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The map label for this gene is glmU

Identifier: 49183083

GI number: 49183083

Start: 51140

End: 52519

Strand: Direct

Name: glmU

Synonym: BAS0048

Alternate gene names: 49183083

Gene position: 51140-52519 (Clockwise)

Preceding gene: 161611187

Following gene: 49183084

Centisome position: 0.98

GC content: 38.33

Gene sequence:

>1380_bases
ATGTCAAACAGATTTGCAGTGATTCTAGCTGCAGGTAAAGGCACACGTATGAAGTCTAAGCTATACAAAGTGCTTCATCC
TGTATGTGGAAAACCTATGGTACAACATGTTGTCGATCAAGTATCTCAATTAGGGTTGCAGAAACTTGTAACAGTCGTAG
GACATGGTGCTGAAATGGTACAAGAACAGCTAGGAAACGTAAGTGAGTTTGCATTACAAGCAGAACAACTTGGTACAGCG
CATGCTGTAGATCAAGCTGCAGGTGTACTTGCAAATGAAGAAGGAACAACTTTAGTTATTTGTGGTGATACGCCGCTAAT
AACTGCTGAAACGATGGAAGCATTACTTCAGCAACATAAAGAAGCAGGGGCAATGGCAACGGTGTTAACAGCTTACATAG
AAGAACCTGCTGGATATGGTCGTATCGTTCGTAATGAGAATGGTCATGTTGAAAAGATTGTTGAGCATAAGGATGCAAAT
GAGAAAGAATTAGCTATTAAAGAAATCAATACAGGTACGTATTGTTTTGATAATAAAGCTTTATTCGCTTCACTTTCTAA
GGTTTCAAATGATAACGTACAAGGTGAATATTACCTGCCAGATGTTATTGAGATTTTAAAAAATGAAGGTCATATTGTAT
CGGCTTATCAAACAGAGCACTTCGATGAAACGTTAGGTGTTAACGACAGAGTCGCTCTATCGCAAGCGGAAATTATTATG
AAAAACCGTATCAACCGAAAGAACATGGTAAATGGTGTTACAATTATTGATCCAAGTAACACGTATATTTCTGCTGATGC
AATTATCGGTAGTGATACAGTTCTTCATCCAGGAACAATTATTGAGGGGAACACTGTAATTGGTTCTGATTGTGAAATTG
GACCGCATACAGTAATTCGCGATAGTGAAATTGGAGATCGTACGACAATTCGTCAATCTACTGTACATGATAGTAAGCTT
GGTACAGAAGTATCGGTTGGTCCATTTGCACATATTCGCCCAGATTCAGTTATTGGAGATGAAGTACGCGTTGGAAACTT
CGTGGAAATCAAAAAAACTGTTTTTGGTAATAGAAGTAAAGCTTCACACTTAAGTTATATCGGGGATGCGCAAGTTGGAG
AAGACGTGAATCTTGGTTGTGGTTCAATTACGGTGAACTATGACGGTAAGAATAAATTCAAAACTGTGATTGGTAACGGG
GTATTTATTGGATGTAATTCAAACCTTGTTGCTCCTGTAACAGTTGAAGATGGTGCTTATGTGGCAGCAGGCTCTACAAT
TACAGAGAATGTTCCATCAAAAGCATTATCTGTAGCACGTGCACGTCAAGTTAACAAAGAAGACTATGTTGATCAATTGC
TGAATAAGAAAAAATCATAA

Upstream 100 bases:

>100_bases
AATTATGGTAAAATTTAATAGTTAAAATGTGTTTCTTGAAATATATGATGATTTAGGATAATATCGTTAATGGATAAATA
GGTTGCGATGGAGGGTCTAT

Downstream 100 bases:

>100_bases
TGTGGAGGGTTAATCTAGATGTCGACTCAATATCTAAATTCTAATTTGAAAGTATTCTCTTTAAACTCTAATAAGGAACT
TGCTGAGCAAATTGCAAAGC

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEMVQEQLGNVSEFALQAEQLGTA
HAVDQAAGVLANEEGTTLVICGDTPLITAETMEALLQQHKEAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDAN
EKELAIKEINTGTYCFDNKALFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEHFDETLGVNDRVALSQAEIIM
KNRINRKNMVNGVTIIDPSNTYISADAIIGSDTVLHPGTIIEGNTVIGSDCEIGPHTVIRDSEIGDRTTIRQSTVHDSKL
GTEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTVFGNRSKASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFKTVIGNG
VFIGCNSNLVAPVTVEDGAYVAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS

Sequences:

>Translated_459_residues
MSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEMVQEQLGNVSEFALQAEQLGTA
HAVDQAAGVLANEEGTTLVICGDTPLITAETMEALLQQHKEAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDAN
EKELAIKEINTGTYCFDNKALFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEHFDETLGVNDRVALSQAEIIM
KNRINRKNMVNGVTIIDPSNTYISADAIIGSDTVLHPGTIIEGNTVIGSDCEIGPHTVIRDSEIGDRTTIRQSTVHDSKL
GTEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTVFGNRSKASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFKTVIGNG
VFIGCNSNLVAPVTVEDGAYVAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS
>Mature_458_residues
SNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEMVQEQLGNVSEFALQAEQLGTAH
AVDQAAGVLANEEGTTLVICGDTPLITAETMEALLQQHKEAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDANE
KELAIKEINTGTYCFDNKALFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEHFDETLGVNDRVALSQAEIIMK
NRINRKNMVNGVTIIDPSNTYISADAIIGSDTVLHPGTIIEGNTVIGSDCEIGPHTVIRDSEIGDRTTIRQSTVHDSKLG
TEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTVFGNRSKASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFKTVIGNGV
FIGCNSNLVAPVTVEDGAYVAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Homo sapiens, GI11761621, Length=359, Percent_Identity=23.9554317548747, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI11761619, Length=340, Percent_Identity=24.1176470588235, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790168, Length=445, Percent_Identity=44.4943820224719, Blast_Score=367, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI133931050, Length=357, Percent_Identity=25.2100840336134, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=363, Percent_Identity=25.068870523416, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21355443, Length=362, Percent_Identity=23.7569060773481, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24644084, Length=362, Percent_Identity=23.7569060773481, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_BACAA (C3P9J5)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002864701.1
- ProteinModelPortal:   C3P9J5
- SMR:   C3P9J5
- EnsemblBacteria:   EBBACT00000128314
- GeneID:   7853493
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_0059
- GeneTree:   EBGT00050000000560
- ProtClustDB:   PRK14354
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00132 Hexapep; PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 49424; Mature: 49292

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 363-363 BINDING 73-73 BINDING 140-140 BINDING 155-155 BINDING 170-170 BINDING 387-387 BINDING 423-423 BINDING 440-440

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEMV
CCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QEQLGNVSEFALQAEQLGTAHAVDQAAGVLANEEGTTLVICGDTPLITAETMEALLQQHK
HHHHCCHHHHHHHHHHCCCHHHHHHHHCEEECCCCCEEEEECCCCEEEHHHHHHHHHHHH
EAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDANEKELAIKEINTGTYCFDNKA
HHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHCCCCCHHEEEEECCCCEEEECCHH
LFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEHFDETLGVNDRVALSQAEIIM
HHHHHHHHCCCCCCCEEECHHHHHHHHCCCCEEEEEEHHCHHHHCCCCCCEEHHHHHHHH
KNRINRKNMVNGVTIIDPSNTYISADAIIGSDTVLHPGTIIEGNTVIGSDCEIGPHTVIR
HHCCCCCHHCCCEEEECCCCCEEEECEEECCCCEECCCEEEECCEEECCCCCCCCCEEEE
DSEIGDRTTIRQSTVHDSKLGTEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTVFGNRSK
CCCCCCCHHHHHHHCCHHHCCCEEECCCCCCCCCCCCCCCCEECCCEEEEHHHHCCCCCC
ASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFKTVIGNGVFIGCNSNLVAPVTVEDGAY
CCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEECCCEEEEECCCEEEEEEECCCCE
VAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS
EEECCCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEMV
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QEQLGNVSEFALQAEQLGTAHAVDQAAGVLANEEGTTLVICGDTPLITAETMEALLQQHK
HHHHCCHHHHHHHHHHCCCHHHHHHHHCEEECCCCCEEEEECCCCEEEHHHHHHHHHHHH
EAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDANEKELAIKEINTGTYCFDNKA
HHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHCCCCCHHEEEEECCCCEEEECCHH
LFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEHFDETLGVNDRVALSQAEIIM
HHHHHHHHCCCCCCCEEECHHHHHHHHCCCCEEEEEEHHCHHHHCCCCCCEEHHHHHHHH
KNRINRKNMVNGVTIIDPSNTYISADAIIGSDTVLHPGTIIEGNTVIGSDCEIGPHTVIR
HHCCCCCHHCCCEEEECCCCCEEEECEEECCCCEECCCEEEECCEEECCCCCCCCCEEEE
DSEIGDRTTIRQSTVHDSKLGTEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTVFGNRSK
CCCCCCCHHHHHHHCCHHHCCCEEECCCCCCCCCCCCCCCCEECCCEEEEHHHHCCCCCC
ASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFKTVIGNGVFIGCNSNLVAPVTVEDGAY
CCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEECCCEEEEECCCEEEEEEECCCCE
VAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS
EEECCCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA