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The map label for this gene is metA

Identifier: 49188242

GI number: 49188242

Start: 5139310

End: 5140215

Strand: Reverse

Name: metA

Synonym: BAS5257

Alternate gene names: 49188242

Gene position: 5140215-5139310 (Counterclockwise)

Preceding gene: 49188243

Following gene: 49188241

Centisome position: 98.31

GC content: 36.64

Gene sequence:

>906_bases
ATGCCGATCATAATTGATAAAGATTTACCAGCTCGCAAAGTATTGCAGGAGGAAAATATTTTTGTAATGACAAAAGAGCG
AGCAGAAACACAAGATATCCGGGCATTGAAAATTGCTATATTAAATTTAATGCCTACGAAGCAAGAAACAGAAGCGCAAT
TACTTCGTTTAATTGGAAATACACCCTTGCAATTAGATGTTCATTTACTTCATATGGAATCACATTTGTCCCGTAATGTA
GCACAGGAACATTTAACAAGTTTTTATAAAACATTCCGTGATATTGAGAATGAGAAATTTGATGGACTCATTATTACAGG
AGCACCAGTTGAAACCCTTTCTTTTGAAGAGGTAGATTATTGGGAAGAACTTAAACGTATTATGGAGTATTCAAAAACGA
ATGTAACATCTACGCTTCATATTTGCTGGGGAGCACAGGCTGGTTTGTATTATCATTATGGCGTTCCAAAGTATCCTCTT
AAGGAAAAAATGTTTGGTGTATTTGAACATGAAGTCCGTGAGCAACATGTGAAATTGTTACAAGGGTTTGATGAATTGTT
TTTCGCCCCGCATTCTCGTCATACAGAAGTACGAGAGAATGATATTAGAGGAGTGAAAGAATTAACATTGTTAGCAAACT
CTGAAGAGGCAGGTGTTCACCTTGTTATTGGACCGGAAGGAAGGCAAGTGTTTGCGCTTGGGCATAGTGAATATAGTTGT
GATACGTTAAAGCAAGAATACGAACGGGACCGCCAAAAAGGGTTAAATATTGATGTGCCGAAAAACTATTTTAAACATAA
TAATCCAAATGAGAAGCCACTTGTACGGTGGAGGAGCCATGGGAATCTATTATTCTCTAATTGGCTGAATTATTACGTGT
ATCAAGAAACCCCTTATGTATTATAA

Upstream 100 bases:

>100_bases
GCTGGCGTCACATCAGATTTAATTCGTTTATCAGTTGGCATAGAAGATGTTTCTGATATTATTGCAGATTTAGAAGCAGC
GCTAGTCGGAGGCAAACAAC

Downstream 100 bases:

>100_bases
AAAAAGATTGTGTCACACGTGGCAACGTTTTCTTTGTAAAGGTTAATCTATATTATTCCGAATGTTCTAAAAACATTGTT
TTTCAGATTTTTTACTCATA

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MPIIIDKDLPARKVLQEENIFVMTKERAETQDIRALKIAILNLMPTKQETEAQLLRLIGNTPLQLDVHLLHMESHLSRNV
AQEHLTSFYKTFRDIENEKFDGLIITGAPVETLSFEEVDYWEELKRIMEYSKTNVTSTLHICWGAQAGLYYHYGVPKYPL
KEKMFGVFEHEVREQHVKLLQGFDELFFAPHSRHTEVRENDIRGVKELTLLANSEEAGVHLVIGPEGRQVFALGHSEYSC
DTLKQEYERDRQKGLNIDVPKNYFKHNNPNEKPLVRWRSHGNLLFSNWLNYYVYQETPYVL

Sequences:

>Translated_301_residues
MPIIIDKDLPARKVLQEENIFVMTKERAETQDIRALKIAILNLMPTKQETEAQLLRLIGNTPLQLDVHLLHMESHLSRNV
AQEHLTSFYKTFRDIENEKFDGLIITGAPVETLSFEEVDYWEELKRIMEYSKTNVTSTLHICWGAQAGLYYHYGVPKYPL
KEKMFGVFEHEVREQHVKLLQGFDELFFAPHSRHTEVRENDIRGVKELTLLANSEEAGVHLVIGPEGRQVFALGHSEYSC
DTLKQEYERDRQKGLNIDVPKNYFKHNNPNEKPLVRWRSHGNLLFSNWLNYYVYQETPYVL
>Mature_300_residues
PIIIDKDLPARKVLQEENIFVMTKERAETQDIRALKIAILNLMPTKQETEAQLLRLIGNTPLQLDVHLLHMESHLSRNVA
QEHLTSFYKTFRDIENEKFDGLIITGAPVETLSFEEVDYWEELKRIMEYSKTNVTSTLHICWGAQAGLYYHYGVPKYPLK
EKMFGVFEHEVREQHVKLLQGFDELFFAPHSRHTEVRENDIRGVKELTLLANSEEAGVHLVIGPEGRQVFALGHSEYSCD
TLKQEYERDRQKGLNIDVPKNYFKHNNPNEKPLVRWRSHGNLLFSNWLNYYVYQETPYVL

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=301, Percent_Identity=51.8272425249169, Blast_Score=332, Evalue=3e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_BACAA (C3P2G5)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002869618.1
- ProteinModelPortal:   C3P2G5
- SMR:   C3P2G5
- EnsemblBacteria:   EBBACT00000130685
- GeneID:   7852744
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_5682
- GeneTree:   EBGT00050000001387
- ProtClustDB:   PRK05368
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 35272; Mature: 35140

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIIIDKDLPARKVLQEENIFVMTKERAETQDIRALKIAILNLMPTKQETEAQLLRLIGN
CCEEECCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
TPLQLDVHLLHMESHLSRNVAQEHLTSFYKTFRDIENEKFDGLIITGAPVETLSFEEVDY
CCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHH
WEELKRIMEYSKTNVTSTLHICWGAQAGLYYHYGVPKYPLKEKMFGVFEHEVREQHVKLL
HHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
QGFDELFFAPHSRHTEVRENDIRGVKELTLLANSEEAGVHLVIGPEGRQVFALGHSEYSC
HHHHHHHCCCCCCCCCHHHHHHCCHHHHEEEECCCCCCEEEEECCCCCEEEEECCCCCCH
DTLKQEYERDRQKGLNIDVPKNYFKHNNPNEKPLVRWRSHGNLLFSNWLNYYVYQETPYV
HHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEEEECCCCEEEECCCCEEEEECCCCC
L
C
>Mature Secondary Structure 
PIIIDKDLPARKVLQEENIFVMTKERAETQDIRALKIAILNLMPTKQETEAQLLRLIGN
CEEECCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
TPLQLDVHLLHMESHLSRNVAQEHLTSFYKTFRDIENEKFDGLIITGAPVETLSFEEVDY
CCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHH
WEELKRIMEYSKTNVTSTLHICWGAQAGLYYHYGVPKYPLKEKMFGVFEHEVREQHVKLL
HHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
QGFDELFFAPHSRHTEVRENDIRGVKELTLLANSEEAGVHLVIGPEGRQVFALGHSEYSC
HHHHHHHCCCCCCCCCHHHHHHCCHHHHEEEECCCCCCEEEEECCCCCEEEEECCCCCCH
DTLKQEYERDRQKGLNIDVPKNYFKHNNPNEKPLVRWRSHGNLLFSNWLNYYVYQETPYV
HHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEEEECCCCEEEECCCCEEEEECCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA