Definition Bacillus anthracis str. Sterne chromosome, complete genome.
Accession NC_005945
Length 5,228,663

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The map label for this gene is mccA [H]

Identifier: 49187265

GI number: 49187265

Start: 4180834

End: 4181757

Strand: Reverse

Name: mccA [H]

Synonym: BAS4269

Alternate gene names: 49187265

Gene position: 4181757-4180834 (Counterclockwise)

Preceding gene: 49187266

Following gene: 49187264

Centisome position: 79.98

GC content: 39.5

Gene sequence:

>924_bases
ATGAATGTATATCGTGGAGTTCATGAGTTAATTGGTCATACACCAATTGTGGAAATTACTCGTTTTTCACTTCCAGAAGG
GGTCCGTTTATTTGCAAAGCTTGAATTTTATAATCCAGGCGGAAGCGTTAAGGACCGGCTAGGAAGAGAATTAATAGAAG
ATGCGCTAGAAAAAGGGCTTGTTACAGAGGGCGGAACAATTATTGAACCGACTGCTGGAAATACTGGTATTGGACTGGCA
CTTGCAGCGTTACAACATGATTTACGCGTTATTGTTTGTGTACCAGAGAAATTTAGTATTGAAAAACAAGAATTAATGAA
AGCACTAGGTGCAACGGTCGTGCATACACCGACTGAGCAAGGGATGACCGGTGCAATTGCAAAAGCGAAAGAGTTAGTAA
ATGAAATACCGAATTCATACTCTCCAAGTCAGTTTGCGAATGAAGCAAACCCTCGTGCTTATTTCAAAACACTAGGTCCT
GAACTTTGGTCGGCACTTAACGGAGAGATTAACATATTTGTTGCAGGAGCAGGAACTGGCGGAACATTTATGGGGACTGC
ATCTTATTTGAAAGAAAAAAATATAGATATAAAAACAGTTATTGTGGAACCAGAAGGATCCATTTTAAATGGTGGTAAAG
CTGGCTCACATGAAACAGAAGGGATTGGCCTTGAATTCATCCCGCCATTTTTGAAAACATCTTATTTTGATGAGATTCAT
ACAATTTCTGATCGAAATGCATTTTTACGAGTGAAAGAATTAGCACAAAAAGAAGGATTGCTCGTTGGGAGCTCTTCAGG
AGCAGCGTTTCATGCAAGTTTACTTGAAGCAGAGAAAGCGGCGCCAGGTACAAATATTGTAACGATTTTTCCTGATAGTA
GTGAGCGCTATTTAAGTAAAGACATATACAAAGGATGGGAATAA

Upstream 100 bases:

>100_bases
TTAGAAGAGTTAAAGTAATGTAACCAAAAGGCAACTGTCTCATATAAAGAAAATACATACAGTTGCCTTTTCTTTATTGG
CAAATAAGGGGGAGAACACG

Downstream 100 bases:

>100_bases
AAAATGAGAGCAAAGACAAAGTTAATTCATGGTATTCGCATAGGAGAACCTTCAACTGGATCTGTAAATGTACCGATTTA
TCAAACGAGTACGTACAAAC

Product: O-acetylserine lyase

Products: L-cysteine; acetate

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MNVYRGVHELIGHTPIVEITRFSLPEGVRLFAKLEFYNPGGSVKDRLGRELIEDALEKGLVTEGGTIIEPTAGNTGIGLA
LAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHTPTEQGMTGAIAKAKELVNEIPNSYSPSQFANEANPRAYFKTLGP
ELWSALNGEINIFVAGAGTGGTFMGTASYLKEKNIDIKTVIVEPEGSILNGGKAGSHETEGIGLEFIPPFLKTSYFDEIH
TISDRNAFLRVKELAQKEGLLVGSSSGAAFHASLLEAEKAAPGTNIVTIFPDSSERYLSKDIYKGWE

Sequences:

>Translated_307_residues
MNVYRGVHELIGHTPIVEITRFSLPEGVRLFAKLEFYNPGGSVKDRLGRELIEDALEKGLVTEGGTIIEPTAGNTGIGLA
LAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHTPTEQGMTGAIAKAKELVNEIPNSYSPSQFANEANPRAYFKTLGP
ELWSALNGEINIFVAGAGTGGTFMGTASYLKEKNIDIKTVIVEPEGSILNGGKAGSHETEGIGLEFIPPFLKTSYFDEIH
TISDRNAFLRVKELAQKEGLLVGSSSGAAFHASLLEAEKAAPGTNIVTIFPDSSERYLSKDIYKGWE
>Mature_307_residues
MNVYRGVHELIGHTPIVEITRFSLPEGVRLFAKLEFYNPGGSVKDRLGRELIEDALEKGLVTEGGTIIEPTAGNTGIGLA
LAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHTPTEQGMTGAIAKAKELVNEIPNSYSPSQFANEANPRAYFKTLGP
ELWSALNGEINIFVAGAGTGGTFMGTASYLKEKNIDIKTVIVEPEGSILNGGKAGSHETEGIGLEFIPPFLKTSYFDEIH
TISDRNAFLRVKELAQKEGLLVGSSSGAAFHASLLEAEKAAPGTNIVTIFPDSSERYLSKDIYKGWE

Specific function: Catalyzes the conversion of O-acetylserine and homocysteine to cystathionine [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=307, Percent_Identity=41.3680781758958, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI295821200, Length=307, Percent_Identity=41.3680781758958, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI4557415, Length=307, Percent_Identity=41.3680781758958, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1788754, Length=304, Percent_Identity=41.7763157894737, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI2367138, Length=298, Percent_Identity=35.9060402684564, Blast_Score=177, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17535051, Length=298, Percent_Identity=39.9328859060403, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI115535073, Length=299, Percent_Identity=42.4749163879599, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17562970, Length=298, Percent_Identity=35.9060402684564, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=36.518771331058, Blast_Score=191, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=36.875, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=34.2281879194631, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI25147552, Length=319, Percent_Identity=36.3636363636364, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=36.3207547169811, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71996324, Length=333, Percent_Identity=27.9279279279279, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=322, Percent_Identity=39.4409937888199, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=35.5828220858896, Blast_Score=148, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24643623, Length=309, Percent_Identity=39.4822006472492, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI20129101, Length=309, Percent_Identity=39.4822006472492, Blast_Score=202, Evalue=2e-52,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: 2.5.1.47

Molecular weight: Translated: 33106; Mature: 33106

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVYRGVHELIGHTPIVEITRFSLPEGVRLFAKLEFYNPGGSVKDRLGRELIEDALEKGL
CCHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCC
VTEGGTIIEPTAGNTGIGLALAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHTPTEQ
CCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCEEEECCCCC
GMTGAIAKAKELVNEIPNSYSPSQFANEANPRAYFKTLGPELWSALNGEINIFVAGAGTG
CCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHCHHHHHHCCCCEEEEEEECCCC
GTFMGTASYLKEKNIDIKTVIVEPEGSILNGGKAGSHETEGIGLEFIPPFLKTSYFDEIH
CCHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCEECCHHHHHHHHHHHH
TISDRNAFLRVKELAQKEGLLVGSSSGAAFHASLLEAEKAAPGTNIVTIFPDSSERYLSK
HCCCCHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHH
DIYKGWE
HHHCCCC
>Mature Secondary Structure
MNVYRGVHELIGHTPIVEITRFSLPEGVRLFAKLEFYNPGGSVKDRLGRELIEDALEKGL
CCHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCC
VTEGGTIIEPTAGNTGIGLALAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHTPTEQ
CCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCEEEECCCCC
GMTGAIAKAKELVNEIPNSYSPSQFANEANPRAYFKTLGPELWSALNGEINIFVAGAGTG
CCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHCHHHHHHCCCCEEEEEEECCCC
GTFMGTASYLKEKNIDIKTVIVEPEGSILNGGKAGSHETEGIGLEFIPPFLKTSYFDEIH
CCHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCEECCHHHHHHHHHHHH
TISDRNAFLRVKELAQKEGLLVGSSSGAAFHASLLEAEKAAPGTNIVTIFPDSSERYLSK
HCCCCHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHH
DIYKGWE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal 5'-phosphate [C]

Metal ions: NA

Kcat value (1/min): 44000 [C]

Specific activity: 1100

Km value (mM): 0.7 {L-Ser}} 0.12 {acetyl-CoA}} 3.6 {S2-}} 0.1 {S2-}} 20 {O-acetyl-L-Ser}} 7.1 {O-acetyl-L-Ser}} 5 {O-acetyl-L-Ser}} [C]

Substrates: O3-acetyl-L-serine; hydrogen sulfide

Specific reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate

General reaction: Elimination; C-O bond cleavage [C]

Inhibitor: acetyl-CoA; D-cycloserine; L-cysteine; NH2OH; semicarbazide [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]