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The map label for this gene is dxs

Identifier: 49187079

GI number: 49187079

Start: 4015391

End: 4017283

Strand: Reverse

Name: dxs

Synonym: BAS4081

Alternate gene names: 49187079

Gene position: 4017283-4015391 (Counterclockwise)

Preceding gene: 49187080

Following gene: 49187078

Centisome position: 76.83

GC content: 39.14

Gene sequence:

>1893_bases
GTGGATCTAACGCAAATTCAAAACCCTAGTTTTTTGAAAGATATGTCTATCAGTGAACTAGAGGGATTGAGTGAGGATAT
TCGTAAGTTTTTAATTGAAGAGCTCTCTCAAACAGGTGGACATATTGCACCTAATTTAGGTGTAGTAGAACTCACAATTG
CTCTGCATAAATTATTTGATAGTCCGAAAGATAAATTTTTATGGGACGTAGGACATCAATCCTATGTACATAAAATTTTA
ACTGGACGTGCAAAAGAATTCGGCACATTAAGGCAATATCAAGGTCTATGTGGTTTCCCAAAACGTTGCGAGAGTGAGCA
CGATGTATGGGAAACTGGCCATAGCTCGACATCATTATCTGCTGCAATGGGAATGGCTCTAGCACGTGATTTAAAGAAAA
CGAAAGAATATGTTATACCAATCATTGGTGATGGTGCTTTAACAGGCGGAATGGCTTTAGAGGCATTGAACCATATTGGA
CATGAAAAAACAGACATGATTGTTATTTTGAATGATAATGAAATGTCAATTGCGCCAAACGTTGGTGCGCTTCATAATGT
GCTTGGGCGTCTACGTACCGCAGGAAAATACCATTGGGTAAAAGACGAACTAGAGTATATATTGAAGAAAATCCCAGCAG
TTGGCGGGAAAGTTGCTGCGACAGCAGAGAAAATAAAAGATAGTCTTAAATATTTATTAGTATCCGGTGTCTTTTTCGAA
GAGTTAGGCTTTACATATTTAGGTCCAGTTGATGGGCATGACTATGAAAAGTTATTCGAAACGTTGCAATATGCAAAGAA
AACAAAAGGCCCAGTGCTTGTTCATGTTATTACGAAAAAAGGAAAAGGTTACAAACCAGCCGAGAGTGATGTTATTGGCA
CTTGGCATGGGACAGGACCTTATAAAATTGAATCAGGTGACTTCGTTAAACCGAAAGAAGTTGCACCAGCATGGAGTGCT
GTCGTTAGTGAAACAGTACTTAAGCTAGCAAGAACGGACGAGCGTATCGTAGCAATTACACCTGCAATGCCTGTTGGATC
AAAACTTGAGAAATTCCAAAAAGAATTCCCAGATCGTATGATTGATGTAGGTATTGCAGAACAGCATGCTACAACAATGG
CAGCGGGTATGGCAACGCAAGGTATGAAGCCATTCTTAGCAATTTATTCAACATTTTTACAAAGAGCATATGACCAAGTT
GTTCATGATATATGCCGCCAAAATTTAAATGTTTTCATTGGGATCGATCGCTCTGGTTTAGTAGGAGCAGATGGTGAAAC
ACATCAAGGTGTATTTGACATCTCATTCTTACGCCACTTGCCGAATATGGTAATTATGATGCCAAAAGATGAAAATGAAG
GGCAACATTTAGTATATACGGCGATGCAATATGAAGATGGACCAATCGCATTACGATATGCGCGCGGTAATGGACTTGGC
GTTCATATGGATGAAGAATTAAAGGCGATTCCAATTGGTTCATGGGAAACGTTAAAAGAAGGTACACAAGCAGCTATTTT
AACATTTGGTACGACAATACCAATGGCAATGGAAGCGGCTGAGCGTCTTGAAAAGGCTGGAGTTTCAGTGAAAGTAGTGA
ACGCTCGTTTTATTAAACCGATGGATGAAGCATATTTACATGATCTCTTAGGAAAGAATATACCGATTTTAACGATTGAA
GAAGCTTGTTTAATCGGTGGTTTTGGAACAGGAGTAGTTGAATTTGCGTCTGAGAACGGGTACCATAGTGCGTTAGTTGA
ACGAATGGGTATTCCAGATCGTTTCATAGAGCACGGTAGTGTAACAAAATTATTAGAAGAAATTGGTTTAACGACAGATG
CTGTTGTAGACCGTATTCATACAATGATTCCATCAAAACAAAAAAGGGCGTAA

Upstream 100 bases:

>100_bases
ACAAGGTGAAAAATAAAAAAGAGAATTTCTTGTTTTGTGTAAATGTTTTTTATAATATTTGACATGTTGACAGATTATGA
AATGAAAGTGAGTGATCCAT

Downstream 100 bases:

>100_bases
CAAATGAGTGCAAAAAAAGAAAGAGTAGATGTACTATTAGTAGAGCGAGGACTTATAGAAACACGTGAGAAAGCAAAACG
CGCCATTATGGCGGGACTTG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MDLTQIQNPSFLKDMSISELEGLSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHKLFDSPKDKFLWDVGHQSYVHKIL
TGRAKEFGTLRQYQGLCGFPKRCESEHDVWETGHSSTSLSAAMGMALARDLKKTKEYVIPIIGDGALTGGMALEALNHIG
HEKTDMIVILNDNEMSIAPNVGALHNVLGRLRTAGKYHWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGVFFE
ELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHGTGPYKIESGDFVKPKEVAPAWSA
VVSETVLKLARTDERIVAITPAMPVGSKLEKFQKEFPDRMIDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAYDQV
VHDICRQNLNVFIGIDRSGLVGADGETHQGVFDISFLRHLPNMVIMMPKDENEGQHLVYTAMQYEDGPIALRYARGNGLG
VHMDEELKAIPIGSWETLKEGTQAAILTFGTTIPMAMEAAERLEKAGVSVKVVNARFIKPMDEAYLHDLLGKNIPILTIE
EACLIGGFGTGVVEFASENGYHSALVERMGIPDRFIEHGSVTKLLEEIGLTTDAVVDRIHTMIPSKQKRA

Sequences:

>Translated_630_residues
MDLTQIQNPSFLKDMSISELEGLSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHKLFDSPKDKFLWDVGHQSYVHKIL
TGRAKEFGTLRQYQGLCGFPKRCESEHDVWETGHSSTSLSAAMGMALARDLKKTKEYVIPIIGDGALTGGMALEALNHIG
HEKTDMIVILNDNEMSIAPNVGALHNVLGRLRTAGKYHWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGVFFE
ELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHGTGPYKIESGDFVKPKEVAPAWSA
VVSETVLKLARTDERIVAITPAMPVGSKLEKFQKEFPDRMIDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAYDQV
VHDICRQNLNVFIGIDRSGLVGADGETHQGVFDISFLRHLPNMVIMMPKDENEGQHLVYTAMQYEDGPIALRYARGNGLG
VHMDEELKAIPIGSWETLKEGTQAAILTFGTTIPMAMEAAERLEKAGVSVKVVNARFIKPMDEAYLHDLLGKNIPILTIE
EACLIGGFGTGVVEFASENGYHSALVERMGIPDRFIEHGSVTKLLEEIGLTTDAVVDRIHTMIPSKQKRA
>Mature_630_residues
MDLTQIQNPSFLKDMSISELEGLSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHKLFDSPKDKFLWDVGHQSYVHKIL
TGRAKEFGTLRQYQGLCGFPKRCESEHDVWETGHSSTSLSAAMGMALARDLKKTKEYVIPIIGDGALTGGMALEALNHIG
HEKTDMIVILNDNEMSIAPNVGALHNVLGRLRTAGKYHWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGVFFE
ELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHGTGPYKIESGDFVKPKEVAPAWSA
VVSETVLKLARTDERIVAITPAMPVGSKLEKFQKEFPDRMIDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAYDQV
VHDICRQNLNVFIGIDRSGLVGADGETHQGVFDISFLRHLPNMVIMMPKDENEGQHLVYTAMQYEDGPIALRYARGNGLG
VHMDEELKAIPIGSWETLKEGTQAAILTFGTTIPMAMEAAERLEKAGVSVKVVNARFIKPMDEAYLHDLLGKNIPILTIE
EACLIGGFGTGVVEFASENGYHSALVERMGIPDRFIEHGSVTKLLEEIGLTTDAVVDRIHTMIPSKQKRA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=614, Percent_Identity=23.9413680781759, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI4507521, Length=614, Percent_Identity=23.9413680781759, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI133778974, Length=425, Percent_Identity=26.5882352941176, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI225637463, Length=432, Percent_Identity=25.2314814814815, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI225637459, Length=432, Percent_Identity=25.2314814814815, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI225637461, Length=432, Percent_Identity=25.2314814814815, Blast_Score=98, Evalue=3e-20,
Organism=Escherichia coli, GI1786622, Length=608, Percent_Identity=45.3947368421053, Blast_Score=539, Evalue=1e-154,
Organism=Escherichia coli, GI48994911, Length=272, Percent_Identity=26.8382352941176, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788808, Length=271, Percent_Identity=25.0922509225092, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17539652, Length=418, Percent_Identity=24.1626794258373, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17538422, Length=233, Percent_Identity=23.175965665236, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24666278, Length=550, Percent_Identity=24.7272727272727, Blast_Score=108, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45551847, Length=670, Percent_Identity=22.8358208955224, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45550715, Length=670, Percent_Identity=22.8358208955224, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24645119, Length=626, Percent_Identity=23.0031948881789, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_BACAA (C3P7V6)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002868471.1
- ProteinModelPortal:   C3P7V6
- SMR:   C3P7V6
- EnsemblBacteria:   EBBACT00000128771
- GeneID:   7852009
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_4418
- GeneTree:   EBGT00070000031844
- ProtClustDB:   PRK05444
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 69428; Mature: 69428

