Click here to switch to the map view.

The map label for this gene is tdh

Identifier: 50841884

GI number: 50841884

Start: 448031

End: 449068

Strand: Direct

Name: tdh

Synonym: PPA0402

Alternate gene names: 50841884

Gene position: 448031-449068 (Clockwise)

Preceding gene: 50841883

Following gene: 50841885

Centisome position: 17.5

GC content: 59.92

Gene sequence:

>1038_bases
ATGAAGGCCTTGGTCAAGACCCGCCCGGAGCCGGGTCTGGAGCTGGTGGAGGTCCCCGACCCGGTCGCTGGCCCCAACGA
CGTCATCGTCAAGGTGATGCGGACAGGAATCTGTGGCACCGACGTTCACATCGATAAATGGGACGGGTGGGCCGCCAAGA
CGGTGCACACCCCGCTGGTCCTCGGCCACGAGTTCTGCGGTGAGATTGTTGAACTCGGTTCGGAGGTCAATGATCTGGAG
GTCGGACAGTTCGTCTCCGGCGAGGGGCACTATGTCTGCGGACGCTGCCGGGCCTGCCTAGCGGGCAAACGTCACCTGTG
CCGCAACACCCAAGGTATTGGATATGCGGTCAACGGTGCCTACTGCCAGTACTTCGTCATGCCGGCTGGCAACGTCTGGG
TACATCACATCCCGGACCTTGACCCCGACGTCGCGGCGATCTTTGACCCGTTCGGCAATGCCGTACACACCGCCTTGCAG
TTCCCCTGCCTGGCCGAGGATGTCCTCGTTTCAGGTGCTGGGCCGATCGGCATCATGGCGGCCCTGGTCGCTCAGTTCCA
AGGGGCGCGCAATGTCGTCGTTACCGACCTGTCCGACGAGAGGCTGGAGCTGGCTCAGCAACTGGGCCTGAAGAACGCCG
TCAATGTTTCCCGCGAAGGTTTGGAGACGGTCTGGGACCGATTCGACATGAAGGAGGGGTTTGACATCGGCCTGGAGATG
TCCGGGTCGGGGACAGCTTTAACATCCATGATTGACAATATGACTCATGGTGGACGGATTGCGTTGCTGGGAACCCCGAG
CACTGACATCACCCTCGACTTTTCCAAGATCATCTTTAACATGATCACAATTCAGGGAGTGACCGGGCGTCAGATCTTCG
AAACGTGGTACACCATGGCCTCCCTCATCCGTTCCGGTCTGGACATCTCCGGAATCATCACCGACCGATACCCCATCACG
GAATTCCGGGAAGCCTTTGACGTCGCAGGCTCGGGCCACGGCGGCAAGGTTGTCATGAACTGGGAATGCCTCGACTGA

Upstream 100 bases:

>100_bases
CTCACGGGAGATATCATAACCGCTGTGCTGCTGTGACGATGGTGGCACAGTGGTGTCAACACGAGGAAGTGTGGGGCGCT
GCCCCGGAAAGTGAGGCTCG

Downstream 100 bases:

>100_bases
TAAGCGACTTAGAGGAAGGACAACTATGTACGGACCTATGAAAGACGAACTCAGCGCCAAGATCGCAGCCCTTAAGGAGG
AGGGGCTGTATAAAGCTGAA

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKALVKTRPEPGLELVEVPDPVAGPNDVIVKVMRTGICGTDVHIDKWDGWAAKTVHTPLVLGHEFCGEIVELGSEVNDLE
VGQFVSGEGHYVCGRCRACLAGKRHLCRNTQGIGYAVNGAYCQYFVMPAGNVWVHHIPDLDPDVAAIFDPFGNAVHTALQ
FPCLAEDVLVSGAGPIGIMAALVAQFQGARNVVVTDLSDERLELAQQLGLKNAVNVSREGLETVWDRFDMKEGFDIGLEM
SGSGTALTSMIDNMTHGGRIALLGTPSTDITLDFSKIIFNMITIQGVTGRQIFETWYTMASLIRSGLDISGIITDRYPIT
EFREAFDVAGSGHGGKVVMNWECLD

Sequences:

>Translated_345_residues
MKALVKTRPEPGLELVEVPDPVAGPNDVIVKVMRTGICGTDVHIDKWDGWAAKTVHTPLVLGHEFCGEIVELGSEVNDLE
VGQFVSGEGHYVCGRCRACLAGKRHLCRNTQGIGYAVNGAYCQYFVMPAGNVWVHHIPDLDPDVAAIFDPFGNAVHTALQ
FPCLAEDVLVSGAGPIGIMAALVAQFQGARNVVVTDLSDERLELAQQLGLKNAVNVSREGLETVWDRFDMKEGFDIGLEM
SGSGTALTSMIDNMTHGGRIALLGTPSTDITLDFSKIIFNMITIQGVTGRQIFETWYTMASLIRSGLDISGIITDRYPIT
EFREAFDVAGSGHGGKVVMNWECLD
>Mature_345_residues
MKALVKTRPEPGLELVEVPDPVAGPNDVIVKVMRTGICGTDVHIDKWDGWAAKTVHTPLVLGHEFCGEIVELGSEVNDLE
VGQFVSGEGHYVCGRCRACLAGKRHLCRNTQGIGYAVNGAYCQYFVMPAGNVWVHHIPDLDPDVAAIFDPFGNAVHTALQ
FPCLAEDVLVSGAGPIGIMAALVAQFQGARNVVVTDLSDERLELAQQLGLKNAVNVSREGLETVWDRFDMKEGFDIGLEM
SGSGTALTSMIDNMTHGGRIALLGTPSTDITLDFSKIIFNMITIQGVTGRQIFETWYTMASLIRSGLDISGIITDRYPIT
EFREAFDVAGSGHGGKVVMNWECLD

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=347, Percent_Identity=28.5302593659942, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI156523966, Length=365, Percent_Identity=22.4657534246575, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=22.5626740947075, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790045, Length=343, Percent_Identity=54.2274052478134, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1788075, Length=363, Percent_Identity=30.0275482093664, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788073, Length=323, Percent_Identity=28.7925696594427, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI226510992, Length=319, Percent_Identity=28.8401253918495, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787863, Length=297, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790718, Length=313, Percent_Identity=25.5591054313099, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87082125, Length=348, Percent_Identity=27.0114942528736, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788407, Length=325, Percent_Identity=27.6923076923077, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786825, Length=280, Percent_Identity=29.2857142857143, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081918, Length=306, Percent_Identity=25.4901960784314, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=321, Percent_Identity=31.7757009345794, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17562878, Length=337, Percent_Identity=31.4540059347181, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17562582, Length=278, Percent_Identity=25.1798561151079, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=335, Percent_Identity=29.5522388059701, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6322619, Length=327, Percent_Identity=24.7706422018349, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=327, Percent_Identity=24.7706422018349, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319257, Length=267, Percent_Identity=27.3408239700375, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=276, Percent_Identity=27.8985507246377, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=272, Percent_Identity=26.8382352941176, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=285, Percent_Identity=27.0175438596491, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=213, Percent_Identity=29.5774647887324, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=227, Percent_Identity=30.3964757709251, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17737897, Length=334, Percent_Identity=27.8443113772455, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17137530, Length=335, Percent_Identity=26.5671641791045, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TDH_PROAC (Q6AAR3)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055111.1
- ProteinModelPortal:   Q6AAR3
- SMR:   Q6AAR3
- GeneID:   2931139
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0402
- NMPDR:   fig|267747.1.peg.388
- HOGENOM:   HBG753318
- OMA:   PMEIASI
- ProtClustDB:   PRK05396
- BioCyc:   PACN267747:PPA0402-MONOMER
- BRENDA:   1.1.1.103
- GO:   GO:0005737
- HAMAP:   MF_00627
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.103

Molecular weight: Translated: 37339; Mature: 37339

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVKTRPEPGLELVEVPDPVAGPNDVIVKVMRTGICGTDVHIDKWDGWAAKTVHTPLV
CCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCHHHHCCHHH
LGHEFCGEIVELGSEVNDLEVGQFVSGEGHYVCGRCRACLAGKRHLCRNTQGIGYAVNGA
HHHHHHHHHHHHCCCCCCCCCCCEECCCCCEEHHHHHHHHHCCHHHHCCCCCCCEEECCE
YCQYFVMPAGNVWVHHIPDLDPDVAAIFDPFGNAVHTALQFPCLAEDVLVSGAGPIGIMA
EEEEEEEECCCEEEEECCCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCHHHHHH
ALVAQFQGARNVVVTDLSDERLELAQQLGLKNAVNVSREGLETVWDRFDMKEGFDIGLEM
HHHHHHCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
SGSGTALTSMIDNMTHGGRIALLGTPSTDITLDFSKIIFNMITIQGVTGRQIFETWYTMA
CCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHH
SLIRSGLDISGIITDRYPITEFREAFDVAGSGHGGKVVMNWECLD
HHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MKALVKTRPEPGLELVEVPDPVAGPNDVIVKVMRTGICGTDVHIDKWDGWAAKTVHTPLV
CCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCHHHHCCHHH
LGHEFCGEIVELGSEVNDLEVGQFVSGEGHYVCGRCRACLAGKRHLCRNTQGIGYAVNGA
HHHHHHHHHHHHCCCCCCCCCCCEECCCCCEEHHHHHHHHHCCHHHHCCCCCCCEEECCE
YCQYFVMPAGNVWVHHIPDLDPDVAAIFDPFGNAVHTALQFPCLAEDVLVSGAGPIGIMA
EEEEEEEECCCEEEEECCCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCHHHHHH
ALVAQFQGARNVVVTDLSDERLELAQQLGLKNAVNVSREGLETVWDRFDMKEGFDIGLEM
HHHHHHCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
SGSGTALTSMIDNMTHGGRIALLGTPSTDITLDFSKIIFNMITIQGVTGRQIFETWYTMA
CCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHH
SLIRSGLDISGIITDRYPITEFREAFDVAGSGHGGKVVMNWECLD
HHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA