Definition | Bacillus anthracis str. Sterne chromosome, complete genome. |
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Accession | NC_005945 |
Length | 5,228,663 |
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The map label for this gene is adhE [H]
Identifier: 49187263
GI number: 49187263
Start: 4176834
End: 4179437
Strand: Reverse
Name: adhE [H]
Synonym: BAS4267
Alternate gene names: 49187263
Gene position: 4179437-4176834 (Counterclockwise)
Preceding gene: 49187264
Following gene: 49187262
Centisome position: 79.93
GC content: 37.63
Gene sequence:
>2604_bases ATGGTAGTCAAAGAGAAAGTTGTAAATGAAATGCAGGAAGTAAAAGAGATGATTGATACGTTAGTGAATAACGGTCGGAA GGCTTTACAAGCATTAGAAAGTTTTACACAAGAGCAAATTGACAACATTGTTCATGAAATGGCATTAGCAGGTGTTGATC AACATATGCCTCTTGCGAAGTTGGCTGTTGAAGAAACAGGTCGTGGTGTATACGAAGATAAATGCATTAAAAATATTTTT GCTACTGAATATATTTGGCATAGCATAAAGAAAGATAAAACAGTAGGGATTATTCACGAAGACCCTCATGAAGAAATAAT AGAAATTGCGGAGCCCGTCGGTGTAGTAGCTGGGGTAACACCAGTAACGAATCCAACATCGACAACAATGTTTAAAGCAT TAATAGCGATAAAAACGAGAAATCCAATTATTTTCGCATTTCATCCTTCAGCACAAAACTGTTCTGTTGCAGCCGCGAAA ACAGTATACGATGCAGCGGTGAAGGCGGGGGCACCAAAACATTGTATTCAGTGGATTGAAAAGCCTTCTGTCGAAGCAAC GAAACAATTAATGAACCATGAAGGTGTTGCGCTTGTTTTAGCAACTGGAGGGGCTGGTATGGTGAAATCAGCTTATTCTA CTGGAAAACCAGCGCTAGGTGTAGGTCCTGGTAATGTACCATGTTATATAGAGAAATCAGCGCATATAAAACGAGCGGTT AATGATTTGATTTTATCAAAAACGTTTGATAACGGGATGATTTGTGCATCAGAACAAGCAATCATTGTAGACAAGGAAAT TTATGATGATGTGAAAACAGAAATGATTACAAATGATTGTTACTTTGTAACAGAGGAAGAGAGAAGAAAATTAGAAAAGC TTGTTATTAATGAAAATACATGTGCAGTAAATAGTGATATTGTAGGGAAATCTGCACAGTATATTGCCGAATTAGTTGGA ATTACTGTACCTAAAAATACAAAAATGCTTGTAGCTGAAATACAAGGCATCGGAGCCGCATATCCACTATCTCGTGAGAA GTTAAGTCCAGTATTAGCTTGTGTAAAAGCAAATTCATTAGAAGAAGGATTTACATATTGTGAAGAAATGTTAAACCTCG GTGGCTTAGGGCATTCAGCAGTTATCCATTCTGTAAATAAAGAAGTGCAAAAGCAATTTGGATTACGTATGAAAGCTTGC CGCCTTATTGTAAATGCTCCTTCATCACAAGGTGGAATCGGTGACATATATAATGGATTTATTCCATCACTTACGCTTGG CTGCGGTTCCTACGGGAAAAACTCGGTTTCTCAAAACGTAACAGCGACGCACTTATTAAATATAAAAAGGTTGGCAAATA GAAAAAAGAATATGCAGTGGTTCAAATTACCACCAAAAATTTATTTTGAAAAACATGCGACAGCATATTTAGCAAATATG CCTAACATTTCACGTGCGTTTATTGTAACGGATCCAGGAATGGTTGAGCATGGATATGTAGATACGGTCGCGCATTATTT ACGTAAACATGCAAATGATGTGAAAGTAGAAGTTTTCTTTGAGGTTGAGCCAGATCCATCAGATGAAACTGTTTTTAAAG GTGCGGAAATGATGAGAAGTTTTCAGCCTGATGTCATCATCGCACTTGGTGGTGGTTCAGCGATGGATGCAGCGAAAGGG ATGTGGCTTTTCTATGAGTACCCAGAAACAACATTCTATGGAATTAAACAGAAGTTTTTAGATATAAGAAAACGTACATG TAAATATCCGGAATTAGGAAGTAAGGCGCAGTTTGTTGCCATTCCAACAACATCTGGAACAGGATCAGAAGTGACACCAT TTGCGGTTATTACAGATAAGAAAAATAATATAAAGTATCCACTTGCCGATTATGAATTAACGCCAGATGTAGCAATTGTT GATCCGCAATTTGTAATGACAGTACCACCACATGTAACAGCAGATACTGGGATGGACGTATTAACGCATGCAATCGAGGC ATATGTGTCTGTTTTAGCAAATGATTATACAGATGGATTAGCATTAAAGGCCATTGATCTCGTATTTAAATATTTACCAA GAGCATTTAAAGATGGACATGATGAAGAAGCACGAGAAAAAATGCATAATGCTTCTGCAATTGCAGGGATGGCATTTGCA AATGCATTCCTAGGTATTAATCACAGTTTAGCGCATAAAATTGGACCAGAATTCCATATTCCGCATGGACGTGCGAATGC AATTCTTATGCCGCACGTAATTCGTTATAATGCTATTAAGCCAAGAAAACATGCATTGTTCCCAAAATATGAGCACTTTG TGGCTGATGAACGCTATGCACATATTGCGAGAATGCTCGGGCTACCAGCAAGTTCGGTGGCAGAAGGTGTAGAATCACTC GACAAAGCAATTATTGATCTCGGAAAAAGTTTAAATATAAATATGAGTATTGCGGGACAAGGAGTTGCTAAAGACCAATT TGAAGAGGTTGTTGGATTATTAGCAGAAAGAGCTTTTGAAGATCAATGTACAACAGCTAATCCGAAATTACCTCTCATTT CAGAGCTGAAAGAAATTTATATGAAAGCATATAAAGGTGAGTAA
Upstream 100 bases:
>100_bases TCATGTAGGAAAGCAATTCTATTTTTTTTGCGCTAATCGGGACTGATTATGACCTATAGGGTCTTATTTAGTCCAAGATA GCAGAATAGGAGGAATTTAC
Downstream 100 bases:
>100_bases TGGTTATGAAAGAGTCGCAGTAAAGCGGCTCTTTTTCTTTTGGAAAACATCTCCCAGAATGGCTGTATTTACTTGTCTTT AAGTTTAGTAGAATATGATA
Product: bifunctional acetaldehyde-CoA/alcohol dehydrogenase
Products: NA
Alternate protein names: Alcohol dehydrogenase; ADH; Acetaldehyde dehydrogenase [acetylating]; ACDH; Pyruvate-formate-lyase deactivase; PFL deactivase [H]
Number of amino acids: Translated: 867; Mature: 867
Protein sequence:
>867_residues MVVKEKVVNEMQEVKEMIDTLVNNGRKALQALESFTQEQIDNIVHEMALAGVDQHMPLAKLAVEETGRGVYEDKCIKNIF ATEYIWHSIKKDKTVGIIHEDPHEEIIEIAEPVGVVAGVTPVTNPTSTTMFKALIAIKTRNPIIFAFHPSAQNCSVAAAK TVYDAAVKAGAPKHCIQWIEKPSVEATKQLMNHEGVALVLATGGAGMVKSAYSTGKPALGVGPGNVPCYIEKSAHIKRAV NDLILSKTFDNGMICASEQAIIVDKEIYDDVKTEMITNDCYFVTEEERRKLEKLVINENTCAVNSDIVGKSAQYIAELVG ITVPKNTKMLVAEIQGIGAAYPLSREKLSPVLACVKANSLEEGFTYCEEMLNLGGLGHSAVIHSVNKEVQKQFGLRMKAC RLIVNAPSSQGGIGDIYNGFIPSLTLGCGSYGKNSVSQNVTATHLLNIKRLANRKKNMQWFKLPPKIYFEKHATAYLANM PNISRAFIVTDPGMVEHGYVDTVAHYLRKHANDVKVEVFFEVEPDPSDETVFKGAEMMRSFQPDVIIALGGGSAMDAAKG MWLFYEYPETTFYGIKQKFLDIRKRTCKYPELGSKAQFVAIPTTSGTGSEVTPFAVITDKKNNIKYPLADYELTPDVAIV DPQFVMTVPPHVTADTGMDVLTHAIEAYVSVLANDYTDGLALKAIDLVFKYLPRAFKDGHDEEAREKMHNASAIAGMAFA NAFLGINHSLAHKIGPEFHIPHGRANAILMPHVIRYNAIKPRKHALFPKYEHFVADERYAHIARMLGLPASSVAEGVESL DKAIIDLGKSLNINMSIAGQGVAKDQFEEVVGLLAERAFEDQCTTANPKLPLISELKEIYMKAYKGE
Sequences:
>Translated_867_residues MVVKEKVVNEMQEVKEMIDTLVNNGRKALQALESFTQEQIDNIVHEMALAGVDQHMPLAKLAVEETGRGVYEDKCIKNIF ATEYIWHSIKKDKTVGIIHEDPHEEIIEIAEPVGVVAGVTPVTNPTSTTMFKALIAIKTRNPIIFAFHPSAQNCSVAAAK TVYDAAVKAGAPKHCIQWIEKPSVEATKQLMNHEGVALVLATGGAGMVKSAYSTGKPALGVGPGNVPCYIEKSAHIKRAV NDLILSKTFDNGMICASEQAIIVDKEIYDDVKTEMITNDCYFVTEEERRKLEKLVINENTCAVNSDIVGKSAQYIAELVG ITVPKNTKMLVAEIQGIGAAYPLSREKLSPVLACVKANSLEEGFTYCEEMLNLGGLGHSAVIHSVNKEVQKQFGLRMKAC RLIVNAPSSQGGIGDIYNGFIPSLTLGCGSYGKNSVSQNVTATHLLNIKRLANRKKNMQWFKLPPKIYFEKHATAYLANM PNISRAFIVTDPGMVEHGYVDTVAHYLRKHANDVKVEVFFEVEPDPSDETVFKGAEMMRSFQPDVIIALGGGSAMDAAKG MWLFYEYPETTFYGIKQKFLDIRKRTCKYPELGSKAQFVAIPTTSGTGSEVTPFAVITDKKNNIKYPLADYELTPDVAIV DPQFVMTVPPHVTADTGMDVLTHAIEAYVSVLANDYTDGLALKAIDLVFKYLPRAFKDGHDEEAREKMHNASAIAGMAFA NAFLGINHSLAHKIGPEFHIPHGRANAILMPHVIRYNAIKPRKHALFPKYEHFVADERYAHIARMLGLPASSVAEGVESL DKAIIDLGKSLNINMSIAGQGVAKDQFEEVVGLLAERAFEDQCTTANPKLPLISELKEIYMKAYKGE >Mature_867_residues MVVKEKVVNEMQEVKEMIDTLVNNGRKALQALESFTQEQIDNIVHEMALAGVDQHMPLAKLAVEETGRGVYEDKCIKNIF ATEYIWHSIKKDKTVGIIHEDPHEEIIEIAEPVGVVAGVTPVTNPTSTTMFKALIAIKTRNPIIFAFHPSAQNCSVAAAK TVYDAAVKAGAPKHCIQWIEKPSVEATKQLMNHEGVALVLATGGAGMVKSAYSTGKPALGVGPGNVPCYIEKSAHIKRAV NDLILSKTFDNGMICASEQAIIVDKEIYDDVKTEMITNDCYFVTEEERRKLEKLVINENTCAVNSDIVGKSAQYIAELVG ITVPKNTKMLVAEIQGIGAAYPLSREKLSPVLACVKANSLEEGFTYCEEMLNLGGLGHSAVIHSVNKEVQKQFGLRMKAC RLIVNAPSSQGGIGDIYNGFIPSLTLGCGSYGKNSVSQNVTATHLLNIKRLANRKKNMQWFKLPPKIYFEKHATAYLANM PNISRAFIVTDPGMVEHGYVDTVAHYLRKHANDVKVEVFFEVEPDPSDETVFKGAEMMRSFQPDVIIALGGGSAMDAAKG MWLFYEYPETTFYGIKQKFLDIRKRTCKYPELGSKAQFVAIPTTSGTGSEVTPFAVITDKKNNIKYPLADYELTPDVAIV DPQFVMTVPPHVTADTGMDVLTHAIEAYVSVLANDYTDGLALKAIDLVFKYLPRAFKDGHDEEAREKMHNASAIAGMAFA NAFLGINHSLAHKIGPEFHIPHGRANAILMPHVIRYNAIKPRKHALFPKYEHFVADERYAHIARMLGLPASSVAEGVESL DKAIIDLGKSLNINMSIAGQGVAKDQFEEVVGLLAERAFEDQCTTANPKLPLISELKEIYMKAYKGE
Specific function: This enzyme has three activities:ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent
COG id: COG1012
COG function: function code C; NAD-dependent aldehyde dehydrogenases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the iron- containing alcohol dehydrogenase family [H]
Homologues:
Organism=Homo sapiens, GI133922590, Length=304, Percent_Identity=28.6184210526316, Blast_Score=99, Evalue=2e-20, Organism=Escherichia coli, GI1787493, Length=862, Percent_Identity=49.5359628770302, Blast_Score=812, Evalue=0.0, Organism=Escherichia coli, GI87082107, Length=339, Percent_Identity=36.8731563421829, Blast_Score=205, Evalue=1e-53, Organism=Escherichia coli, GI48994951, Length=387, Percent_Identity=34.8837209302326, Blast_Score=202, Evalue=6e-53, Organism=Escherichia coli, GI1789163, Length=382, Percent_Identity=33.7696335078534, Blast_Score=187, Evalue=3e-48, Organism=Escherichia coli, GI1788797, Length=379, Percent_Identity=30.8707124010554, Blast_Score=159, Evalue=5e-40, Organism=Escherichia coli, GI1789386, Length=330, Percent_Identity=25.7575757575758, Blast_Score=83, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17537053, Length=251, Percent_Identity=30.6772908366534, Blast_Score=110, Evalue=3e-24, Organism=Saccharomyces cerevisiae, GI6321181, Length=441, Percent_Identity=34.0136054421769, Blast_Score=220, Evalue=6e-58, Organism=Drosophila melanogaster, GI24657991, Length=312, Percent_Identity=30.4487179487179, Blast_Score=97, Evalue=6e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001670 - InterPro: IPR018211 - InterPro: IPR016161 - InterPro: IPR016163 - InterPro: IPR016162 - InterPro: IPR015590 - InterPro: IPR012079 [H]
Pfam domain/function: PF00171 Aldedh; PF00465 Fe-ADH [H]
EC number: =1.1.1.1; =1.2.1.10 [H]
Molecular weight: Translated: 95266; Mature: 95266
Theoretical pI: Translated: 6.69; Mature: 6.69
Prosite motif: PS00913 ADH_IRON_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 4.7 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 4.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVVKEKVVNEMQEVKEMIDTLVNNGRKALQALESFTQEQIDNIVHEMALAGVDQHMPLAK CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH LAVEETGRGVYEDKCIKNIFATEYIWHSIKKDKTVGIIHEDPHEEIIEIAEPVGVVAGVT HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCC PVTNPTSTTMFKALIAIKTRNPIIFAFHPSAQNCSVAAAKTVYDAAVKAGAPKHCIQWIE CCCCCCHHHHHHHHHHEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHC KPSVEATKQLMNHEGVALVLATGGAGMVKSAYSTGKPALGVGPGNVPCYIEKSAHIKRAV CCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCEEEECHHHHHHHH NDLILSKTFDNGMICASEQAIIVDKEIYDDVKTEMITNDCYFVTEEERRKLEKLVINENT HHHHHHHCCCCCEEEECCCEEEEEHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCC CAVNSDIVGKSAQYIAELVGITVPKNTKMLVAEIQGIGAAYPLSREKLSPVLACVKANSL CEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEHHCCCCCCCCCHHHHHHHHHHHHCCCH EEGFTYCEEMLNLGGLGHSAVIHSVNKEVQKQFGLRMKACRLIVNAPSSQGGIGDIYNGF HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHEEECCCCCCCCCHHHHCH IPSLTLGCGSYGKNSVSQNVTATHLLNIKRLANRKKNMQWFKLPPKIYFEKHATAYLANM HCHHEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCC PNISRAFIVTDPGMVEHGYVDTVAHYLRKHANDVKVEVFFEVEPDPSDETVFKGAEMMRS CCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHH FQPDVIIALGGGSAMDAAKGMWLFYEYPETTFYGIKQKFLDIRKRTCKYPELGSKAQFVA CCCCEEEEECCCCHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE IPTTSGTGSEVTPFAVITDKKNNIKYPLADYELTPDVAIVDPQFVMTVPPHVTADTGMDV EECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCCCHHH LTHAIEAYVSVLANDYTDGLALKAIDLVFKYLPRAFKDGHDEEAREKMHNASAIAGMAFA HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH NAFLGINHSLAHKIGPEFHIPHGRANAILMPHVIRYNAIKPRKHALFPKYEHFVADERYA HHHHCCCHHHHHHCCCCEECCCCCCCEEECCHHHHCCCCCCHHHCCCCCHHHHHHHHHHH HIARMLGLPASSVAEGVESLDKAIIDLGKSLNINMSIAGQGVAKDQFEEVVGLLAERAFE HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH DQCTTANPKLPLISELKEIYMKAYKGE CCCCCCCCCCCHHHHHHHHHHHHHCCC >Mature Secondary Structure MVVKEKVVNEMQEVKEMIDTLVNNGRKALQALESFTQEQIDNIVHEMALAGVDQHMPLAK CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH LAVEETGRGVYEDKCIKNIFATEYIWHSIKKDKTVGIIHEDPHEEIIEIAEPVGVVAGVT HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCC PVTNPTSTTMFKALIAIKTRNPIIFAFHPSAQNCSVAAAKTVYDAAVKAGAPKHCIQWIE CCCCCCHHHHHHHHHHEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHC KPSVEATKQLMNHEGVALVLATGGAGMVKSAYSTGKPALGVGPGNVPCYIEKSAHIKRAV CCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCEEEECHHHHHHHH NDLILSKTFDNGMICASEQAIIVDKEIYDDVKTEMITNDCYFVTEEERRKLEKLVINENT HHHHHHHCCCCCEEEECCCEEEEEHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCC CAVNSDIVGKSAQYIAELVGITVPKNTKMLVAEIQGIGAAYPLSREKLSPVLACVKANSL CEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEHHCCCCCCCCCHHHHHHHHHHHHCCCH EEGFTYCEEMLNLGGLGHSAVIHSVNKEVQKQFGLRMKACRLIVNAPSSQGGIGDIYNGF HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHEEECCCCCCCCCHHHHCH IPSLTLGCGSYGKNSVSQNVTATHLLNIKRLANRKKNMQWFKLPPKIYFEKHATAYLANM HCHHEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCC PNISRAFIVTDPGMVEHGYVDTVAHYLRKHANDVKVEVFFEVEPDPSDETVFKGAEMMRS CCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHH FQPDVIIALGGGSAMDAAKGMWLFYEYPETTFYGIKQKFLDIRKRTCKYPELGSKAQFVA CCCCEEEEECCCCHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE IPTTSGTGSEVTPFAVITDKKNNIKYPLADYELTPDVAIVDPQFVMTVPPHVTADTGMDV EECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCCCHHH LTHAIEAYVSVLANDYTDGLALKAIDLVFKYLPRAFKDGHDEEAREKMHNASAIAGMAFA HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH NAFLGINHSLAHKIGPEFHIPHGRANAILMPHVIRYNAIKPRKHALFPKYEHFVADERYA HHHHCCCHHHHHHCCCCEECCCCCCCEEECCHHHHCCCCCCHHHCCCCCHHHHHHHHHHH HIARMLGLPASSVAEGVESLDKAIIDLGKSLNINMSIAGQGVAKDQFEEVVGLLAERAFE HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH DQCTTANPKLPLISELKEIYMKAYKGE CCCCCCCCCCCHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]