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTQIQNPSFLKDMSISELEGLSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHKLFD
CCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
SPKDKFLWDVGHQSYVHKILTGRAKEFGTLRQYQGLCGFPKRCESEHDVWETGHSSTSLS
CCCHHHEECCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHCCCCCHHHHCCCCCCHHH
AAMGMALARDLKKTKEYVIPIIGDGALTGGMALEALNHIGHEKTDMIVILNDNEMSIAPN
HHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCC
VGALHNVLGRLRTAGKYHWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGVFFE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHGTGP
HCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCC
YKIESGDFVKPKEVAPAWSAVVSETVLKLARTDERIVAITPAMPVGSKLEKFQKEFPDRM
EEECCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCHHH
IDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAYDQVVHDICRQNLNVFIGIDRSGL
HHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
VGADGETHQGVFDISFLRHLPNMVIMMPKDENEGQHLVYTAMQYEDGPIALRYARGNGLG
CCCCCCCCCCEEHHHHHHHCCCEEEEECCCCCCCCEEEEEEEEECCCCEEEEEECCCCCE
VHMDEELKAIPIGSWETLKEGTQAAILTFGTTIPMAMEAAERLEKAGVSVKVVNARFIKP
EEECCCCCEECCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECHHHCCC
MDEAYLHDLLGKNIPILTIEEACLIGGFGTGVVEFASENGYHSALVERMGIPDRFIEHGS
HHHHHHHHHHCCCCCEEEECCHHEECCCCCCHHHHCCCCCHHHHHHHHHCCCHHHHCCCH
VTKLLEEIGLTTDAVVDRIHTMIPSKQKRA
HHHHHHHHCCCHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MDLTQIQNPSFLKDMSISELEGLSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHKLFD
CCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
SPKDKFLWDVGHQSYVHKILTGRAKEFGTLRQYQGLCGFPKRCESEHDVWETGHSSTSLS
CCCHHHEECCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHCCCCCHHHHCCCCCCHHH
AAMGMALARDLKKTKEYVIPIIGDGALTGGMALEALNHIGHEKTDMIVILNDNEMSIAPN
HHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCC
VGALHNVLGRLRTAGKYHWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGVFFE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHGTGP
HCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCC
YKIESGDFVKPKEVAPAWSAVVSETVLKLARTDERIVAITPAMPVGSKLEKFQKEFPDRM
EEECCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCHHH
IDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAYDQVVHDICRQNLNVFIGIDRSGL
HHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
VGADGETHQGVFDISFLRHLPNMVIMMPKDENEGQHLVYTAMQYEDGPIALRYARGNGLG
CCCCCCCCCCEEHHHHHHHCCCEEEEECCCCCCCCEEEEEEEEECCCCEEEEEECCCCCE
VHMDEELKAIPIGSWETLKEGTQAAILTFGTTIPMAMEAAERLEKAGVSVKVVNARFIKP
EEECCCCCEECCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECHHHCCC
MDEAYLHDLLGKNIPILTIEEACLIGGFGTGVVEFASENGYHSALVERMGIPDRFIEHGS
HHHHHHHHHHCCCCCEEEECCHHEECCCCCCHHHHCCCCCHHHHHHHHHCCCHHHHCCCH
VTKLLEEIGLTTDAVVDRIHTMIPSKQKRA
HHHHHHHHCCCHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA