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The map label for this gene is fhuB [H]

Identifier: 49187420

GI number: 49187420

Start: 4334898

End: 4336934

Strand: Direct

Name: fhuB [H]

Synonym: BAS4425

Alternate gene names: 49187420

Gene position: 4334898-4336934 (Clockwise)

Preceding gene: 49187419

Following gene: 49187421

Centisome position: 82.91

GC content: 40.16

Gene sequence:

>2037_bases
ATGAATAACTTACAACATACACTTCGAGCAAGTCTTGTATTCGGAGGAGGAGGAGCTCTCTTGCTCCTCCTTTTCTTTAT
TCATATCGGACAAGGTCAAGCAAACATTTCCTATAGTATGATTATTGATGCTCTTATCTCACCGAACCAATCGCTAGAAC
ACCAAACTTTAATTATGCTTCGATTACCTAGAGCTGTAATCGCCATTTTAGCTGGCGGTGCTCTTGCTGCATCTGGGGTC
ATTTTACAAACGTTAACAAAAAATCCACTTGCTGAATCCAGTACAATGGGTATTCACTCTGGTGCATATTTCTTTCTAGT
AGCGGCTACAATTTTCTTACCGAAAGGTCTGCAAATTAACTCACTTCTTTTCACATTTATCGGTGGTGCTATTACTGCTT
TATTTGTATACCGTATTTCTGGTGAAAAAAAGGGAACCCCACTTAGAATGGCACTAGCTGGTATGGTCGTTACATTAATG
CTTTCTGCCTTTACTGGAACGATGCAACTTTTCTATGAAAATGAAACAGCTGGTTTATTTTTATGGGGAGCTGGCTCTCT
TATTCAAAATAACTGGGATGGCGTTCAATTTTCTTTTCCATTTATCATTATTTCTTTCCTAGTTTTACTTGGCATATCTC
GCAAACTCAACATTCTCTTACTTGGTGATGATGTTGCGGTTTCTCTTGGCGAAAAAACAGCAGTAACACGTCTTATCGCC
TTCATTGCTGCAATCTTTTTAACAGCAGTCATTGTTACTGTCGTTGGACCAATTGGTTTTGTCGGCTTAGTTGCACCTCA
TTTAATGCGCCTGATAGGATACCGTCAACACTTTACTCTTCTTCTCTCTTCTTTCTTATGGGGAGCAGTATTATTACTTG
GAGCAGATGTTGCTGGTAGACTAATAGATCCAACCGGTGCCGAACTTCCTGTTGGGGCAGTCACGGCAATGATTGGATCG
CCTTGGCTTATTTACTTAGTGTATCGGATGATGAAGTCAAAACAATATATGAATGATAACGGTGCGAATACAGCTGGAGC
TAGTTCCCGCTATTACTCTTATAAAAAGGTAATCATTATATCTATCACACTCTGTATTGTGACAATTGCTCTTGGTGTTA
CAATCGGTAGTAACGCTTATATCGAAAGCATTACAAATGTTATATCAGGCCAATTAACACAATTTGATAAAAACATGATG
ATGAACCTTCGTTTACCAAGAATGCTCGTTGCTGCTATCGCTGGTGCATGCCTTGCAATAAGCGGGCTTGTTTTCCAAGG
TATATTACGAAACCCACTCGCAGATCCTTCTATTATCGGGATTTCATCAGGAGCTGGTGTTGGTGCTTTAACTATTATGT
ATGTCTTTCCTACACTTCCTGGTTTCTTCCTACCTATTGGTGCATTTATCGGGGGACTACTTGCAGTTGGAATTGTCCTC
TTCTTCTCATGGAAATCAGGATTCAGCCCAACAGCTCTTGCTTTAATAGGAATCGGTATTTCAGCTCTTGGCTCAGCGAT
TATTCAAATCTTTATCGTTAAAGCAAATTTGAACGTTGCTGCTGCTTTAACATGGCTATCAGGTAGTACGTATGCAAGAG
GATGGAATCACTTAGAAAATATCATTCTATATCCATCGCTAATTCTTGTATTGATTATCTTTTTCTTAATAAAACAACTT
GACGTTCTCGTACTTGGAGATGATTTAGCAACAGGACTCGGGCAACCAGTAAATAAAACGCGCCTTGCCCTCATTGTGTT
AGCAACACTACTTGCATCTGTAAATATCGCAGCTGTCGGTACAATTGCCTTTCTAGGCCTTGTCGCACCACACTTAGCGC
GAATTGTTGTTGGAATGAATCACCAAAGACTATTCGTTTGTTCTGCACTGTTTGGAGCAATCCTTCTTTCCATCGCTGAC
TTACTCGGACGAACAATTGCATACCCGAAAGAAATCCCTTCAGGTCTTGTAGTTGCTGTACTTGGCGCACCTTATTTCTT
ATGGCTAATGAGAAAGAGTGGGAAGAAGGTTAATTAA

Upstream 100 bases:

>100_bases
AAATTAAAAGGCGACACTTGGATTTTCGGTGGTCCTGAGTCTGCAACATCTTTAGCAACACAAGTAGCAGATGTAATGAC
AGCGAAGAAGTGATTACACG

Downstream 100 bases:

>100_bases
AAAAGAGGCTTCTTATGTGAGAAGCCTCTTTTTTCATTCATTCTCATAAGCCCGAAGGAAACTATCTTTTTTTCACGAAT
TTAACCTATGAACATAACTA

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 678; Mature: 678

Protein sequence:

>678_residues
MNNLQHTLRASLVFGGGGALLLLLFFIHIGQGQANISYSMIIDALISPNQSLEHQTLIMLRLPRAVIAILAGGALAASGV
ILQTLTKNPLAESSTMGIHSGAYFFLVAATIFLPKGLQINSLLFTFIGGAITALFVYRISGEKKGTPLRMALAGMVVTLM
LSAFTGTMQLFYENETAGLFLWGAGSLIQNNWDGVQFSFPFIIISFLVLLGISRKLNILLLGDDVAVSLGEKTAVTRLIA
FIAAIFLTAVIVTVVGPIGFVGLVAPHLMRLIGYRQHFTLLLSSFLWGAVLLLGADVAGRLIDPTGAELPVGAVTAMIGS
PWLIYLVYRMMKSKQYMNDNGANTAGASSRYYSYKKVIIISITLCIVTIALGVTIGSNAYIESITNVISGQLTQFDKNMM
MNLRLPRMLVAAIAGACLAISGLVFQGILRNPLADPSIIGISSGAGVGALTIMYVFPTLPGFFLPIGAFIGGLLAVGIVL
FFSWKSGFSPTALALIGIGISALGSAIIQIFIVKANLNVAAALTWLSGSTYARGWNHLENIILYPSLILVLIIFFLIKQL
DVLVLGDDLATGLGQPVNKTRLALIVLATLLASVNIAAVGTIAFLGLVAPHLARIVVGMNHQRLFVCSALFGAILLSIAD
LLGRTIAYPKEIPSGLVVAVLGAPYFLWLMRKSGKKVN

Sequences:

>Translated_678_residues
MNNLQHTLRASLVFGGGGALLLLLFFIHIGQGQANISYSMIIDALISPNQSLEHQTLIMLRLPRAVIAILAGGALAASGV
ILQTLTKNPLAESSTMGIHSGAYFFLVAATIFLPKGLQINSLLFTFIGGAITALFVYRISGEKKGTPLRMALAGMVVTLM
LSAFTGTMQLFYENETAGLFLWGAGSLIQNNWDGVQFSFPFIIISFLVLLGISRKLNILLLGDDVAVSLGEKTAVTRLIA
FIAAIFLTAVIVTVVGPIGFVGLVAPHLMRLIGYRQHFTLLLSSFLWGAVLLLGADVAGRLIDPTGAELPVGAVTAMIGS
PWLIYLVYRMMKSKQYMNDNGANTAGASSRYYSYKKVIIISITLCIVTIALGVTIGSNAYIESITNVISGQLTQFDKNMM
MNLRLPRMLVAAIAGACLAISGLVFQGILRNPLADPSIIGISSGAGVGALTIMYVFPTLPGFFLPIGAFIGGLLAVGIVL
FFSWKSGFSPTALALIGIGISALGSAIIQIFIVKANLNVAAALTWLSGSTYARGWNHLENIILYPSLILVLIIFFLIKQL
DVLVLGDDLATGLGQPVNKTRLALIVLATLLASVNIAAVGTIAFLGLVAPHLARIVVGMNHQRLFVCSALFGAILLSIAD
LLGRTIAYPKEIPSGLVVAVLGAPYFLWLMRKSGKKVN
>Mature_678_residues
MNNLQHTLRASLVFGGGGALLLLLFFIHIGQGQANISYSMIIDALISPNQSLEHQTLIMLRLPRAVIAILAGGALAASGV
ILQTLTKNPLAESSTMGIHSGAYFFLVAATIFLPKGLQINSLLFTFIGGAITALFVYRISGEKKGTPLRMALAGMVVTLM
LSAFTGTMQLFYENETAGLFLWGAGSLIQNNWDGVQFSFPFIIISFLVLLGISRKLNILLLGDDVAVSLGEKTAVTRLIA
FIAAIFLTAVIVTVVGPIGFVGLVAPHLMRLIGYRQHFTLLLSSFLWGAVLLLGADVAGRLIDPTGAELPVGAVTAMIGS
PWLIYLVYRMMKSKQYMNDNGANTAGASSRYYSYKKVIIISITLCIVTIALGVTIGSNAYIESITNVISGQLTQFDKNMM
MNLRLPRMLVAAIAGACLAISGLVFQGILRNPLADPSIIGISSGAGVGALTIMYVFPTLPGFFLPIGAFIGGLLAVGIVL
FFSWKSGFSPTALALIGIGISALGSAIIQIFIVKANLNVAAALTWLSGSTYARGWNHLENIILYPSLILVLIIFFLIKQL
DVLVLGDDLATGLGQPVNKTRLALIVLATLLASVNIAAVGTIAFLGLVAPHLARIVVGMNHQRLFVCSALFGAILLSIAD
LLGRTIAYPKEIPSGLVVAVLGAPYFLWLMRKSGKKVN

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=647, Percent_Identity=31.2210200927357, Blast_Score=249, Evalue=6e-67,
Organism=Escherichia coli, GI1790740, Length=274, Percent_Identity=40.5109489051095, Blast_Score=180, Evalue=3e-46,
Organism=Escherichia coli, GI1790741, Length=298, Percent_Identity=32.8859060402685, Blast_Score=136, Evalue=5e-33,
Organism=Escherichia coli, GI1786805, Length=305, Percent_Identity=34.4262295081967, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786804, Length=332, Percent_Identity=32.2289156626506, Blast_Score=119, Evalue=9e-28,
Organism=Escherichia coli, GI1788004, Length=276, Percent_Identity=32.9710144927536, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 72026; Mature: 72026

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLQHTLRASLVFGGGGALLLLLFFIHIGQGQANISYSMIIDALISPNQSLEHQTLIML
CCCHHHHHHHHEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHH
RLPRAVIAILAGGALAASGVILQTLTKNPLAESSTMGIHSGAYFFLVAATIFLPKGLQIN
HHHHHHHHHHHCCHHHHCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHH
SLLFTFIGGAITALFVYRISGEKKGTPLRMALAGMVVTLMLSAFTGTMQLFYENETAGLF
HHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEE
LWGAGSLIQNNWDGVQFSFPFIIISFLVLLGISRKLNILLLGDDVAVSLGEKTAVTRLIA
EEECCHHHHCCCCCEEEEHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCHHHHHHHHH
FIAAIFLTAVIVTVVGPIGFVGLVAPHLMRLIGYRQHFTLLLSSFLWGAVLLLGADVAGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
LIDPTGAELPVGAVTAMIGSPWLIYLVYRMMKSKQYMNDNGANTAGASSRYYSYKKVIII
CCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
SITLCIVTIALGVTIGSNAYIESITNVISGQLTQFDKNMMMNLRLPRMLVAAIAGACLAI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
SGLVFQGILRNPLADPSIIGISSGAGVGALTIMYVFPTLPGFFLPIGAFIGGLLAVGIVL
HHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FFSWKSGFSPTALALIGIGISALGSAIIQIFIVKANLNVAAALTWLSGSTYARGWNHLEN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEEECCCCCHHCCHHHHHH
IILYPSLILVLIIFFLIKQLDVLVLGDDLATGLGQPVNKTRLALIVLATLLASVNIAAVG
HHHHHHHHHHHHHHHHHHHCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
TIAFLGLVAPHLARIVVGMNHQRLFVCSALFGAILLSIADLLGRTIAYPKEIPSGLVVAV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHH
LGAPYFLWLMRKSGKKVN
HHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNNLQHTLRASLVFGGGGALLLLLFFIHIGQGQANISYSMIIDALISPNQSLEHQTLIML
CCCHHHHHHHHEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHH
RLPRAVIAILAGGALAASGVILQTLTKNPLAESSTMGIHSGAYFFLVAATIFLPKGLQIN
HHHHHHHHHHHCCHHHHCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHH
SLLFTFIGGAITALFVYRISGEKKGTPLRMALAGMVVTLMLSAFTGTMQLFYENETAGLF
HHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEE
LWGAGSLIQNNWDGVQFSFPFIIISFLVLLGISRKLNILLLGDDVAVSLGEKTAVTRLIA
EEECCHHHHCCCCCEEEEHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCHHHHHHHHH
FIAAIFLTAVIVTVVGPIGFVGLVAPHLMRLIGYRQHFTLLLSSFLWGAVLLLGADVAGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
LIDPTGAELPVGAVTAMIGSPWLIYLVYRMMKSKQYMNDNGANTAGASSRYYSYKKVIII
CCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
SITLCIVTIALGVTIGSNAYIESITNVISGQLTQFDKNMMMNLRLPRMLVAAIAGACLAI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
SGLVFQGILRNPLADPSIIGISSGAGVGALTIMYVFPTLPGFFLPIGAFIGGLLAVGIVL
HHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FFSWKSGFSPTALALIGIGISALGSAIIQIFIVKANLNVAAALTWLSGSTYARGWNHLEN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEEECCCCCHHCCHHHHHH
IILYPSLILVLIIFFLIKQLDVLVLGDDLATGLGQPVNKTRLALIVLATLLASVNIAAVG
HHHHHHHHHHHHHHHHHHHCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
TIAFLGLVAPHLARIVVGMNHQRLFVCSALFGAILLSIADLLGRTIAYPKEIPSGLVVAV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHH
LGAPYFLWLMRKSGKKVN
HHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]