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The map label for this gene is 50841791

Identifier: 50841791

GI number: 50841791

Start: 353478

End: 354203

Strand: Reverse

Name: 50841791

Synonym: PPA0303

Alternate gene names: NA

Gene position: 354203-353478 (Counterclockwise)

Preceding gene: 50841792

Following gene: 50841790

Centisome position: 13.83

GC content: 62.67

Gene sequence:

>726_bases
ATGACCACAAATCCTGCCGATCTCGTCAAGCCCCCAGTTGTTGTTCCCCGTGACGACTCCCACGACAAATTCGTGACGAC
TTTGAAGCAGGCCGGTTATGGAGTGATCCACACAGCGCTGACGCGCACCGTCACCTTGCCGGATGCGGAGAGGCTTACTG
CCCCTGACCTGTGGCAGGCCGACTGGCTGGTCGTCACCTCGAAGACCACCGTCGGACTGCTCCCTACCCCGTTGCCGAAT
CCCAACATCAAAGTAGCTGCGGTCGGCGCCGCTACCTCTGCTGCGCTGCGCACACGTGGGATTGACGTCGACTTCGTCCC
CGAGAATCACAGCGGCGCTGGTCTGGTCGCCGAGTGGCCAGGTGGAGTCGCCAATATCCTCCTACCAGCGTCCCAGTTAA
CCGCCGATACCGTACCGCTGGGGCTGACGAAGGTCGGCTGCACGGTAAACCGATTGGAGATCTATACCACCGCTGCCGTC
GAGAAACTGCCTGAGGTCATCGCCCAGTCGTGGCCGTCTGTCGGGGTCGTCGTCGTCACTGCCTCCTCGGTGGGACGTGC
CCTCGTCGAGCTGGTGGAGCCGCTGGGATGGCGTCGTCAGAAGCTCGTCGCCCTCGGTAAGCCCACTGCAAGAACACTCG
AAGTACTCGGTCACCCAGCGCATGCGGTGGCCTCCTCCCCCACTCCTGAAGCCGTCCTTGAGGCGGTTGAGTCCTTGGTC
GCCTGA

Upstream 100 bases:

>100_bases
CGCTGGCGGCGGCGCATACGCTGGGGGTGACGGCTGCCGAAGAGTTACTGGACGATGGTGCCGCCGACGTTGCAGATCTC
AAAGCTTCAGGAAGCACTCG

Downstream 100 bases:

>100_bases
CCGACGGCCGTTCGCGAAGGAAGTTGATCATGAACCCGTACCTGCCTGATGCCAGTGATCCCCGCATGGCTGGGGTCAAG
CCATTGCCCGAGGGGCTGCG

Product: uroporphyrinogen-III synthase, HemD

Products: uroporphyrinogen III; H2O

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MTTNPADLVKPPVVVPRDDSHDKFVTTLKQAGYGVIHTALTRTVTLPDAERLTAPDLWQADWLVVTSKTTVGLLPTPLPN
PNIKVAAVGAATSAALRTRGIDVDFVPENHSGAGLVAEWPGGVANILLPASQLTADTVPLGLTKVGCTVNRLEIYTTAAV
EKLPEVIAQSWPSVGVVVVTASSVGRALVELVEPLGWRRQKLVALGKPTARTLEVLGHPAHAVASSPTPEAVLEAVESLV
A

Sequences:

>Translated_241_residues
MTTNPADLVKPPVVVPRDDSHDKFVTTLKQAGYGVIHTALTRTVTLPDAERLTAPDLWQADWLVVTSKTTVGLLPTPLPN
PNIKVAAVGAATSAALRTRGIDVDFVPENHSGAGLVAEWPGGVANILLPASQLTADTVPLGLTKVGCTVNRLEIYTTAAV
EKLPEVIAQSWPSVGVVVVTASSVGRALVELVEPLGWRRQKLVALGKPTARTLEVLGHPAHAVASSPTPEAVLEAVESLV
A
>Mature_240_residues
TTNPADLVKPPVVVPRDDSHDKFVTTLKQAGYGVIHTALTRTVTLPDAERLTAPDLWQADWLVVTSKTTVGLLPTPLPNP
NIKVAAVGAATSAALRTRGIDVDFVPENHSGAGLVAEWPGGVANILLPASQLTADTVPLGLTKVGCTVNRLEIYTTAAVE
KLPEVIAQSWPSVGVVVVTASSVGRALVELVEPLGWRRQKLVALGKPTARTLEVLGHPAHAVASSPTPEAVLEAVESLVA

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 25205; Mature: 25074

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNPADLVKPPVVVPRDDSHDKFVTTLKQAGYGVIHTALTRTVTLPDAERLTAPDLWQA
CCCCCHHHCCCCEEECCCCCCHHHHHHHHHCCCHHEEHHHHHEEECCCHHHCCCCCCCCC
DWLVVTSKTTVGLLPTPLPNPNIKVAAVGAATSAALRTRGIDVDFVPENHSGAGLVAEWP
CEEEEECCCEEEECCCCCCCCCEEEEEECCHHHHHHHHCCCCEEECCCCCCCCEEEEECC
GGVANILLPASQLTADTVPLGLTKVGCTVNRLEIYTTAAVEKLPEVIAQSWPSVGVVVVT
CCHHHEEECHHHHCCCCCCCCCHHHCCEEEEEEEEHHHHHHHHHHHHHHCCCCCEEEEEE
ASSVGRALVELVEPLGWRRQKLVALGKPTARTLEVLGHPAHAVASSPTPEAVLEAVESLV
CCHHHHHHHHHHHHCCCCHHHHEECCCCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHC
A
C
>Mature Secondary Structure 
TTNPADLVKPPVVVPRDDSHDKFVTTLKQAGYGVIHTALTRTVTLPDAERLTAPDLWQA
CCCCHHHCCCCEEECCCCCCHHHHHHHHHCCCHHEEHHHHHEEECCCHHHCCCCCCCCC
DWLVVTSKTTVGLLPTPLPNPNIKVAAVGAATSAALRTRGIDVDFVPENHSGAGLVAEWP
CEEEEECCCEEEECCCCCCCCCEEEEEECCHHHHHHHHCCCCEEECCCCCCCCEEEEECC
GGVANILLPASQLTADTVPLGLTKVGCTVNRLEIYTTAAVEKLPEVIAQSWPSVGVVVVT
CCHHHEEECHHHHCCCCCCCCCHHHCCEEEEEEEEHHHHHHHHHHHHHHCCCCCEEEEEE
ASSVGRALVELVEPLGWRRQKLVALGKPTARTLEVLGHPAHAVASSPTPEAVLEAVESLV
CCHHHHHHHHHHHHCCCCHHHHEECCCCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA