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The map label for this gene is prs

Identifier: 49183084

GI number: 49183084

Start: 52538

End: 53491

Strand: Direct

Name: prs

Synonym: BAS0049

Alternate gene names: 49183084

Gene position: 52538-53491 (Clockwise)

Preceding gene: 49183083

Following gene: 49183085

Centisome position: 1.0

GC content: 37.21

Gene sequence:

>954_bases
ATGTCGACTCAATATCTAAATTCTAATTTGAAAGTATTCTCTTTAAACTCTAATAAGGAACTTGCTGAGCAAATTGCAAA
GCACATTGGAGTAGGACTAGGAAAATGTTCTGTTGATCGTTTTAGTGATGGAGAAGTTCAAATTAACATTGAAGAAAGTA
TCCGTGGTTGCGATGTATTCATTATTCAATCTACAAGCTTCCCAGTAAACGAACATATCATGGAATTACTTATTATGATC
GATGCATTAAAGCGTGCATCTGCAAAAACAATTAATATTGTTATTCCTTACTATGGTTATGCGCGTCAAGACCGTAAAGC
GCGTTCTCGTGAACCAATTACATCGAAACTTGTAGCAAACTTGCTTGAAACAGCAGGTGCAACCCGTGTAATCACTCTAG
ATTTACATGCTCCACAAATTCAAGGGTTCTTTGATATCCCAATTGACCACCTAATGGGTGTACCGATTCTTTCAGATTAC
TTTGAAACAAAAGGTCTTAAAGATATCGTAATCGTGTCACCTGACCACGGTGGAGTAACTCGTGCTAGAAAAATGGCAGA
TCGCCTAAAAGCACCAATCGCTATTATTGATAAGCGTCGTCCTCGTCCGAACGTATCTGAGGTAATGAACATTATCGGTA
ATATTGAAGGTAAAACAGCAATTTTAATTGATGACATCATTGATACAGCTGGTACAATTACATTAGCAGCAAACGCTCTT
GTTGAGAACGGTGCTTCTGAAGTATATGCTTGCTGTACACACCCAGTATTATCTGGTCCAGCAATTGAGCGTATCCAAAA
CTCAAATATTAAAGAGTTAGTTGTAACGAACTCTATCGTATTACCAGAAGAGAAGAAAATTGACAAAGTACATGAACTTT
CAGTTGCTCCACTAATCGGAGAAGCAATCATTCGTGTATACGAAGAAGAATCTGTAAGTGTATTATTCAATTAA

Upstream 100 bases:

>100_bases
AAAAGCATTATCTGTAGCACGTGCACGTCAAGTTAACAAAGAAGACTATGTTGATCAATTGCTGAATAAGAAAAAATCAT
AATGTGGAGGGTTAATCTAG

Downstream 100 bases:

>100_bases
TTGGATAGAATGAGACGTAACCAAGATTGGTTACGTCTTTTCGTATCGAAAAAAGAAAGTAGTGGTACAAGAATGAAATT
GATAGTAGGACTTGGGAACC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSTQYLNSNLKVFSLNSNKELAEQIAKHIGVGLGKCSVDRFSDGEVQINIEESIRGCDVFIIQSTSFPVNEHIMELLIMI
DALKRASAKTINIVIPYYGYARQDRKARSREPITSKLVANLLETAGATRVITLDLHAPQIQGFFDIPIDHLMGVPILSDY
FETKGLKDIVIVSPDHGGVTRARKMADRLKAPIAIIDKRRPRPNVSEVMNIIGNIEGKTAILIDDIIDTAGTITLAANAL
VENGASEVYACCTHPVLSGPAIERIQNSNIKELVVTNSIVLPEEKKIDKVHELSVAPLIGEAIIRVYEEESVSVLFN

Sequences:

>Translated_317_residues
MSTQYLNSNLKVFSLNSNKELAEQIAKHIGVGLGKCSVDRFSDGEVQINIEESIRGCDVFIIQSTSFPVNEHIMELLIMI
DALKRASAKTINIVIPYYGYARQDRKARSREPITSKLVANLLETAGATRVITLDLHAPQIQGFFDIPIDHLMGVPILSDY
FETKGLKDIVIVSPDHGGVTRARKMADRLKAPIAIIDKRRPRPNVSEVMNIIGNIEGKTAILIDDIIDTAGTITLAANAL
VENGASEVYACCTHPVLSGPAIERIQNSNIKELVVTNSIVLPEEKKIDKVHELSVAPLIGEAIIRVYEEESVSVLFN
>Mature_316_residues
STQYLNSNLKVFSLNSNKELAEQIAKHIGVGLGKCSVDRFSDGEVQINIEESIRGCDVFIIQSTSFPVNEHIMELLIMID
ALKRASAKTINIVIPYYGYARQDRKARSREPITSKLVANLLETAGATRVITLDLHAPQIQGFFDIPIDHLMGVPILSDYF
ETKGLKDIVIVSPDHGGVTRARKMADRLKAPIAIIDKRRPRPNVSEVMNIIGNIEGKTAILIDDIIDTAGTITLAANALV
ENGASEVYACCTHPVLSGPAIERIQNSNIKELVVTNSIVLPEEKKIDKVHELSVAPLIGEAIIRVYEEESVSVLFN

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family

Homologues:

Organism=Homo sapiens, GI4506127, Length=314, Percent_Identity=45.859872611465, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI4506129, Length=314, Percent_Identity=45.5414012738853, Blast_Score=278, Evalue=6e-75,
Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=44.9044585987261, Blast_Score=274, Evalue=9e-74,
Organism=Homo sapiens, GI84875539, Length=317, Percent_Identity=45.1104100946372, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=38.8405797101449, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI194018537, Length=345, Percent_Identity=36.5217391304348, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI310128524, Length=136, Percent_Identity=33.8235294117647, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310115209, Length=136, Percent_Identity=33.8235294117647, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310118259, Length=136, Percent_Identity=33.8235294117647, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310119946, Length=136, Percent_Identity=33.8235294117647, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=51.4469453376206, Blast_Score=320, Evalue=7e-89,
Organism=Caenorhabditis elegans, GI25149168, Length=312, Percent_Identity=47.4358974358974, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17554702, Length=312, Percent_Identity=47.4358974358974, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71989924, Length=312, Percent_Identity=47.4358974358974, Blast_Score=284, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=47.2491909385113, Blast_Score=281, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17570245, Length=340, Percent_Identity=34.1176470588235, Blast_Score=195, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=45.5128205128205, Blast_Score=266, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6319403, Length=313, Percent_Identity=43.4504792332268, Blast_Score=259, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6321776, Length=314, Percent_Identity=45.859872611465, Blast_Score=255, Evalue=7e-69,
Organism=Saccharomyces cerevisiae, GI6322667, Length=201, Percent_Identity=39.8009950248756, Blast_Score=155, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6324511, Length=270, Percent_Identity=34.4444444444444, Blast_Score=149, Evalue=7e-37,
Organism=Drosophila melanogaster, GI21355239, Length=314, Percent_Identity=47.1337579617834, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI45551540, Length=337, Percent_Identity=44.213649851632, Blast_Score=267, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=34.9295774647887, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=34.9295774647887, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=34.9295774647887, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=34.9295774647887, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24651462, Length=374, Percent_Identity=33.9572192513369, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24651464, Length=374, Percent_Identity=33.9572192513369, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI45552010, Length=374, Percent_Identity=33.9572192513369, Blast_Score=191, Evalue=6e-49,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KPRS_BACAN (Q81VZ0)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_842618.1
- RefSeq:   YP_016652.1
- RefSeq:   YP_026336.1
- ProteinModelPortal:   Q81VZ0
- SMR:   Q81VZ0
- EnsemblBacteria:   EBBACT00000011646
- EnsemblBacteria:   EBBACT00000017210
- EnsemblBacteria:   EBBACT00000022143
- GeneID:   1084386
- GeneID:   2816256
- GeneID:   2851335
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_0049
- KEGG:   bar:GBAA_0049
- KEGG:   bat:BAS0049
- TIGR:   BA_0049
- TIGR:   GBAA_0049
- GeneTree:   EBGT00050000003045
- HOGENOM:   HBG519284
- OMA:   CATHAVF
- ProtClustDB:   PRK01259
- BioCyc:   BANT260799:BAS0049-MONOMER
- BioCyc:   BANT261594:GBAA0049-MONOMER
- BRENDA:   2.7.6.1
- GO:   GO:0005737
- HAMAP:   MF_00583_B
- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01251

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.7.6.1

Molecular weight: Translated: 34837; Mature: 34706

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00114 PRPP_SYNTHASE; PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQYLNSNLKVFSLNSNKELAEQIAKHIGVGLGKCSVDRFSDGEVQINIEESIRGCDVF
CCCCEECCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHCCCCCEEE
IIQSTSFPVNEHIMELLIMIDALKRASAKTINIVIPYYGYARQDRKARSREPITSKLVAN
EEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHHHHH
LLETAGATRVITLDLHAPQIQGFFDIPIDHLMGVPILSDYFETKGLKDIVIVSPDHGGVT
HHHHCCCCEEEEEEECCCCCCCEEECCHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCHH
RARKMADRLKAPIAIIDKRRPRPNVSEVMNIIGNIEGKTAILIDDIIDTAGTITLAANAL
HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEHHHCCCCCEEEEHHHH
VENGASEVYACCTHPVLSGPAIERIQNSNIKELVVTNSIVLPEEKKIDKVHELSVAPLIG
HHCCCHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEECCEECCCHHHHHHHHHHHHHHHHH
EAIIRVYEEESVSVLFN
HHHHHHHCCCCEEEEEC
>Mature Secondary Structure 
STQYLNSNLKVFSLNSNKELAEQIAKHIGVGLGKCSVDRFSDGEVQINIEESIRGCDVF
CCCEECCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHCCCCCEEE
IIQSTSFPVNEHIMELLIMIDALKRASAKTINIVIPYYGYARQDRKARSREPITSKLVAN
EEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHHHHH
LLETAGATRVITLDLHAPQIQGFFDIPIDHLMGVPILSDYFETKGLKDIVIVSPDHGGVT
HHHHCCCCEEEEEEECCCCCCCEEECCHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCHH
RARKMADRLKAPIAIIDKRRPRPNVSEVMNIIGNIEGKTAILIDDIIDTAGTITLAANAL
HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEHHHCCCCCEEEEHHHH
VENGASEVYACCTHPVLSGPAIERIQNSNIKELVVTNSIVLPEEKKIDKVHELSVAPLIG
HHCCCHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEECCEECCCHHHHHHHHHHHHHHHHH
EAIIRVYEEESVSVLFN
HHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629