Definition Bacillus anthracis str. Sterne chromosome, complete genome.
Accession NC_005945
Length 5,228,663

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The map label for this gene is mccB [H]

Identifier: 49187264

GI number: 49187264

Start: 4179697

End: 4180830

Strand: Reverse

Name: mccB [H]

Synonym: BAS4268

Alternate gene names: 49187264

Gene position: 4180830-4179697 (Counterclockwise)

Preceding gene: 49187265

Following gene: 49187263

Centisome position: 79.96

GC content: 36.77

Gene sequence:

>1134_bases
ATGAGAGCAAAGACAAAGTTAATTCATGGTATTCGCATAGGAGAACCTTCAACTGGATCTGTAAATGTACCGATTTATCA
AACGAGTACGTACAAACAAGAAGCAGTTGGTAAGCATCAAGGATATGAATATTCACGTACAGGAAACCCAACACGTGCAG
CTTTAGAAGAAATGATTGCTGTATTAGAAAACGGTCATGCTGGTTTTGCATTTGGCTCAGGAATGGCGGCTATTACAGCT
ACGATTATGTTGTTCTCAAAAGGTGACCACGTTATTTTAACAGATGATGTGTATGGTGGAACGTACCGCGTGATTACGAA
AGTATTAAACCGCTTCGGTATTGAGCATACATTTGTAGATACAACAAACTTAGAGGAAGTCGAAGAAGCGATTCGTCCAA
ATACGAAAGCAATTTATGTAGAAACACCAACGAATCCATTACTAAAAATTACTGATATTAAAAAAATATCTACTCTTGCT
AAAGAGAAAGGTTTATTAACAATTATTGATAACACATTCATGACGCCATATTGGCAGTCGCCGATCTCTTTAGGAGCAGA
TATTGTACTTCATAGTGCAACGAAATATTTAGGAGGTCATAGTGACGTAGTTGCAGGTTTAGTAGTTGTAAATAGCCCGC
AATTAGCAGAAGACCTTCACTTTGTACAAAACTCAACAGGAGGTATTCTTGGCCCGCAAGATAGCTTCTTACTACTTCGT
GGTTTAAAAACATTAGGAATTCGAATGGAAGAGCATGAAACGAATTCACGCGCAATTGCTGAGTTTTTAAATAATCATCC
AAAAGTAAATAAAGTATATTACCCAGGTCTTGCATCACATCAAAACCATGAATTAGCAACAGAACAAGCAAATGGATTTG
GTGCTATTATCTCATTTGATGTAGATAGCGAAGAAACATTAAATAAAGTACTTGAGAGATTACAATACTTTACACTAGCG
GAAAGTTTAGGAGCAGTAGAAAGTTTAATTTCTATCCCATCTCAAATGACACATGCATCAATCCCAGCAGATCGTCGCAA
AGAACTAGGAATTACAGATACATTAATTCGAATTTCTGTCGGTATTGAAGACGGAGAAGATTTAATTGAAGATTTAGCAC
AAGCGTTAGCATAG

Upstream 100 bases:

>100_bases
AGCAGAGAAAGCGGCGCCAGGTACAAATATTGTAACGATTTTTCCTGATAGTAGTGAGCGCTATTTAAGTAAAGACATAT
ACAAAGGATGGGAATAAAAA

Downstream 100 bases:

>100_bases
TAAAAATGCACTGCTAGTATAGGCAGTGCATTTTTATTACATTATTTTGTGAAACAATTCACAAAATAGACAAACACAAA
TGAAATAAATTCATGTATAT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MRAKTKLIHGIRIGEPSTGSVNVPIYQTSTYKQEAVGKHQGYEYSRTGNPTRAALEEMIAVLENGHAGFAFGSGMAAITA
TIMLFSKGDHVILTDDVYGGTYRVITKVLNRFGIEHTFVDTTNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTLA
KEKGLLTIIDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPQLAEDLHFVQNSTGGILGPQDSFLLLR
GLKTLGIRMEEHETNSRAIAEFLNNHPKVNKVYYPGLASHQNHELATEQANGFGAIISFDVDSEETLNKVLERLQYFTLA
ESLGAVESLISIPSQMTHASIPADRRKELGITDTLIRISVGIEDGEDLIEDLAQALA

Sequences:

>Translated_377_residues
MRAKTKLIHGIRIGEPSTGSVNVPIYQTSTYKQEAVGKHQGYEYSRTGNPTRAALEEMIAVLENGHAGFAFGSGMAAITA
TIMLFSKGDHVILTDDVYGGTYRVITKVLNRFGIEHTFVDTTNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTLA
KEKGLLTIIDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPQLAEDLHFVQNSTGGILGPQDSFLLLR
GLKTLGIRMEEHETNSRAIAEFLNNHPKVNKVYYPGLASHQNHELATEQANGFGAIISFDVDSEETLNKVLERLQYFTLA
ESLGAVESLISIPSQMTHASIPADRRKELGITDTLIRISVGIEDGEDLIEDLAQALA
>Mature_377_residues
MRAKTKLIHGIRIGEPSTGSVNVPIYQTSTYKQEAVGKHQGYEYSRTGNPTRAALEEMIAVLENGHAGFAFGSGMAAITA
TIMLFSKGDHVILTDDVYGGTYRVITKVLNRFGIEHTFVDTTNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTLA
KEKGLLTIIDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPQLAEDLHFVQNSTGGILGPQDSFLLLR
GLKTLGIRMEEHETNSRAIAEFLNNHPKVNKVYYPGLASHQNHELATEQANGFGAIISFDVDSEETLNKVLERLQYFTLA
ESLGAVESLISIPSQMTHASIPADRRKELGITDTLIRISVGIEDGEDLIEDLAQALA

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=355, Percent_Identity=49.2957746478873, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI299473759, Length=355, Percent_Identity=45.0704225352113, Blast_Score=288, Evalue=8e-78,
Organism=Homo sapiens, GI25453487, Length=354, Percent_Identity=44.3502824858757, Blast_Score=273, Evalue=2e-73,
Organism=Escherichia coli, GI1790375, Length=356, Percent_Identity=46.0674157303371, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1789383, Length=392, Percent_Identity=30.1020408163265, Blast_Score=179, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17560056, Length=369, Percent_Identity=48.2384823848238, Blast_Score=343, Evalue=8e-95,
Organism=Caenorhabditis elegans, GI17538055, Length=375, Percent_Identity=48, Blast_Score=335, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI71980708, Length=367, Percent_Identity=42.7792915531335, Blast_Score=277, Evalue=6e-75,
Organism=Saccharomyces cerevisiae, GI6319307, Length=367, Percent_Identity=44.6866485013624, Blast_Score=308, Evalue=7e-85,
Organism=Saccharomyces cerevisiae, GI6321254, Length=383, Percent_Identity=35.509138381201, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6323333, Length=419, Percent_Identity=36.0381861575179, Blast_Score=195, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6321170, Length=315, Percent_Identity=31.4285714285714, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6321904, Length=343, Percent_Identity=34.1107871720117, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322970, Length=309, Percent_Identity=27.1844660194175, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323557, Length=337, Percent_Identity=24.6290801186944, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322590, Length=304, Percent_Identity=24.3421052631579, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922554, Length=376, Percent_Identity=48.1382978723404, Blast_Score=370, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 41188; Mature: 41188

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAKTKLIHGIRIGEPSTGSVNVPIYQTSTYKQEAVGKHQGYEYSRTGNPTRAALEEMIA
CCCCHHEHEEEECCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
VLENGHAGFAFGSGMAAITATIMLFSKGDHVILTDDVYGGTYRVITKVLNRFGIEHTFVD
HHHCCCCCEEECCCHHHHHHHHHEEECCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEC
TTNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTLAKEKGLLTIIDNTFMTPYWQS
CCCHHHHHHHHCCCCEEEEEECCCCCCEEEECHHHHHHHHHHCCEEEEECCCCCCCCCCC
PISLGADIVLHSATKYLGGHSDVVAGLVVVNSPQLAEDLHFVQNSTGGILGPQDSFLLLR
HHHCCHHHHHHHHHHHHCCCHHHHEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHH
GLKTLGIRMEEHETNSRAIAEFLNNHPKVNKVYYPGLASHQNHELATEQANGFGAIISFD
HHHHHCCEEECCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHCCCCCEEEEEEC
VDSEETLNKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDTLIRISV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHCCCCEEEEEEEE
GIEDGEDLIEDLAQALA
CCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MRAKTKLIHGIRIGEPSTGSVNVPIYQTSTYKQEAVGKHQGYEYSRTGNPTRAALEEMIA
CCCCHHEHEEEECCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
VLENGHAGFAFGSGMAAITATIMLFSKGDHVILTDDVYGGTYRVITKVLNRFGIEHTFVD
HHHCCCCCEEECCCHHHHHHHHHEEECCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEC
TTNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTLAKEKGLLTIIDNTFMTPYWQS
CCCHHHHHHHHCCCCEEEEEECCCCCCEEEECHHHHHHHHHHCCEEEEECCCCCCCCCCC
PISLGADIVLHSATKYLGGHSDVVAGLVVVNSPQLAEDLHFVQNSTGGILGPQDSFLLLR
HHHCCHHHHHHHHHHHHCCCHHHHEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHH
GLKTLGIRMEEHETNSRAIAEFLNNHPKVNKVYYPGLASHQNHELATEQANGFGAIISFD
HHHHHCCEEECCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHCCCCCEEEEEEC
VDSEETLNKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDTLIRISV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHCCCCEEEEEEEE
GIEDGEDLIEDLAQALA
CCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]