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The map label for this gene is kbl [C]

Identifier: 50841885

GI number: 50841885

Start: 449094

End: 450290

Strand: Direct

Name: kbl [C]

Synonym: PPA0403

Alternate gene names: 50841885

Gene position: 449094-450290 (Clockwise)

Preceding gene: 50841884

Following gene: 50841890

Centisome position: 17.54

GC content: 59.48

Gene sequence:

>1197_bases
ATGTACGGACCTATGAAAGACGAACTCAGCGCCAAGATCGCAGCCCTTAAGGAGGAGGGGCTGTATAAAGCTGAAGCCCC
GTTGACCAGCCCCCAGTCGGGCAAGATCACCGTCGATGATGGGCGCGAGGTCATTAACCTGTGCGCGAATAATTACCTCG
GTTTGGCTGATTCCCCGGTGCTCATTGAGGCTGCCAAGAAGGCTCTCGATGAATGGGGATTTGGGATGGCCTCGGTGCGG
TTTATTTGTGGCACCCAGACCCTCCACCAGAAGCTCGAGCGAGCCATCACCGAATTCCTTCACCCCGATGACCCCGACAA
CTGGGACACCATTCTTTACTCATCCTGCTTTGACGCCAACGGCGGTCTTTTCGAGGTCCTTCTCGGCCCTGACGACGCGA
TCATTTCCGACGAGCTTAACCATGCCTCGATCATCGATGGGGTCCGGTTGTGCAAGGCCCAGCGCTTCCGTTACCGTAAC
CAGGACATGGCCGATCTTGAGGCCCAGCTGCAGGCTGCGAAGGACTGCAGGCACATCATGATCGCCACCGACGGCGTTTT
CTCGATGGACGGGTTTGTTGCCCCGCTGCCGCAGATCTGTGACCTCGCCGAAAAGTATGGTGCCATGGTTATGGTCGACG
ACTCCCACGCTGTCGGGTTCGTCGGTGAACACGGCGCCGGGACCCCCGAGCAGTGGGGCGTTCGCGACCGCGTTGACGTC
CTTACAGGCACCCTTGGCAAGGCATTGGGCGGTGCCTCAGGCGGCTACACCTGCTCCCATCGGGAAGTCGTCGAGATGCT
GCGACAGAATTCGCGGCCCTATCTGTTTTCTAACTCGCTTGCCCCATCGATCGCCGGAGCATCGCTTGCTACCCTTGACT
TGCTCAAATCCTCCGGCGACCTGCTCACCAAACTGCGCGAGAATACCGAGTACTTCCGCTCCGAGATGACTCGTCGCGGT
TTCGAGATCCCCGAGTCAGATCACCCGATCGTGCCCGTCATGGTGGGTGACGCGGTCAAGGCCGCGAAGATGGCCGACGC
CATGCTCGCCAAGGGCATTTATGTTCGCGCCTTCAGCTACCCGGTGGTTCCTAAGGGGAAGGCTCGCATCCGTACCCAGA
TGTCTGCCGGGCTCACCCGGGAACAGCTCGACAAGGCTATTAAGGCCTTCGAGGAGGCACGCGCGGAAATAGGCTAA

Upstream 100 bases:

>100_bases
TTCCGGGAAGCCTTTGACGTCGCAGGCTCGGGCCACGGCGGCAAGGTTGTCATGAACTGGGAATGCCTCGACTGATAAGC
GACTTAGAGGAAGGACAACT

Downstream 100 bases:

>100_bases
ACCATTGGCTGGCCGATTATGAGGCCAGCCCCCTTTGTGCTAACCAATCCTTGGCGATGGTGGCTGCGGATGCTTTTTCG
TCTCCCTGAAAGCGCTGGTT

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MYGPMKDELSAKIAALKEEGLYKAEAPLTSPQSGKITVDDGREVINLCANNYLGLADSPVLIEAAKKALDEWGFGMASVR
FICGTQTLHQKLERAITEFLHPDDPDNWDTILYSSCFDANGGLFEVLLGPDDAIISDELNHASIIDGVRLCKAQRFRYRN
QDMADLEAQLQAAKDCRHIMIATDGVFSMDGFVAPLPQICDLAEKYGAMVMVDDSHAVGFVGEHGAGTPEQWGVRDRVDV
LTGTLGKALGGASGGYTCSHREVVEMLRQNSRPYLFSNSLAPSIAGASLATLDLLKSSGDLLTKLRENTEYFRSEMTRRG
FEIPESDHPIVPVMVGDAVKAAKMADAMLAKGIYVRAFSYPVVPKGKARIRTQMSAGLTREQLDKAIKAFEEARAEIG

Sequences:

>Translated_398_residues
MYGPMKDELSAKIAALKEEGLYKAEAPLTSPQSGKITVDDGREVINLCANNYLGLADSPVLIEAAKKALDEWGFGMASVR
FICGTQTLHQKLERAITEFLHPDDPDNWDTILYSSCFDANGGLFEVLLGPDDAIISDELNHASIIDGVRLCKAQRFRYRN
QDMADLEAQLQAAKDCRHIMIATDGVFSMDGFVAPLPQICDLAEKYGAMVMVDDSHAVGFVGEHGAGTPEQWGVRDRVDV
LTGTLGKALGGASGGYTCSHREVVEMLRQNSRPYLFSNSLAPSIAGASLATLDLLKSSGDLLTKLRENTEYFRSEMTRRG
FEIPESDHPIVPVMVGDAVKAAKMADAMLAKGIYVRAFSYPVVPKGKARIRTQMSAGLTREQLDKAIKAFEEARAEIG
>Mature_398_residues
MYGPMKDELSAKIAALKEEGLYKAEAPLTSPQSGKITVDDGREVINLCANNYLGLADSPVLIEAAKKALDEWGFGMASVR
FICGTQTLHQKLERAITEFLHPDDPDNWDTILYSSCFDANGGLFEVLLGPDDAIISDELNHASIIDGVRLCKAQRFRYRN
QDMADLEAQLQAAKDCRHIMIATDGVFSMDGFVAPLPQICDLAEKYGAMVMVDDSHAVGFVGEHGAGTPEQWGVRDRVDV
LTGTLGKALGGASGGYTCSHREVVEMLRQNSRPYLFSNSLAPSIAGASLATLDLLKSSGDLLTKLRENTEYFRSEMTRRG
FEIPESDHPIVPVMVGDAVKAAKMADAMLAKGIYVRAFSYPVVPKGKARIRTQMSAGLTREQLDKAIKAFEEARAEIG

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=389, Percent_Identity=52.9562982005141, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI284448556, Length=415, Percent_Identity=49.6385542168675, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI83977442, Length=362, Percent_Identity=34.5303867403315, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI83977440, Length=362, Percent_Identity=34.5303867403315, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI83977444, Length=362, Percent_Identity=34.5303867403315, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4502025, Length=335, Percent_Identity=34.3283582089552, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI40316939, Length=335, Percent_Identity=34.3283582089552, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4758668, Length=379, Percent_Identity=32.1899736147757, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI119220554, Length=369, Percent_Identity=33.3333333333333, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI5454084, Length=292, Percent_Identity=28.0821917808219, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1790046, Length=400, Percent_Identity=59, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI1786993, Length=361, Percent_Identity=31.0249307479224, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71994529, Length=387, Percent_Identity=53.2299741602067, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI32566772, Length=374, Percent_Identity=31.8181818181818, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17560912, Length=364, Percent_Identity=31.043956043956, Blast_Score=168, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17560914, Length=365, Percent_Identity=30.958904109589, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI71982617, Length=298, Percent_Identity=25.1677852348993, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71982625, Length=298, Percent_Identity=25.1677852348993, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320438, Length=382, Percent_Identity=33.2460732984293, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6320267, Length=369, Percent_Identity=30.0813008130081, Blast_Score=172, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6323954, Length=403, Percent_Identity=23.8213399503722, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24662918, Length=389, Percent_Identity=53.9845758354756, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI17137420, Length=381, Percent_Identity=31.2335958005249, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17136286, Length=385, Percent_Identity=30.3896103896104, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24653280, Length=393, Percent_Identity=25.4452926208651, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24653276, Length=393, Percent_Identity=25.4452926208651, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24653278, Length=393, Percent_Identity=25.4452926208651, Blast_Score=118, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43358; Mature: 43358

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGPMKDELSAKIAALKEEGLYKAEAPLTSPQSGKITVDDGREVINLCANNYLGLADSPV
CCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCH
LIEAAKKALDEWGFGMASVRFICGTQTLHQKLERAITEFLHPDDPDNWDTILYSSCFDAN
HHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCC
GGLFEVLLGPDDAIISDELNHASIIDGVRLCKAQRFRYRNQDMADLEAQLQAAKDCRHIM
CCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEE
IATDGVFSMDGFVAPLPQICDLAEKYGAMVMVDDSHAVGFVGEHGAGTPEQWGVRDRVDV
EEECCCEECCCCCCCHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCCHHCCCHHHHHH
LTGTLGKALGGASGGYTCSHREVVEMLRQNSRPYLFSNSLAPSIAGASLATLDLLKSSGD
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHCCCHHHHHHHHHCCCH
LLTKLRENTEYFRSEMTRRGFEIPESDHPIVPVMVGDAVKAAKMADAMLAKGIYVRAFSY
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECC
PVVPKGKARIRTQMSAGLTREQLDKAIKAFEEARAEIG
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYGPMKDELSAKIAALKEEGLYKAEAPLTSPQSGKITVDDGREVINLCANNYLGLADSPV
CCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCH
LIEAAKKALDEWGFGMASVRFICGTQTLHQKLERAITEFLHPDDPDNWDTILYSSCFDAN
HHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCC
GGLFEVLLGPDDAIISDELNHASIIDGVRLCKAQRFRYRNQDMADLEAQLQAAKDCRHIM
CCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEE
IATDGVFSMDGFVAPLPQICDLAEKYGAMVMVDDSHAVGFVGEHGAGTPEQWGVRDRVDV
EEECCCEECCCCCCCHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCCHHCCCHHHHHH
LTGTLGKALGGASGGYTCSHREVVEMLRQNSRPYLFSNSLAPSIAGASLATLDLLKSSGD
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHCCCHHHHHHHHHCCCH
LLTKLRENTEYFRSEMTRRGFEIPESDHPIVPVMVGDAVKAAKMADAMLAKGIYVRAFSY
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECC
PVVPKGKARIRTQMSAGLTREQLDKAIKAFEEARAEIG
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]