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The map label for this gene is ispA [C]

Identifier: 49187080

GI number: 49187080

Start: 4017585

End: 4018475

Strand: Reverse

Name: ispA [C]

Synonym: BAS4082

Alternate gene names: 49187080

Gene position: 4018475-4017585 (Counterclockwise)

Preceding gene: 49187081

Following gene: 49187079

Centisome position: 76.85

GC content: 37.15

Gene sequence:

>891_bases
GTGACAATTGCTTTTGATACTTTTTTAAAAGAAAGTAAAACTTTTGTAGAAGAGAAGCTTGTAAGCTATGCAAATGAATT
ACAATGTCCAAATGTACTTCGTGAAGCGATGGCATATTCTTTGGAAGCGGGTGGAAAGCGTCTCCGCCCGTTACTTTTAT
TTGCAACATTACAAGCGTTTGATAAAGAAAGAAATCTTGGAGTAGGTGCAGCTTGTGCTCTTGAAATGATACATACATAC
TCGTTAGTTCATGATGATTTACCTTGTATGGATGATGATGATTTAAGAAGAGGAAAGCCCACAAATCATAAAGTATTTGG
TGAAGCGATGGCAGTTTTAGCAGGTGATGGTTTATTAACGTATGCTTTTCAAGTTATTATGGCATATGGACAAAAGGAAA
TCTCTGCTGAGAAAAAAGTAAGACTTGTACTTGAGCTTGCAAAAGCGGCAGGGCCAGAGGGAATGGTTGGCGGACAAGTG
GCAGATATGGAAGCGGAAGGGAAACAGCTTACGATCGATGAGCTAGAGTATATTCATAAGCATAAGACTGGGAAACTACT
TGAATTCGCTGTACTTGCAGGATCGATACTTTCTGATGCCACAGAAGAACAAGAAGAAAAATTACTTGAGTTTGCAAAAT
ATATCGGCTTAGCTTTCCAAATTCGAGATGATATTTTAGATGTGGAAGGAACCGAAGAAGAGATTGGAAAACCGATTGGT
AGTGATGTTTCCAACGAAAAGAGCACATATACAACGTTGTTTACTGTAGATAGAGCAAAGGATATTTTAGATGAAACTAT
TGCAAAAGCAAAAGATGCTATTGGTTCCTTGCAATTACAAGATGAATATTTACTATCTATTTGCGATTTGATTGCAAAAC
GTAATAACTAA

Upstream 100 bases:

>100_bases
TTTGTGATGAGAAGTTGAAGAACGTACAAGAACAAATGGCAGTTATTCTTGGGGAAGATGGAGAGCTTGAACCGTTTACT
GCTTTAGGAGATGAAGCATA

Downstream 100 bases:

>100_bases
TATAACAGCGTTTTCATTTGTTGAGTCATTCATCATTTTATGATATAAATGTAGGAAAAGGTTTTTCTTTTCTTGTTATT
GGCAAAAATATATGTAGATT

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTIAFDTFLKESKTFVEEKLVSYANELQCPNVLREAMAYSLEAGGKRLRPLLLFATLQAFDKERNLGVGAACALEMIHTY
SLVHDDLPCMDDDDLRRGKPTNHKVFGEAMAVLAGDGLLTYAFQVIMAYGQKEISAEKKVRLVLELAKAAGPEGMVGGQV
ADMEAEGKQLTIDELEYIHKHKTGKLLEFAVLAGSILSDATEEQEEKLLEFAKYIGLAFQIRDDILDVEGTEEEIGKPIG
SDVSNEKSTYTTLFTVDRAKDILDETIAKAKDAIGSLQLQDEYLLSICDLIAKRNN

Sequences:

>Translated_296_residues
MTIAFDTFLKESKTFVEEKLVSYANELQCPNVLREAMAYSLEAGGKRLRPLLLFATLQAFDKERNLGVGAACALEMIHTY
SLVHDDLPCMDDDDLRRGKPTNHKVFGEAMAVLAGDGLLTYAFQVIMAYGQKEISAEKKVRLVLELAKAAGPEGMVGGQV
ADMEAEGKQLTIDELEYIHKHKTGKLLEFAVLAGSILSDATEEQEEKLLEFAKYIGLAFQIRDDILDVEGTEEEIGKPIG
SDVSNEKSTYTTLFTVDRAKDILDETIAKAKDAIGSLQLQDEYLLSICDLIAKRNN
>Mature_295_residues
TIAFDTFLKESKTFVEEKLVSYANELQCPNVLREAMAYSLEAGGKRLRPLLLFATLQAFDKERNLGVGAACALEMIHTYS
LVHDDLPCMDDDDLRRGKPTNHKVFGEAMAVLAGDGLLTYAFQVIMAYGQKEISAEKKVRLVLELAKAAGPEGMVGGQVA
DMEAEGKQLTIDELEYIHKHKTGKLLEFAVLAGSILSDATEEQEEKLLEFAKYIGLAFQIRDDILDVEGTEEEIGKPIGS
DVSNEKSTYTTLFTVDRAKDILDETIAKAKDAIGSLQLQDEYLLSICDLIAKRNN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=234, Percent_Identity=31.1965811965812, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1786623, Length=265, Percent_Identity=44.5283018867925, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1789578, Length=257, Percent_Identity=33.4630350194552, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17505681, Length=251, Percent_Identity=29.0836653386454, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24651612, Length=239, Percent_Identity=27.1966527196653, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32706; Mature: 32575

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAFDTFLKESKTFVEEKLVSYANELQCPNVLREAMAYSLEAGGKRLRPLLLFATLQAF
CEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DKERNLGVGAACALEMIHTYSLVHDDLPCMDDDDLRRGKPTNHKVFGEAMAVLAGDGLLT
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCCHHHH
YAFQVIMAYGQKEISAEKKVRLVLELAKAAGPEGMVGGQVADMEAEGKQLTIDELEYIHK
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCEECHHHHHHHHH
HKTGKLLEFAVLAGSILSDATEEQEEKLLEFAKYIGLAFQIRDDILDVEGTEEEIGKPIG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCCCHHHHCCCCC
SDVSNEKSTYTTLFTVDRAKDILDETIAKAKDAIGSLQLQDEYLLSICDLIAKRNN
CCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIAFDTFLKESKTFVEEKLVSYANELQCPNVLREAMAYSLEAGGKRLRPLLLFATLQAF
EEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DKERNLGVGAACALEMIHTYSLVHDDLPCMDDDDLRRGKPTNHKVFGEAMAVLAGDGLLT
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCCHHHH
YAFQVIMAYGQKEISAEKKVRLVLELAKAAGPEGMVGGQVADMEAEGKQLTIDELEYIHK
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCEECHHHHHHHHH
HKTGKLLEFAVLAGSILSDATEEQEEKLLEFAKYIGLAFQIRDDILDVEGTEEEIGKPIG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCCCHHHHCCCCC
SDVSNEKSTYTTLFTVDRAKDILDETIAKAKDAIGSLQLQDEYLLSICDLIAKRNN
CCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]