAFICGKGLKMEKLQGVSIVGAISGAMHVHLMAEHYGVPVVLHTDHCAKNLLPWVE
CCCCCEEEECCCCCHHHHCCEEEEEECCCCEEEEEEHHHCCCEEEEECCHHHHHHHHHHH
GLLEYGEKYYSQHKRPLFSSHMLDLSEEPIKENIEISKKFLERMAKIEMFLEIELGITGG
HHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEECCC
EEDGVDNSDRALHELFSTPEDIYYGYSELLKISPNFQIAAAFGNVHGVYKPGNVKLTPKV
CCCCCCCHHHHHHHHHCCHHHHHHCHHHHEEECCCCEEEEEECCCCCEECCCCEEECHHH
LKDGQDYVISKTGVNVTKPVSYVFHGGSGSTIDEINEALSYGVVKMNIDTDTQWAAWEGV
HCCCCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEECCCCCCHHHHHHH
LNYYKKNESRLQGQLGDGKDIDIPNKKFYDPRVWLREAEVSIKERVKIACKNLNNINRN
HHHHHCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GVLDKIKPGVVYGKELHSLYEICKKEGFAIPSINCIGTNSINAVLEAAKEINSPIMIQF
CCCHHCCCCEEEHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEE
SNSGSAFICGKGLKMEKLQGVSIVGAISGAMHVHLMAEHYGVPVVLHTDHCAKNLLPWVE
CCCCCEEEECCCCCHHHHCCEEEEEECCCCEEEEEEHHHCCCEEEEECCHHHHHHHHHHH
GLLEYGEKYYSQHKRPLFSSHMLDLSEEPIKENIEISKKFLERMAKIEMFLEIELGITGG
HHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEECCC
EEDGVDNSDRALHELFSTPEDIYYGYSELLKISPNFQIAAAFGNVHGVYKPGNVKLTPKV
CCCCCCCHHHHHHHHHCCHHHHHHCHHHHEEECCCCEEEEEECCCCCEECCCCEEECHHH
LKDGQDYVISKTGVNVTKPVSYVFHGGSGSTIDEINEALSYGVVKMNIDTDTQWAAWEGV
HCCCCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEECCCCCCHHHHHHH
LNYYKKNESRLQGQLGDGKDIDIPNKKFYDPRVWLREAEVSIKERVKIACKNLNNINRN
HHHHHCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685; 2738156 [H]