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The map label for this gene is trxA [H]

Identifier: 50364994

GI number: 50364994

Start: 208059

End: 208367

Strand: Direct

Name: trxA [H]

Synonym: Mfl178

Alternate gene names: 50364994

Gene position: 208059-208367 (Clockwise)

Preceding gene: 50364993

Following gene: 50364995

Centisome position: 26.23

GC content: 29.13

Gene sequence:

>309_bases
ATGGCAGAAATGATTAAAGTTTCAACAAAAGAAGAATTTGACAAAATTATTAGCGAAGGTAAAACATTTGTTGATTTTAA
CGCTACATGATGTGGACCTTGTAAAATGCAAATGCCTTTAGTACATATGCTTGCACAAAAAACTGAAGGTGTTAAATTTA
TCGACTTAGATGTAGATTTAGTTCCTGAAGTAGCTAAGGAATACCAAGTTATGTCAATTCCAACTTTAATGTTGTTTGAA
AACGGAAAAGAATCTAAAAAAAATGTAGGATTTATGGATCCAACAAAATTAGATAACTTTGTAAAATAA

Upstream 100 bases:

>100_bases
ACAACAATTAAGTTAAATGAATTTAAAAATATGATTACAGATTTAATTTGTAATAAGAAGTAGTTTGATATAAACTATAA
ATACAAAGGAGAAAAAGATT

Downstream 100 bases:

>100_bases
TTCAAAAAGACGCAAGTCTTTTTTTATTTGGAAAATTATCCATCATTTTAGATATAATTAATAAAAATAAAAAAAACAAA
TCAAAACTTTTGGTTTTTTT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 102; Mature: 101

Protein sequence:

>102_residues
MAEMIKVSTKEEFDKIISEGKTFVDFNATWCGPCKMQMPLVHMLAQKTEGVKFIDLDVDLVPEVAKEYQVMSIPTLMLFE
NGKESKKNVGFMDPTKLDNFVK

Sequences:

>Translated_102_residues
MAEMIKVSTKEEFDKIISEGKTFVDFNAT*CGPCKMQMPLVHMLAQKTEGVKFIDLDVDLVPEVAKEYQVMSIPTLMLFE
NGKESKKNVGFMDPTKLDNFVK
>Mature_101_residues
AEMIKVSTKEEFDKIISEGKTFVDFNAT*CGPCKMQMPLVHMLAQKTEGVKFIDLDVDLVPEVAKEYQVMSIPTLMLFEN
GKESKKNVGFMDPTKLDNFVK

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=34.6153846153846, Blast_Score=63, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=83, Percent_Identity=45.7831325301205, Blast_Score=71, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=87, Percent_Identity=39.0804597701149, Blast_Score=67, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=102, Percent_Identity=37.2549019607843, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11421; Mature: 11289

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
7.8 %Met     (Translated Protein)
9.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
6.9 %Met     (Mature Protein)
8.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEMIKVSTKEEFDKIISEGKTFVDFNATCGPCKMQMPLVHMLAQKTEGVKFIDLDVDLV
CCCCEECCCHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCHH
PEVAKEYQVMSIPTLMLFENGKESKKNVGFMDPTKLDNFVK
HHHHHCCCHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AEMIKVSTKEEFDKIISEGKTFVDFNATCGPCKMQMPLVHMLAQKTEGVKFIDLDVDLV
CCCEECCCHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCHH
PEVAKEYQVMSIPTLMLFENGKESKKNVGFMDPTKLDNFVK
HHHHHCCCHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]