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The map label for this gene is glyQS [H]

Identifier: 50365084

GI number: 50365084

Start: 306551

End: 307906

Strand: Direct

Name: glyQS [H]

Synonym: Mfl268

Alternate gene names: 50365084

Gene position: 306551-307906 (Clockwise)

Preceding gene: 50365083

Following gene: 50365085

Centisome position: 38.65

GC content: 29.06

Gene sequence:

>1356_bases
ATGGAAAAATTAATTGCCCATTTAAAATCTCAAGGTTTTATTTTTCAAGGTTCAGAAATTTATGGTGGACTAGCTAATTC
TTGAGATTATGGACCATTGGGTGTAGAAGTTAAAAATAAATTAAAGCAAGCTTGATGAAATCATTTTGTTAGAAAAAACC
CTTACAATATTGGTTTAGATAGTTCAATCATTTTGAACTCAAGTGTTTGAAAAGCTAGTGGTCATATAGATGGATTTAAC
GATCCATTAATTGATTGCAAAAAATGTAACAGTAGATGAAGAGCAGATAAATTAATTGAAGAATTTAATTCTGAAATTAA
TGCTGGAGTTATGACAGAAAATCAAATGGAAGAGTTTATTAGAGAACAAAACATAAAGTGTCCAAAATGTCAGGCATGTG
ATTTTACACAAATAAGAAAATTTGCACTAATGTTTAAAACTAATCAAGGAGTTCTTGAAGATGAATCTTCTTCTGTATAT
TTAAGACCTGAAACAGCGCAAGGTATTTTTATAAACTTTAAAAATGCTCAAAGATCATTGAGAAAAAAATTACCTTTTGG
TATTGGTCAAATTGGTAAATCTTTCAGAAATGAAATTACACCAGGTAACTTTATTTTTAGAACACGTGAATTTGAACAAA
TGGAATTAGAATTCTTTTTTAATCCATCTGATGAAAAAGATTGATTCTCATACTGATTAAATGAAGTTGAAACATTCTTA
CAAGATAAAATTCAAATTAATAAAGAAAATTACAGAGTTAGAAGTCATGAAAAAGATGAATTAGCACATTACTCAACAGC
AACTAGTGATATTGAATTTAAATTCCCATTTGGTTGAGGAGAGTTATGAGGAGTTGCACATAGAGGTAATTTTGACTTAA
ATGCTCATCAAGAAGCATCTAAGCAAGATTTAACTTATTTAGATCCAACTACTAATCAAAAAGTTTTACCACATGTAATT
GAACCAAGTGTTGGTGTTGAAAGAATGATGTTAGCTATTTTATGACAAGCATATCATGAAGAAGATTTAGGTGAAGGGAA
TTCACGTATAGTTATGAAATTACCATATAACCTAGCTCCGTATCAAATTGCTGTTATGCCTTTACAAAAACAACAAAATG
ATCAAGCACAAGCTCTATATTCAAATCTTTTAAATAATTTTGATGTTACTTATGATGAAACAGGAAATGTTGGTAAAAGA
TATAGAAGACAAGATGCAATTGGAACACCATTTGTGATAACAGTTGACTTTGACACACCAGAAACAAATTCAGTTACAGT
AAGAGAAAGAGACTCAATGGAACAAGTACGTATTAATTTAGATGAACTTGAAGCATATTTAAAAGCAAAATTTTAA

Upstream 100 bases:

>100_bases
AGTATTTAAAGGTAAAATCATTTATAATTGAAATAGTTTTATGTCAGCCAAATGCTGACTTTTGTTATTTTATATACAAG
ACTATTAAGGAGAAAAAAAT

Downstream 100 bases:

>100_bases
TTTTTAATTTTGAAAGGAAGTGATACTCATGTTAATACCAAAAGAAGTTATTGATGATATTATTGAAAAATCAGACATAG
TTTCAATTGTAAGCGAAAGA

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MEKLIAHLKSQGFIFQGSEIYGGLANSWDYGPLGVEVKNKLKQAWWNHFVRKNPYNIGLDSSIILNSSVWKASGHIDGFN
DPLIDCKKCNSRWRADKLIEEFNSEINAGVMTENQMEEFIREQNIKCPKCQACDFTQIRKFALMFKTNQGVLEDESSSVY
LRPETAQGIFINFKNAQRSLRKKLPFGIGQIGKSFRNEITPGNFIFRTREFEQMELEFFFNPSDEKDWFSYWLNEVETFL
QDKIQINKENYRVRSHEKDELAHYSTATSDIEFKFPFGWGELWGVAHRGNFDLNAHQEASKQDLTYLDPTTNQKVLPHVI
EPSVGVERMMLAILWQAYHEEDLGEGNSRIVMKLPYNLAPYQIAVMPLQKQQNDQAQALYSNLLNNFDVTYDETGNVGKR
YRRQDAIGTPFVITVDFDTPETNSVTVRERDSMEQVRINLDELEAYLKAKF

Sequences:

>Translated_451_residues
MEKLIAHLKSQGFIFQGSEIYGGLANS*DYGPLGVEVKNKLKQA**NHFVRKNPYNIGLDSSIILNSSV*KASGHIDGFN
DPLIDCKKCNSR*RADKLIEEFNSEINAGVMTENQMEEFIREQNIKCPKCQACDFTQIRKFALMFKTNQGVLEDESSSVY
LRPETAQGIFINFKNAQRSLRKKLPFGIGQIGKSFRNEITPGNFIFRTREFEQMELEFFFNPSDEKD*FSY*LNEVETFL
QDKIQINKENYRVRSHEKDELAHYSTATSDIEFKFPFG*GEL*GVAHRGNFDLNAHQEASKQDLTYLDPTTNQKVLPHVI
EPSVGVERMMLAIL*QAYHEEDLGEGNSRIVMKLPYNLAPYQIAVMPLQKQQNDQAQALYSNLLNNFDVTYDETGNVGKR
YRRQDAIGTPFVITVDFDTPETNSVTVRERDSMEQVRINLDELEAYLKAKF
>Mature_451_residues
MEKLIAHLKSQGFIFQGSEIYGGLANS*DYGPLGVEVKNKLKQA**NHFVRKNPYNIGLDSSIILNSSV*KASGHIDGFN
DPLIDCKKCNSR*RADKLIEEFNSEINAGVMTENQMEEFIREQNIKCPKCQACDFTQIRKFALMFKTNQGVLEDESSSVY
LRPETAQGIFINFKNAQRSLRKKLPFGIGQIGKSFRNEITPGNFIFRTREFEQMELEFFFNPSDEKD*FSY*LNEVETFL
QDKIQINKENYRVRSHEKDELAHYSTATSDIEFKFPFG*GEL*GVAHRGNFDLNAHQEASKQDLTYLDPTTNQKVLPHVI
EPSVGVERMMLAIL*QAYHEEDLGEGNSRIVMKLPYNLAPYQIAVMPLQKQQNDQAQALYSNLLNNFDVTYDETGNVGKR
YRRQDAIGTPFVITVDFDTPETNSVTVRERDSMEQVRINLDELEAYLKAKF

Specific function: Catalyzes the attachment of glycine to tRNA(Gly) [H]

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI116805340, Length=394, Percent_Identity=30.4568527918782, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17554996, Length=363, Percent_Identity=30.5785123966942, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32564541, Length=363, Percent_Identity=30.5785123966942, Blast_Score=125, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6325338, Length=366, Percent_Identity=28.9617486338798, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6319597, Length=210, Percent_Identity=31.4285714285714, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24664462, Length=353, Percent_Identity=30.5949008498584, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI21357965, Length=353, Percent_Identity=30.5949008498584, Blast_Score=125, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.14 [H]

Molecular weight: Translated: 50325; Mature: 50325

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50862 AA_TRNA_LIGASE_II ; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLIAHLKSQGFIFQGSEIYGGLANSDYGPLGVEVKNKLKQANHFVRKNPYNIGLDSSI
CHHHHHHHHCCCEEEECCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEE
ILNSSVKASGHIDGFNDPLIDCKKCNSRRADKLIEEFNSEINAGVMTENQMEEFIREQNI
EEECCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCC
KCPKCQACDFTQIRKFALMFKTNQGVLEDESSSVYLRPETAQGIFINFKNAQRSLRKKLP
CCCCCCCCCHHHHHHHHHEEECCCCCEECCCCEEEECCCCCCEEEEEEHHHHHHHHHHCC
FGIGQIGKSFRNEITPGNFIFRTREFEQMELEFFFNPSDEKDFSYLNEVETFLQDKIQIN
CCHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEC
KENYRVRSHEKDELAHYSTATSDIEFKFPFGGELGVAHRGNFDLNAHQEASKQDLTYLDP
CCCCEECCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECC
TTNQKVLPHVIEPSVGVERMMLAILQAYHEEDLGEGNSRIVMKLPYNLAPYQIAVMPLQK
CCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEECCC
QQNDQAQALYSNLLNNFDVTYDETGNVGKRYRRQDAIGTPFVITVDFDTPETNSVTVRER
CCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECC
DSMEQVRINLDELEAYLKAKF
CCHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure
MEKLIAHLKSQGFIFQGSEIYGGLANSDYGPLGVEVKNKLKQANHFVRKNPYNIGLDSSI
CHHHHHHHHCCCEEEECCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEE
ILNSSVKASGHIDGFNDPLIDCKKCNSRRADKLIEEFNSEINAGVMTENQMEEFIREQNI
EEECCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCC
KCPKCQACDFTQIRKFALMFKTNQGVLEDESSSVYLRPETAQGIFINFKNAQRSLRKKLP
CCCCCCCCCHHHHHHHHHEEECCCCCEECCCCEEEECCCCCCEEEEEEHHHHHHHHHHCC
FGIGQIGKSFRNEITPGNFIFRTREFEQMELEFFFNPSDEKDFSYLNEVETFLQDKIQIN
CCHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEC
KENYRVRSHEKDELAHYSTATSDIEFKFPFGGELGVAHRGNFDLNAHQEASKQDLTYLDP
CCCCEECCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECC
TTNQKVLPHVIEPSVGVERMMLAILQAYHEEDLGEGNSRIVMKLPYNLAPYQIAVMPLQK
CCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEECCC
QQNDQAQALYSNLLNNFDVTYDETGNVGKRYRRQDAIGTPFVITVDFDTPETNSVTVRER
CCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECC
DSMEQVRINLDELEAYLKAKF
CCHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA