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The map label for this gene is icd [H]

Identifier: 49187482

GI number: 49187482

Start: 4400714

End: 4402021

Strand: Reverse

Name: icd [H]

Synonym: BAS4487

Alternate gene names: 49187482

Gene position: 4402021-4400714 (Counterclockwise)

Preceding gene: 49187483

Following gene: 49187481

Centisome position: 84.19

GC content: 38.46

Gene sequence:

>1308_bases
ATGGGGGTTATCACATTGACGACAGGTGAAAAAATTACTGTAACTAATGGTGTTATGAATGTACCAAACAATCCGATTAT
TCCATTTATCGAAGGAGATGGAATTGGTCCTGATATTTGGGCAGCTGCATCTCGTGTACTAGAAGCAGCAGTTGAAAAAG
CTTATGATGGTGAGAAGAAAATCGTTTGGAAAGAAGTGCTTGCAGGGGAAAAAGCATTCAACCAAACAGGCGAGTGGTTA
CCAGAAGAAACTTTAAATTTAATTCGTGAATATTTAATCGCGATTAAAGGTCCACTTACAACTCCAGTTGGCGGTGGTAT
TCGTTCTCTAAACGTAGCACTTCGTCAAGAATTAGATTTATATGTATGTCTACGTCCAGTTCGTTATTTTGAAGGTGTTC
CTTCACCTGTAAAACGTCCGGAAGATACTGATATGGTTATTTTCCGTGAAAATACAGAAGACATTTATGCTGGAATTGAA
TATGCGCAAGGATCTCCAGAAGCAGAAAAAGTTCTTGCTTTCTTAAAAGAAGCAATGGGTGTTAATAAAATCCGCTTCCC
AGAAACATCTGGTATTGGTATTAAACCAATCTCAGAAGAAGGGACAAAGCGTCTTGTTCGTGCTGCAATTCAATATGCAA
TTAACGAAAAACGCTCTTCTGTTACATTAGTTCATAAAGGAAACATTATGAAATTCACAGAAGGTGCTTTCAAAAACTGG
GGTTACGAAGTAGCGGAACAAGAATTCGGCGACAAAGTATTTACTTGGGCTGAATATGATCGTATCGTTGAGAAAGATGG
TAAAGATGCAGCGAATAAAGCGATGGCAGACGCTGAAGTGGCTGGAAAAATCATCGTAAAAGATTCTATTGCAGACATCT
TCTTACAACAAATTTTAACTCGTCCACGTGAGTTCGATGTTGTTGCAACAATGAACTTAAACGGAGACTACATCTCTGAT
GCACTTGCTGCACAAGTAGGTGGAATTGGTATTGCACCTGGTGCAAACATTAACTATGTGACTGGACATGCTATCTTTGA
AGCTACGCACGGTACAGCTCCAAAATATGCAGGTTTAGATAAAGTAAACCCATCTTCAGTTCTTCTTTCTGGTGTATTAT
TATTAGAGCACTTAGGATGGAACGAAGCTGCGAAATTAGTAACTGCTTCAGTTGAGAAAACAATTGCTTCAAAAGTAGTA
ACTTATGATTTCGCACGCTTAATGGAAGGTGCAACAGAAGTGAAATGTTCTGAGTTCGCTAATGAACTTATTAAAAACAT
GGATGTAGCGATAATCAAAAACGCATAA

Upstream 100 bases:

>100_bases
GATTTTTTCGGAAAGATGTAATGATTAGAATATTTTAATTTGACTAACGGTTTGAACTGAGGGGTTATTCCCTCAGTTTC
ATACATATGAAATTTCAAAC

Downstream 100 bases:

>100_bases
TTAAAGCGGGGGGTAAATTATGACAATCAAACGCAAGAAAGTTTCAGTCATCGGTGCAGGATTTACAGGAGCAACAACAG
CATTCTTATTAGCACAAAAA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MGVITLTTGEKITVTNGVMNVPNNPIIPFIEGDGIGPDIWAAASRVLEAAVEKAYDGEKKIVWKEVLAGEKAFNQTGEWL
PEETLNLIREYLIAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFEGVPSPVKRPEDTDMVIFRENTEDIYAGIE
YAQGSPEAEKVLAFLKEAMGVNKIRFPETSGIGIKPISEEGTKRLVRAAIQYAINEKRSSVTLVHKGNIMKFTEGAFKNW
GYEVAEQEFGDKVFTWAEYDRIVEKDGKDAANKAMADAEVAGKIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISD
ALAAQVGGIGIAPGANINYVTGHAIFEATHGTAPKYAGLDKVNPSSVLLSGVLLLEHLGWNEAAKLVTASVEKTIASKVV
TYDFARLMEGATEVKCSEFANELIKNMDVAIIKNA

Sequences:

>Translated_435_residues
MGVITLTTGEKITVTNGVMNVPNNPIIPFIEGDGIGPDIWAAASRVLEAAVEKAYDGEKKIVWKEVLAGEKAFNQTGEWL
PEETLNLIREYLIAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFEGVPSPVKRPEDTDMVIFRENTEDIYAGIE
YAQGSPEAEKVLAFLKEAMGVNKIRFPETSGIGIKPISEEGTKRLVRAAIQYAINEKRSSVTLVHKGNIMKFTEGAFKNW
GYEVAEQEFGDKVFTWAEYDRIVEKDGKDAANKAMADAEVAGKIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISD
ALAAQVGGIGIAPGANINYVTGHAIFEATHGTAPKYAGLDKVNPSSVLLSGVLLLEHLGWNEAAKLVTASVEKTIASKVV
TYDFARLMEGATEVKCSEFANELIKNMDVAIIKNA
>Mature_434_residues
GVITLTTGEKITVTNGVMNVPNNPIIPFIEGDGIGPDIWAAASRVLEAAVEKAYDGEKKIVWKEVLAGEKAFNQTGEWLP
EETLNLIREYLIAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFEGVPSPVKRPEDTDMVIFRENTEDIYAGIEY
AQGSPEAEKVLAFLKEAMGVNKIRFPETSGIGIKPISEEGTKRLVRAAIQYAINEKRSSVTLVHKGNIMKFTEGAFKNWG
YEVAEQEFGDKVFTWAEYDRIVEKDGKDAANKAMADAEVAGKIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDA
LAAQVGGIGIAPGANINYVTGHAIFEATHGTAPKYAGLDKVNPSSVLLSGVLLLEHLGWNEAAKLVTASVEKTIASKVVT
YDFARLMEGATEVKCSEFANELIKNMDVAIIKNA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=409, Percent_Identity=33.0073349633252, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI28178821, Length=365, Percent_Identity=27.1232876712329, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI28178816, Length=365, Percent_Identity=27.1232876712329, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI4758582, Length=368, Percent_Identity=27.7173913043478, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI28178838, Length=379, Percent_Identity=27.1767810026385, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1787381, Length=427, Percent_Identity=64.4028103044497, Blast_Score=556, Evalue=1e-160,
Organism=Escherichia coli, GI1788101, Length=396, Percent_Identity=28.5353535353535, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI87081683, Length=412, Percent_Identity=25.4854368932039, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71986051, Length=390, Percent_Identity=31.2820512820513, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI25144293, Length=377, Percent_Identity=28.3819628647215, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17505779, Length=373, Percent_Identity=26.5415549597855, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324709, Length=376, Percent_Identity=31.6489361702128, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322097, Length=376, Percent_Identity=30.3191489361702, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6324291, Length=410, Percent_Identity=28.5365853658537, Blast_Score=132, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24643270, Length=439, Percent_Identity=31.8906605922551, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24643268, Length=402, Percent_Identity=33.0845771144279, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24661184, Length=402, Percent_Identity=32.3383084577114, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI161078639, Length=315, Percent_Identity=28.8888888888889, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161078637, Length=293, Percent_Identity=29.3515358361775, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161078633, Length=293, Percent_Identity=29.3515358361775, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24650122, Length=293, Percent_Identity=29.3515358361775, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161078635, Length=293, Percent_Identity=29.3515358361775, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI281362242, Length=411, Percent_Identity=26.5206812652068, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24648872, Length=411, Percent_Identity=26.5206812652068, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI20130355, Length=393, Percent_Identity=23.1552162849873, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 47457; Mature: 47326

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVITLTTGEKITVTNGVMNVPNNPIIPFIEGDGIGPDIWAAASRVLEAAVEKAYDGEKK
CCEEEEECCCEEEEECCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHH
IVWKEVLAGEKAFNQTGEWLPEETLNLIREYLIAIKGPLTTPVGGGIRSLNVALRQELDL
HHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCH
YVCLRPVRYFEGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAQGSPEAEKVLAFLKEAMG
HHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHCCHHCCCCCHHHHHHHHHHHHHC
VNKIRFPETSGIGIKPISEEGTKRLVRAAIQYAINEKRSSVTLVHKGNIMKFTEGAFKNW
CCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCHHHHC
GYEVAEQEFGDKVFTWAEYDRIVEKDGKDAANKAMADAEVAGKIIVKDSIADIFLQQILT
CHHHHHHHCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHC
RPREFDVVATMNLNGDYISDALAAQVGGIGIAPGANINYVTGHAIFEATHGTAPKYAGLD
CCCCEEEEEEEECCCHHHHHHHHHHHCCEEECCCCCCEEEECCEEEEECCCCCCCCCCCC
KVNPSSVLLSGVLLLEHLGWNEAAKLVTASVEKTIASKVVTYDFARLMEGATEVKCSEFA
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
NELIKNMDVAIIKNA
HHHHHCCCEEEEECC
>Mature Secondary Structure 
GVITLTTGEKITVTNGVMNVPNNPIIPFIEGDGIGPDIWAAASRVLEAAVEKAYDGEKK
CEEEEECCCEEEEECCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHH
IVWKEVLAGEKAFNQTGEWLPEETLNLIREYLIAIKGPLTTPVGGGIRSLNVALRQELDL
HHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCH
YVCLRPVRYFEGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAQGSPEAEKVLAFLKEAMG
HHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHCCHHCCCCCHHHHHHHHHHHHHC
VNKIRFPETSGIGIKPISEEGTKRLVRAAIQYAINEKRSSVTLVHKGNIMKFTEGAFKNW
CCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCHHHHC
GYEVAEQEFGDKVFTWAEYDRIVEKDGKDAANKAMADAEVAGKIIVKDSIADIFLQQILT
CHHHHHHHCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHC
RPREFDVVATMNLNGDYISDALAAQVGGIGIAPGANINYVTGHAIFEATHGTAPKYAGLD
CCCCEEEEEEEECCCHHHHHHHHHHHCCEEECCCCCCEEEECCEEEEECCCCCCCCCCCC
KVNPSSVLLSGVLLLEHLGWNEAAKLVTASVEKTIASKVVTYDFARLMEGATEVKCSEFA
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
NELIKNMDVAIIKNA
HHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045898; 9387221; 9384377; 11751849; 11290745 [H]