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The map label for this gene is hom [H]

Identifier: 49188241

GI number: 49188241

Start: 5137915

End: 5139168

Strand: Reverse

Name: hom [H]

Synonym: BAS5256

Alternate gene names: 49188241

Gene position: 5139168-5137915 (Counterclockwise)

Preceding gene: 49188242

Following gene: 49188239

Centisome position: 98.29

GC content: 38.68

Gene sequence:

>1254_bases
ATGAAAGAAATTCAAGTTGGTTTATTAGGTCTTGGGACGGTTGGTAGCGGTGTAGTTCGTATCATTACAGATCATCAAGA
GCGACTTATACACCAAGTAGGTTGTCCTGTGAAAGTAACGAAAGTACTAGTGCAAAATATTGAAAAAGAGAGAGAAGTAG
AGGTACCCTCTACTCTATTAACACAAGATGCACATGAAATTTTAGATAATCCAAATATTGACGTTGTCATCGAAGTAATG
GGTGGCATTGATGATGCAAAAGCATATATTCTGCAAGCTTTACAAAGTGGGAAGCACGTTGTGACTGCGAATAAAGATTT
AATGGCGTTGCACGGGGCGGAACTACTAGCGGTAGCAAAAGATAATAAAGCAGATTTGTTTTACGAAGCAAGTGTAGCCG
GAGGGATTCCAATTTTACGAAGTATCGTAGAAGGGCTTTCTTCAGATCTTATTACGAAAGTAATGGGAATTGTAAATGGA
ACGACTAATTTTATTTTGACGAAAATGTCAGATGAAGGGAGAGCATATAACGACGTGTTAAAAGAAGCCCAGCAACTTGG
ATTTGCAGAAGCGGATCCAACATCAGATGTAGAAGGTTTAGATGCAGCAAGAAAAATGACAATATTGGCTACCCTTGGTT
TCTCTACAAATGTAGAGCTTGGAGATGTCAAGGTAAAAGGGATTACTTCTATTACAGAGGAAGATATCGAATACAGTAAG
AGTTTAGGGTACACGATTAAACTAATCGGTCTTGCGAAGCGAGATGGTGAAAAATTAGAGGTTACAGTTGAACCGACTTT
ACTTCCAAATACACATCCTCTTGCGGCCGTGCAAAACGAATATAACGCTGTATATGTGTATGGTGAAGCAGTTGGAGAAA
CGATGTTTTATGGACCAGGTGCAGGAAGCTTACCGACAGCAACCGCTGTTGTTTCTGATTTAGTAGCTGTAATGCAAAAC
ATTAGATTAGGAGTAACAGGAAATAGTGCTGTAGTTCCTCAATATCAAAAGGTATTAAAAGAGCCAGATGAAATTGTTGT
ATTTGCAAAAATTACTTCCTTATTCTCTGAGCGTGGTGTTAGCTTTGAAAAGATTATTCAAATGCCGCTTGAAGAGAAAG
GAAAGGCTGAAATTGTCATTGTAACGCACCGTGCGTCTCTTGCTGATTATGATTATATTCTACATACGTTGCAAGGGTAT
GAAGAAATAGATTGTTTGAAAGCAAACTATCGAATTGAAGGGGATGCAAAGTAG

Upstream 100 bases:

>100_bases
GTTAATCTATATTATTCCGAATGTTCTAAAAACATTGTTTTTCAGATTTTTTACTCATATAATTTCATCTAAACACAATT
TTTGAGGGGTGGACAGTATT

Downstream 100 bases:

>100_bases
TATCTCCACTAATAAAGAACCTATTAAGCGGCTTGCTTAATAGGTTCTTTTCTATTTAAACTGTGCGTGCCAACTTGAAT
AAATGCTTGAATAATCCAGC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MKEIQVGLLGLGTVGSGVVRIITDHQERLIHQVGCPVKVTKVLVQNIEKEREVEVPSTLLTQDAHEILDNPNIDVVIEVM
GGIDDAKAYILQALQSGKHVVTANKDLMALHGAELLAVAKDNKADLFYEASVAGGIPILRSIVEGLSSDLITKVMGIVNG
TTNFILTKMSDEGRAYNDVLKEAQQLGFAEADPTSDVEGLDAARKMTILATLGFSTNVELGDVKVKGITSITEEDIEYSK
SLGYTIKLIGLAKRDGEKLEVTVEPTLLPNTHPLAAVQNEYNAVYVYGEAVGETMFYGPGAGSLPTATAVVSDLVAVMQN
IRLGVTGNSAVVPQYQKVLKEPDEIVVFAKITSLFSERGVSFEKIIQMPLEEKGKAEIVIVTHRASLADYDYILHTLQGY
EEIDCLKANYRIEGDAK

Sequences:

>Translated_417_residues
MKEIQVGLLGLGTVGSGVVRIITDHQERLIHQVGCPVKVTKVLVQNIEKEREVEVPSTLLTQDAHEILDNPNIDVVIEVM
GGIDDAKAYILQALQSGKHVVTANKDLMALHGAELLAVAKDNKADLFYEASVAGGIPILRSIVEGLSSDLITKVMGIVNG
TTNFILTKMSDEGRAYNDVLKEAQQLGFAEADPTSDVEGLDAARKMTILATLGFSTNVELGDVKVKGITSITEEDIEYSK
SLGYTIKLIGLAKRDGEKLEVTVEPTLLPNTHPLAAVQNEYNAVYVYGEAVGETMFYGPGAGSLPTATAVVSDLVAVMQN
IRLGVTGNSAVVPQYQKVLKEPDEIVVFAKITSLFSERGVSFEKIIQMPLEEKGKAEIVIVTHRASLADYDYILHTLQGY
EEIDCLKANYRIEGDAK
>Mature_417_residues
MKEIQVGLLGLGTVGSGVVRIITDHQERLIHQVGCPVKVTKVLVQNIEKEREVEVPSTLLTQDAHEILDNPNIDVVIEVM
GGIDDAKAYILQALQSGKHVVTANKDLMALHGAELLAVAKDNKADLFYEASVAGGIPILRSIVEGLSSDLITKVMGIVNG
TTNFILTKMSDEGRAYNDVLKEAQQLGFAEADPTSDVEGLDAARKMTILATLGFSTNVELGDVKVKGITSITEEDIEYSK
SLGYTIKLIGLAKRDGEKLEVTVEPTLLPNTHPLAAVQNEYNAVYVYGEAVGETMFYGPGAGSLPTATAVVSDLVAVMQN
IRLGVTGNSAVVPQYQKVLKEPDEIVVFAKITSLFSERGVSFEKIIQMPLEEKGKAEIVIVTHRASLADYDYILHTLQGY
EEIDCLKANYRIEGDAK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=265, Percent_Identity=25.6603773584906, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790376, Length=370, Percent_Identity=24.5945945945946, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=133, Percent_Identity=31.5789473684211, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45111; Mature: 45111

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIQVGLLGLGTVGSGVVRIITDHQERLIHQVGCPVKVTKVLVQNIEKEREVEVPSTLL
CCCEEEEEEECCCCCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHH
TQDAHEILDNPNIDVVIEVMGGIDDAKAYILQALQSGKHVVTANKDLMALHGAELLAVAK
HHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCEEEECCCEEEEEEC
DNKADLFYEASVAGGIPILRSIVEGLSSDLITKVMGIVNGTTNFILTKMSDEGRAYNDVL
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
KEAQQLGFAEADPTSDVEGLDAARKMTILATLGFSTNVELGDVKVKGITSITEEDIEYSK
HHHHHCCCCCCCCCCCCHHHHHHHEEEEEEEECCCCCCEECCEEEECCCHHHHHHHHHHH
SLGYTIKLIGLAKRDGEKLEVTVEPTLLPNTHPLAAVQNEYNAVYVYGEAVGETMFYGPG
CCCCEEEEEEEECCCCCEEEEEECCEECCCCCCCHHCCCCCCEEEEEECCCCCEEEECCC
AGSLPTATAVVSDLVAVMQNIRLGVTGNSAVVPQYQKVLKEPDEIVVFAKITSLFSERGV
CCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHCCC
SFEKIIQMPLEEKGKAEIVIVTHRASLADYDYILHTLQGYEEIDCLKANYRIEGDAK
CHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCHHHHHEECCEEECCCCC
>Mature Secondary Structure
MKEIQVGLLGLGTVGSGVVRIITDHQERLIHQVGCPVKVTKVLVQNIEKEREVEVPSTLL
CCCEEEEEEECCCCCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHH
TQDAHEILDNPNIDVVIEVMGGIDDAKAYILQALQSGKHVVTANKDLMALHGAELLAVAK
HHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCEEEECCCEEEEEEC
DNKADLFYEASVAGGIPILRSIVEGLSSDLITKVMGIVNGTTNFILTKMSDEGRAYNDVL
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
KEAQQLGFAEADPTSDVEGLDAARKMTILATLGFSTNVELGDVKVKGITSITEEDIEYSK
HHHHHCCCCCCCCCCCCHHHHHHHEEEEEEEECCCCCCEECCEEEECCCHHHHHHHHHHH
SLGYTIKLIGLAKRDGEKLEVTVEPTLLPNTHPLAAVQNEYNAVYVYGEAVGETMFYGPG
CCCCEEEEEEEECCCCCEEEEEECCEECCCCCCCHHCCCCCCEEEEEECCCCCEEEECCC
AGSLPTATAVVSDLVAVMQNIRLGVTGNSAVVPQYQKVLKEPDEIVVFAKITSLFSERGV
CCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHCCC
SFEKIIQMPLEEKGKAEIVIVTHRASLADYDYILHTLQGYEEIDCLKANYRIEGDAK
CHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCHHHHHEECCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]