Definition | Bacillus anthracis str. Sterne chromosome, complete genome. |
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Accession | NC_005945 |
Length | 5,228,663 |
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The map label for this gene is mccA [H]
Identifier: 49187265
GI number: 49187265
Start: 4180834
End: 4181757
Strand: Reverse
Name: mccA [H]
Synonym: BAS4269
Alternate gene names: 49187265
Gene position: 4181757-4180834 (Counterclockwise)
Preceding gene: 49187266
Following gene: 49187264
Centisome position: 79.98
GC content: 39.5
Gene sequence:
>924_bases ATGAATGTATATCGTGGAGTTCATGAGTTAATTGGTCATACACCAATTGTGGAAATTACTCGTTTTTCACTTCCAGAAGG GGTCCGTTTATTTGCAAAGCTTGAATTTTATAATCCAGGCGGAAGCGTTAAGGACCGGCTAGGAAGAGAATTAATAGAAG ATGCGCTAGAAAAAGGGCTTGTTACAGAGGGCGGAACAATTATTGAACCGACTGCTGGAAATACTGGTATTGGACTGGCA CTTGCAGCGTTACAACATGATTTACGCGTTATTGTTTGTGTACCAGAGAAATTTAGTATTGAAAAACAAGAATTAATGAA AGCACTAGGTGCAACGGTCGTGCATACACCGACTGAGCAAGGGATGACCGGTGCAATTGCAAAAGCGAAAGAGTTAGTAA ATGAAATACCGAATTCATACTCTCCAAGTCAGTTTGCGAATGAAGCAAACCCTCGTGCTTATTTCAAAACACTAGGTCCT GAACTTTGGTCGGCACTTAACGGAGAGATTAACATATTTGTTGCAGGAGCAGGAACTGGCGGAACATTTATGGGGACTGC ATCTTATTTGAAAGAAAAAAATATAGATATAAAAACAGTTATTGTGGAACCAGAAGGATCCATTTTAAATGGTGGTAAAG CTGGCTCACATGAAACAGAAGGGATTGGCCTTGAATTCATCCCGCCATTTTTGAAAACATCTTATTTTGATGAGATTCAT ACAATTTCTGATCGAAATGCATTTTTACGAGTGAAAGAATTAGCACAAAAAGAAGGATTGCTCGTTGGGAGCTCTTCAGG AGCAGCGTTTCATGCAAGTTTACTTGAAGCAGAGAAAGCGGCGCCAGGTACAAATATTGTAACGATTTTTCCTGATAGTA GTGAGCGCTATTTAAGTAAAGACATATACAAAGGATGGGAATAA
Upstream 100 bases:
>100_bases TTAGAAGAGTTAAAGTAATGTAACCAAAAGGCAACTGTCTCATATAAAGAAAATACATACAGTTGCCTTTTCTTTATTGG CAAATAAGGGGGAGAACACG
Downstream 100 bases:
>100_bases AAAATGAGAGCAAAGACAAAGTTAATTCATGGTATTCGCATAGGAGAACCTTCAACTGGATCTGTAAATGTACCGATTTA TCAAACGAGTACGTACAAAC
Product: O-acetylserine lyase
Products: L-cysteine; acetate
Alternate protein names: NA
Number of amino acids: Translated: 307; Mature: 307
Protein sequence:
>307_residues MNVYRGVHELIGHTPIVEITRFSLPEGVRLFAKLEFYNPGGSVKDRLGRELIEDALEKGLVTEGGTIIEPTAGNTGIGLA LAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHTPTEQGMTGAIAKAKELVNEIPNSYSPSQFANEANPRAYFKTLGP ELWSALNGEINIFVAGAGTGGTFMGTASYLKEKNIDIKTVIVEPEGSILNGGKAGSHETEGIGLEFIPPFLKTSYFDEIH TISDRNAFLRVKELAQKEGLLVGSSSGAAFHASLLEAEKAAPGTNIVTIFPDSSERYLSKDIYKGWE
Sequences:
>Translated_307_residues MNVYRGVHELIGHTPIVEITRFSLPEGVRLFAKLEFYNPGGSVKDRLGRELIEDALEKGLVTEGGTIIEPTAGNTGIGLA LAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHTPTEQGMTGAIAKAKELVNEIPNSYSPSQFANEANPRAYFKTLGP ELWSALNGEINIFVAGAGTGGTFMGTASYLKEKNIDIKTVIVEPEGSILNGGKAGSHETEGIGLEFIPPFLKTSYFDEIH TISDRNAFLRVKELAQKEGLLVGSSSGAAFHASLLEAEKAAPGTNIVTIFPDSSERYLSKDIYKGWE >Mature_307_residues MNVYRGVHELIGHTPIVEITRFSLPEGVRLFAKLEFYNPGGSVKDRLGRELIEDALEKGLVTEGGTIIEPTAGNTGIGLA LAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHTPTEQGMTGAIAKAKELVNEIPNSYSPSQFANEANPRAYFKTLGP ELWSALNGEINIFVAGAGTGGTFMGTASYLKEKNIDIKTVIVEPEGSILNGGKAGSHETEGIGLEFIPPFLKTSYFDEIH TISDRNAFLRVKELAQKEGLLVGSSSGAAFHASLLEAEKAAPGTNIVTIFPDSSERYLSKDIYKGWE
Specific function: Catalyzes the conversion of O-acetylserine and homocysteine to cystathionine [H]
COG id: COG0031
COG function: function code E; Cysteine synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]
Homologues:
Organism=Homo sapiens, GI295821202, Length=307, Percent_Identity=41.3680781758958, Blast_Score=226, Evalue=3e-59, Organism=Homo sapiens, GI295821200, Length=307, Percent_Identity=41.3680781758958, Blast_Score=226, Evalue=3e-59, Organism=Homo sapiens, GI4557415, Length=307, Percent_Identity=41.3680781758958, Blast_Score=226, Evalue=3e-59, Organism=Escherichia coli, GI1788754, Length=304, Percent_Identity=41.7763157894737, Blast_Score=199, Evalue=3e-52, Organism=Escherichia coli, GI2367138, Length=298, Percent_Identity=35.9060402684564, Blast_Score=177, Evalue=6e-46, Organism=Caenorhabditis elegans, GI17535051, Length=298, Percent_Identity=39.9328859060403, Blast_Score=213, Evalue=1e-55, Organism=Caenorhabditis elegans, GI115535073, Length=299, Percent_Identity=42.4749163879599, Blast_Score=196, Evalue=1e-50, Organism=Caenorhabditis elegans, GI17562970, Length=298, Percent_Identity=35.9060402684564, Blast_Score=194, Evalue=6e-50, Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=36.518771331058, Blast_Score=191, Evalue=3e-49, Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=36.875, Blast_Score=174, Evalue=6e-44, Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=34.2281879194631, Blast_Score=167, Evalue=7e-42, Organism=Caenorhabditis elegans, GI25147552, Length=319, Percent_Identity=36.3636363636364, Blast_Score=166, Evalue=2e-41, Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=36.3207547169811, Blast_Score=142, Evalue=1e-34, Organism=Caenorhabditis elegans, GI71996324, Length=333, Percent_Identity=27.9279279279279, Blast_Score=72, Evalue=5e-13, Organism=Saccharomyces cerevisiae, GI6321594, Length=322, Percent_Identity=39.4409937888199, Blast_Score=207, Evalue=2e-54, Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=35.5828220858896, Blast_Score=148, Evalue=9e-37, Organism=Drosophila melanogaster, GI24643623, Length=309, Percent_Identity=39.4822006472492, Blast_Score=202, Evalue=2e-52, Organism=Drosophila melanogaster, GI20129101, Length=309, Percent_Identity=39.4822006472492, Blast_Score=202, Evalue=2e-52,
Paralogues:
None
Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001216 - InterPro: IPR001926 [H]
Pfam domain/function: PF00291 PALP [H]
EC number: 2.5.1.47
Molecular weight: Translated: 33106; Mature: 33106
Theoretical pI: Translated: 5.11; Mature: 5.11
Prosite motif: PS00901 CYS_SYNTHASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 1.3 %Met (Translated Protein) 1.6 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 1.3 %Met (Mature Protein) 1.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNVYRGVHELIGHTPIVEITRFSLPEGVRLFAKLEFYNPGGSVKDRLGRELIEDALEKGL CCHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCC VTEGGTIIEPTAGNTGIGLALAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHTPTEQ CCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCEEEECCCCC GMTGAIAKAKELVNEIPNSYSPSQFANEANPRAYFKTLGPELWSALNGEINIFVAGAGTG CCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHCHHHHHHCCCCEEEEEEECCCC GTFMGTASYLKEKNIDIKTVIVEPEGSILNGGKAGSHETEGIGLEFIPPFLKTSYFDEIH CCHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCEECCHHHHHHHHHHHH TISDRNAFLRVKELAQKEGLLVGSSSGAAFHASLLEAEKAAPGTNIVTIFPDSSERYLSK HCCCCHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHH DIYKGWE HHHCCCC >Mature Secondary Structure MNVYRGVHELIGHTPIVEITRFSLPEGVRLFAKLEFYNPGGSVKDRLGRELIEDALEKGL CCHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCC VTEGGTIIEPTAGNTGIGLALAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHTPTEQ CCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCEEEECCCCC GMTGAIAKAKELVNEIPNSYSPSQFANEANPRAYFKTLGPELWSALNGEINIFVAGAGTG CCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHCHHHHHHCCCCEEEEEEECCCC GTFMGTASYLKEKNIDIKTVIVEPEGSILNGGKAGSHETEGIGLEFIPPFLKTSYFDEIH CCHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCEECCHHHHHHHHHHHH TISDRNAFLRVKELAQKEGLLVGSSSGAAFHASLLEAEKAAPGTNIVTIFPDSSERYLSK HCCCCHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHH DIYKGWE HHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: Pyridoxal 5'-phosphate [C]
Metal ions: NA
Kcat value (1/min): 44000 [C]
Specific activity: 1100
Km value (mM): 0.7 {L-Ser}} 0.12 {acetyl-CoA}} 3.6 {S2-}} 0.1 {S2-}} 20 {O-acetyl-L-Ser}} 7.1 {O-acetyl-L-Ser}} 5 {O-acetyl-L-Ser}} [C]
Substrates: O3-acetyl-L-serine; hydrogen sulfide
Specific reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
General reaction: Elimination; C-O bond cleavage [C]
Inhibitor: acetyl-CoA; D-cycloserine; L-cysteine; NH2OH; semicarbazide [C]
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9308178; 9384377 [H]