Click here to switch to the map view.

The map label for this gene is hemC

Identifier: 50841792

GI number: 50841792

Start: 354200

End: 355300

Strand: Reverse

Name: hemC

Synonym: PPA0304

Alternate gene names: 50841792

Gene position: 355300-354200 (Counterclockwise)

Preceding gene: 50841793

Following gene: 50841791

Centisome position: 13.88

GC content: 62.67

Gene sequence:

>1101_bases
TTGCCGCTCTGGTGCCGCAGGCCCGCCGAACTGTCCGTCAACTTGTCTGATTGCAGGCTGGAATCGGCGTCGGTACTGAG
TGCCACAATAGGCAATATGTCTGCGATCCGTCTGGGAACCCGTGCCAGCACTCTGGCCACTACTCAATCAGAGATGGTTG
CGGGGCTGCTCAGGTCGGAGGGGCTGGACGTCAATCTGACGACGATCACTACTCACGGGGACACCTCGACGGCCTCGTTA
GCGGCCATGGGAGGAATCGGGGTGTTCGCCTCGGCGATCCGTGCGGCCCTCCTCGAGGGAGAAGCCGACATTGCCGTCCA
CTCCTTCAAAGATCTACCGACAGGACGTCCGTTAGGACTGGCGATCGGTGCCGTTCCAGCTCGAGCAGACCCGCGTGACG
CTTTGGTGGCCCGCGATGGGCTCACCCTTCACGACCTCCCGCAAGAAGCTAGCGTCGGGACGGGCTCGCCACGTCGGGCC
GCACAGTTGTTGGCGGTCAGACCGGACCTGACGATCGTCGATATCCGTGGAAATGTCGACACTCGGCTGGGTCGCGTCAA
AGGACTCGGCCGCTACGCCAAAAACGGTGGCAAGGAGGACCTCGACGCCGTCGTGCTCGCAGCCTCCGGACTAGCTCGAC
TAGGTCATAGCGGCGCCGTCACTGAGTTCCTCGACCCGTCGGTAGTACTGCCTGCCCCTGCTCAGGGAGCGCTAGCCGTC
GAATGCCGGACCGCTGATTCACGTCATGGCAAGCTCGCCAAAGCGCTGGCACGGATTGACGACCGCAGAACCAGGCTGGC
CGCCACCGCCGAACGTGCGGTGCTCTCCCATCTAGAGGCGGGGTGCGCTGCCCCCATCGGAGCATTAGCTCAACTCAAGC
CTGTTTCGGGAAAATCCCTACAAGTGTTAACCCTGGATGTTGTAGTGGCTGCTGTCGACGGTTCCCGCACCGTTCGGGAA
CAGGTCAGCGTCGAATTACCCGCGGAGGTCGAACCAGCGCTGGCGGCGGCGCATACGCTGGGGGTGACGGCTGCCGAAGA
GTTACTGGACGATGGTGCCGCCGACGTTGCAGATCTCAAAGCTTCAGGAAGCACTCGATGA

Upstream 100 bases:

>100_bases
CGAGCATGGCGCGATGGTCTGCACCGCCAGCTAGAGGTATTGAACCAGTCTGGACAGGGACGGATCGGCTTAGTGGGGTC
GTGGGCATCGGGTTCGGGCA

Downstream 100 bases:

>100_bases
CCACAAATCCTGCCGATCTCGTCAAGCCCCCAGTTGTTGTTCCCCGTGACGACTCCCACGACAAATTCGTGACGACTTTG
AAGCAGGCCGGTTATGGAGT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MPLWCRRPAELSVNLSDCRLESASVLSATIGNMSAIRLGTRASTLATTQSEMVAGLLRSEGLDVNLTTITTHGDTSTASL
AAMGGIGVFASAIRAALLEGEADIAVHSFKDLPTGRPLGLAIGAVPARADPRDALVARDGLTLHDLPQEASVGTGSPRRA
AQLLAVRPDLTIVDIRGNVDTRLGRVKGLGRYAKNGGKEDLDAVVLAASGLARLGHSGAVTEFLDPSVVLPAPAQGALAV
ECRTADSRHGKLAKALARIDDRRTRLAATAERAVLSHLEAGCAAPIGALAQLKPVSGKSLQVLTLDVVVAAVDGSRTVRE
QVSVELPAEVEPALAAAHTLGVTAAEELLDDGAADVADLKASGSTR

Sequences:

>Translated_366_residues
MPLWCRRPAELSVNLSDCRLESASVLSATIGNMSAIRLGTRASTLATTQSEMVAGLLRSEGLDVNLTTITTHGDTSTASL
AAMGGIGVFASAIRAALLEGEADIAVHSFKDLPTGRPLGLAIGAVPARADPRDALVARDGLTLHDLPQEASVGTGSPRRA
AQLLAVRPDLTIVDIRGNVDTRLGRVKGLGRYAKNGGKEDLDAVVLAASGLARLGHSGAVTEFLDPSVVLPAPAQGALAV
ECRTADSRHGKLAKALARIDDRRTRLAATAERAVLSHLEAGCAAPIGALAQLKPVSGKSLQVLTLDVVVAAVDGSRTVRE
QVSVELPAEVEPALAAAHTLGVTAAEELLDDGAADVADLKASGSTR
>Mature_365_residues
PLWCRRPAELSVNLSDCRLESASVLSATIGNMSAIRLGTRASTLATTQSEMVAGLLRSEGLDVNLTTITTHGDTSTASLA
AMGGIGVFASAIRAALLEGEADIAVHSFKDLPTGRPLGLAIGAVPARADPRDALVARDGLTLHDLPQEASVGTGSPRRAA
QLLAVRPDLTIVDIRGNVDTRLGRVKGLGRYAKNGGKEDLDAVVLAASGLARLGHSGAVTEFLDPSVVLPAPAQGALAVE
CRTADSRHGKLAKALARIDDRRTRLAATAERAVLSHLEAGCAAPIGALAQLKPVSGKSLQVLTLDVVVAAVDGSRTVREQ
VSVELPAEVEPALAAAHTLGVTAAEELLDDGAADVADLKASGSTR

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=354, Percent_Identity=35.0282485875706, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI20149500, Length=355, Percent_Identity=34.9295774647887, Blast_Score=171, Evalue=7e-43,
Organism=Escherichia coli, GI48994974, Length=326, Percent_Identity=40.4907975460123, Blast_Score=193, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319996, Length=335, Percent_Identity=30.7462686567164, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI20130425, Length=300, Percent_Identity=37.3333333333333, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 37540; Mature: 37409

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLWCRRPAELSVNLSDCRLESASVLSATIGNMSAIRLGTRASTLATTQSEMVAGLLRSE
CCCCCCCCCCEEEEHHHHCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHC
GLDVNLTTITTHGDTSTASLAAMGGIGVFASAIRAALLEGEADIAVHSFKDLPTGRPLGL
CCEEEEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCCEE
AIGAVPARADPRDALVARDGLTLHDLPQEASVGTGSPRRAAQLLAVRPDLTIVDIRGNVD
EEECCCCCCCCCHHEEECCCCCCCCCCCCCCCCCCCHHHHHHHEEECCCEEEEEECCCCH
TRLGRVKGLGRYAKNGGKEDLDAVVLAASGLARLGHSGAVTEFLDPSVVLPAPAQGALAV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEECCCCCCCEEE
ECRTADSRHGKLAKALARIDDRRTRLAATAERAVLSHLEAGCAAPIGALAQLKPVSGKSL
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCE
QVLTLDVVVAAVDGSRTVREQVSVELPAEVEPALAAAHTLGVTAAEELLDDGAADVADLK
EEEEEEEEEEECCCCHHHHHHHCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHC
ASGSTR
CCCCCC
>Mature Secondary Structure 
PLWCRRPAELSVNLSDCRLESASVLSATIGNMSAIRLGTRASTLATTQSEMVAGLLRSE
CCCCCCCCCEEEEHHHHCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHC
GLDVNLTTITTHGDTSTASLAAMGGIGVFASAIRAALLEGEADIAVHSFKDLPTGRPLGL
CCEEEEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCCEE
AIGAVPARADPRDALVARDGLTLHDLPQEASVGTGSPRRAAQLLAVRPDLTIVDIRGNVD
EEECCCCCCCCCHHEEECCCCCCCCCCCCCCCCCCCHHHHHHHEEECCCEEEEEECCCCH
TRLGRVKGLGRYAKNGGKEDLDAVVLAASGLARLGHSGAVTEFLDPSVVLPAPAQGALAV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEECCCCCCCEEE
ECRTADSRHGKLAKALARIDDRRTRLAATAERAVLSHLEAGCAAPIGALAQLKPVSGKSL
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCE
QVLTLDVVVAAVDGSRTVREQVSVELPAEVEPALAAAHTLGVTAAEELLDDGAADVADLK
EEEEEEEEEEECCCCHHHHHHHCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHC
ASGSTR
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA