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The map label for this gene is csd [H]

Identifier: 50365064

GI number: 50365064

Start: 278264

End: 279490

Strand: Direct

Name: csd [H]

Synonym: Mfl248

Alternate gene names: 50365064

Gene position: 278264-279490 (Clockwise)

Preceding gene: 50365060

Following gene: 50365065

Centisome position: 35.08

GC content: 25.84

Gene sequence:

>1227_bases
ATGAAAGACTTAAAAAAATATTTCCCTTTTTATGATAAACAAAGCAATCTAATTTATTTTGATAGCTCAGCTACTAGTCT
TAAAATTAAGAGCGTAATTGATGCTGAAATGAAATTTTTGAGTGAAAATGGTTCAAATCCTCATGCAGTTGATTATAAAA
AAGGATTTGAAGCTTTTGAAATAATTAAAAATGCTAGACAGTTAACTCAAGAATTTATTAATGCTAAAAAAGTAAATGAA
ATAATATTTACAAGTGGAACAACCCATTCAATAAATCTATTAGCAAACGGACTTAAAAAAATAATAAAAAAGGATGATGA
AATTTTGGTTACAGAATTAGAACATTCAGCTAATTTATTGCCATGAATTGCTTTAGCAAATTCTGTTGGTGCAAAAGTTA
AAAAAATTAAGTTAAATGAAGACTTTACAATTGATCATGAATCATTAAAACTACAGTTATCAGATAAAACAAAAATAGTT
TCATTTGCTAGTGTTTATAATACTGTTGGGGCTAAAAATGATGTTAAACTAATTACTAAAGTAATTAAAGAGTTTAATAT
TAATATAATTGTTCATGTTGATGCAGCACAATCAATTGGTCACACAAAAACTGATGTTACGGATTCAAATATTGATTTTA
TGTCTTGATCTTTTCATAAAATGTATGGACCATTTGGTGTTGGTTGTTTATATGGAAAATACGAATTACTTAATCAATTA
GAACCATTGTTTTATGGCGGTGGAATGAGTTTGAAAATTGAAGAAAATTTAATTGATTATTCCTTATCTTCATTACCAGA
AAAATTAGAAGGTGGAACACCAAACATAAGTGCTATTGCAGGGGTTGTTGAATCAATTAAATTTATTAACTTAATAGGTT
TAGATCAAATTGAAGAACATGAAATAACATTAAAAGATTACTTTAAAATTAAAGTTAAAGAAAATAACCTAAATGATCAC
ATAACTTTTTATAATTTAGATACTAAATCACCCATAATACTATTTAATGTTAAAGGTGTAAATCCACAAGATATAACTAA
TTTTTTAGATGAAAAATACAATATTTTAGTGCGTGGCGGTGCTAATTGTGCTAGAAGAATTGAAGGTGTTATTGGAACAA
AAATAGCCATTAGAGCTAGTTTTGGAATCAATAATAATAAAGCTGAAATTGATCAATTTATAGAAGCTTTAAAAGATACA
AATAGTTTCTTAGATGTGCTATTTTAA

Upstream 100 bases:

>100_bases
ATATAAGCATTGATAATATTATAACTCAAAACCCTATAAAATTACCAAACTTTTAATTCTAAAATAGTATAATAACAAAG
ATAGAAAAGTAGGTTTATGG

Downstream 100 bases:

>100_bases
AGGAGAAAAATGATAGATATAAGTGATGATATTTTATTAAGAAAAATTTTAATGAAACATTTTACTGAGCCTGAAAATTT
GGGATTAAAAAATATTACAA

Product: selenocysteine lyase, class V pyridoxal phosphate aminotransferase, cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MKDLKKYFPFYDKQSNLIYFDSSATSLKIKSVIDAEMKFLSENGSNPHAVDYKKGFEAFEIIKNARQLTQEFINAKKVNE
IIFTSGTTHSINLLANGLKKIIKKDDEILVTELEHSANLLPWIALANSVGAKVKKIKLNEDFTIDHESLKLQLSDKTKIV
SFASVYNTVGAKNDVKLITKVIKEFNINIIVHVDAAQSIGHTKTDVTDSNIDFMSWSFHKMYGPFGVGCLYGKYELLNQL
EPLFYGGGMSLKIEENLIDYSLSSLPEKLEGGTPNISAIAGVVESIKFINLIGLDQIEEHEITLKDYFKIKVKENNLNDH
ITFYNLDTKSPIILFNVKGVNPQDITNFLDEKYNILVRGGANCARRIEGVIGTKIAIRASFGINNNKAEIDQFIEALKDT
NSFLDVLF

Sequences:

>Translated_408_residues
MKDLKKYFPFYDKQSNLIYFDSSATSLKIKSVIDAEMKFLSENGSNPHAVDYKKGFEAFEIIKNARQLTQEFINAKKVNE
IIFTSGTTHSINLLANGLKKIIKKDDEILVTELEHSANLLP*IALANSVGAKVKKIKLNEDFTIDHESLKLQLSDKTKIV
SFASVYNTVGAKNDVKLITKVIKEFNINIIVHVDAAQSIGHTKTDVTDSNIDFMS*SFHKMYGPFGVGCLYGKYELLNQL
EPLFYGGGMSLKIEENLIDYSLSSLPEKLEGGTPNISAIAGVVESIKFINLIGLDQIEEHEITLKDYFKIKVKENNLNDH
ITFYNLDTKSPIILFNVKGVNPQDITNFLDEKYNILVRGGANCARRIEGVIGTKIAIRASFGINNNKAEIDQFIEALKDT
NSFLDVLF
>Mature_408_residues
MKDLKKYFPFYDKQSNLIYFDSSATSLKIKSVIDAEMKFLSENGSNPHAVDYKKGFEAFEIIKNARQLTQEFINAKKVNE
IIFTSGTTHSINLLANGLKKIIKKDDEILVTELEHSANLLP*IALANSVGAKVKKIKLNEDFTIDHESLKLQLSDKTKIV
SFASVYNTVGAKNDVKLITKVIKEFNINIIVHVDAAQSIGHTKTDVTDSNIDFMS*SFHKMYGPFGVGCLYGKYELLNQL
EPLFYGGGMSLKIEENLIDYSLSSLPEKLEGGTPNISAIAGVVESIKFINLIGLDQIEEHEITLKDYFKIKVKENNLNDH
ITFYNLDTKSPIILFNVKGVNPQDITNFLDEKYNILVRGGANCARRIEGVIGTKIAIRASFGINNNKAEIDQFIEALKDT
NSFLDVLF

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=245, Percent_Identity=30.6122448979592, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI156713448, Length=439, Percent_Identity=25.0569476082005, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1787970, Length=403, Percent_Identity=31.0173697270471, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1789175, Length=396, Percent_Identity=31.3131313131313, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI48994898, Length=233, Percent_Identity=33.0472103004292, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25143064, Length=247, Percent_Identity=30.7692307692308, Blast_Score=114, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6319831, Length=231, Percent_Identity=34.6320346320346, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI20129463, Length=246, Percent_Identity=32.1138211382114, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45431; Mature: 45431

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDLKKYFPFYDKQSNLIYFDSSATSLKIKSVIDAEMKFLSENGSNPHAVDYKKGFEAFE
CCCHHHHCCCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHCCCCCCCEECHHHCHHHHH
IIKNARQLTQEFINAKKVNEIIFTSGTTHSINLLANGLKKIIKKDDEILVTELEHSANLL
HHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCEE
PIALANSVGAKVKKIKLNEDFTIDHESLKLQLSDKTKIVSFASVYNTVGAKNDVKLITKV
EEEECCCCCCEEEEEEECCCEEEECCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHH
IKEFNINIIVHVDAAQSIGHTKTDVTDSNIDFMSSFHKMYGPFGVGCLYGKYELLNQLEP
HHHCCCEEEEEECCHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
LFYGGGMSLKIEENLIDYSLSSLPEKLEGGTPNISAIAGVVESIKFINLIGLDQIEEHEI
EEECCCEEEEEECHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCE
TLKDYFKIKVKENNLNDHITFYNLDTKSPIILFNVKGVNPQDITNFLDEKYNILVRGGAN
EEEEEEEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCEEEEECCCH
CARRIEGVIGTKIAIRASFGINNNKAEIDQFIEALKDTNSFLDVLF
HHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHCC
>Mature Secondary Structure
MKDLKKYFPFYDKQSNLIYFDSSATSLKIKSVIDAEMKFLSENGSNPHAVDYKKGFEAFE
CCCHHHHCCCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHCCCCCCCEECHHHCHHHHH
IIKNARQLTQEFINAKKVNEIIFTSGTTHSINLLANGLKKIIKKDDEILVTELEHSANLL
HHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCEE
PIALANSVGAKVKKIKLNEDFTIDHESLKLQLSDKTKIVSFASVYNTVGAKNDVKLITKV
EEEECCCCCCEEEEEEECCCEEEECCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHH
IKEFNINIIVHVDAAQSIGHTKTDVTDSNIDFMSSFHKMYGPFGVGCLYGKYELLNQLEP
HHHCCCEEEEEECCHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
LFYGGGMSLKIEENLIDYSLSSLPEKLEGGTPNISAIAGVVESIKFINLIGLDQIEEHEI
EEECCCEEEEEECHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCE
TLKDYFKIKVKENNLNDHITFYNLDTKSPIILFNVKGVNPQDITNFLDEKYNILVRGGAN
EEEEEEEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCEEEEECCCH
CARRIEGVIGTKIAIRASFGINNNKAEIDQFIEALKDTNSFLDVLF
HHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11048724 [H]